{"id":12692,"date":"2020-05-15T12:00:47","date_gmt":"2020-05-15T10:00:47","guid":{"rendered":"https:\/\/idibell.cat\/?p=12692"},"modified":"2020-05-16T18:14:45","modified_gmt":"2020-05-16T16:14:45","slug":"lidibell-ha-participat-en-un-estudi-que-descriu-que-la-capacitat-de-produir-proteines-defineix-les-cellules-mare-tumorals","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2020\/05\/lidibell-ha-participat-en-un-estudi-que-descriu-que-la-capacitat-de-produir-proteines-defineix-les-cellules-mare-tumorals\/","title":{"rendered":"L’IDIBELL ha participat en un estudi que descriu que la capacitat de produir prote\u00efnes defineix les c\u00e8l\u00b7lules mare tumorals"},"content":{"rendered":"

\"\"La composici\u00f3 cel\u00b7lular dels tumors de c\u00e0ncer de c\u00f2lon<\/strong> \u00e9s heterog\u00e8nia, hi podem trobar des de c\u00e8l\u00b7lules diferenciades, semblants a les del mateix teixit del colon, fins a c\u00e8l\u00b7lules mare o pluripotents, responsables del creixement del tumor i la met\u00e0stasi. Un estudi publicat a la revista Cell Stem Cell<\/em><\/a> liderat pel Dr\u00a0 Edurad Batlle del l’Institut de Recerca Biom\u00e8dica (IRB<\/a>) i en que hi han participat l\u2019equip del Dr. Alberto Villanueva de l’IDIBELL<\/a>\/ICO<\/a>, demostra que la capacitat de sintetitzar prote\u00efnes, capacitat biosint\u00e8tica<\/strong>, \u00e9s la que converteix les c\u00e8l\u00b7lules en pluripotents i la que els hi permet contribuir en el creixement del tumor de manera il\u00b7limitada.<\/p>\n

Per estudiar la capacitat biosint\u00e8tica de les c\u00e8l\u00b7lules mare tumorals s’han utilitzat diversos models, entre ells, la implantaci\u00f3 de tumors de c\u00e0ncer colorectal humans en ratolins<\/strong>, model desenvolupat per l’equip del Dr. Villanueva. El conjunt dels models han posat en evid\u00e8ncia que en bloquejar la capacitat biosint\u00e8tica de les c\u00e8l\u00b7lules, o en eliminar les c\u00e8l\u00b7lules que tenen aquesta capacitat, es frena per complet el creixement tumoral, el que converteix aquesta funci\u00f3 en una diana ideal per a futurs tractaments.<\/p>\n

L’estudi descriu que la capacitat de produir prote\u00efnes es troba restringida a les regions del tumor on es troben les c\u00e8l\u00b7lules pluripotents, i que a m\u00e9s, els tumors presenten un gradient de producci\u00f3 de prote\u00efnes, i aquelles c\u00e8l\u00b7lules que han perdut aquesta capacitat per complet no poden tornar a l’estat de c\u00e8l\u00b7lules mare.<\/p>\n

Text adaptat de la p\u00e0gina web del IRB: https:\/\/www.irbbarcelona.org\/ca\/news\/la-capacitat-biosintetica-clau-per-erradicar-les-cellules-mare-tumorals<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

La producci\u00f3 de prote\u00efnes \u00e9s el que defineix les c\u00e8l\u00b7lules mare tumorals, el que converteix aquesta funci\u00f3 en una diana terap\u00e8utica ideal.<\/p>\n","protected":false},"author":8,"featured_media":12695,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[332,447,346],"tags":[],"class_list":["post-12692","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cancer","category-p-de-mecanismes-molelculars-i-terapia-experimental-en-oncologia-oncobell","category-quimioresistencia-tumoral-i-estromal"],"publishpress_future_action":{"enabled":false,"date":"2024-12-25 22:59:00","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/12692","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=12692"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/12692\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/12695"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=12692"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=12692"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=12692"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}