{"id":18577,"date":"2021-07-28T10:40:02","date_gmt":"2021-07-28T08:40:02","guid":{"rendered":"https:\/\/idibell.cat\/?p=18577"},"modified":"2021-07-28T11:06:42","modified_gmt":"2021-07-28T09:06:42","slug":"lempremta-immunologica-condiciona-la-resposta-al-sars-cov-2","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2021\/07\/lempremta-immunologica-condiciona-la-resposta-al-sars-cov-2\/","title":{"rendered":"L&#8217;empremta immunol\u00f2gica condiciona la resposta al SARS-CoV-2"},"content":{"rendered":"<p>Un estudi de l\u2019IDIBELL, l&#8217;Hospital de Bellvitge i la Icahn School of Medicine del Mount Sinai, a Nova York, publicat a la revista <a href=\"https:\/\/www.nature.com\/articles\/s41467-021-23977-1\"><em>Nature Communications<\/em><\/a>, ha demostrat per primera vegada que el fenomen de <strong>l&#8217;empremta immunol\u00f2gica existeix en el cas de la Covid-19<\/strong>, \u00e9s a dir, la immunitat preexistent contra altres coronavirus que influeix en una possible immunitat contra al SARS-CoV-2. Es tracta d&#8217;un fet d&#8217;especial inter\u00e8s donada l&#8217;aparici\u00f3 de noves variants de la SARS-CoV-2, a m\u00e9s de la potencial interacci\u00f3 amb la vacunaci\u00f3 de la immunitat preexistent.<\/p>\n<p>Moltes infeccions deixen una empremta immunit\u00e0ria en les persones que les pateixen. En el cas d&#8217;alguns virus aquesta mem\u00f2ria immunol\u00f2gica t\u00e9 influ\u00e8ncia i pot canviar la resposta immunol\u00f2gica quan es produeix una infecci\u00f3 posterior amb un nou virus per\u00f2 de caracter\u00edstiques semblants al primer. Aquest proc\u00e9s \u00e9s conegut com a <em>imprinting<\/em> immunol\u00f2gica i en algunes ocasions la influ\u00e8ncia pot ser protectora, per\u00f2 en d\u2019altres pot resultar perjudicial. El fenomen est\u00e0 molt ben descrit en els virus de la grip i t\u00e9 import\u00e0ncia tamb\u00e9 en les respostes immunit\u00e0ries a les vacunes.<\/p>\n<p>L&#8217;estudi col\u00b7laboratiu permet constatar que els pacients m\u00e9s greus triguen m\u00e9s temps a produir anticossos neutralitzants contra al SARS-CoV-2. M\u00e9s important fins i tot va ser observar que infeccions pr\u00e8vies d&#8217;alguns coronavirus (els betacoronavirus OC43 i HKU1, per\u00f2 no l&#8217;alphacoronavirus com 229E) deixen una mem\u00f2ria immunol\u00f2gica que condiciona la resposta d&#8217;anticossos contra la Covid-19. Aquesta influ\u00e8ncia sembla ser negativa, ja que pacients amb m\u00e9s immunitat pr\u00e8via contra els betacoronavirus OC43 i HKU1 trigaven m\u00e9s temps a desenvolupar anticossos neutralitzants contra al SARS-CoV-2. No obstant aix\u00f2 encara no \u00e9s possible valorar amb exactitud quina \u00e9s la seva import\u00e0ncia cl\u00ednica. Com a segona fase de la feina s&#8217;han reclutat m\u00e9s pacients amb la intenci\u00f3 de corroborar els primers resultats i intentar constatar si hi ha una correlaci\u00f3 cl\u00ednica.<\/p>\n<p>L&#8217;estudi \u00e9s fruit de la col\u00b7laboraci\u00f3 del grup de recerca en <a href=\"https:\/\/idibell.cat\/recerca\/area-de-medicina-translacional\/programa-de-malalties-infeccioses-i-transplantaments\/\">infeccions respirat\u00f2ries i en l&#8217;hoste immunocomprom\u00e8s<\/a> de l\u2019IDIBELL i l\u2019Hospital de Bellvitge amb un equip de professionals de la Icahn School of Medicine at Mount Sinai, a Nova York. Es van incloure a 37 pacients ingressats per Covid-19 durant la primera onada de la pand\u00e8mia a l&#8217;Hospital Universitari de Bellvitge. Es van obtenir mostres sangu\u00ednies d&#8217;aquests pacients despr\u00e9s de les primeres 24 h del seu ingr\u00e9s; als tres dies; als set i finalment als 46 dies. D&#8217;aquesta manera es va aconseguir una caracteritzaci\u00f3 din\u00e0mica de la resposta immunit\u00e0ria humoral (basada en anticossos) la Covid-19 i es va poder avaluar la influ\u00e8ncia que la immunitat pr\u00e8via d&#8217;altres coronavirus (que produeixen el refredat com\u00fa) pogu\u00e9s tenir sobre la immunitat contra la Covid-19.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><em>L\u2019Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00e9s un centre de recerca en biomedicina creat l\u2019any 2004. Est\u00e0 participat per l&#8217;Hospital Universitari de Bellvitge i l\u2019Hospital de Viladecans de l&#8217;Institut Catal\u00e0 de la Salut, l&#8217;Institut Catal\u00e0 d&#8217;Oncologia, la Universitat de Barcelona i l\u2019Ajuntament de l\u2019Hospitalet de Llobregat.<\/em><\/p>\n<p><em>L\u2019IDIBELL \u00e9s membre del Campus d&#8217;Excel\u00b7l\u00e8ncia Internacional de la Universitat de Barcelona HUBc i forma part de la instituci\u00f3 CERCA de la Generalitat de Catalunya. L&#8217;any 2009 es va convertir en un dels cinc primers centres d\u2019investigaci\u00f3 espanyols acreditats com a institut d\u2019investigaci\u00f3 sanit\u00e0ria per l\u2019Instituto de Salud Carlos III. A m\u00e9s, forma part del programa \u201cHR Excellence in Research\u201d de la Uni\u00f3 Europea i \u00e9s membre de EATRIS i REGIC. Des de l\u2019any 2018, l\u2019IDIBELL \u00e9s un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un estudi de l\u2019IDIBELL, l&#8217;Hospital de Bellvitge i la Icahn School of Medicine ha demostrat per primera vegada que la immunitat preexistent contra altres coronavirus influeix en una possible immunitat contra al SARS-CoV-2<\/p>\n","protected":false},"author":8,"featured_media":18578,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[391,334,479],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-11 16:28:52","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/18577"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=18577"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/18577\/revisions"}],"predecessor-version":[{"id":18580,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/18577\/revisions\/18580"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/18578"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=18577"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=18577"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=18577"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}