{"id":17165,"date":"2021-04-15T10:15:30","date_gmt":"2021-04-15T08:15:30","guid":{"rendered":"https:\/\/idibell.cat\/?p=17165"},"modified":"2021-12-22T15:57:20","modified_gmt":"2021-12-22T14:57:20","slug":"descobriment-de-factors-epigenetics-que-prediuen-la-gravetat-de-la-malaltia-covid-19","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2021\/04\/descobriment-de-factors-epigenetics-que-prediuen-la-gravetat-de-la-malaltia-covid-19\/","title":{"rendered":"Descobriment de factors epigen\u00e8tics que prediuen la gravetat de la malaltia COVID-19"},"content":{"rendered":"<p>La malaltia COVID-19 a causa de la infecci\u00f3 pel virus SARS-CoV2 ha canviat les pautes de conducta de la humanitat al convertir-se en una pand\u00e8mia d&#8217;abast internacional. A dia d&#8217;avui han patit la malaltia m\u00e9s de 136 milions de persones i m\u00e9s de 2.9 milions de les mateixes han perdut la vida. \u00c9s important recordar que els s\u00edmptomes de la infecci\u00f3 varien molt en la poblaci\u00f3, des d&#8217;individus que no presenten cap cl\u00ednica fins a aquells que necessiten ingr\u00e9s a l&#8217;UCI amb respiraci\u00f3 assistida d&#8217;urg\u00e8ncia. Es desconeix en bona part quins factors s\u00f3n responsables d&#8217;aquest ventall de quadres cl\u00ednics tan diferents. Avui, un article publicat a la revista <a href=\"https:\/\/www.thelancet.com\/journals\/ebiom\/article\/PIIS2352-3964(21)00132-8\/fulltext\"><em>EBiomedicine<\/em><\/a>, la revista germana de <em>The Lancet<\/em> per troballes de laboratori, pel grup del <strong>Dr. Manel Esteller<\/strong>, director de l&#8217;Institut de Recerca contra la Leuc\u00e8mia Josep Carreras (<a href=\"https:\/\/www.carrerasresearch.org\/es\">IJC<\/a>), Professor d&#8217;Investigaci\u00f3 ICREA i Catedr\u00e0tic de Gen\u00e8tica a la Universitat de Barcelona i la <strong>Dra. Aurora Pujol<\/strong>, tamb\u00e9 Professora ICREA, genetista del Consorcio de Investigaci\u00f3n en Red de Enfermedades Raras (CIBERER) i cap del <a href=\"https:\/\/idibell.cat\/recerca\/area-de-neurociencies\/programa-de-neurociencies\/malalties-neurometaboliques\/\">Grup de Malalties Neurometab\u00f2liques<\/a> de l\u2019Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), demostra que <strong>la dotaci\u00f3 epigen\u00e8tica de cada persona influeix en la severitat de la malaltia COVID-19<\/strong>.<\/p>\n<p>\u201c<em>Les dades complementen i confirmen la implicaci\u00f3 de la resposta antiviral dirigida per l\u2019interfer\u00f3 i la seva import\u00e0ncia en l\u2019evoluci\u00f3 de la malaltia<\/em>, <em>com v\u00e0rem explicar <\/em><em>en <\/em><a href=\"https:\/\/idibell.cat\/2020\/09\/linterfero-la-clau-de-molts-dels-casos-mes-greus-de-covid-19-en-persones-joves\/\"><em>un estudi de seq\u00fcenciaci\u00f3 del genoma complert publicat a la revista Science<\/em><\/a><em> el darrer setembre\u201d, <\/em>apunta la <strong>Dra. Pujol<\/strong> i segueix: \u201c<em>Amb aquestes eines avan\u00e7ades de medicina personalitzada, tant del camp de <\/em><em>la<\/em><em> gen\u00f2mica com de l\u2019epigen\u00f2mica, \u00e9s possible dissenyar models predictius que permetin detectar pacients a risc de pitjor pron\u00f2stic i per tant, millorar el seu tractament i evitar el col\u00b7lapse del sistema sanitari<\/em>\u201d.<\/p>\n<p>&#8220;<em>A causa de l&#8217;elevat nombre de persones infectades pel virus que han saturat tots els sistemes sanitaris del m\u00f3n, estaria b\u00e9 tenir formes de predir amb antelaci\u00f3 si la infecci\u00f3 pel virus en un determinat individu requerir\u00e0 hospitalitzaci\u00f3 o simplement pot ser controlada de forma ambulat\u00f2ria. Sabem que l&#8217;edat avan\u00e7ada i la coexist\u00e8ncia d&#8217;altres patologies (cardiovasculars, obesitat, diabetis, defectes immunes) s&#8217;associa a una major gravetat de la infecci\u00f3, \u00bfPer\u00f2 qu\u00e8 passa amb la resta de la poblaci\u00f3 que tamb\u00e9 arriba a la UCI sense aquests factors?<\/em> \u201c- es va preguntar el <strong>Dr. Esteller<\/strong> a l&#8217;article a la revista <em>EBiomedicine<\/em> i afegeix &#8220;<em>Vam decidir estudiar m\u00e9s de 400 persones que havien donat positiu per al test de COVID-19 que no pertanyien a cap d&#8217;aquests grups de risc i estudiar el seu material gen\u00e8tic en funci\u00f3 de si no havien tingut s\u00edmptomes, o van ser molt lleus, o si, en canvi, havien estat ingressats a l&#8217;hospital requerint assist\u00e8ncia respirat\u00f2ria. Hem trobat que existeixen variacions epigen\u00e8tiques, en els interruptors qu\u00edmics que regulen l&#8217;activitat de l&#8217;ADN, en els positius pel virus que desenvolupaven un COVID-19 greu. Aquestes modificacions succeeixen principalment en gens associats amb una excessiva resposta inflamat\u00f2ria i en gens que reflecteixen una tend\u00e8ncia general a un pitjor estat de salut. Interessantment, el 13% de la poblaci\u00f3 mundial presenta aquesta signatura epigen\u00e8tica (EPICOVID), per tant \u00e9s la poblaci\u00f3 de m\u00e0xim risc per la qual haurem de tenir una preocupaci\u00f3 especial.<\/em> &#8221; &#8211; conclou l&#8217;investigador.<\/p>\n<p>L&#8217;article publicat avui mostra els resultats de la recerca duta a terme aquests mesos d&#8217;estratificaci\u00f3 pron\u00f2stica en COVID-19, amb la intenci\u00f3 de contribuir a millorar el maneig cl\u00ednic de pacients infectats amb SARS-CoV-2. Els resultats d&#8217;aquestes investigacions impactaran favorablement en la salut de la poblaci\u00f3 en general, particularment en les persones afectades per les leuc\u00e8mies i les malalties hematol\u00f2giques malignes, especialment vulnerables a aquesta malaltia.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><em>L\u2019Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00e9s un centre de recerca en biomedicina creat l\u2019any 2004. Est\u00e0 participat per l&#8217;Hospital Universitari de Bellvitge i l\u2019Hospital de Viladecans de l&#8217;Institut Catal\u00e0 de la Salut, l&#8217;Institut Catal\u00e0 d&#8217;Oncologia, la Universitat de Barcelona i l\u2019Ajuntament de l\u2019Hospitalet de Llobregat.<\/em><\/p>\n<p><em>L\u2019IDIBELL \u00e9s membre del Campus d&#8217;Excel\u00b7l\u00e8ncia Internacional de la Universitat de Barcelona HUBc i forma part de la instituci\u00f3 CERCA de la Generalitat de Catalunya. L&#8217;any 2009 es va convertir en un dels cinc primers centres d\u2019investigaci\u00f3 espanyols acreditats com a institut d\u2019investigaci\u00f3 sanit\u00e0ria per l\u2019Instituto de Salud Carlos III. A m\u00e9s, forma part del programa \u201cHR Excellence in Research\u201d de la Uni\u00f3 Europea i \u00e9s membre de EATRIS i REGIC. Des de l\u2019any 2018, l\u2019IDIBELL \u00e9s un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hem trobat que existeixen variacions epigen\u00e8tiques, en els interruptors qu\u00edmics que regulen l&#8217;activitat de l&#8217;ADN, en els positius pel virus que desenvolupaven un COVID-19 greu.<\/p>\n","protected":false},"author":8,"featured_media":17166,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[380,340,457],"tags":[],"class_list":["post-17165","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-malalties-neurometaboliques","category-neurociencies","category-p-de-neurociencies"],"publishpress_future_action":{"enabled":false,"date":"2024-12-25 05:50:25","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/17165","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=17165"}],"version-history":[{"count":1,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/17165\/revisions"}],"predecessor-version":[{"id":20065,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/17165\/revisions\/20065"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/17166"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=17165"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=17165"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=17165"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}