{"id":15029,"date":"2020-10-08T11:00:37","date_gmt":"2020-10-08T09:00:37","guid":{"rendered":"https:\/\/idibell.cat\/?p=15029"},"modified":"2020-10-08T11:17:34","modified_gmt":"2020-10-08T09:17:34","slug":"desenvolupen-un-programa-capac-de-detectar-de-manera-automatica-biomarcadors-de-neurodegeneracio-a-traves-de-ressonancies-magnetiques","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2020\/10\/desenvolupen-un-programa-capac-de-detectar-de-manera-automatica-biomarcadors-de-neurodegeneracio-a-traves-de-ressonancies-magnetiques\/","title":{"rendered":"Desenvolupen un programa capa\u00e7 de detectar de manera autom\u00e0tica biomarcadors de neurodegeneraci\u00f3 a trav\u00e9s de resson\u00e0ncies magn\u00e8tiques"},"content":{"rendered":"<p>La <strong>resson\u00e0ncia magn\u00e8tica<\/strong> \u00e9s la t\u00e8cnica m\u00e9s sensible i fiable per a diagnosticar i fer el seguiment de les malalties neurodegeneratives. A trav\u00e9s de les imatges que se n&#8217;obtenen podem fer un an\u00e0lisi anat\u00f2mic complet del cervell i detectar atr\u00f2fia en regions concretes. No obstant, la inspecci\u00f3 de les imatges sol ser visual, el que comporta que certs signes de neurodegeneraci\u00f3, invisibles per l&#8217;ull hum\u00e0, no siguin detectats fins que el dany ja est\u00e0 avan\u00e7at.<\/p>\n<p>La Dra. Estela C\u00e0mara de l&#8217;Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (<a href=\"https:\/\/idibell.cat\/recerca\/area-de-neurociencies\/programa-de-neurociencies\/cognicio-i-plasticitat-cerebral\/\">IDIBELL<\/a>) i de la Facultat Psicologia i l\u2019Institut de Neuroci\u00e8ncies de la Universitat de Barcelona (<a href=\"http:\/\/www.neurociencies.ub.edu\/\">UBNeuro<\/a>), juntament amb Alicia Palomar, han dissenyat un programa inform\u00e0tic que permet l&#8217;an\u00e0lisi quantitativa de les imatges de resson\u00e0ncia de manera f\u00e0cil, r\u00e0pida i adaptable a qualsevol afectaci\u00f3 del cervell. Aquest programa, anomenat <strong>SeSBAT<\/strong> (de l&#8217;angl\u00e9s Single Subject Brain Analysis Toolbox), integra diferents protocols d&#8217;an\u00e0lisi d&#8217;imatges que poden mesurar el volum de regions concretes del cervell o realitzar una exploraci\u00f3 general d&#8217;aquest, essent capa\u00e7 de detectar petits canvis, invisibles per l&#8217;ull, per\u00f2 que podrien predir el risc de desenvolupar una malaltia degenerativa.<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-15030 aligncenter\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/10\/toolbox-300x196.png\" alt=\"\" width=\"490\" height=\"320\" srcset=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/10\/toolbox-300x196.png 300w, https:\/\/idibell.cat\/wp-content\/uploads\/2020\/10\/toolbox-1024x669.png 1024w, https:\/\/idibell.cat\/wp-content\/uploads\/2020\/10\/toolbox-768x501.png 768w, https:\/\/idibell.cat\/wp-content\/uploads\/2020\/10\/toolbox-1536x1003.png 1536w, https:\/\/idibell.cat\/wp-content\/uploads\/2020\/10\/toolbox.png 1827w\" sizes=\"(max-width: 490px) 100vw, 490px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>Amb SeSBAT s&#8217;obre la porta a la identificaci\u00f3 de nous biomarcadors que ajudarien a millorar la detecci\u00f3 preco\u00e7 i el seguiment de les malalties neurodegeneratives. Al tractar-se d&#8217;una an\u00e0lisi quantitativa <strong>\u00e9s capa\u00e7 d&#8217;identificar modificacions anat\u00f2miques del cervell que tenen lloc abans de l&#8217;aparici\u00f3 dels s\u00edmptomes<\/strong>.<\/p>\n<p>Amb aquest tipus d&#8217;an\u00e0lisi integrat es poden extreure dades d&#8217;un sol individu, evitant la variabilitat interindividual de treballar amb grups. Aix\u00f2 permet el <strong>seguiment individualitzat<\/strong> d&#8217;un pacient al llarg del temps, el que seria molt \u00fatil per a determinar l&#8217;efic\u00e0cia de determinats f\u00e0rmacs en assajos cl\u00ednics, o b\u00e9, monitoritzar persones en risc de desenvolupar una malaltia neurodegenerativa.<\/p>\n<p>L&#8217;equip de la Dra. C\u00e0mara ha testat la precisi\u00f3 d&#8217;aquesta nova eina en imatges de resson\u00e0ncia magn\u00e8tica de pacients amb la malaltia neurodegenerativa de Huntington. Els resultats, publicats a la revista <a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnsys.2020.488652\/full\"><em>Frontiers in Systems Neuroscience<\/em><\/a>, mostren com aquesta eina \u00e9s capa\u00e7 d&#8217;identificar aquells pacients que es troben en etapes primerenques de la malaltia, i fins i tot aquells que encara no han presentat els primers s\u00edmptomes.<\/p>\n<blockquote><p>&#8220;Es tracta d&#8217;un programa molt vers\u00e0til que es podria adaptar i personalitzar a cada tipus de malaltia neurodegenerativa o projecte&#8221;<\/p><\/blockquote>\n<p>La Dra. C\u00e0mara afirma que es tracta d&#8217;un programa molt vers\u00e0til que es podria adaptar i personalitzar a cada tipus de malaltia neurodegenerativa o projecte. El <a href=\"https:\/\/brainvitge.org\/\">grup de C\u00e0mara<\/a> obre les portes a noves col\u00b7laboracions amb grups interessats a aplicar aquesta tecnologia als seus projectes. De la mateixa manera, una eina com aquesta podria ser f\u00e0cilment aplicada a la pr\u00e0ctica cl\u00ednica de rutina, el que permetria una an\u00e0lisi molt m\u00e9s profund de les imatges de resson\u00e0ncia i un maneig m\u00e9s acurats dels pacients amb malalties neurodegeneratives.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Aquesta eina pot identificar de manera individualitzada signes de neurodegeneraci\u00f3 abans que apareguin els s\u00edmptomes, el que podria aplanar el cam\u00ed cap a una medicina m\u00e9s efectiva i personalitzada.<\/p>\n","protected":false},"author":8,"featured_media":15032,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[368,340,457],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-05 04:10:39","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/15029"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=15029"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/15029\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/15032"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=15029"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=15029"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=15029"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}