{"id":14197,"date":"2020-09-02T12:00:39","date_gmt":"2020-09-02T10:00:39","guid":{"rendered":"https:\/\/idibell.cat\/?p=14197"},"modified":"2020-10-19T10:56:11","modified_gmt":"2020-10-19T08:56:11","slug":"la-intelligencia-artificial-una-nova-aliada-contra-la-leucemia","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2020\/09\/la-intelligencia-artificial-una-nova-aliada-contra-la-leucemia\/","title":{"rendered":"La intel\u00b7lig\u00e8ncia artificial, una nova aliada contra la leuc\u00e8mia"},"content":{"rendered":"<p><strong>La Dra. M. Carolina Florian (Programa de Medicina Regenerativa, l&#8217;IDIBELL) i el Prof. Medhanie Mulaw (Universitat d&#8217;Ulm, Alemanya) rebran m\u00e9s de 800.000 euros de la Fundaci\u00f3 &#8220;La Caixa&#8221; per aplicar l&#8217;aprenentatge profund (<em>deep learning<\/em>) en la investigaci\u00f3 de la leuc\u00e8mia en persones grans.<\/strong><\/p>\n<p><strong>Aquest prestigi\u00f3s premi dona suport a les iniciatives m\u00e9s prometedores d&#8217;excel\u00b7l\u00e8ncia cient\u00edfica que presenten un alt potencial social, sigui en investigaci\u00f3 b\u00e0sica, cl\u00ednica o translacional.<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p>La <strong>leuc\u00e8mia mieloide aguda<\/strong> (LMA) es caracteritza per una maduraci\u00f3 incompleta dels gl\u00f2buls blancs a la sang i la medul\u00b7la \u00f2ssia. Malauradament, aquest tipus de c\u00e0ncer \u00e9s molt m\u00e9s agressiu i t\u00e9 una incid\u00e8ncia deu vegades m\u00e9s gran en persones majors de 65 anys, que poden arribar a tenir una esperan\u00e7a de vida de pocs mesos despr\u00e9s del diagn\u00f2stic.<\/p>\n<p>El consorci, format per l&#8217;equip de la Dra. Carolina M. Florian del Programa de Medicina Regenerativa de l&#8217;<a href=\"https:\/\/idibell.cat\/recerca\/area-medicina-regenerativa\/programa-de-medicina-regenerativa\/envelliment-de-cellules-mare\/\">IDIBELL<\/a> i del <a href=\"https:\/\/p-cmrc.cat\/research\/florian-group\/\">P-CMR[C]<\/a>, juntament amb l&#8217;equip del Prof. Medhanie Mulaw de la <a href=\"https:\/\/www.uni-ulm.de\/en\/\">Universitat d&#8217;Ulm<\/a>, iniciar\u00e0 un projecte titulat &#8220;Aprenentatge profund (<em>deep learning<\/em>) per definir les interaccions entre les c\u00e8l\u00b7lules leuc\u00e8miques i el seu n\u00ednxol envellit&#8221;. El projecte ha estat seleccionat per rebre 800.000 euros de la <strong>Fundaci\u00f3 &#8220;La Caixa&#8221;<\/strong> que es destinaran a identificar els mecanismes d&#8217;inici i progressi\u00f3 de la LMA. En el projecte s&#8217;aplicar\u00e0 la <strong>intel\u00b7lig\u00e8ncia artificial<\/strong> per analitzar dades histol\u00f2giques i de seq\u00fcenciaci\u00f3 unicel\u00b7lular de l&#8217;ARN per determinar la interacci\u00f3 de les c\u00e8l\u00b7lules leuc\u00e8miques amb el seu entorn.<\/p>\n<p>El projecte est\u00e0 dirigit per l&#8217;equip de la Dra. M. Carolina Florian de l&#8217;IDIBELL, que utilitzar\u00e0 models de ratol\u00ed per obtenir dades histol\u00f2giques i d&#8217;expressi\u00f3 g\u00e8nica. L&#8217;equip de professor Mulaw aplicar\u00e0 la intel\u00b7lig\u00e8ncia artificial (IA) i l&#8217;aprenentatge profund a aquest conjunt de dades amb l&#8217;objectiu d\u2019identificar <strong>patrons d&#8217;interacci\u00f3 entre les c\u00e8l\u00b7lules leuc\u00e8miques i el seu n\u00ednxol<\/strong>.<\/p>\n<p>Tal com diu la Dra. Florian: &#8220;Fins ara els estudis suggereixen que les c\u00e8l\u00b7lules leuc\u00e8miques poden modificar el seu microambient per propagar-se i sobreviure als tractaments de quimioter\u00e0pia. No obstant, es necessita una millor comprensi\u00f3 d&#8217;aquest proc\u00e9s per dissenyar nous enfocaments terap\u00e8utics&#8221;.<\/p>\n<p>&#8220;Estem molt contents que el nostre projecte hagi rebut suport financer&#8221;, afirma el Prof. Mulaw. &#8220;Aix\u00f2 enfortir\u00e0 les nostres col\u00b7laboracions ja en marxa. Per exemple, recentment, hem demostrat la import\u00e0ncia dels enfocaments d&#8217;aprenentatge profund (deep learning) per predir l&#8217;envelliment de les c\u00e8l\u00b7lules mare hematopo\u00e8tiques en funci\u00f3 de la seva dist\u00e0ncia del n\u00ednxol de la medul\u00b7la \u00f2ssia&#8221;.<\/p>\n<p>Ara els investigadors combinaran la seva experi\u00e8ncia en l&#8217;envelliment de les c\u00e8l\u00b7lules mare, el n\u00ednxol de la medul\u00b7la \u00f2ssia, la biologia de la leuc\u00e8mia i la gen\u00f2mica funcional per identificar noves dianes terap\u00e8utics de la LMA.<\/p>\n<p>&nbsp;<\/p>\n<p>Imatge de la Dra. Carolina M. Florian realitzada per <a href=\"https:\/\/aleronchi.com\/\">Alessandro Ronchi\u00a0<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>El projecte de la Dra. Carolina M. Florian ha estat seleccionat per les convocatories La Caixa Health Research<\/p>\n","protected":false},"author":8,"featured_media":14199,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[484,349,482],"tags":[],"class_list":["post-14197","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-envelliment-de-cellules-mare","category-medicina-regenerativa","category-p-de-medicina-regenerativa"],"publishpress_future_action":{"enabled":false,"date":"2025-01-25 08:49:58","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/14197","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=14197"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/14197\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/14199"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=14197"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=14197"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=14197"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}