{"id":15178,"date":"2020-10-27T11:53:08","date_gmt":"2020-10-27T10:53:08","guid":{"rendered":"https:\/\/idibell.cat\/?p=15178"},"modified":"2020-11-02T11:12:39","modified_gmt":"2020-11-02T10:12:39","slug":"la-falta-dinteraccio-entre-dos-receptors-neuronals-es-un-factor-determinant-en-lesquizofrenia","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2020\/10\/la-falta-dinteraccio-entre-dos-receptors-neuronals-es-un-factor-determinant-en-lesquizofrenia\/","title":{"rendered":"La falta d\u2019interacci\u00f3 entre dos receptors neuronals \u00e9s un factor determinant en l\u2019esquizofr\u00e8nia"},"content":{"rendered":"<p>L&#8217;esquizofr\u00e8nia \u00e9s un trastorn neuropsiqui\u00e0tric greu que es manifesta a trav\u00e9s d&#8217;al\u00b7lucinacions, deliris i trastorns de comportament i motors. Hist\u00f2ricament, aquesta malaltia ha estat associada a una<strong> hiperactivaci\u00f3 dels circuits neuronals dopamin\u00e8rgics<\/strong>, el qu\u00e8, segons una hip\u00f2tesi recent, podria estar vinculat a una<strong> disminuci\u00f3 de la transmissi\u00f3 adenosin\u00e8rgica<\/strong>, la seva via inhibidora, al nostre cervell. Aix\u00ed doncs, es postula que la disminuci\u00f3 del contingut d\u2019adenosina, dels seus receptors i\/o l\u2019alteraci\u00f3 de les interaccions d\u2019aquest receptors podria estar darrera d\u2019aquest desequilibri en la neurotransmissi\u00f3 dopamin\u00e8rgica.<\/p>\n<p>Un equip de l&#8217;Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (<a href=\"https:\/\/idibell.cat\/recerca\/area-de-neurociencies\/programa-de-neurociencies\/neurofarmacologia-i-dolor\/\">IDIBELL<\/a>), la Facultat de Medicina i Ci\u00e8ncies de la Salut i l&#8217;Institut de Neuroci\u00e8ncies de la Universitat de Barcelona (<a href=\"http:\/\/www.neurociencies.ub.edu\/\">UBNeuro<\/a>), liderat pel Dr. Francisco Ciruela, ha detectat en models animals i mostres <em>postmorten<\/em> de pacients d\u2019esquizofr\u00e8nia una <strong>reducci\u00f3 en la interacci\u00f3 entre els receptors de dopamina i d\u2019adenosina<\/strong>, el que explicaria la sobreestimulaci\u00f3 de la via dopamin\u00e8rgica observada en aquest pacients. A m\u00e9s, els resultats mostren que aquesta alteraci\u00f3 \u00e9s independent dels nivells d&#8217;expressi\u00f3 d&#8217;ambd\u00f3s receptors.<\/p>\n<p>&#8220;<em>Els resultats posen el focus en la manca d&#8217;interacci\u00f3 entre els receptors neuronals per explicar el desequilibri observat en l&#8217;esquizofr\u00e8nia<\/em>&#8221; apunta el<strong> Dr. Ciruela<\/strong>. I afegeix &#8220;<em>aquests descobriments proposen que f\u00e0rmacs que promouen la interacci\u00f3 dels dos receptors serien una bona estrat\u00e8gia en el maneig de l&#8217;esquizofr\u00e8nia<\/em>&#8220;.<\/p>\n<p>En la seg\u00fcent fase de l&#8217;estudi, publicat a la revista <a href=\"https:\/\/www.nature.com\/articles\/s41386-020-00872-9\"><em>Neuropsichopharmacology<\/em><\/a>, els investigadors demostren que el tractament cr\u00f2nic amb antipsic\u00f2tics cl\u00e0ssics, es a dir, que bloquegen els receptors dopamin\u00e8rgics, restableixen la interacci\u00f3 entre els dos receptors en models de ratol\u00ed. El que podria explicar l&#8217;efecte benefici\u00f3s d&#8217;aquests f\u00e0rmacs per alguns dels s\u00edmptomes de l&#8217;esquizofr\u00e8nia.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>La interacci\u00f3 dels dos receptors comporta la inhibici\u00f3 de la via dopamin\u00e8rgica, que en el cas d&#8217;aquest trastorn es troba anormalment activa. Aquest descobriment obre la porta al disseny de nous f\u00e0rmacs pel tractament de l&#8217;esquizofr\u00e8nia que actu\u00efn sobre aquesta interacci\u00f3.<\/p>\n","protected":false},"author":8,"featured_media":15296,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[340,344,457],"tags":[],"class_list":["post-15178","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-neurociencies","category-neurofarmacologia-i-dolor","category-p-de-neurociencies"],"publishpress_future_action":{"enabled":false,"date":"2024-12-01 07:22:49","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/15178","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=15178"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/15178\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/15296"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=15178"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=15178"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=15178"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}