{"id":3942,"date":"2020-01-15T10:53:24","date_gmt":"2020-01-15T09:53:24","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=3942"},"modified":"2024-10-14T12:46:54","modified_gmt":"2024-10-14T10:46:54","slug":"potencia-de-cellules-mare","status":"publish","type":"page","link":"https:\/\/idibell.cat\/recerca\/area-medicina-regenerativa\/programa-de-medicina-regenerativa\/potencia-de-cellules-mare\/","title":{"rendered":"Pot\u00e8ncia de c\u00e8l\u00b7lules mare"},"content":{"rendered":"\n<h1>\n\t\tPot\u00e8ncia de c\u00e8l\u00b7lules mare\n\t<\/h1>\n<h3>\n\t\tResum\n\t<\/h3>\n\t<p>Durant el desenvolupament de l&#8217;embri\u00f3, la pot\u00e8ncia del zigot es desplega a trav\u00e9s de canvis coordinats i estereot\u00edpics en els comportaments cel\u00b7lulars i processos de disseny de teixits, el que finalment resulta en la formaci\u00f3 d&#8217;un organisme complet i altament complex en un per\u00edode de temps relativament curt. Al llarg d&#8217;aquest proc\u00e9s, la pot\u00e8ncia de desenvolupament de les c\u00e8l\u00b7lules individuals, \u00e9s a dir, la seva capacitat de donar lloc a c\u00e8l\u00b7lules d&#8217;un tipus diferent del seu, es perd progressivament, de manera que les c\u00e8l\u00b7lules som\u00e0tiques en individus adults retenen una pot\u00e8ncia molt limitada (com en les c\u00e8l\u00b7lules mare adultes rares) o no mostren pot\u00e8ncia alguna.<\/p>\n<p>El nostre laboratori est\u00e0 interessat en comprendre els mecanismes que governen el grau de pot\u00e8ncia de les c\u00e8l\u00b7lules som\u00e0tiques humanes, i com es pot augmentar experimentalment per condicions en qu\u00e8 fer-ho pot tenir rellev\u00e0ncia biom\u00e8dica. Espec\u00edficament, el context en el qual vam investigar aquests problemes se centra principalment en el paradigma de la regeneraci\u00f3\/reparaci\u00f3 card\u00edaca. En general, la nostra investigaci\u00f3 aprofita una varietat de paradigmes experimentals (regeneraci\u00f3 de cor del peix zebra, generaci\u00f3 i diferenciaci\u00f3 iPSC humana), abordats des d&#8217;una perspectiva multidisciplin\u00e0ria, que abasta des d&#8217;enfocaments de bioenginyeria fins a la diferenciaci\u00f3 de c\u00e8l\u00b7lules mare 3D fins a l&#8217;an\u00e0lisi de rastreig de llinatge gen\u00e8tic de c\u00e8l\u00b7lules individuals i manipulaci\u00f3 gen\u00e8tica de c\u00e8l\u00b7lules humanes, dirigida a abordar importants problemes actuals en biologia i biomedicina, com els mecanismes que controlen l&#8217;establiment i manteniment de la pot\u00e8ncia del desenvolupament, l&#8217;inici i la progressi\u00f3 del proc\u00e9s regeneratiu, i la diferenciaci\u00f3 i maduraci\u00f3 funcional dels cardiomi\u00f2cits humans, i el desenvolupament de models genu\u00efnament humans de malalties humanes.<\/p>\n<h2>204<\/h2>\n<h2>Publicacions<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/04\/Stem-Cell-Potency.png\" alt=\"Stem-Cell-Potency\" itemprop=\"image\" height=\"300\" width=\"600\" title=\"Stem-Cell-Potency\" onerror=\"this.style.display='none'\"  \/>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\">L\u00ednies estrat\u00e8giques<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\"><i>Expand<\/i><\/a>\n\t\t\t\t\tRegeneraci\u00f3 de el cor en el peix zebra<br \/>\nmodelatge de malalties basat en iPSC<br \/>\nEnginyeria de teixit card\u00edac<br \/>\nReprogramaci\u00f3 d&#8217;estrat\u00e8gies per a la reparaci\u00f3 de el cor.\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\">Publicacions seleccionades<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>Pesce,M;Duda,GN;Forte,G;Girao,H;Raya,A;Roca Cusachs,P;Sluijter,JPG et al,<strong> Cardiac fibroblasts and mechanosensation in heart development, health and disease<\/strong>, Nat. Rev. Cardiol., 2023;20(5):309-324, doi:10.1038\/s41569-022-00799-2<\/li>\n<li>Siguero \u00c1lvarez,M;Salguero Jim\u00e9nez,A;Grego Bessa,J;de la Barrera,J; MacGrogan,D;Prados,B; S\u00e1nchez S\u00e1ez,F et al,<strong> Human Hereditary Cardiomyopathy Shares a Genetic Substrate With Bicuspid Aortic Valve<\/strong>., Circulation, 2023;147(1):47-65, doi:10.1161\/CIRCULATIONAHA.121.058767<\/li>\n<li>Tristan Noguero,A;Fernandez Carasa,I;Calatayud,C;Bermejo Casadesus,C;Pons Espinal,M; Baldeschi,AC;Campa,L et al, <strong>iPSC-based modeling of THD recapitulates disease phenotypes and reveals neuronal malformation<\/strong>, EMBO Mol. Med. 2023;15(3):doi:10.15252\/emmm.202215847<\/li>\n<li>Kuebler,B;Alvarez Palomo,B;Aran,B;Casta\u00f1o,J;Rodriguez,L;Raya,A;Giner,SQ et al, <strong>Generation of a bank of clinical-grade, HLA-homozygous iPSC lines with high coverage of the Spanish population<\/strong>, Stem Cell Res. Ther., 2023;14(1):366-366, doi:10.1186\/s13287-023-03576-1<\/li>\n<li>Escriba,R;Larranaga Moreira,JM;Richaud Patin,Y;Pourchet,L;Lazis,I;Jimenez Delgado,S; Morillas Garcia,A et al,<strong> iPSC-Based Modeling of Variable Clinical Presentation in Hypertrophic Cardiomyopathy<\/strong>, Circ.Res., 2023;133(2):108-119, doi:10.1161\/CIRCRESAHA.122.321951<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\">Projectes seleccionats<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>MCI21048. <strong>Estudio de las adaptaciones del microambiente que controlan la regeneraci\u00f3n\/reparaci\u00f3n cardiaca<\/strong>. Ministerio de Ciencia e Innovaci\u00f3n. Budget: 311938. 2022-2025. PI: RAYA CHAMORRO, ANGEL.<\/li>\n<li>LCX22024. <strong>Novel genetic and mechanistic studies of hypertrophic cardiomyopathy<\/strong>. FUNDACI\u00d3 &#8220;LA CAIXA&#8221;. Budget: 252.306,38\u20ac. 2023-2026. PI: RAYA CHAMORRO, ANGEL.<\/li>\n<li>CEE21007. <strong>PhyCaR:Pseudohypoxia-mediated cardiac regeneration<\/strong>. COMISSI\u00d3 EUROPEA. Budget: 160.932,48\u20ac. 2022-2024. PI: URIBE BRANGE, DANIEL ALEJANDRO.<\/li>\n<li>MAR23009. <strong>Advancing the clinical translation of iPSC-based cell therapies for heart failure<\/strong>. Fundaci\u00f3 La Marat\u00f3 de TV3. Budget: 159.756,51\u20ac. 2023- . PI: RAYA CHAMORRO, ANGEL.<\/li>\n<li>20MEC019. <strong>AYUDAS PARA LA FORMACION DE DOCTORES DEL PROGRAMA NACIONAL DE FORMACION DE PROFESORADO UNIVERSITARIO (FPU). MINISTERIO DE EDUCACI\u00d3N Y FORMACI\u00d3N PROFESIONAL<\/strong>. Budget: 144.048,76\u20ac. 2020-2026. PI: RAYA CHAMORRO, ANGEL.<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-3\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-3\">Transfer\u00e8ncia de tecnologia<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-3\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-3\"><i>Expand<\/i><\/a>\n\t\t\t\t\tPAT072-Composition for Improving the Culture and Implantation of Mammalian Embryos, Preparation Method and Use Thereof<br \/>\nIP: Samuel Ojosnegros (patent que es va incorpora al IDIBELL amb l&#8217;adquisici\u00f3 del CMRB)<br \/>\nEP 19382106\nLicense: Composition for improving the culture and implantation of mammalian embryos preparation method and use thereof<br \/>\nPI: Dr. \u00c1ngel Raya\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/02\/angel_royo-150x150.png\" alt=\"Raya Chamorro, \u00c1ngel\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Raya Chamorro, \u00c1ngel\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tRaya Chamorro, \u00c1ngel\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:caraya@idibell.cat\" title=\"araya@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\taraya@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tInvestigadors principals\n\t<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/02\/angel_royo-150x150.png\" alt=\"Raya Chamorro, \u00c1ngel\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Raya Chamorro, \u00c1ngel\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tRaya Chamorro, \u00c1ngel\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:caraya@idibell.cat\" title=\"araya@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\taraya@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\tENLLA\u00c7OS RELACIONATS\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/p-cmrc.cat\/\" title=\"P-CMR[C]\" target=\"_blank\" rel=\"noopener\">\n\t\tP-CMR[C]\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/twitter.com\/p_cmrc\" title=\"@p_cmrc\" target=\"_blank\" rel=\"noopener\">\n\t\t@p_cmrc\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/www.icrea.cat\/Web\/ScientificStaff\/angel-raya--chamorro-354\" title=\"ICREA\" target=\"_blank\" rel=\"noopener\">\n\t\tICREA\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"http:\/\/www.red-tercel.com\/grupo.asp?id=RD16\/0011\/0024\" title=\"RED-TERCEL\" target=\"_blank\" rel=\"noopener\">\n\t\tRED-TERCEL\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/www.ciber-bbn.es\/grupos\/grupo-de-investigacion?id=3618\" title=\"CIBER-BBN\" target=\"_blank\" rel=\"noopener\">\n\t\tCIBER-BBN\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tEquip\n\t<\/h2>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-0\" data-index=\"0\" aria-selected=\"true\" aria-controls=\"fl-tabs--panel-0\" aria-expanded=\"true\" role=\"tab\" tabindex=\"0\">\t\t\t\tCaps de grup\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-1\" data-index=\"1\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-1\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es postdoctorals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-2\" data-index=\"2\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-2\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadores\/as predoctorales\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-3\" data-index=\"3\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-3\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tSuport cient\u00edfic\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-4\" data-index=\"4\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-4\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tSuport de gesti\u00f3\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-5\" data-index=\"5\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-5\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tCol\u00b7laboradors\/es\t\t\t\t<\/a>\n\t\t\t\t\t\tCaps de grup\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Raya Chamorro, \u00c1ngel<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es postdoctorals\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Castillo Robles, Jorge Luis<\/li>\n<li>Boix Besora, Arnau<\/li>\n<li>Nieto Romero, Virginia<\/li>\n<li>Fredericksen Quilodran, Fernanda Valentina<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadores\/as predoctorales\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Casado Medina, Laura<\/li>\n<li>Yuan, Yang<\/li>\n<li>Quasem, Taqwa<\/li>\n<\/ul>\n\t\t\t\t\t\tSuport cient\u00edfic\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Morillas Garc\u00eda, Alba<\/li>\n<li>Richaud Patin, Ivonne<\/li>\n<li>Garc\u00eda Pastor, Cristina<\/li>\n<li>Mularoni, Loris<\/li>\n<li>Jimenez Delgado, Senda<\/li>\n<li>Lorenzo Serrano, Edgar<\/li>\n<\/ul>\n\t\t\t\t\t\tSuport de gesti\u00f3\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Van Dongen, Maria Johanna<\/li>\n<li>Rodr\u00edguez Aguilar, Ester<\/li>\n<\/ul>\n\t\t\t\t\t\tCol\u00b7laboradors\/es\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Uribe Brange, Daniel Alejandro<\/li>\n<li>Tadevosyan, Karine<\/li>\n<\/ul>\n<h2>\n\t\tNot\u00edcies relacionades\n\t<\/h2>\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/25060\" content=\"Identifiquen un f\u00e0rmac modulador del sistema immune potencialment \u00fatil per bloquejar la malaltia del Parkinson\" \/><meta itemprop=\"datePublished\" content=\"2024-02-15\" \/><meta itemprop=\"dateModified\" content=\"2024-02-14\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/wp-content\/uploads\/2023\/03\/cropped-Marca-B.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/wp-content\/uploads\/2024\/02\/Consiglio-JCI-2024-3-scaled.jpg\" 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-->\n\n","protected":false},"excerpt":{"rendered":"<p>Pot\u00e8ncia de c\u00e8l\u00b7lules mare Resum Durant el desenvolupament de l&#8217;embri\u00f3, la pot\u00e8ncia del zigot es desplega a trav\u00e9s de canvis coordinats i estereot\u00edpics en els comportaments cel\u00b7lulars i processos de disseny de teixits, el que finalment resulta en la formaci\u00f3 d&#8217;un organisme complet i altament complex en un per\u00edode de temps relativament curt. 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