{"id":18844,"date":"2021-08-31T12:24:19","date_gmt":"2021-08-31T10:24:19","guid":{"rendered":"https:\/\/idibell.cat\/?p=18844"},"modified":"2021-08-31T12:25:20","modified_gmt":"2021-08-31T10:25:20","slug":"envelliment-del-ninxol-de-cellules-mare-hematopoetiques","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2021\/08\/envelliment-del-ninxol-de-cellules-mare-hematopoetiques\/","title":{"rendered":"Envelliment del n\u00ednxol de c\u00e8l\u00b7lules mare hematopo\u00e8tiques"},"content":{"rendered":"<p>Carolina Florian, presentar\u00e0 dem\u00e0 els \u00faltims aven\u00e7os sobre l&#8217;envelliment del n\u00ednxol de c\u00e8l\u00b7lules mare hematopo\u00e8tiques en la confer\u00e8ncia anual de recerca sobre l&#8217;envelliment i descobriment de f\u00e0rmacs m\u00e9s gran de m\u00f3n (8a ARDD). Actualment, \u00e9s la cap del grup de Envelliment de C\u00e8l\u00b7lules Mare de l&#8217;Institut d&#8217;Investigacions Biom\u00e8diques de Bellvitge (<a href=\"https:\/\/idibell.cat\/en\/research\/area-medicina-regenerativa-english\/regenerative-medicine-program\/stem-cell-aging\/\">IDIBELL<\/a>) i del Programa de Medicina Regenerativa de Catalunya (<a href=\"https:\/\/p-cmrc.cat\/research\/florian-group\/\">P-CMR [C]<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<p>A l\u2019ARDD, els l\u00edders en el camp de l&#8217;envelliment, la longevitat i el descobriment de f\u00e0rmacs descriuran els \u00faltims aven\u00e7os en les bases moleculars, cel\u00b7lulars i org\u00e0niques de l&#8217;envelliment i la recerca d&#8217;intervencions farmacol\u00f2giques. A m\u00e9s, la trobada comptar\u00e0 amb l\u00edders d&#8217;opini\u00f3 en intel\u00b7lig\u00e8ncia artificial per discutir els \u00faltims aven\u00e7os d&#8217;aquesta tecnologia en el sector biofarmac\u00e8utic i com es poden aplicar a aquestes investigacions.<\/p>\n<p>&nbsp;<\/p>\n<p>En particular, les activitats d&#8217;aquest any inclouen un taller espec\u00edficament per a metges on es descriur\u00e0 el coneixement d&#8217;avantguarda de les intervencions cl\u00edniques per a una longevitat saludable. L\u2019ARRD t\u00e9 la intenci\u00f3 d&#8217;unir la investigaci\u00f3 cl\u00ednica, acad\u00e8mica i comercial i fomentar col\u00b7laboracions que resultin en solucions pr\u00e0ctiques a un dels problemes m\u00e9s desafiadors de la humanitat: l&#8217;envelliment. Les actes de la confer\u00e8ncia de la ARDD es publiquen comunament en revistes cient\u00edfiques i les xerrades estan disponibles a <a href=\"http:\/\/www.agingpharma.org\/\">www.agingpharma.org<\/a>.<\/p>\n<p>&nbsp;<\/p>\n<p>Florian, doctorada de la Universitat de Mil\u00e0, va realitzar una estan\u00e7a postdoctoral a l&#8217;Institut de Medicina Molecular de la Universitat d&#8217;Ulm de 2009 a 2015. Posteriorment, va rebre una Beca Emmy Noether de la Fundaci\u00f3 d&#8217;Investigaci\u00f3 Alemanya dedicada a investigadors joves excepcionals, la qual va permetre-li establir el seu equip d&#8217;investigaci\u00f3 independent sobre l&#8217;epigen\u00e8tica de l&#8217;envelliment de les c\u00e8l\u00b7lules mare.<\/p>\n<p>&nbsp;<\/p>\n<p>La seva investigaci\u00f3 en els \u00faltims anys ha desafiat el concepte que l&#8217;envelliment \u00e9s un proc\u00e9s irreversible i va demostrar que \u00e9s possible atacar farmacol\u00f2gicament l&#8217;alteraci\u00f3 dependent de l&#8217;envelliment de la polaritat epigen\u00e8tica de les c\u00e8l\u00b7lules mare i rejovenir funcionalment i en ratolins les c\u00e8l\u00b7lules mare de la sang envellides.<\/p>\n<p>&nbsp;<\/p>\n<p>Les c\u00e8l\u00b7lules mare som\u00e0tiques s\u00f3n fonamentals per a la home\u00f2stasi i la regeneraci\u00f3 dels teixits. El seu declivi funcional dependent de l&#8217;edat constitueix un segell distintiu del desgast dels teixits amb l&#8217;envelliment, el que finalment limita la vida \u00fatil i la salut. El treball de la Dra. Florian est\u00e0 enfocat a augmentar encara m\u00e9s la comprensi\u00f3 de les alteracions que afecten les c\u00e8l\u00b7lules mare som\u00e0tiques envellides i est\u00e0 investigant canvis en l&#8217;arquitectura epigen\u00e8tica que impulsen l&#8217;envelliment de les c\u00e8l\u00b7lules mare, per millorar el desgast dels teixits amb l&#8217;edat o fins i tot per prevenir malalties associades a l&#8217;envelliment.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>M. Carolina Florian, cap del grup d\u2019Envelliment de C\u00e8l\u00b7lules Mare, presentar\u00e0 una nova investigaci\u00f3 sobre la biologia de l&#8217;envelliment en la confer\u00e8ncia d&#8217;investigaci\u00f3 m\u00e9s gran de m\u00f3n sobre aquest tema<\/p>\n","protected":false},"author":8,"featured_media":18845,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[484,349,482],"tags":[],"class_list":["post-18844","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-envelliment-de-cellules-mare","category-medicina-regenerativa","category-p-de-medicina-regenerativa"],"publishpress_future_action":{"enabled":false,"date":"2025-03-03 03:36:55","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/18844","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=18844"}],"version-history":[{"count":4,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/18844\/revisions"}],"predecessor-version":[{"id":18849,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/18844\/revisions\/18849"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/18845"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=18844"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=18844"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=18844"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}