{"id":450,"date":"2019-05-08T15:57:41","date_gmt":"2019-05-08T13:57:41","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=450"},"modified":"2024-04-11T08:10:50","modified_gmt":"2024-04-11T06:10:50","slug":"cancer-colorectal-2","status":"publish","type":"page","link":"https:\/\/idibell.cat\/recerca\/area-de-cancer\/programa-de-mecanismes-molleculars-i-terapia-experimental-en-oncologia-oncobell\/cancer-colorectal-2\/","title":{"rendered":"C\u00e0ncer Colorectal"},"content":{"rendered":"\n
El grup de recerca del C\u00e0ncer colorectal (CRC), liderat per V\u00edctor Moreno i Ramon Salazar, se centra en el descobriment i validaci\u00f3 de noves signatures moleculars de diagn\u00f2stic, pron\u00f2stic i predicci\u00f3 i en la identificaci\u00f3 o optimitzaci\u00f3 de noves dianes terap\u00e8utiques i classificacions moleculars de CRC a trav\u00e9s d’un enfocament integr\u00f2mic, combinant el coneixement de l’epidemiologia gen\u00e8tica, la bioinform\u00e0tica de dades i la farmacologia.<\/p>\n
Pinato DJ, Aguilar Company J, Ferrante D, Hanbury G, Bower M, Salazar R, Mirallas O, Sureda A, Plaja A, Cucurull M, Mesia R, Townsend S, Jackson A, Dalla Pria A, Newsom Davis T, Handford J, Sita Lumsden A, Apthorp E, Vincenzi B, Bertuzzi A, Brunet J, Lambertini M, Maluquer C, Pedrazzoli P, Biello F, Sinclair A, Bawany S, Khalique S, Rossi S, Rogers L, Murphy C, Belessiotis K, Carmona Garc\u00eda MC, Sharkey R, Garc\u00eda Illescas D, Rizzo G, Perachino M, Saoudi Gonzalez N, Doonga K, Fox L, Rold\u00e1n E, Gaidano G, Ruiz Camps I, Bruna R, Patriarca A, Martinez Vila C, Cantini L, Zambelli A, Giusti R, Mazzoni F, Caliman E, Santoro A, Grosso F, Parisi A, Queirolo P, Aujayeb A, Rimassa L, Prat A, Tucci M, Libertini M, Grisanti S, Mukherjee U, Diamantis N, Fusco V, Generali D, Provenzano S, Gennari A, Tabernero J, Cortellini A, OnCovid study G. Outcomes of the SARS-CoV-2 omicron (B.1.1.529) variant outbreak among vaccinated and unvaccinated patients with cancer in Europe: results from the retrospective, multicentre, OnCovid registry study<\/strong>. Lancet Oncol. 2022;23(7):865-875. doi:10.1016\/S1470-2045(22)00273-X.<\/p>\n Jimenez Fonseca P, Salazar R, Valenti V, Msaouel P, Carmona Bayonas A. Is short-course radiotherapy and total neoadjuvant therapy the new standard of care in locally advanced rectal cancer? A sensitivity analysis of the RAPIDO clinical trial<\/strong>. Ann. Oncol. 2022;33(8):786-793. doi:10.1016\/j.annonc.2022.04.010.<\/p>\n Olivera I, Sanz Pamplona R, Bolanos E, Rodriguez I, Etxeberria I, Cirella A, Egea J, Garasa S, Migueliz I, Eguren Santamaria I, Sanmamed MF, Glez Vaz J, Azpilikueta A, Alvarez M, Ochoa MC, Malacrida B, Propper D, de Andrea CE, Berraondo P, Balkwill FR, Teijeira A, Melero I. A therapeutically actionable pro-tumoral axis of cytokines involving interleukin-8, TNFa and IL-1B<\/strong>. Cancer Discov. 2022;12(9):2140-2157. doi:10.1158\/2159-8290.CD-21-1115.<\/p>\n OnCovid Study G, Pinato DJ, Patel M, Scotti L, Colomba E, Dolly S, Loizidou A, Chester J, Mukherjee U, Zambelli A, Dalla Pria A, Aguilar Company J, Bower M, Salazar R, Bertuzzi A, Brunet J, Lambertini M, Tagliamento M, Pous A, Sita Lumsden A, Srikandarajah K, Colomba J, Pommeret F, Segu\u00ed E, Generali D, Grisanti S, Pedrazzoli P, Rizzo G, Libertini M, Moss C, Evans JS, Russell B, Harbeck N, Vincenzi B, Biello F, Bertulli R, Ottaviani D, Li\u00f1an R, Rossi S, Carmona Garc\u00eda MC, Tondini C, Fox L, Baggi A, Fotia V, Parisi A, Porzio G, Queirolo P, Cruz CA, Saoudi Gonzalez N, Felip E, Roqu\u00e9 Lloveras A, Newsom Davis T, Sharkey R, Rold\u00e1n E, Reyes R, Zoratto F, Earnshaw I, Ferrante D, Marco Hern\u00e1ndez J, Ruiz Camps I, Gaidano G, Patriarca A, Bruna R, Sureda A, Martinez Vila C, Sanchez de Torre A, Berardi R, Giusti R, Mazzoni F, Guida A, Rimassa L, Chiudinelli L, Franchi M, Krengli M, Santoro A, Prat A, Tabernero J, Van Hemelrijck M, Diamantis N, Gennari A, Cortellini A. Time-Dependent COVID-19 Mortality in Patients With Cancer: An Updated Analysis of the OnCovid Registry<\/strong>. JAMA Oncol. 2022;8(1):114-122. doi:10.1001\/jamaoncol.2021.6199.<\/p>\n Herpers B, Eppink B, James MI, Cortina C, Ca\u00f1ellas Socias A, Boj SF, Hernando Momblona X, Glodzik D, Roovers RC, van de Wetering M, Bartelink Clements C, Zondag van der Zande V, Mateos JG, Yan K, Salinaro L, Basmeleh A, Fatrai S, Maussang D, Lammerts van Bueren JJ, Chicote I, Serna G, Cabellos L, Ram\u00edrez L, Nuciforo P, Salazar R, Santos C, Villanueva A, Stephan Otto Attolini C, Sancho E, Palmer HG, Tabernero J, Stratton MR, de Kruif J, Logtenberg T, Clevers H, Price LS, Vries RGJ, Batlle E, Throsby M. Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR \u00d7 LGR5 bispecific antibody with efficacy in epithelial tumors<\/strong>. Nat. Cancer. 2022;3(4):418-436. doi:10.1038\/s43018-022-00359-0.<\/p>\n\t\t\t\t\tProjectes seleccionats<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t FIS22041. Understanding TIL composition and anti-tumor rEactivity in liver metastases from colorectal cancer patients (u-TIL-e)<\/strong>. Instituto de Salud Carlos III (ISCIII). Budget: 130680. 2023-2025. PI: Salazar Soler, Ram\u00f3n \/ Losa Gasp\u00e0 Ferran.<\/p>\n 18INT006. ACRCelerate: Colorectal Cancer Stratified Medicine Network<\/strong>. WORLD CANCER RESEARCH FUND INTERNATIONAL WCRFI. Budget: 78756,34. 2018-2023. PI: Salazar Soler, Ram\u00f3n.<\/p>\n 21FIS026. \u00bfC\u00f3mo influye el microambiente inmune en el patr\u00f3n de diseminaci\u00f3n metast\u00e1sica y supervivencia en<\/strong>. Instituto de Salud Carlos III (ISCIII). Budget: 123420. 2021-2023. PI: Santos Vivas, Cristina.<\/p>\n 18FIS005. Estudio de las interacciones microbioma-anfitri\u00f3n para la prevenci\u00f3n del c\u00e1ncer colorrectal (Colonbiome)<\/strong>. Instituto de Salud Carlos III (ISCIII). Budget: 202070. 2018-2022. PI: Moreno Aguado, V\u00edctor; Pimenoff, Ville Nikolai.<\/p>\n 21ACL057. AN OPEN-LABEL STUDY OF THE EFFECT OF TESETAXEL ON THE QTC INTERVAL AND THE EFFECT OF FOOD, ITRACONAZOLE, AND RIFAMPIN ON TESETAXEL PHARMACOKINETICS IN PATIENTS WITH ADVANCED SOLID TUMORS<\/strong>. Budget: 178620. 2021- . PI: Mulet Margalef, N\u00faria.<\/p>\n\t\t\t\t\tM\u00e9s informaci\u00f3<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\tParticipaci\u00f3\u00a0en consorcis internacionals MOTRICOLOR (assajos dirigits molecularment\u00a0amb estrat\u00e8gies espec\u00edfiques de tractament\u00a0en pacients amb nous subtipus\u00a0moleculars de c\u00e0ncer colorrectal avan\u00e7at) i FIGI (Utilitzaci\u00f3\u00a0de la gen\u00f2mica funcional per\u00a0informar de les interaccions gen\u00e8tiques del CRC). C\u00e0ncer Colorectal Resum El grup de recerca del C\u00e0ncer colorectal (CRC), liderat per V\u00edctor Moreno i Ramon Salazar, se centra en el descobriment i validaci\u00f3 de noves signatures moleculars de diagn\u00f2stic, pron\u00f2stic i predicci\u00f3 i en la identificaci\u00f3 o optimitzaci\u00f3 de noves dianes terap\u00e8utiques i classificacions moleculars de CRC a trav\u00e9s d’un enfocament integr\u00f2mic, combinant […]<\/p>\n","protected":false},"author":1,"featured_media":4233,"parent":448,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"publishpress_future_action":{"enabled":false,"date":"2024-05-09 20:18:37","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages\/450"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=450"}],"version-history":[{"count":6,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages\/450\/revisions"}],"predecessor-version":[{"id":25399,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages\/450\/revisions\/25399"}],"up":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages\/448"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/4233"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=450"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nColon\u00f2mica com a\u00a0plataforma per al descobriment\u00a0de biomarcadors i la caracteritzaci\u00f3\u00a0del CRC.
\nValidaci\u00f3\u00a0cl\u00ednica de ColoPrint\u00ae, una firma gen\u00e8tica pron\u00f2stica de la fase II i el nou\u00a0consens\u00a0de classificaci\u00f3\u00a0de subtipus moleculars (CMS 1-4)\n\t\t\t\t\n\n\t\tMoreno Aguado, Victor Raul\n\t<\/h4>\n
\n\t\t\n\t\tvmoreno@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\n
\n\t\tSalazar Soler, Ramon\n\t<\/h4>\n
\n\t\t\n\t\trsalazar@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n
\n\t\tInvestigadors principals\n\t<\/h2>\n\t\t\t\t\n
\n\t\tMoreno Aguado, Victor Raul\n\t<\/h4>\n
\n\t\t\n\t\tvmoreno@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\n
\n\t\tSalazar Soler, Ramon\n\t<\/h4>\n\t\t\t\t\n
\n\t\tSoler Gonz\u00e1lez, Gemma\n\t<\/h4>\n
\n\t\t\n\t\tgsolerg@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\n
\n\t\tDuell, Eric\n\t<\/h4>\n
\n\t\t\n\t\teduell@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n
\n\t\t\n\t\trsalazar@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\n
\n\t\tSantos Vivas, Cristina\n\t<\/h4>\n
\n\t\t\n\t\tcsantos@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\n
\n\t\tMartinez Villacampa, Mercedes\n\t<\/h4>\n
\n\t\t\n\t\tmmartinezv@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n
\n\t\tENLLA\u00c7OS RELACIONATS\n\t<\/h4>\n
\n\t\t\n\t\tColonomics\n\t\t<\/a>\n\t<\/h4>\n
\n\t\t\n\t\tMotricolor\n\t\t<\/a>\n\t<\/h4>\n
\n\t\t\n\t\tEstudio Colscreen\n\t\t<\/a>\n\t<\/h4>\n
\n\t\t\n\t\t@RamonSalazarS\n\t\t<\/a>\n\t<\/h4>\n
\n\t\t\n\t\t@PamplonaSanz\n\t\t<\/a>\n\t<\/h4>\n
\n\t\tEquip\n\t<\/h2>\n\t\t\t\t\t\t\t\t\t\t\t\tCap de grup\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadors\/es principals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadors\/es cl\u00ednics\/ques\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadors\/es postdoctorals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadores\/as predoctorales\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tSoporte cient\u00edfico\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tSuport de gesti\u00f3\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tCol\u00b7laboradors\/es\t\t\t\t<\/a>\n\t\t\t\t\t\tCap de grup\n\t\t\t\t\t\t\t\t\t\t\t
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\n\t\tNot\u00edcies relacionades\n\t<\/h2>\n\t\t\n\t\t\t\t<\/a>\n\t\t\tUn estudi identifica per primer cop m\u00e9s de 100 nous factors gen\u00e8tics vinculats al desenvolupament de c\u00e0ncer colorrectal<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t11\/01\/2023\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tDesenvolupen un model que millora el cribratge del c\u00e0ncer colorectal<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t19\/07\/2022\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tDescobreixen un conjunt de marcadors de mal pron\u00f2stic en pacients amb c\u00e0ncer de c\u00f2lon i recte<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t03\/06\/2022\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tUn assaig cl\u00ednic mostra la seguretat i el potencial d’un virus oncol\u00edtic contra el c\u00e0ncer de p\u00e0ncrees avan\u00e7at<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t04\/05\/2022\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tUn estudi presenta MCLA-158, el primer candidat a f\u00e0rmac dirigit a c\u00e8l\u00b7lules mare canceroses de tumors s\u00f2lids<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t26\/04\/2022\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tL’IDIBELL rep m\u00e9s d’un mili\u00f3 i mig d’euros de l’AECC per finan\u00e7ar projectes d’investigaci\u00f3 contra el c\u00e0ncer<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t17\/11\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tL’estudi de variants gen\u00e8tiques per la detecci\u00f3 preco\u00e7 del c\u00e0ncer colorectal: estat actual i perspectives de futur<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t10\/11\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tIdentificats nous gens de susceptibilitat a patir malalties inflamat\u00f2ries intestinals<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t14\/09\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tCinc projectes de l’IDIBELL reben finan\u00e7ament de La Marat\u00f3 2020 dedicada a la COVID-19<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t12\/06\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tIDIBELL celebra el Kickoff Meeting sobre els Projectes d’Investigaci\u00f3 en Salut concedits per l’ISCIII<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t20\/04\/2021\t\t\t\t\t\t\t\n\t\t\n\n","protected":false},"excerpt":{"rendered":"