{"id":12727,"date":"2020-04-28T12:00:35","date_gmt":"2020-04-28T10:00:35","guid":{"rendered":"https:\/\/idibell.cat\/?p=12727"},"modified":"2021-03-04T10:11:20","modified_gmt":"2021-03-04T09:11:20","slug":"una-nova-plataforma-per-al-diagnostic-de-lencefalitis-autoimmune-rep-fons-de-les-ajudes-europees-erc-proof-of-concept","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2020\/04\/una-nova-plataforma-per-al-diagnostic-de-lencefalitis-autoimmune-rep-fons-de-les-ajudes-europees-erc-proof-of-concept\/","title":{"rendered":"Una nova plataforma per al diagn\u00f2stic de l&#8217;encefalitis autoimmune rep fons de les ajudes europees ERC Proof of Concept"},"content":{"rendered":"<ul>\n<li><strong>El grup de la Dra. Antonella Consiglio rebr\u00e0 150.000 euros per a un projecte de 18 mesos.<\/strong><\/li>\n<li><strong>El projecte t\u00e9 com a objectiu desenvolupar un m\u00e8tode de diagn\u00f2stic basat en c\u00e8l\u00b7lules mare per a la detecci\u00f3 de l&#8217;encefalitis autoimmune.<\/strong><\/li>\n<\/ul>\n<p>L&#8217;<strong>encefalitis autoimmune (EA) <\/strong>\u00e9s una malaltia que afecta 2-3 persones de cada 100.000, en la qual el sistema immunitari ataca el mateix cervell causant s\u00edmptomes neurol\u00f2gics i psiqui\u00e0trics. Fins ara nom\u00e9s coneixem el 50% de les dianes o ant\u00edgens de les nostres neurones contra els que generem anticossos durant l&#8217;EA. No obstant aix\u00f2, el grup de la Dra. Antonella Consiglio ha dissenyat una nova plataforma, basada en <strong>c\u00e8l\u00b7lules mare<\/strong>, capa\u00e7 de detectar una \u00e0mplia varietat d&#8217;anticossos contra les neurones en el s\u00e8rum sanguini o el l\u00edquid cefalorraquidi.<\/p>\n<p>El potencial d&#8217;innovaci\u00f3, el significatiu impacte i la qualitat del projecte de la Dra. Antonella Consiglio, ICREA academy de l&#8217;Institut d&#8217;Investigaci\u00f3 Biom\u00e8dic Bellvitge (IDIBELL) i Professora Associada del Departament de Patologia i Ter\u00e0pia Experimental de la Facultat de Medicina i Ci\u00e8ncies de la Salut de la Universitat de Barcelona, l&#8217;han ajudat a ser seleccionat per rebre la beca <em>Proof of Concept<\/em> del <strong>Consell Europeu de Recerca (ERC)<\/strong>. El grup rebr\u00e0 una quantitat total de 150.000 euros per un per\u00edode de 18 mesos, i es destinar\u00e0 a explorar oportunitats de negocis, patents i aplicacions pr\u00e0ctiques dels resultats de recerca del grup. Segons la Dra. Consiglio, &#8220;la subvenci\u00f3 \u00e9s una gran oportunitat per desenvolupar un nou i innovador enfocament per a detectar una gran varietat d&#8217;autoant\u00edgens neuronals, i aix\u00ed desenvolupar un diagn\u00f2stic m\u00e9s r\u00e0pid i prec\u00eds dels trastorns autoimmunitaris del sistema nervi\u00f3s central que l&#8217;acostin al mercat&#8221;.<\/p>\n<p>Les subvencions de <em>Proof of Concept<\/em> tenen com a objectiu explorar el potencial social i\/o comercial dels resultats assolits en projectes anteriors finan\u00e7ats a trav\u00e9s de l&#8217;ERC, en el marc del Programa de Recerca i Innovaci\u00f3 de la Uni\u00f3 Europea, Horizon 2020. El pressupost total del programa ascendeix a 25 milions d&#8217;euros.<\/p>\n<p>&nbsp;<\/p>\n<h4>Una poderosa nova plataforma basada en c\u00e8l\u00b7lules mare<\/h4>\n<p>&nbsp;<\/p>\n<p>El 2013, l&#8217;ERC li va atorgar a Antonella Consiglio una subvenci\u00f3 de 1,32 milions d&#8217;euros per desenvolupar el seu projecte d&#8217;identificaci\u00f3 de mecanismes patog\u00e8nics primerencs de la neurodegeneraci\u00f3 en la malaltia de Parkinson, a trav\u00e9s d&#8217;un model in vitro din\u00e0mic humanitzat. Gr\u00e0cies a aquesta subvenci\u00f3, el laboratori va emprendre diverses iniciatives de col\u00b7laboraci\u00f3 exitoses, com ara el projecte amb el <strong>Dr. Dalmau<\/strong> i el <strong>Dr. Mart\u00ednez<\/strong> de l&#8217;Hospital Cl\u00ednic, que ha arribat a obrir una nova l\u00ednia d&#8217;investigaci\u00f3 centrada en el desenvolupament d&#8217;un dispositiu prototip per al diagn\u00f2stic millorat de l\u2019EA.<\/p>\n<p>El grup d&#8217;Antonella Consiglio proposa una nova plataforma de diagn\u00f2stic, en qu\u00e8 els anticossos contra les mateixes neurones, presents en el s\u00e8rum o el l\u00edquid cefalorraquidi dels pacients, siguin verificats en neurones humanes procedents de la diferenciaci\u00f3 in vitro de c\u00e8l\u00b7lules mare pluripotents.<\/p>\n<p>Aquesta nova plataforma ens permetria recon\u00e8ixer, no nom\u00e9s aquells anticossos que reconeixen ant\u00edgens coneguts causants de l&#8217;EA, sin\u00f3 tamb\u00e9 qualsevol autoantic\u00f2s que reconegui les seves prote\u00efnes com estranyes. A m\u00e9s, at\u00e8s que \u00e9s un model completament hum\u00e0, no hi ha la possibilitat de manca de reconeixement entre antigen i antic\u00f2s a causa de les difer\u00e8ncies entre esp\u00e8cies. Finalment, aquesta plataforma reconeix amb alta fiabilitat els falsos positius que puguin oc\u00f3rrer.<\/p>\n<p>&nbsp;<\/p>\n<blockquote><p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-16744 alignleft\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/04\/LOGO_ERC-FLAG_EU_-300x122.jpg\" alt=\"\" width=\"300\" height=\"122\" srcset=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/04\/LOGO_ERC-FLAG_EU_-300x122.jpg 300w, https:\/\/idibell.cat\/wp-content\/uploads\/2020\/04\/LOGO_ERC-FLAG_EU_-1024x417.jpg 1024w, https:\/\/idibell.cat\/wp-content\/uploads\/2020\/04\/LOGO_ERC-FLAG_EU_-768x313.jpg 768w, https:\/\/idibell.cat\/wp-content\/uploads\/2020\/04\/LOGO_ERC-FLAG_EU_.jpg 1200w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>Aquest projecte ha rebut finan\u00e7ament de el Consell Europeu de Recerca (ERC) en el marc del programa de recerca i innovaci\u00f3 Horitz\u00f3 2020 de la Uni\u00f3 Europea (acord de subvenci\u00f3 no 957.581).<\/p><\/blockquote>\n","protected":false},"excerpt":{"rendered":"<p>La plataforma, basada en c\u00e8l\u00b7lules mare, possibilitaria un diagn\u00f2stic m\u00e9s acurat de la malaltia, ja que detectaria amb alta presici\u00f3 una amplia gamma d&#8217;autoanticossos<\/p>\n","protected":false},"author":8,"featured_media":12728,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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21:00:52","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/12727"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=12727"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/12727\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/12728"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=12727"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=12727"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=12727"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}