{"id":17420,"date":"2021-05-04T09:48:52","date_gmt":"2021-05-04T07:48:52","guid":{"rendered":"https:\/\/idibell.cat\/?p=17420"},"modified":"2021-05-04T16:15:32","modified_gmt":"2021-05-04T14:15:32","slug":"identifiquen-una-possible-terapia-contra-la-malaltia-de-rendu-osler","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2021\/05\/identifiquen-una-possible-terapia-contra-la-malaltia-de-rendu-osler\/","title":{"rendered":"Identifiquen una possible ter\u00e0pia contra la malaltia de Rendu-Osler"},"content":{"rendered":"<p>Investigadors de l\u2019Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), l\u2019Hospital Universitari de Bellvitge i el Centre de Recerca Biom\u00e8dica de La Rioja (CIBIR) han dut a terme un estudi conjunt que ha perm\u00e8s identificar un possible tractament farmacol\u00f2gic mitjan\u00e7ant la modulaci\u00f3 de la prote\u00efna <strong>adrenomedulina<\/strong>. Els autors de la troballa han demostrat la implicaci\u00f3 d\u2019aquesta prote\u00efna en el desenvolupament de l\u2019HHT (telangiect\u00e0sia hemorr\u00e1gica heredit\u00e0ria), tamb\u00e9 coneguda com a malaltia de <strong>Rendu-Osler<\/strong>.<\/p>\n<p>El descobriment de la Unitat d\u2019Angiog\u00e8nesi del CIBIR, coordinada pel Dr. Alfredo Mart\u00ednez, i de la Unitat d\u2019HHT de l&#8217;Hospital Universitari de Bellvitge, la que t\u00e9 un nombre m\u00e9s alt de pacients d\u2019Espanya, liderada pel Dr. Antoni Riera-Mestre, tamb\u00e9 de l&#8217;IDIBELL, obre la porta a l\u2019\u00fas de noves ter\u00e0pies basades en la modulaci\u00f3 de l\u2019adrenomedulina com un possible futur tractament de la malaltia.<\/p>\n<p>L\u2019HHT \u00e9s una malaltia minorit\u00e0ria que afecta una de cada 6.000 persones, causant-los <strong>malformacions vasculars<\/strong>, tant en capil\u00b7lars (denominades telangiect\u00e0sies), com en vasos de m\u00e9s calibre, sobretot a nivell pulmonar i hep\u00e0tic. La patologia, que en l&#8217;actualitat no t\u00e9 cura, t\u00e9 com a manifestaci\u00f3 cl\u00ednica m\u00e9s freq\u00fcent les hemorr\u00e0gies nasals de repetici\u00f3, per la pres\u00e8ncia de telangiect\u00e0sies a aquest nivell.<\/p>\n<p>En el seu estudi, els cient\u00edfics van plantejar la implicaci\u00f3 de l\u2019adrenomedulina en el desenvolupament de la malaltia. En condicions fisiol\u00f2giques normals, l\u2019adrenomedulina \u00e9s un p\u00e8ptid vasodilatador que regula la secreci\u00f3 d&#8217;hormones com ara la insulina, modula la resposta inflamat\u00f2ria, promou la regeneraci\u00f3 despr\u00e9s d\u2019un dany i, pel que fa als vasos sanguinis, contribueix a la regulaci\u00f3 de l\u2019estabilitat de l&#8217;endoteli vascular.<\/p>\n<p>Per demostrar la seva hip\u00f2tesi, els investigadors van comparar els nivells d\u2019adrenomedulina en mostres de sang de 45 pacients de la unitat d\u2019HHT de l&#8217;Hospital Universitari de Bellvitge amb els de 50 voluntaris sans entre donants habituals del Banc de Sang de l\u2019Hospital San Pedro, de Logro\u00f1o, els quals van participar-hi com grup de control. Posteriorment, les mostres van ser anonimitzades i enviades al CIBIR per a la seva an\u00e0lisi.<\/p>\n<p>Com a objectiu secundari, els investigadors van realitzar estudis immunohistoqu\u00edmics d\u2019adrenomedulina en bi\u00f2psies de telangiect\u00e0sies cut\u00e0nies del tou de les mans de pacients amb HHT, que al seu torn van ser comparades amb mostres de pell sana (dels voltants de l&#8217;extracci\u00f3 de melanomes cutanis).<\/p>\n<p>L&#8217;estudi va descobrir que, tant en les an\u00e0lisis de sang com en les bi\u00f2psies de les telangiect\u00e0sies, els nivells d\u2019adrenomedulina dels pacients amb HHT eren m\u00e9s elevats que en els voluntaris sans.<\/p>\n<p>Es tracta, doncs, d&#8217;un treball d&#8217;investigaci\u00f3 traslacional col\u00b7laboratiu entre els dos centres, que ha estat publicat a la prestigiosa revista <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0953620521001114?dgcid=author\"><em>European Journal of Internal Medicine<\/em><\/a>. Aquesta publicaci\u00f3 forma part de la tesi doctoral de la Dra. Adriana Iriarte (de la Unitat d\u2019HHT, Servei de Medicina Interna, Hospital Universitari de Bellvitge i de l\u2019IDIBELL), primera signant del treball.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><em>L\u2019Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00e9s un centre de recerca en biomedicina creat l\u2019any 2004. Est\u00e0 participat per l&#8217;Hospital Universitari de Bellvitge i l\u2019Hospital de Viladecans de l&#8217;Institut Catal\u00e0 de la Salut, l&#8217;Institut Catal\u00e0 d&#8217;Oncologia, la Universitat de Barcelona i l\u2019Ajuntament de l\u2019Hospitalet de Llobregat.<\/em><\/p>\n<p><em>L\u2019IDIBELL \u00e9s membre del Campus d&#8217;Excel\u00b7l\u00e8ncia Internacional de la Universitat de Barcelona HUBc i forma part de la instituci\u00f3 CERCA de la Generalitat de Catalunya. L&#8217;any 2009 es va convertir en un dels cinc primers centres d\u2019investigaci\u00f3 espanyols acreditats com a institut d\u2019investigaci\u00f3 sanit\u00e0ria per l\u2019Instituto de Salud Carlos III. A m\u00e9s, forma part del programa \u201cHR Excellence in Research\u201d de la Uni\u00f3 Europea i \u00e9s membre de EATRIS i REGIC. Des de l\u2019any 2018, l\u2019IDIBELL \u00e9s un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Es tracta d&#8217;una malaltia minorit\u00e0ria causant de malformacions en vasos sanguinis. L\u2019estudi ha descobert la implicaci\u00f3 d&#8217;una prote\u00efna en el desenvolupament de la patologia.<\/p>\n","protected":false},"author":8,"featured_media":17421,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[332,427,334,466,447,452,425],"tags":[],"class_list":["post-17420","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cancer","category-malalties-sistemiques-i-envelliment","category-medicina-translacional","category-p-de-malalties-cardiovasculars-respiratories-sistemiques-i-denvelliment-cellular","category-p-de-mecanismes-molelculars-i-terapia-experimental-en-oncologia-oncobell","category-procure","category-senyalitzacio-molecular"],"publishpress_future_action":{"enabled":false,"date":"2025-01-29 08:55:08","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/17420","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=17420"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/17420\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/17421"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=17420"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=17420"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=17420"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}