{"id":18738,"date":"2021-08-11T11:54:12","date_gmt":"2021-08-11T09:54:12","guid":{"rendered":"https:\/\/idibell.cat\/?p=18738"},"modified":"2021-08-12T09:38:05","modified_gmt":"2021-08-12T07:38:05","slug":"limpuls-de-les-cellules-beta-pancreatiques-en-ratolins-obre-la-porta-a-futurs-tractaments-per-a-la-diabetis","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2021\/08\/limpuls-de-les-cellules-beta-pancreatiques-en-ratolins-obre-la-porta-a-futurs-tractaments-per-a-la-diabetis\/","title":{"rendered":"L&#8217;impuls de les c\u00e8l\u00b7lules beta pancre\u00e0tiques en ratolins obre la porta a futurs tractaments per a la diabetis"},"content":{"rendered":"<p>Un equip d&#8217;investigaci\u00f3 ha impulsat amb \u00e8xit la formaci\u00f3 de c\u00e8l\u00b7lules beta pancre\u00e0tiques en ratolins. Els resultats han estat possibles gr\u00e0cies a la identificaci\u00f3 d&#8217;un gen que \u00e9s fonamental per a la regulaci\u00f3 del nombre de c\u00e8l\u00b7lules productores d&#8217;insulina durant el desenvolupament embrionari del p\u00e0ncrees. Les troballes, publicades avui a la revista <em><a href=\"https:\/\/doi.org\/10.1101\/gad.348501.121\">Genes and Development<\/a><\/em>, poden impulsar futurs tractaments de la malaltia.<\/p>\n<p>L&#8217;equip d&#8217;investigaci\u00f3, de l&#8217;Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), el Centre de Regulaci\u00f3 Gen\u00f2mica (CRG) i la Universitat de Barcelona, han estudiat el gen del factor de transcripci\u00f3 silenciador RE1, tamb\u00e9 conegut com REST per les sigles en angl\u00e8s, usant models de ratol\u00ed i peix zebra. Tamb\u00e9 han estudiat organoides pancre\u00e0tics humans. L&#8217;equip sospitava que REST tenia un paper decisiu en el desenvolupament del p\u00e0ncrees, per\u00f2 els estudis fins ara no havien estat concloents.<\/p>\n<p>L&#8217;equip ha descobert que REST s&#8217;expressa en les c\u00e8l\u00b7lules pancre\u00e0tiques embrion\u00e0ries que encara no s&#8217;han diferenciat, tamb\u00e9 conegudes com a c\u00e8l\u00b7lules progenitores, aix\u00ed com en les c\u00e8l\u00b7lules adultes que formen el conducte pancre\u00e0tic. Els investigadors no han detectat rastres de l&#8217;activitat de REST en les c\u00e8l\u00b7lules beta adultes que produeixen insulina.<\/p>\n<p>&nbsp;<\/p>\n<figure id=\"attachment_18741\" aria-describedby=\"caption-attachment-18741\" style=\"width: 300px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-18741 size-medium\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2021\/08\/Image-1-Ferrer-Rovira-300x300.jpg\" alt=\"\" width=\"300\" height=\"300\" srcset=\"https:\/\/idibell.cat\/wp-content\/uploads\/2021\/08\/Image-1-Ferrer-Rovira-300x300.jpg 300w, https:\/\/idibell.cat\/wp-content\/uploads\/2021\/08\/Image-1-Ferrer-Rovira.jpg 1024w, https:\/\/idibell.cat\/wp-content\/uploads\/2021\/08\/Image-1-Ferrer-Rovira-150x150.jpg 150w, https:\/\/idibell.cat\/wp-content\/uploads\/2021\/08\/Image-1-Ferrer-Rovira-768x768.jpg 768w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-18741\" class=\"wp-caption-text\"><em>Una secci\u00f3 transversal dels illots de Langerhans, un grup de c\u00e8l\u00b7lules dins el p\u00e0ncrees que s\u00f3n responsables de la producci\u00f3 i alliberament d&#8217;hormones que regulen els nivells de glucosa. Cr\u00e8dit: Miguel Angel Mestre\/CRG.<\/em><\/figcaption><\/figure>\n<p>Els experiments amb models de ratol\u00ed han revelat que en eliminar el gen REST en l&#8217;etapa embrion\u00e0ria primerenca, abans que es formi el p\u00e0ncrees, es duplica el nombre de c\u00e8l\u00b7lules productores d&#8217;insulina. Els ratolins mantenien les c\u00e8l\u00b7lules en la seva edat adulta i tenien un pes normal. Experiments en paral\u00b7lel amb models de peix zebra van obtenir resultats similars.<\/p>\n<p>La inactivaci\u00f3 de REST no impulsava la formaci\u00f3 de c\u00e8l\u00b7lules beta despr\u00e9s de la formaci\u00f3 del p\u00e0ncrees. La inactivaci\u00f3 de REST en ratolins nounats resultava en la formaci\u00f3 de c\u00e8l\u00b7lules endocrines, per\u00f2 aquestes no es mantenien fins a l&#8217;edat adulta. La inactivaci\u00f3 de REST en organoides pancre\u00e0tics humans tampoc impulsava la formaci\u00f3 de c\u00e8l\u00b7lules beta, encara que els investigadors van detectar un increment en l&#8217;activitat de gens endocrins.<\/p>\n<p>&#8220;<em>Encara que \u00e9s important per al desenvolupament del p\u00e0ncrees, hem demostrat que REST no \u00e9s l&#8217;\u00fanic guardi\u00e0 de la diferenciaci\u00f3 endocrina. No obstant aix\u00f2, si algun dia se&#8217;ns ocorregu\u00e9s un futur c\u00f2ctel de medicaments per estimular les c\u00e8l\u00b7lules productores d&#8217;insulina al p\u00e0ncrees, sospito que els inhibidors de REST serien part de la recepta. Ara estem provant si els inhibidors de REST es poden utilitzar per estimular artificialment la formaci\u00f3 de c\u00e8l\u00b7lules beta en cultiu<\/em>&#8220;, afirma <strong>Jorge Ferrer<\/strong>, autor principal de l&#8217;estudi i cap del grup de Regulaci\u00f3 Gen\u00f2mica i Diabetis al CRG.<\/p>\n<p>Les noves ter\u00e0pies i tractaments que poden augmentar o reempla\u00e7ar la quantitat de c\u00e8l\u00b7lules beta en el p\u00e0ncrees transformarien el tractament de la diabetis, que afecta m\u00e9s de 400 milions de persones a tot el m\u00f3n. Per exemple, per a les persones amb diabetis tipus 1, l&#8217;\u00fanic tractament alternatiu a les injeccions di\u00e0ries d&#8217;insulina s\u00f3n els trasplantaments, que tenen efectes secundaris, i requereixen prendre medicaments immunosupressors. Tamb\u00e9 hi ha escassetat de donants d&#8217;\u00f2rgans. Ser capa\u00e7os d&#8217;augmentar el nombre existent de c\u00e8l\u00b7lules directament en el p\u00e0ncrees evitaria molts d&#8217;aquests reptes.<\/p>\n<p>&#8220;<em>REST se suma a una llista molt curta de supressores dominants de la diferenciaci\u00f3 endocrina durant el desenvolupament del p\u00e0ncrees<\/em>&#8220;, afirma <strong>Meritxell Rovira<\/strong>, coautora de l&#8217;estudi i investigadora amb afiliaci\u00f3 conjunta amb l&#8217;IDIBELL i la Universitat de Barcelona. &#8220;<em>Els moduladors REST probablement jugaran un paper important per a futures manipulacions per promoure l&#8217;endocrinog\u00e8nesi en sistemes de models experimentals o ter\u00e0pies de reempla\u00e7ament per a la diabetis<\/em>&#8220;.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><em>L\u2019Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00e9s un centre de recerca en biomedicina creat l\u2019any 2004. Est\u00e0 participat per l&#8217;Hospital Universitari de Bellvitge i l\u2019Hospital de Viladecans de l&#8217;Institut Catal\u00e0 de la Salut, l&#8217;Institut Catal\u00e0 d&#8217;Oncologia, la Universitat de Barcelona i l\u2019Ajuntament de l\u2019Hospitalet de Llobregat.<\/em><\/p>\n<p><em>L\u2019IDIBELL \u00e9s membre del Campus d&#8217;Excel\u00b7l\u00e8ncia Internacional de la Universitat de Barcelona HUBc i forma part de la instituci\u00f3 CERCA de la Generalitat de Catalunya. L&#8217;any 2009 es va convertir en un dels cinc primers centres d\u2019investigaci\u00f3 espanyols acreditats com a institut d\u2019investigaci\u00f3 sanit\u00e0ria per l\u2019Instituto de Salud Carlos III. A m\u00e9s, forma part del programa \u201cHR Excellence in Research\u201d de la Uni\u00f3 Europea i \u00e9s membre de EATRIS i REGIC. Des de l\u2019any 2018, l\u2019IDIBELL \u00e9s un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un equip d&#8217;investigaci\u00f3 de l&#8217;IDIBELL, el CRG i la UB ha impulsat amb \u00e8xit la formaci\u00f3 de c\u00e8l\u00b7lules beta pancre\u00e0tiques en ratolins. Els resultats han estat possibles gr\u00e0cies a la identificaci\u00f3 d&#8217;un gen que \u00e9s fonamental per a la regulaci\u00f3 del nombre de c\u00e8l\u00b7lules productores d&#8217;insulina durant el desenvolupament embrionari del p\u00e0ncrees.<\/p>\n","protected":false},"author":8,"featured_media":18739,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[349,482,489],"tags":[],"class_list":["post-18738","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicina-regenerativa","category-p-de-medicina-regenerativa","category-regeneracio-de-lpancrees-progenitors-pancreatics-i-els-seus-ninxols"],"publishpress_future_action":{"enabled":false,"date":"2024-11-24 21:15:16","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/18738","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=18738"}],"version-history":[{"count":5,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/18738\/revisions"}],"predecessor-version":[{"id":18749,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/18738\/revisions\/18749"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/18739"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=18738"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=18738"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=18738"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}