{"id":17228,"date":"2021-04-20T09:19:26","date_gmt":"2021-04-20T07:19:26","guid":{"rendered":"https:\/\/idibell.cat\/?p=17228"},"modified":"2021-04-20T09:20:06","modified_gmt":"2021-04-20T07:20:06","slug":"identifiquen-els-mecanismes-genetics-dadquisicio-de-resistencia-als-antibiotics-de-h-parainfluenzae","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2021\/04\/identifiquen-els-mecanismes-genetics-dadquisicio-de-resistencia-als-antibiotics-de-h-parainfluenzae\/","title":{"rendered":"Identifiquen els mecanismes gen\u00e8tics d\u2019adquisici\u00f3 de resist\u00e8ncia als antibi\u00f2tics de H. parainfluenzae"},"content":{"rendered":"<p><em>Haemophilus parainfluenzae<\/em> \u00e9s un <strong>bacteri oportunista<\/strong>, \u00e9s a dir, que pot viure en l&#8217;hoste sense causar problemes, per\u00f2 en moments determinats, quan per exemple el sistema immunitari est\u00e0 debilitat, pot causar malalties greus que incl\u00fas poden posar en risc la vida.<\/p>\n<p>La <strong>resist\u00e8ncia als antibi\u00f2tics<\/strong> \u00e9s un fenomen natural en el qual els bacteris s&#8217;adapten i evolucionen per a fer-se resistents al tractament amb antibi\u00f2tics. No obstant aix\u00f2, l&#8217;\u00fas indegut d&#8217;aquests f\u00e0rmacs en persones i animals n&#8217;est\u00e0 accelerant el proc\u00e9s convertint-lo en un dels majors problemes de salut p\u00fablica a nivell mundial.<\/p>\n<p>En el cas de <em>H. parainfluenzae<\/em> l&#8217;adquisici\u00f3 de resist\u00e8ncies es pot donar per mutacions puntals del genoma o per l&#8217;addici\u00f3 de nous gens que li confereixen resist\u00e8ncia. Aquest segon mecanisme t\u00e9 lloc gr\u00e0cies a l&#8217;exist\u00e8ncia de petits fragments d&#8217;ADN, anomenats transposons, amb la capacitat de moure&#8217;s de manera autosuficient, mecanisme habitual en moltes esp\u00e8cies bacterianes.<\/p>\n<p>El <a href=\"https:\/\/idibell.cat\/recerca\/area-de-medicina-translacional\/programa-de-malalties-infeccioses-i-transplantaments\/epidemiologia-de-les-infeccions-bacterianes-investigacio-de-la-patogenesis-i-bases-moleculars-de-la-resistencia-als-antimicrobians\/\">grup de recerca en Epidemiologia de les Infeccions Bacterianes<\/a> de l&#8217;Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) i l&#8217;Hospital Universitari de Bellvitge (HUB), liderats per la <strong>Dra. Sara Mart\u00ed<\/strong> conjuntament amb la Dra. <strong>Carme Ardanuy<\/strong>, han realitzat un estudi gen\u00f2mic per tal de caracteritzar en detall els mecanismes d&#8217;adquisici\u00f3 de resist\u00e8ncia de <em>H. parainfluenzae<\/em> a\u00efllats del tracte urogenital i respiratori. Aquest estudi ha format part de dues tesis doctorals que van ser defensades al campus de Bellvitge el passat mes de juliol per dos membres del servei de microbiologia, <strong>Yanik Sierra<\/strong> i <strong>Aida Gonz\u00e1lez<\/strong>.<\/p>\n<p>Els resultats, publicats a la revista <a href=\"https:\/\/academic.oup.com\/jac\/advance-article-abstract\/doi\/10.1093\/jac\/dkab109\/6207544?redirectedFrom=fulltext\"><em>Journal of Antimicrobial Chemotherapy<\/em><\/a>, han identificat grans fragments m\u00f2bils d&#8217;ADN que contenen fins a tres transposons que confereixen resist\u00e8ncia a diferents antibi\u00f2tics. Aix\u00f2, segons la <strong>Dra. Mart\u00ed<\/strong> indica que &#8220;<em>els elements transferibles podrien estar jugant un paper molt important en la transmissi\u00f3 de resist\u00e8ncies<\/em>&#8220;, i afegeix, &#8220;<em>aquests elements podrien contribuir a la propagaci\u00f3 d&#8217;aquestes resist\u00e8ncies d&#8217;uns bacteris als altres<\/em>&#8220;.<\/p>\n<p>Estudis recents del mateix grup havien reportat que soques de <em>H. parainfluenzae<\/em> a\u00efllades del tracte urogenital, i resistents a diversos antibi\u00f2tics, havien desenvolupat <strong>c\u00e0psules de polisac\u00e0rids<\/strong>, caracter\u00edstica no descrita fins al moment en aquesta esp\u00e8cie bacteriana. &#8220;<em>Aquests embolcalls compostos de sucres es consideren un factor de virul\u00e8ncia, ja que protegeixen els bacteris de l&#8217;atac del sistema immunitari i altres agressions<\/em>&#8220;, indica la <strong>Dra. Ardanuy<\/strong>.<\/p>\n<p>Les an\u00e0lisis gen\u00f2miques realitzades en l&#8217;estudi actual, nom\u00e9s han trobat els gens codificants per la c\u00e0psula en aquelles soques a\u00efllades del tracte urogenital, el qu\u00e8, segons les Dres. Mart\u00ed i Ardanuy podria indicar la capacitat del <em>H. parainfluenzae<\/em> a adaptar-se als diferents ambients.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><em>L\u2019Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00e9s un centre de recerca en biomedicina creat l\u2019any 2004. Est\u00e0 participat per l&#8217;Hospital Universitari de Bellvitge i l\u2019Hospital de Viladecans de l&#8217;Institut Catal\u00e0 de la Salut, l&#8217;Institut Catal\u00e0 d&#8217;Oncologia, la Universitat de Barcelona i l\u2019Ajuntament de l\u2019Hospitalet de Llobregat.<\/em><\/p>\n<p><em>L\u2019IDIBELL \u00e9s membre del Campus d&#8217;Excel\u00b7l\u00e8ncia Internacional de la Universitat de Barcelona HUBc i forma part de la instituci\u00f3 CERCA de la Generalitat de Catalunya. L&#8217;any 2009 es va convertir en un dels cinc primers centres d\u2019investigaci\u00f3 espanyols acreditats com a institut d\u2019investigaci\u00f3 sanit\u00e0ria per l\u2019Instituto de Salud Carlos III. A m\u00e9s, forma part del programa \u201cHR Excellence in Research\u201d de la Uni\u00f3 Europea i \u00e9s membre de EATRIS i REGIC. Des de l\u2019any 2018, l\u2019IDIBELL \u00e9s un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>El treball del grup de recerca en Epidemiologia de les Infeccions Bacterianes de l&#8217;IDIBELL i el HUB indica que el bacteri podria aconseguir resist\u00e8ncia a trav\u00e9s de l\u2019adquisici\u00f3 de fragments d&#8217;ADN m\u00f2bils.<\/p>\n","protected":false},"author":8,"featured_media":17229,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[480,334,479],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-11 13:47:55","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/17228"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=17228"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/17228\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/17229"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=17228"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=17228"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=17228"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}