{"id":14026,"date":"2020-08-07T11:23:25","date_gmt":"2020-08-07T09:23:25","guid":{"rendered":"https:\/\/idibell.cat\/?p=14026"},"modified":"2020-08-07T11:23:25","modified_gmt":"2020-08-07T09:23:25","slug":"cientifics-de-lidibell-troben-un-compost-que-esten-lesperanca-de-vida-en-ratolins","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2020\/08\/cientifics-de-lidibell-troben-un-compost-que-esten-lesperanca-de-vida-en-ratolins\/","title":{"rendered":"Cient\u00edfics de l’IDIBELL troben un compost que est\u00e9n l’esperan\u00e7a de vida en ratolins"},"content":{"rendered":"

L’envelliment de la poblaci\u00f3 est\u00e0 causant un augment de les malalties relacionades amb l’edat a tot el m\u00f3n, la seva prevenci\u00f3 s’est\u00e0 convertint en un important problema social, econ\u00f2mic i m\u00e8dic. Per aquesta ra\u00f3, necessitem comprendre millor els mecanismes moleculars i cel\u00b7lulars involucrats en aquest proc\u00e9s, i aix\u00ed dissenyar estrat\u00e8gies que permetin un envelliment saludable.<\/p>\n

En aquest sentit, m\u00faltiples estudis, en organismes que van des de mosques fins humans, ja han demostrat que la gen\u00e8tica juga un paper important en la determinaci\u00f3 de la longevitat. No obstant aix\u00f2, tamb\u00e9 existeixen m\u00e8todes s\u00f2lids i reprodu\u00efbles que estenen l’esperan\u00e7a de vida per mitjans no gen\u00e8tics, com la restricci\u00f3 diet\u00e8tica o els compostos farmacol\u00f2gics, cosa que obre la porta a noves estrat\u00e8gies terap\u00e8utiques.<\/p>\n

Per exemple, investigacions anteriors han demostrat que l’activitat d’una prote\u00efna anomenada Cdc42 estava elevada al cor, cervell, pulmons, fetge, medul\u00b7la \u00f2ssia, melsa i ronyons dels ratolins d’edat avan\u00e7ada. Despr\u00e9s es va demostrar que aquesta activitat elevada limitava la vida \u00fatil dels ratolins. Ara, en un estudi liderat per la Dra. M. Carolina Florian, cap de grup del Programa de Medicina Regenerativa de l’IDIBELL<\/a> i del Programa de Translaci\u00f3 Cl\u00ednica de la Medicina Regenerativa de Catalunya (P-CMR[C]<\/a>), i pel Prof. Hartmut Geiger de la Universitat Alemanya d’Ulm<\/a>, ha demostrat que un tractament de 4 dies en ratolins d’edat avan\u00e7ada amb un inhibidor espec\u00edfic de l’activitat de Cdc42, anomenat CASIN<\/strong>, est\u00e9n la vida mitjana i m\u00e0xima murina a m\u00e9s del 10%.<\/p>\n

Aquesta innovadora investigaci\u00f3, realitzada en col\u00b7laboraci\u00f3 amb el professor Yi Zheng del Centre M\u00e8dic de l’Hospital Infantil de Cincinnati (EE. UU.), s’ha publicat a la revista Aging Cell<\/em><\/a> aquesta setmana. Les dades publicades demostren que els animals tractats tamb\u00e9 mostraven nivells juvenils de citocines inflamat\u00f2ries associades a l’envelliment<\/strong> (INFg, IL-1a i IL-1b) i tenien senyals epigen\u00e8tiques pr\u00f2pies d’edats m\u00e9s primerenques<\/strong>, tal com mostraven els nivells de metilaci\u00f3 de l’ADN de les c\u00e8l\u00b7lules sangu\u00ednies. Sorprenentment, tots aquests efectes van ser visibles quan els ratolins ja tenien una edat avan\u00e7ada i havien estat tractats per tan sols 4 dies.<\/p>\n

Les troballes de Florian i els seus companys se sumen a la creixent evid\u00e8ncia que el deteriorament funcional dels organismes podria ser reversible mitjan\u00e7ant intervencions farmacol\u00f2giques. Aquests resultats podrien conduir a tractaments de patologies associades a l’edat i ajudar a mantenir la capacitat regenerativa de les c\u00e8l\u00b7lules, el que seria benefici\u00f3s per estendre l’esperan\u00e7a de vida.<\/p>\n","protected":false},"excerpt":{"rendered":"

Cient\u00edfics del Programa de Medicina Regenerativa de l’IDIBELL, en col\u00b7laboraci\u00f3 amb socis de la Universitat Ulm (Alemanya), han demostrat que la inhibici\u00f3 de Cdc42 amb CASIN pot prolongar farmacol\u00f2gicament l’esperan\u00e7a de vida.<\/p>\n","protected":false},"author":8,"featured_media":14027,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[484,349,482],"tags":[],"class_list":["post-14026","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-envelliment-de-cellules-mare","category-medicina-regenerativa","category-p-de-medicina-regenerativa"],"publishpress_future_action":{"enabled":false,"date":"2024-12-29 12:54:53","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/14026","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=14026"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/14026\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/14027"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=14026"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=14026"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=14026"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}