{"id":12783,"date":"2020-05-20T12:48:24","date_gmt":"2020-05-20T10:48:24","guid":{"rendered":"https:\/\/idibell.cat\/?p=12783"},"modified":"2020-05-20T12:48:24","modified_gmt":"2020-05-20T10:48:24","slug":"les-cellules-del-sistema-nervios-de-lintesti-i-els-oligodendrocits-estan-afectades-en-la-malaltia-de-parkinson","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2020\/05\/les-cellules-del-sistema-nervios-de-lintesti-i-els-oligodendrocits-estan-afectades-en-la-malaltia-de-parkinson\/","title":{"rendered":"Les c\u00e8l\u00b7lules del sistema nervi\u00f3s de l\u2019intest\u00ed i els oligodendr\u00f2cits estan afectades en la malaltia de Parkinson"},"content":{"rendered":"<p>Els doctors Fernando Fern\u00e1ndez-Aranda i Susana Jim\u00e9nez-Murcia, investigadors de l&#8217;<a href=\"http:\/\/www.idibell.cat\/\">IDIBELL<\/a> i de <a href=\"https:\/\/bellvitgehospital.cat\/ca\">l&#8217;Hospital Universitari de Bellvitge<\/a>, a m\u00e9s de professors de la Facultat de Ci\u00e8ncies de la Salut de la <a href=\"https:\/\/www.ub.edu\/web\/ub\/ca\/\">Universitat de Barcelona<\/a> (UB) i investigadors del <a href=\"https:\/\/www.ciberobn.es\/\">CIBERobn<\/a>, conjuntament amb els doctors Bru Cormand i Raquel Rabionet, investigadors i professors de la Facultat de Biologia de la UB, i tamb\u00e9 investigadors del <a href=\"https:\/\/www.ciberer.es\/\">Ciber-er<\/a>, l\u2019instut de recerca de Sant Joan de Deu (<a href=\"http:\/\/www.fsjd.org\/ca\/irsjd_146921\">IRSJD<\/a>) i l\u2019<a href=\"http:\/\/www.ub.edu\/ibub\/\">IBUB<\/a>, han participat en un estudi internacional que ha identificat els tipus cel\u00b7lulars implicats en diversos trastorns del cervell. El treball, publicat a la revista <a href=\"https:\/\/www.nature.com\/articles\/s41588-020-0610-9\"><em>Nature Genetics<\/em><\/a>, destaca la implicaci\u00f3 de les c\u00e8l\u00b7lules de sistema nervi\u00f3s de l&#8217;intest\u00ed en la malaltia de Parkinson, suggerint que la malaltia podria tenir all\u00e0 el seu origen. A m\u00e9s, tamb\u00e9 han vist que els oligodendr\u00f2cits es veuen afectats prematurament.<\/p>\n<p>El sistema nervi\u00f3s est\u00e0 format per centenars de tipus cel\u00b7lulars amb funcions ben diferenciades. \u00c9s vital entendre quins s\u00f3n els tipus cel\u00b7lulars afectats en cada trastorn per desxifrar-ne les causes, i en \u00faltima inst\u00e0ncia, dissenyar-ne un tractament.<\/p>\n<p>Els estudis gen\u00e8tics ens indiquen quins s\u00f3n els gens alterats en cada trastorn, per\u00f2 no sabem en quines c\u00e8l\u00b7lules aquets gens s&#8217;estan expressant de manera irregular. Els investigadors d&#8217;aquest estudi, liderat per <a href=\"https:\/\/ki.se\/en?_ga=2.24827770.1719125979.1589354545-1165862723.1588943779\">l&#8217;Institut Karolinska<\/a> i la <a href=\"http:\/\/news.unchealthcare.org\/\">Universitat de Carolina del Nord<\/a>, han combinat els coneixements d&#8217;an\u00e0lisi gen\u00e8tica en humans amb els patrons coneguts d&#8217;expressi\u00f3 de gens en cada tipus cel\u00b7lular en ratol\u00ed.<\/p>\n<p>A l&#8217;estudi s&#8217;ha fet especial \u00e8mfasi a con\u00e8ixer els tipus cel\u00b7lulars afectats en trastorns com el <strong>Parkinson<\/strong>, una malaltia neurodegenerativa amb afectacions cognitives i motores. Per a la malaltia de Parkinson, tal com era d&#8217;esperar, s&#8217;han trobat afectacions de les neurones dopamin\u00e8rgiques, per\u00f2, sorprenentment, tamb\u00e9 s&#8217;han observat alteracions en les <strong>neurones ent\u00e8riques<\/strong>, suggerint una possible relaci\u00f3 de <strong>l\u2019intest\u00ed<\/strong> amb la malaltia.<\/p>\n<p>Un altre descobriment sorprenent de l&#8217;estudi \u00e9s l&#8217;afectaci\u00f3 de les neurones de suport del cervell, els <strong>oligodendr\u00f2cits<\/strong>. Aquestes es veuen afectades de manera primerenca, abans que hi hagi afectaci\u00f3 de les neurones dopamin\u00e8rgiques, el que les converteix en una diana molt interessant per al disseny de tractaments preco\u00e7os.<\/p>\n<p>Noticia adaptada de la web del Institut Karolinska: <a href=\"https:\/\/news.ki.se\/parkinsons-disease-may-start-in-the-gut\">https:\/\/news.ki.se\/parkinsons-disease-may-start-in-the-gut<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>l&#8217;IDIBELL ha participat en un estudi publicat al Nature Genetics que descriu alteracions en les neurones de l&#8217;intest\u00ed i els oligodendr\u00f2cits en la malaltia de Parkinson<\/p>\n","protected":false},"author":8,"featured_media":12784,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[340,457,429],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-13 20:56:54","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/12783"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=12783"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/12783\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/12784"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=12783"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=12783"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=12783"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}