{"id":13124,"date":"2020-06-11T09:21:24","date_gmt":"2020-06-11T07:21:24","guid":{"rendered":"https:\/\/idibell.cat\/?p=13124"},"modified":"2020-06-12T09:08:05","modified_gmt":"2020-06-12T07:08:05","slug":"el-desenvolupament-dels-vasos-sanguinis-depen-de-lestat-de-maduracio-dels-pericits-que-els-envolten","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2020\/06\/el-desenvolupament-dels-vasos-sanguinis-depen-de-lestat-de-maduracio-dels-pericits-que-els-envolten\/","title":{"rendered":"El desenvolupament dels vasos sanguinis dep\u00e8n de l\u2019estat de maduraci\u00f3 dels per\u00edcits que els envolten"},"content":{"rendered":"<p>Els vasos sanguinis estan formats per l&#8217;endoteli, que recobreix la llum dels vasos, i les c\u00e8l\u00b7lules murals, on s&#8217;hi inclouen els <strong>per\u00edcits<\/strong>. Aquest \u00e9s un tipus cel\u00b7lular altament implicat en el desenvolupament i el manteniment de la funcionalitat dels vasos sanguinis. De fet, la seva afectaci\u00f3 est\u00e0 relacionada amb l\u2019aparici\u00f3 o progressi\u00f3 de malalties com les complicacions de la <strong>diabetis, les malformacions vasculars, l&#8217;ictus o el c\u00e0ncer<\/strong>. Tot i aix\u00ed, el paper concret que juguen els per\u00edcits en aquestes malalties encara \u00e9s desconegut. Un grup de l&#8217;IDIBELL, acaba de publicar, a la revista <a href=\"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.119.042354\"><em>Circulation<\/em><\/a>, un treball en el qual descriu la maduraci\u00f3 dels per\u00edcits durant l&#8217;angiog\u00e8nesi i les vies moleculars que regulen aquest proc\u00e9s. &#8220;Con\u00e8ixer com els per\u00edcits estan implicats en el desenvolupament vascular ens pot donar informaci\u00f3 de quin paper juguen en un entorn patol\u00f2gic&#8221;, assegura la Dra. Mariona Graupera, l\u00edder del projecte.<\/p>\n<p>L&#8217;equip de la Dra. Graupera, ha identificat i definit els diferents <strong>estats de maduraci\u00f3<\/strong> dels per\u00edcits en funci\u00f3 de la seva morfologia i els gens que expressen en cada moment. Concretament defineix la via de <strong>la quinasa PI3K<\/strong> com a eix regulador central de la maduraci\u00f3 dels per\u00edcits en l&#8217;angiog\u00e8nesi. &#8220;La formaci\u00f3 de vasos requereix una din\u00e0mica de maduraci\u00f3 dels per\u00edcits \u00f2ptima, la qual s&#8217;aconsegueix a trav\u00e9s d&#8217;una regulaci\u00f3 acurada de la via de la PI3K quinasa&#8221;, assegura Graupera, investigadora de l&#8217;Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (<a href=\"https:\/\/idibell.cat\/recerca\/area-de-cancer\/programa-de-mecanismes-molleculars-i-terapia-experimental-en-oncologia-oncobell\/biologia-i-senyalitzacio-vascular\/\">IDIBELL<\/a>) i del CIBER de C\u00e0ncer (<a href=\"https:\/\/www.ciberonc.es\/\">CIBERONC<\/a>). Aquests descobriments donen les claus per poder entendre el paper dels per\u00edcits en un ambient patol\u00f2gic i aix\u00ed poder abordar-ho.<\/p>\n<p>&nbsp;<\/p>\n<h3>Regulaci\u00f3 molecular de la maduraci\u00f3 dels per\u00edcits<\/h3>\n<p>Les quinases PI3K \u00e9s una fam\u00edlia d\u2019enzims que regulen la senyalitzaci\u00f3 cel\u00b7lular, a m\u00e9s estan implicades en malalties cong\u00e8nites, inflamat\u00f2ries i en el c\u00e0ncer. En el context de la maduraci\u00f3 dels per\u00edcits, sorprenentment, la variant de la quinasa PI3K que regula el proc\u00e9s \u00e9s diferent de la de la majoria de malalties, es tracta de la \u03b2 enlloc de la m\u00e9s freq\u00fcentment implicada en la formaci\u00f3 dels vasos sanguinis \u03b1. Aix\u00f2 converteix la variant \u03b2 en una candidata ideal per a futurs tractaments, ja que permetria un atac m\u00e9s selectiu d&#8217;aquelles malalties causades per alteracions en la maduraci\u00f3 dels per\u00edcits, sense afectar l\u2019activitat de les quinases que actuen en altres processos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Noves eines per l&#8217;estudi dels per\u00edcits<\/h3>\n<p><strong>\u00a0<\/strong>Per a realitzar aquests estudis han utilitzat t\u00e8cniques que els hi permetien determinar els gens que s&#8217;expressen espec\u00edficament en els per\u00edcits dels ratolins in vivo. Aix\u00f2, combinat amb l&#8217;\u00fas de ratolins que, gr\u00e0cies a marcadors fluorescents, els hi permetien observar per\u00edcits a\u00efllats i determinar-ne la morfologia, els hi ha perm\u00e8s creuar ambdues dades, \u00e9s a dir, determinar l&#8217;estat de maduraci\u00f3 dels per\u00edcits a trav\u00e9s de la seva morfologia i identificar els gens que expressen en aquell moment.<\/p>\n<p>Es tracta de t\u00e8cniques molt senzilles i informatives que podrien ser utilitzades en contextos patol\u00f2gics. Aix\u00f2 permetria estudiar l&#8217;estat de maduraci\u00f3 i la signatura molecular dels per\u00edcits en diverses patologies per buscar-ne la implicaci\u00f3 i possibles tractaments.<\/p>\n<p>&nbsp;<\/p>\n<h3>Finan\u00e7ament i col\u00b7laboracions<\/h3>\n<p>Aquest projecte ha estat gr\u00e0cies al finan\u00e7ament de les beques Leonardo de la Fundaci\u00f3n BBVA, una beca predoctoral ITN Marie Curie, una ajuda Juan de la Cierva i el suport del CIBERONC i de l\u2019AECC.<\/p>\n<p>Tamb\u00e9 s&#8217;ha contat amb la col\u00b7laboraci\u00f3 de Dr. Ralf H Adams del Institut Max Planck, una gran emin\u00e8ncia en el camp de l&#8217;angiog\u00e8nesi, a m\u00e9s de la col\u00b7laboraci\u00f3 del Dr. Arkaitz Carracedo del CIC bioGUNE i la Universitat del Pa\u00eds Vasc (UPV\/EHU).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>S\u00f3n moltes les malalties  associades a la desregulaci\u00f3 en la formaci\u00f3 de vasos sanguinis. Ara un equip de l\u2019IDIBELL ha definit un model de maduraci\u00f3 dels per\u00edcits durant la formaci\u00f3 dels vasos i ha desenvolupat les eines d\u2019estudi, el que podria ajudar a desxifrar la seva contribuci\u00f3 en aquestes malalties.<\/p>\n","protected":false},"author":8,"featured_media":13125,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[451,332,447],"tags":[],"class_list":["post-13124","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biologia-i-senyalitzacio-vascular","category-cancer","category-p-de-mecanismes-molelculars-i-terapia-experimental-en-oncologia-oncobell"],"publishpress_future_action":{"enabled":false,"date":"2024-12-02 02:21:30","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/13124","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=13124"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/13124\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/13125"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=13124"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=13124"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=13124"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}