{"id":3935,"date":"2020-01-15T09:59:29","date_gmt":"2020-01-15T08:59:29","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=3935"},"modified":"2025-01-07T14:39:50","modified_gmt":"2025-01-07T13:39:50","slug":"envelliment-de-cellules-mare","status":"publish","type":"page","link":"https:\/\/idibell.cat\/recerca\/area-medicina-regenerativa\/programa-de-medicina-regenerativa\/envelliment-de-cellules-mare\/","title":{"rendered":"Envelliment de C\u00e8l\u00b7lules Mare"},"content":{"rendered":"\n<h1>\n\t\tEnvelliment de c\u00e8l\u00b7lules mare\n\t<\/h1>\n<h3>\n\t\tResum\n\t<\/h3>\nLes c\u00e8l\u00b7lules mare som\u00e0tiques tenen la capacitat de regenerar els teixits amb el pas del temps. Aquesta capacitat disminueix amb l&#8217;edat, interrompent el manteniment dels teixits. Comprendre com envelleixen les c\u00e8l\u00b7lules mare i identificar estrat\u00e8gies d&#8217;intervenci\u00f3 per mantenir la capacitat regeneradora de c\u00e8l\u00b7lules mare conduiran a nous enfocaments terap\u00e8utics per mantenir la nostra salut a mesura que envellim. El nostre laboratori utilitza models de ratol\u00ed per explorar la biologia de la funci\u00f3 i regeneraci\u00f3 de les c\u00e8l\u00b7lules mare i per identificar mecanismes de disfunci\u00f3 de les c\u00e8l\u00b7lules mare relacionades amb l&#8217;edat. El nostre objectiu es centra en les alteracions epigen\u00e8tiques que es poden orientar farmacol\u00f2gicament i en les interaccions entre c\u00e8l\u00b7lules mare i el seu n\u00ednxol. \u00c9s probable que les intervencions que promoguin la salut de les c\u00e8l\u00b7lules mare proporcionin noves vies per tractar o prevenir una \u00e0mplia gamma de malalties relacionades amb l&#8217;edat. L&#8217;aplicaci\u00f3 d&#8217;una visi\u00f3 fonamental de la biologia de les c\u00e8l\u00b7lules mare a l&#8217;exploraci\u00f3 d&#8217;aquestes estrat\u00e8gies d&#8217;intervenci\u00f3 ajudar\u00e0 a la identificaci\u00f3 de nous i prometedors enfocaments terap\u00e8utics.\n<h2>65<\/h2>\n<h2>Publicacions<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/04\/Stem-Cell-Aging.png\" alt=\"Stem-Cell-Aging\" itemprop=\"image\" height=\"300\" width=\"600\" title=\"Stem-Cell-Aging\" onerror=\"this.style.display='none'\"  \/>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\">L\u00ednies estrat\u00e8giques<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-0\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\t<p>&nbsp;<\/p>\n<ul>\n<li>Alteracions epigen\u00e8tiques de c\u00e8l\u00b7lules mare hematopo\u00e8tiques envellides<\/li>\n<li>N\u00ednxol de c\u00e8l\u00b7lules mare i envelliment<\/li>\n<li>Leuc\u00e8mia mieloide aguda, envelliment i epigen\u00e8tica<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\">Publicacions seleccionades<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-1\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>Montserrat Vazquez S, Ali NJ, Matteini F, Lozano J, Zhaowei T, Mejia Ramirez E, Marka G, Vollmer A, Soller K, Sacma M, Sakk V, Mularoni L, Mallm JP, Plass M, Zheng Y, Geiger H, Florian MC. <strong>Transplanting rejuvenated blood stem cells extends lifespan of aged immunocompromised mice.<\/strong> npj Regen. Med. 2022;7(1):doi:10.1038\/s41536-022-00275-y.<\/li>\n<li>Andersson R, Florian MC. <strong>Living a longer life: unique lessons from the naked mole-rat blood system.<\/strong> EMBO J. 2022;doi:10.15252\/embj.2022111759.<\/li>\n<li>Matteini F, Florian MC. <strong>The gut-bone marrow axis a novel player in HSC aging Comment.<\/strong> Blood. 2022;139(1):3-4. doi:10.1182\/blood.2021014134.<\/li>\n<li>Bogeska R, Mikecin AM, Kaschutnig P, Fawaz M, B\u00fcchler Sch\u00e4ff M, Le D, Ganuza M, Vollmer A, Paffenholz SV, Asada N, Rodriguez Correa E, Frauhammer F, Buettner F, Ball M, Knoch J, St\u00e4ble S, Walter D, Petri A, Carre\u00f1o Gonzalez MJ, Wagner V, Brors B, Haas S, Lipka DB, Essers M, Weru V, Holland Letz T, Mallm JP, Rippe K, Kr\u00e4mer S, Schlesner M, McKinney Freeman S, Florian MC, King KY, Frenette PS, Rieger MA, Milsom MD. <strong>Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging.<\/strong> Cell Stem Cell. 2022;doi:10.1016\/j.stem.2022.06.012.<\/li>\n<li>Meron E, Thaysen M, Angeli S, Antebi A, Barzilai N, Baur JA, Bekker Jensen S, Birkisdottir M, Bischof E, Bruening J, Brunet A, Buchwalter A, Cabreiro F, Cai S, Chen BH, Ermolaeva M, Ewald CY, Ferrucci L, Florian MC, Fortney K, Freund A, Georgievskaya A, Gladyshev VN, Glass D, Golato T, Gorbunova V, Hoejimakers J, Houtkooper RH, Jager S, Jaksch F, Janssens G, Jensen MB, Kaeberlein M, Karsenty G, de Keizer P, Kennedy B, Kirkland JL, Kjaer M, Kroemer G, Lee KF, Lemaitre JM, Liaskos D, Longo VD, Lu YX, MacArthur MR, Maier AB, Manakanatas C, Mitchell SJ, Moskalev A, Niedernhofer L, Ozerov I, Partridge L, Passegu\u00e9 E, Petr MA, Peyer J, Radenkovic D, Rando TA, Rattan S, Riedel CG, Rudolph L, Ai R, Serrano M, Schumacher B, Sinclair DA, Smith R, Suh Y, Taub P, Trapp A, Trendelenburg AU, Valenzano DR, Verburgh K, Verdin E, Vijg J, Westendorp RGJ, Zonari A, Bakula D, Zhavoronkov A, Scheibye Knudsen M. <strong>Meeting Report: Aging Research and Drug Discovery.<\/strong> Aging (Albany NY). 2022;14(undefined):530-543. doi:10.18632\/aging.203859.<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\">Projectes seleccionats<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-2\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>21CEE002. <strong>ReSinAge: Regeneration of Sinusoidal niches to preserve hematopoiesis after chemotherapy on Ageing<\/strong>. COMISSI\u00d3 EUROPEA. Budget: 1.997.360\u20ac. 2021-2026. PI: FLORIAN, MARIA CAROLINA.<\/li>\n<li>20PSJ026. <strong>Deep Learning to Dissect the Interaction between Leukemic Cells and the Ageing Niche<\/strong>. FUNDACI\u00d3 &#8220;LA CAIXA&#8221;. Budget: 652.045,7967\u20ac. 2020-2024. PI: FLORIAN, MARIA CAROLINA.<\/li>\n<li>FIS23072. <strong>Smart Health Community (SHC), promoviendo la medicina basada en el valor<\/strong>. Instituto de Salud Carlos III (ISCIII). Budget: 416.724\u20ac. 2024-2027. PI: FLORIAN, MARIA CAROLINA.<\/li>\n<li>ERA21005. <strong>PIXEL -TRANSCAN-3<\/strong>. Instituto de Salud Carlos III (ISCIII). Budget: 242.529\u20ac. 2022-2025. PI: FLORIAN, MARIA CAROLINA.<\/li>\n<li>20MEC008. <strong>Ayudas Ram\u00f3n y Cajal<\/strong>. Ministerio de Ciencia e Innovaci\u00f3n. Budget: 208.600\u20ac. 2020-2023. PI: FLORIAN, MARIA CAROLINA.<\/li>\n<\/ul>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/02\/florian-maria-carolina-150x150.png\" alt=\"Florian, Maria Carolina\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Florian, Maria Carolina\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tFlorian, Maria Carolina\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:mflorian@idibell.cat\" title=\"mflorian@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tmflorian@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tInvestigadors principals\n\t<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/02\/florian-maria-carolina-150x150.png\" alt=\"Florian, Maria Carolina\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Florian, Maria Carolina\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tFlorian, Maria Carolina\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:mflorian@idibell.cat\" title=\"mflorian@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tmflorian@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/www.icrea.cat\/Web\/ScientificStaff\/maria-carolina-florian-414771\" title=\"ICREA Research Professor\" target=\"_blank\" rel=\"noopener\">\n\t\t ICREA Research Professor \n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\tENLLA\u00c7OS RELACIONATS\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/orcid.org\/0000-0002-5791-1310\" title=\"ORCID\" target=\"_blank\" rel=\"noopener\">\n\t\tORCID\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/scholar.google.de\/citations?hl=en&#038;user=egtLB0MAAAAJ&#038;scilu=&#038;scisig=AMstHGQAAAAAWpVdGdRvKzKKKnUghe-ByZuDVA5VB66V&#038;gmla=AJsN-F6MZ91F18zZvp4ur1jppCs6C_zfuAkx3hmSFnMopTTaP4fguhDrddQI2jDg9939dLV6VQPjr2Uj_2ITu-xQFDomUFVHUu9_PuRvbzVZfdrdfUepWpc&#038;sciund=10483286704014995420\" title=\"Google Scholar\" target=\"_blank\" rel=\"noopener\">\n\t\tGoogle Scholar\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/p-cmrc.cat\/\" title=\"P-CMR[C]\" target=\"_blank\" rel=\"noopener\">\n\t\tP-CMR[C]\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/twitter.com\/Florian_SCaging\" title=\"@Florian_SCaging\" target=\"_blank\" rel=\"noopener\">\n\t\t@Florian_SCaging\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/publons.com\/researcher\/3155501\/m-carolina-florian\/%20\" title=\"Publons\" target=\"_blank\" rel=\"noopener\">\n\t\tPublons\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/www.linkedin.com\/in\/m-carolina-florian-666bb783\/\" title=\"Linkedin\" target=\"_blank\" rel=\"noopener\">\n\t\tLinkedin\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tEquip\n\t<\/h2>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-0\" data-index=\"0\" aria-selected=\"true\" aria-controls=\"fl-tabs--panel-0\" aria-expanded=\"true\" role=\"tab\" tabindex=\"0\">\t\t\t\tCaps de grup\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-1\" data-index=\"1\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-1\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es postdoctorals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-2\" data-index=\"2\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-2\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es predoctorals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-3\" data-index=\"3\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-3\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tSuport cient\u00edfic\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-4\" data-index=\"4\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-4\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tEstudiants\t\t\t\t<\/a>\n\t\t\t\t\t\tCaps de grup\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Florian, Maria Carolina<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es postdoctorals\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Matteini, Francesca<\/li>\n<li>Cayre, Surya<\/li>\n<li>Andersson, Rebecca<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es predoctorals\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Ferrer Perez, Alba<\/li>\n<li>Nikolopoulou, Eleni<\/li>\n<li>Sole Castilla, Laia<\/li>\n<\/ul>\n\t\t\t\t\t\tSuport cient\u00edfic\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Montserrat Vazquez, Sara<\/li>\n<li>Lozano Bartolome, Javier<\/li>\n<li>Mej\u00eda Ram\u00edrez de Arellano, Eva Mar\u00eda<\/li>\n<\/ul>\n\t\t\t\t\t\tEstudiants\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Di Bari, Dario<\/li>\n<\/ul>\n<h2>\n\t\tNot\u00edcies relacionades\n\t<\/h2>\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/25982\" content=\"M\u00e9s de cent experts es reuneixen a Barcelona per discutir els \u00faltims aven\u00e7os en el tractament de les malalties onco-hematol\u00f2giques\" \/><meta itemprop=\"datePublished\" content=\"2024-06-18\" \/><meta itemprop=\"dateModified\" content=\"2024-06-18\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/wp-content\/uploads\/2023\/03\/cropped-Marca-B.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/wp-content\/uploads\/2024\/06\/IMG20240617115548-scaled.jpg\" \/><meta itemprop=\"width\" content=\"2560\" \/><meta itemprop=\"height\" content=\"1440\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/2024\/06\/mes-de-cent-experts-es-reuneixen-a-barcelona-per-discutir-els-ultims-avencos-en-el-tractament-de-les-malalties-onco-hematologiques\/\" title=\"M\u00e9s de cent experts es reuneixen a Barcelona per discutir els \u00faltims aven\u00e7os en el tractament de les malalties onco-hematol\u00f2giques\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/2024\/06\/mes-de-cent-experts-es-reuneixen-a-barcelona-per-discutir-els-ultims-avencos-en-el-tractament-de-les-malalties-onco-hematologiques\/\" title=\"M\u00e9s de cent experts es reuneixen a Barcelona per discutir els \u00faltims aven\u00e7os en el tractament de les malalties onco-hematol\u00f2giques\">M\u00e9s de cent experts es reuneixen a Barcelona per discutir els \u00faltims aven\u00e7os en el tractament de les malalties onco-hematol\u00f2giques<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/author\/comunicacio\/\">comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t18\/06\/2024\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/25664\" content=\"M. 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Carolina Florian, investigadora pionera en c\u00e8l\u00b7lules mare, destacada a la revista Nature<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/author\/comunicacio\/\">comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t21\/05\/2024\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/22856\" content=\"M Carolina Florian nova professora de recerca ICREA\" \/><meta itemprop=\"datePublished\" content=\"2023-02-09\" \/><meta itemprop=\"dateModified\" content=\"2023-02-09\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/wp-content\/uploads\/2023\/03\/cropped-Marca-B.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/wp-content\/uploads\/2023\/02\/NO14-ICREA-Florian-Imatge-noti.jpg\" \/><meta 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Aquesta capacitat disminueix amb l&#8217;edat, interrompent el manteniment dels teixits. 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