{"id":18898,"date":"2021-09-03T09:57:03","date_gmt":"2021-09-03T07:57:03","guid":{"rendered":"https:\/\/idibell.cat\/?p=18898"},"modified":"2021-09-03T10:15:20","modified_gmt":"2021-09-03T08:15:20","slug":"el-trasplantament-de-pulmo-es-efectiu-per-als-malalts-de-fibrosi-pulmonar-amb-telomers-curts","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2021\/09\/el-trasplantament-de-pulmo-es-efectiu-per-als-malalts-de-fibrosi-pulmonar-amb-telomers-curts\/","title":{"rendered":"El trasplantament de pulm\u00f3 \u00e9s efectiu per als malalts de fibrosi pulmonar amb tel\u00f2mers curts"},"content":{"rendered":"<p>Un estudi liderat per la Unitat Funcional d\u2019Interstici Pulmonar (UFIP) del <a href=\"https:\/\/bellvitgehospital.cat\/ca\/especialitats\/pneumologia\">Servei de Pneumologia de l\u2019Hospital Universitari de Bellvitge<\/a> i el <a href=\"https:\/\/idibell.cat\/es\/investigacion\/area-de-medicina-traslacional\/programa-de-enfermedades-cardiovasculares-respiratorias-sistemicas-y-de-envejecimiento-celular\/neumologia\/\">grup de recerca en Pneumologia de l\u2019IDIBELL<\/a>, en estreta col\u00b7laboraci\u00f3 amb el Programa de Trasplantament Pulmonar del <a href=\"https:\/\/www.vallhebron.com\/es\/especialidades\/neumologia\">Servei de Pneumologia de l\u2019Hospital Universitari Vall d\u2019Hebron<\/a>, i amb el Servei de Telomeropaties de l\u2019<a href=\"https:\/\/www.iib.uam.es\/portal\/web\/iibm\/home\">Instituto de Investigaciones Biom\u00e9dicas Alberto Sols<\/a> i la Divisi\u00f3 de Gen\u00f2mica de l\u2019<a href=\"https:\/\/www.iter.es\/\">Instituto Tecnol\u00f3gico y de Energ\u00edas Renovables (ITER)<\/a>, ha determinat que el trasplantament de pulm\u00f3 tamb\u00e9 millora la superviv\u00e8ncia i la qualitat de vida d\u2019aquells pacients de fibrosi pulmonar progressiva que presenten tel\u00f2mers curts. L\u2019estudi s\u2019ha publicat al darrer n\u00famero de la prestigiosa revista cient\u00edfica <a href=\"https:\/\/www.frontiersin.org\/article\/10.3389\/fmed.2021.695919\"><em>Frontiers in Medicine<\/em><\/a>.<\/p>\n<p>&nbsp;<\/p>\n<p>En la fibrosi pulmonar, determinades c\u00e8l\u00b7lules dels teixits dels pulmons perden la capacitat de regenerar-se i reparar. Se sap que, en alguns casos, aquesta incapacitat de regenerar-se prov\u00e9 en part de mutacions que fan que els tel\u00f2mers \u2013sequ\u0308\u00e8ncies d\u2019ADN situades a l\u2019extrem dels cromosomes\u2013 siguin cr\u00edticament curts o disfuncionals.<\/p>\n<p>&nbsp;<\/p>\n<p>En moltes ocasions els pacients amb fibrosi pulmonar amb disfunci\u00f3 telom\u00e8rica empitjoren malgrat el tractament, pel que requereixen trasplantament de pulm\u00f3 com a la \u00fanica alternativa efica\u00e7 per millorar la seva superviv\u00e8ncia. Tanmateix, en els darrers anys alguns estudis han suggerit que el trasplantament de pulm\u00f3 t\u00e9 una mala evoluci\u00f3 en pacients amb disfunci\u00f3 als tel\u00f2mers, i alguns centres trasplantadors d\u2019altres pa\u00efsos havien plantejat aquesta disfunci\u00f3 com a contraindicaci\u00f3 relativa.<\/p>\n<p>&nbsp;<\/p>\n<p>Per primera vegada, aquest estudi ha fet un seguiment prospectiu detallat de la mortalitat, la morbilitat i la qualitat de vida d\u2019aquests malalts trasplantats, comparant els resultats dels que patien disfunci\u00f3 telom\u00e8rica amb els dels que no la patien. A m\u00e9s, l\u2019estudi identifica que fins la meitat de pacients amb fibrosi pulmonar que requereixen trasplantament presenta tel\u00f2mers curts i mutacions telom\u00e8riques.<\/p>\n<p>&nbsp;<\/p>\n<p>El treball s\u2019ha realitzat amb pacients de la Unitat Funcional d\u2019Interstici Pulmonar de l\u2019Hospital Universitari de Bellvitge que havien estat testats per tel\u00f2mers al diagn\u00f2stic i que van requerir un trasplantament de pulm\u00f3 a l\u2019Hospital Universitari Vall d\u2019Hebron entre el juny de 2013 i l\u2019octubre de 2018.<\/p>\n<p>&nbsp;<\/p>\n<p>Els resultats dels estudis i el seguiment han indicat que la superviv\u00e8ncia a l\u2019any despr\u00e9s del trasplantament va ser superior al 80% independentment de la disfunci\u00f3 dels tel\u00f2mers, i que hi va haver una notable millora en la qualitat de vida tant en un grup com en l\u2019altre.<\/p>\n<p>&nbsp;<\/p>\n<blockquote><p>S\u00ed que es van detectar difer\u00e8ncies en la morbiditat, ja que els pacients amb tel\u00f2mers curts van necessitar m\u00e9s sovint circulaci\u00f3 extracorp\u00f2ria, van patir m\u00e9s complicacions hematol\u00f2giques precoces, i van tenir m\u00e9s estades a l\u2019UCI i ingressos hospitalaris de llarga durada, per\u00f2 s\u00f3n complicacions previsibles i tractables.<\/p><\/blockquote>\n<p>&nbsp;<\/p>\n<p>Els centres participants a l\u2019estudi han estat l\u2019Hospital Universitari de Bellvitge-IDIBELL, l\u2019Hospital Universitari Vall d\u2019Hebron, l\u2019Instituto de Investigaci\u00f3n Biom\u00e9dica CSIC\/UAM\u2013IdIPAZ de Madrid, l\u2019Instituto Tecnol\u00f3gico y de Energ\u00edas Renovables de Santa Cruz de Tenerife. Els quatre grups de recerca participants formen part de la xarxa nacional de recerca CIBER (CIBERES; Dra. M. Molina-IDIBELL, Dr. A. Roman-HUVH, Dr. C. Flores-ITER, i CIBERES; Dra. R. Perona-IIB CSIC\/UAM-IdIPAZ).<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><em>L\u2019Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00e9s un centre de recerca en biomedicina creat l\u2019any 2004. Est\u00e0 participat per l&#8217;Hospital Universitari de Bellvitge i l\u2019Hospital de Viladecans de l&#8217;Institut Catal\u00e0 de la Salut, l&#8217;Institut Catal\u00e0 d&#8217;Oncologia, la Universitat de Barcelona i l\u2019Ajuntament de l\u2019Hospitalet de Llobregat.<\/em><\/p>\n<p><em>L\u2019IDIBELL \u00e9s membre del Campus d&#8217;Excel\u00b7l\u00e8ncia Internacional de la Universitat de Barcelona HUBc i forma part de la instituci\u00f3 CERCA de la Generalitat de Catalunya. L&#8217;any 2009 es va convertir en un dels cinc primers centres d\u2019investigaci\u00f3 espanyols acreditats com a institut d\u2019investigaci\u00f3 sanit\u00e0ria per l\u2019Instituto de Salud Carlos III. A m\u00e9s, forma part del programa \u201cHR Excellence in Research\u201d de la Uni\u00f3 Europea i \u00e9s membre de EATRIS i REGIC. Des de l\u2019any 2018, l\u2019IDIBELL \u00e9s un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>L\u2019estudi mostra que la superviv\u00e8ncia a l\u2019any despr\u00e9s del trasplantament \u00e9s superior al 80% independentment de si hi havia una disfunci\u00f3 dels tel\u00f2mers.<\/p>\n","protected":false},"author":8,"featured_media":18900,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[334,466,467],"tags":[],"class_list":["post-18898","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicina-translacional","category-p-de-malalties-cardiovasculars-respiratories-sistemiques-i-denvelliment-cellular","category-pneumologia"],"publishpress_future_action":{"enabled":false,"date":"2024-12-29 20:27:05","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/18898","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=18898"}],"version-history":[{"count":4,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/18898\/revisions"}],"predecessor-version":[{"id":18904,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/18898\/revisions\/18904"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/18900"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=18898"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=18898"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=18898"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}