{"id":13653,"date":"2020-07-23T09:08:03","date_gmt":"2020-07-23T07:08:03","guid":{"rendered":"https:\/\/idibell.cat\/?p=13653"},"modified":"2020-07-23T09:08:52","modified_gmt":"2020-07-23T07:08:52","slug":"utilitzen-un-model-de-ratoli-per-a-determinar-el-tractament-personalitzat-dun-pacient-de-cancer","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2020\/07\/utilitzen-un-model-de-ratoli-per-a-determinar-el-tractament-personalitzat-dun-pacient-de-cancer\/","title":{"rendered":"Utilitzen un model de ratol\u00ed per a determinar el tractament personalitzat d\u2019un pacient de c\u00e0ncer"},"content":{"rendered":"<p>Un equip de <a href=\"https:\/\/idibell.cat\/\">l&#8217;IDIBELL<\/a> i de l&#8217;<a href=\"http:\/\/ico.gencat.cat\/ca\/inici\">ICO<\/a>, utilitzant un model ortot\u00f2pic de ratol\u00ed, ha fet un <strong>estudi d\u2019oncologia personalitzada<\/strong> a temps real per testar la millor opci\u00f3 terap\u00e8utica pel tractament d&#8217;un tipus de sarcoma a la recaiguda. Els tumors malignes de la beina dels nervis perif\u00e8rics (MPNST, de les sigles en angl\u00e8s) s\u00f3n molt agressius i no solen tenir un bon pron\u00f2stic, especialment si no s&#8217;aconsegueixen eliminar completament per cirurgia. Per a generar el model ortot\u00f2pic, un petit fragment en fresc \u00a0del tumor del pacient es va implantar el mateix dia de la cirurgia en el mateix teixit del ratol\u00ed. Una vegada que el tumor havia crescut en el ratol\u00ed, \u00a0es van assajar diversos tractaments i se\u2019n va analitzar la resposta.<\/p>\n<p>En l&#8217;estudi, co-liderat per la Dra. Conxi L\u00e1zaro i el Dr. Alberto Villanueva, ambd\u00f3s del programa Oncobell de l&#8217;IDIBELL i investigadors de l&#8217;Institut Catal\u00e0 d&#8217;Oncologia, la <strong>creaci\u00f3 del model ortot\u00f2pic de MPNST<\/strong> va permetre realitzar, mitjan\u00e7ant t\u00e8cniques de <em>Next Generation Sequencing<\/em>, an\u00e0lisis gen\u00e8tiques per determinar les mutacions que presentava el pacient.<\/p>\n<p>En funci\u00f3 de les an\u00e0lisis gen\u00e8tiques, la disponibilitat de f\u00e0rmacs, i els resultats publicats pr\u00e8viament, en coordinaci\u00f3 amb l&#8217;equip d\u2019onc\u00f2legs que tractaven el pacient pedi\u00e0tric de l\u2019Hospital Sant Joan de D\u00e9u, es van testar 10 f\u00e0rmacs en 7 tractaments possibles en el model de ratol\u00ed. Basant-se en els resultats obtinguts en el ratol\u00ed, dos r\u00e8gims de tractament van ser administrats successivament al pacient, que pr\u00e8viament havia desenvolupat met\u00e0stasi pulmonar. El pacient no va mostrar una resposta completa als tractaments per\u00f2 juntament amb una metastasectomia del pulm\u00f3 porta 46 mesos lliure de malaltia.<\/p>\n<p>Juana Fern\u00e1ndez Rodr\u00edguez, primera autora del treball, indica que tot i que aquest model de ratol\u00ed no ha recapitulat exactament el que passa en hum\u00e0, es tracta d&#8217;<strong>una prova pilot per identificar aspectes clau de la ter\u00e0pia personalitzada<\/strong>. &#8220;L&#8217;experi\u00e8ncia guanyada en aquest assaig pot ajudar a planificar millor aquest tipus de model mur\u00ed en temps real&#8221;, assegura Fern\u00e1ndez Rodr\u00edguez, &#8220;i ajudar a omplir el buit entre les alteracions gen\u00e8tiques espec\u00edfiques de cada tumor i els tractaments dels pacients, permetent seleccionar les millors opcions terap\u00e8utiques&#8221;.<\/p>\n<p>Aquest estudi que s&#8217;ha realitzat en coordinaci\u00f3 amb l&#8217;Hospital de Sant Joan de D\u00e9u de Barcelona, l&#8217;IGTP de Badalona, i ha comptat amb el finan\u00e7ament, entre d&#8217;altres, de la Fundaci\u00f3n Proyecto Neurofibromatosis a l\u2019\u00e0mbit estatal i de l&#8217;activitat de RSC (Acci\u00f3 Social Corporativa) de l&#8217;spin-off Xenopat S.L.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un equip de l&#8217;IDIBELL i de l&#8217;ICO, utilitzant un model ortot\u00f2pic de ratol\u00ed, ha fet un estudi d\u2019oncologia personalitzada a temps real per testar la millor opci\u00f3 terap\u00e8utica pel tractament d&#8217;un tipus de sarcoma a la recaiguda.<\/p>\n","protected":false},"author":8,"featured_media":13655,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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14:16:57","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/13653"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=13653"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/13653\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/13655"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=13653"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=13653"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=13653"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}