{"id":17865,"date":"2021-06-01T09:30:04","date_gmt":"2021-06-01T07:30:04","guid":{"rendered":"https:\/\/idibell.cat\/?p=17865"},"modified":"2021-06-01T09:30:23","modified_gmt":"2021-06-01T07:30:23","slug":"la-definicio-de-les-caracteristiques-metaboliques-del-cancer-de-mama-obre-les-portes-a-noves-estrategies-terapeutiques","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2021\/06\/la-definicio-de-les-caracteristiques-metaboliques-del-cancer-de-mama-obre-les-portes-a-noves-estrategies-terapeutiques\/","title":{"rendered":"La definici\u00f3 de les caracter\u00edstiques metab\u00f2liques del c\u00e0ncer de mama obre les portes a noves estrat\u00e8gies terap\u00e8utiques"},"content":{"rendered":"<p>Es creu que quan una c\u00e8l\u00b7lula esdev\u00e9 cancer\u00edgena utilitza les <strong>vies metab\u00f2liques<\/strong> que ja t\u00e9 actives per a obtenir l&#8217;energia necess\u00e0ria per proliferar de manera descontrolada, per tant, el metabolisme de les c\u00e8l\u00b7lules canceroses vindr\u00e0 determinat pel seu teixit d&#8217;origen. En el cas del <strong>c\u00e0ncer de mama<\/strong>, aquest postulat es complica, ja que aquest tipus de c\u00e0ncer pot tenir diferents or\u00edgens que donaran lloc a diferents tipus de c\u00e0ncer de mama. A m\u00e9s, les vies metab\u00f2liques predominants en cada subtipus de c\u00e8l\u00b7lula mamaria no cancerosa encara no estan definides, a m\u00e9s, tampoc est\u00e0 clar si els diferents tipus de c\u00e0ncers de mama retenen les caracter\u00edstiques metab\u00f2liques de les c\u00e8l\u00b7lules d&#8217;origen.<\/p>\n<p>Un estudi internacional, amb la participaci\u00f3 del <a href=\"https:\/\/idibell.cat\/recerca\/area-de-cancer\/programa-de-mecanismes-molleculars-i-terapia-experimental-en-oncologia-oncobell\/cancer-de-mama\/\">grup de recerca en c\u00e0ncer de mama<\/a> de l&#8217;IDIBELL i de l&#8217;ICO, ha publicat a la revista <a href=\"https:\/\/www-nature-com.sire.ub.edu\/articles\/s42255-021-00388-6\"><em>Nature Metabolism<\/em><\/a> un article que demostra que en efecte les diferents poblacions de c\u00e8l\u00b7lules mam\u00e0ries presenten programes metab\u00f2lics espec\u00edfics, i afegeix que, la identitat metab\u00f2lica de les c\u00e8l\u00b7lules mam\u00e0ries normals explica l&#8217;heterogene\u00eftat metab\u00f2lica dels tumors.<\/p>\n<p>&#8220;<em>Aquestes troballes obren noves oportunitats terap\u00e8utiques contra el c\u00e0ncer de mama, basades en caracter\u00edstiques metab\u00f2liques especifiques de cada tumor <\/em>&#8221; apunta el <strong>Dr. Miquel \u00c0ngel<\/strong> Pujana l\u00edder del grup en c\u00e0ncer de mama. I explica, &#8220;<em>si sabem quines vies metab\u00f2liques fa servir una determinada poblaci\u00f3 de c\u00e8l\u00b7lules canceroses en funci\u00f3 del seu origen, serem capa\u00e7os de con\u00e8ixer tamb\u00e9 les vulnerabilitats de la utilitzaci\u00f3 d&#8217;aquestes vies, i per tant, atacar-les<\/em>&#8220;.<\/p>\n<p>En les c\u00e8l\u00b7lules epitelials de les gl\u00e0ndules mam\u00e0ries distingim les c\u00e8l\u00b7lules luminals, encarregades de la producci\u00f3 de la llet i que poden tenir diferents estats de diferenciaci\u00f3, i les c\u00e8l\u00b7lules basals contr\u00e0ctils. Cadascun d&#8217;aquests tipus cel\u00b7lular d\u00f3na lloc a un tipus de c\u00e0ncer de mama. En el present estudi, gr\u00e0cies a t\u00e8cniques prote\u00f2miques i a la inhibici\u00f3 farmacol\u00f2gica es defineixen les identitats metab\u00f2liques de cada tipus de c\u00e8l\u00b7lula epitelial mam\u00e0ria. Per altra banda, les an\u00e0lisis computacionals realitzades indiquen que les c\u00e8l\u00b7lules canceroses de la mama retenen les caracter\u00edstiques metab\u00f2liques de les seves progenitores.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><em>L\u2019Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00e9s un centre de recerca en biomedicina creat l\u2019any 2004. Est\u00e0 participat per l&#8217;Hospital Universitari de Bellvitge i l\u2019Hospital de Viladecans de l&#8217;Institut Catal\u00e0 de la Salut, l&#8217;Institut Catal\u00e0 d&#8217;Oncologia, la Universitat de Barcelona i l\u2019Ajuntament de l\u2019Hospitalet de Llobregat.<\/em><\/p>\n<p><em>L\u2019IDIBELL \u00e9s membre del Campus d&#8217;Excel\u00b7l\u00e8ncia Internacional de la Universitat de Barcelona HUBc i forma part de la instituci\u00f3 CERCA de la Generalitat de Catalunya. L&#8217;any 2009 es va convertir en un dels cinc primers centres d\u2019investigaci\u00f3 espanyols acreditats com a institut d\u2019investigaci\u00f3 sanit\u00e0ria per l\u2019Instituto de Salud Carlos III. A m\u00e9s, forma part del programa \u201cHR Excellence in Research\u201d de la Uni\u00f3 Europea i \u00e9s membre de EATRIS i REGIC. Des de l\u2019any 2018, l\u2019IDIBELL \u00e9s un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un estudi internacional amb participaci\u00f3 de l\u2019IDIBELL i de l\u2019ICO determina que el metabolisme de les c\u00e8l\u00b7lules tumorals mam\u00e0ries ve definit pel seu origen.<\/p>\n","protected":false},"author":8,"featured_media":17866,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[332,390,447,452],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-08 15:04:09","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/17865"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=17865"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/17865\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/17866"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=17865"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=17865"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=17865"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}