{"id":2949,"date":"2019-10-09T19:39:32","date_gmt":"2019-10-09T17:39:32","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=2949"},"modified":"2024-05-08T16:21:43","modified_gmt":"2024-05-08T14:21:43","slug":"immunitat-innata-i-patologia-del-malalt-critic","status":"publish","type":"page","link":"https:\/\/idibell.cat\/recerca\/area-de-medicina-translacional\/programa-de-malalties-infeccioses-i-transplantaments\/immunitat-innata-i-patologia-del-malalt-critic\/","title":{"rendered":"Immunitat innata i patologia del malalt cr\u00edtic"},"content":{"rendered":"\n<h1>\n\t\tImmunitat innata i patologia del malalt cr\u00edtic\n\t<\/h1>\n<h3>\n\t\tResum\n\t<\/h3>\n\t<p>En aquest grup s&#8217;estudien els mecanismes del sistema immune relacionats amb trasplantaments, s\u00e8psia i recuperaci\u00f3 postoperat\u00f2ria despr\u00e9s de cirurgia complexa (card\u00edaca per exemple). Tamb\u00e9 s&#8217;estudia l&#8217;impacte d&#8217;aquests mecanismes en la millora de les activitats cl\u00edniques, aix\u00ed com d&#8217;altres factors que influeixen en el pron\u00f2stic i evoluci\u00f3 dels pacients cr\u00edtics.<\/p>\n<h2>520<\/h2>\n<h2>Publicacions<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/04\/ucihospital.jpeg\" alt=\"ucihospital\" itemprop=\"image\" height=\"300\" width=\"600\" title=\"ucihospital\" onerror=\"this.style.display='none'\"  \/>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\">L\u00ednies Estrat\u00e8giques<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\"><i>Expand<\/i><\/a>\n\t\t\t\t\tImmunitat innata en el xenotrasplantament i en la medicina regenerativa<br \/>\nDepleci\u00f3 d&#8217;anticossos naturals com mecanisme\u00a0 d&#8217;augment de la immunitat<br \/>\nResposta inflamat\u00f2ria en la s\u00e8psies<br \/>\nFactors pron\u00f2stics en el malalt neurocr\u00edtic<br \/>\nFactors pron\u00f2stic s en el postoperatori immediat de cirurgia card\u00edaca<br \/>\nDisfunci\u00f3 renal en el malalt cr\u00edtic\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\">Publicacions seleccionades<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>Galli,F;Bindo,F;Motos,A;Fernandez Barat,L;Barbeta,E;Gabarrus,A;Ceccato,A et al, <strong>Procalcitonin and C-reactive protein to rule out early bacterial coinfection in COVID-19 critically ill patients<\/strong>, Intensive Care Med., 2023;49(8):934-945, doi:10.1007\/s00134-023-07161-1<\/li>\n<li>Riera,J;Barbeta,E;Tormos,A;Mellado Artigas,R;Ceccato,A;Motos,A;Fernandez Barat,L et al, <strong>Effects of intubation timing in patients with COVID-19 throughout the four waves of the pandemic: a matched analysis<\/strong>, Eur. Resp. J., 2023;61(3)\u00a0 doi:10.1183\/13993003.01426-2022<\/li>\n<li>P\u00e9rez Galera,S;Bravo Ferrer,JM;Paniagua,M;Kostyanev,T;de Kraker,M;Feifel,J;Sojo Dorado,J et al, <strong>Risk factors for infections caused by carbapenem-resistant Enterobacterales: an international matched case-control-control study (EURECA)<\/strong>., EClinicalMedicine, 2023;57101871-101871, doi:10.1016\/j.eclinm.2023.101871<\/li>\n<li>Matuozzo,D;Talouarn,E;Marchal,A;Zhang,P;Manry,J;Seeleuthner,Y;Zhang,Y et al, <strong>Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19<\/strong>., Genome Med., 2023;15(1):22-22, doi:10.1186\/s13073-023-01173-8<\/li>\n<li>Olivera Ardid,S;Bello Gil,D;Perez Cruz,M;Costa,C;Camoez,M;Dominguez,MA;Ferrero Alves,Y et al, <strong>Removal of natural anti-aGal antibodies elicits protective immunity against Gram-negative bacterial infections<\/strong>, Front. Immunol., 2023;141232924-1232924, doi:10.3389\/fimmu.2023.1232924<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\">Projectes seleccionats<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>2022-311-1. <strong>ESTUDIO MULTIC\u00c9NTRICO, ALEATORIZADO, DOBLE CIEGO (PARTICIPANTE E INVESTIGADOR) Y CONTROLADO CON PLACEBO EN EL QUE SE EVAL\u00daAN LA SEGURIDAD, LA TOLERABILIDAD Y LA EFICACIA DE TIN816 EN PACIENTES ADULTOS CON RIESGO DE LESI\u00d3N RENAL AGUDA TRAS UNA CIRUG\u00cdA CARD\u00cdACA<\/strong>. Novartis Farmac\u00e9utica, S.A. Budget: 123.832\u20ac. 2023- . PI: Sabater Riera, Joan.<\/li>\n<li>20CEE013. <strong>ENVISION: Intelligent plug-and-play digital tool for real-time surveillance of COVID-19 patients and smart decision-making in Intensive Care Units<\/strong>. COMISSI\u00d3 EUROPEA. Budget: 115.000\u20ac. 2020-2023. PI: M\u00e1\u00f1ez Mendiluce, Rafael.<\/li>\n<li>CEE21011. <strong>COVend: Biomarker and AI-supported FX06 therapy to prevent progression from mild and moderate to severe stages of COVID-19<\/strong>. COMISSI\u00d3 EUROPEA. Budget: 114.101,66\u20ac. 2021-2024. PI: M\u00e1\u00f1ez Mendiluce, Rafael.<\/li>\n<li>2023-472-1. <strong>ESTUDIO DE VALIDACI\u00d3N DEL TEST SEPTILOOP LATERAL FLOW ASSAY EN PACIENTES S\u00c9PTICOS. ESTUDIO PROSPECTIVO OBSERVACIONAL<\/strong>. LOOP DIAGNOSTICS SL. Budget: 42.000\u20ac. 2023- . PI: Sabater Riera, Joan.<\/li>\n<li>2022-208-1. <strong>ESTUDIO DE FASE IIA, MULTIC\u00c9NTRICO, DOBLE CIEGO (PARTICIPANTE E INVESTIGADOR), ALEATORIZADO Y CONTROLADO CON PLACEBO EN EL QUE SE INVESTIGAN LA FARMACOCIN\u00c9TICA, LA FARMACODIN\u00c1MICA, LA SEGURIDAD Y LA TOLERABILIDAD DE TIN816 EN EL TRATAMIENTO DE PACIENTES CON LESI\u00d3N RENAL AGUDA ASOCIADA A SEPSIS<\/strong>. Novartis Farmac\u00e9utica, S.A. Budget: 15.424\u20ac. 2022- . PI: Sabater Riera, Joan.<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-3\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-3\">Transfer\u00e8ncia de tecnologia<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-3\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-3\"><i>Expand<\/i><\/a>\n\t\t\t\t\tPAT082-M\u00c9TODO Y KIT PARA LA DETECCI\u00d3N TEMPRANA DE SEPSIS<br \/>\nIP: Joan Sabater<br \/>\nEP 20382462\nPAT049-Methods for Prevention And\/or Treatment of Infection<br \/>\nIP: Rafel Ma\u00f1ez<br \/>\nEP 3183003\nLicense: METHOD AND KIT FOR THE EARLY DETECTION OF SEPSIS<br \/>\nPI: Dr. Joan Sabater\nLicense: Methods and reagents for prevention and\/or treatment of infection (PAT049)<br \/>\nPI: Dr. Rafael M\u00e1\u00f1ez\nSpin-off: RemAb Therapeutics<br \/>\nPI: Dr. Rafael M\u00e1\u00f1ez\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-4\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-4\">M\u00e9s informaci\u00f3<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-4\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-4\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<p><i>Proyectos financiados por el Instituto de Salud Carlos III (ISCIII) y cofinanciados por el Fondo Europeo de Desarrollo Regional (FEDER):<\/i><\/p>\n<p>\u00a0<\/p>\n<p><b>Papel de los Anticuerpos Anti-Acido Hialur\u00f3nico y de la Inmunidad Innata Celular en el Deterioro Estructural Valvular de Pr\u00f3tesis Cardiacas Biol\u00f3gicas<\/b><\/p>\n<p>PI13\/01098. 01\/2014-12\/2016. 57.500 \u20ac. IP: Rafael M\u00e1\u00f1ez Mendiluce.<\/p>\n<p>Analizar el papel de la xenoinmunidad y autoinmunidad en el desarrollo de deterioro estructural valvular (DEV), en v\u00e1lvulas card\u00edacas biol\u00f3gicas a\u00f3rticas de origen porcino y bovino. Estudiar la inmunidad innata humoral (anticuerpos naturales contra oligosac\u00e1ridos del \u00e1cido hialur\u00f3nico) y celular mediada por macr\u00f3fagos y c\u00e9lulas NK, y el potencial papel de las mismas en el desarrollo de DEV.<\/p>\n<p>\u00a0<\/p>\n<p><b>Estudio precl\u00ednico y traslacional de nuevos agentes anticancerosos derivados de tambjaminas para el tratamiento del c\u00e1ncer de pulm\u00f3n humano<\/b><\/p>\n<p>\u00a0<\/p>\n<p>PI13\/00089. 01\/2014-12\/2016. 57.500 \u20ac. IP: Ricardo P\u00e9rez Tom\u00e1s.<\/p>\n<p>Identificar nuevas mol\u00e9culas m\u00e1s eficaces para combatir el c\u00e1ncer de pulm\u00f3n, bajo diversas perspectivas como son la qu\u00edmica m\u00e9dica, formulaci\u00f3n de nuevos f\u00e1rmacos, simulaci\u00f3n computacional, biolog\u00eda celular in vitro y t\u00e9cnicas bioqu\u00edmicas, transcript\u00f3mica y an\u00e1lisis de prote\u00f3mica, as\u00ed como en investigaci\u00f3n traslacional en modelos de xenotrasplante, permitir\u00e1 que seamos capaces de completar con \u00e9xito los estudios precl\u00ednicos de una prometedora nueva familia de compuestos anticancerosos. La desregulaci\u00f3n del pH es una caracter\u00edstica com\u00fan que confiere ventajas adaptativas a las c\u00e9lulas cancerosas. Proponemos que mol\u00e9culas que selectivamente poseen la capacidad de disminuir el pH intracelular ser\u00edan de gran inter\u00e9s como nuevos agentes quimioterap\u00e9uticos para el tratamiento del c\u00e1ncer de pulm\u00f3n. Evaluar la seguridad y eficacia de estos compuestos in vivo, desarrollar una innovadora nanoformulaci\u00f3n farmacol\u00f3gica con el fin de mejorar la selectividad y la eficacia, as\u00ed como ensayar una nueva y prometedora v\u00eda de administraci\u00f3n del f\u00e1rmaco.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/04\/image12.png\" alt=\"\" width=\"249\" height=\"150\" \/><\/p>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2022\/11\/Rafael-Manez22-150x150.jpg\" alt=\"Rafael-Ma\u00f1ez22\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Rafael-Ma\u00f1ez22\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tMa\u00f1ez Mendiluce, Rafael\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:rmanez@idibell.cat\" title=\"rmanez@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\trmanez@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tInvestigadors principals\n\t<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2022\/11\/Rafael-Manez22-150x150.jpg\" alt=\"Rafael-Ma\u00f1ez22\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Rafael-Ma\u00f1ez22\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tMa\u00f1ez Mendiluce, Rafael\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:rmanez@idibell.cat\" title=\"rmanez@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\trmanez@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2019\/10\/avatar-188-150x150.jpeg\" alt=\"avatar-188\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"avatar-188\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tSabater Riera, Joan\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:jsabater@idibell.cat\" title=\"jsabater@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tjsabater@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tEquip\n\t<\/h2>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-0\" data-index=\"0\" aria-selected=\"true\" aria-controls=\"fl-tabs--panel-0\" aria-expanded=\"true\" role=\"tab\" tabindex=\"0\">\t\t\t\tCaps de grup\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-1\" data-index=\"1\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-1\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es principals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-2\" data-index=\"2\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-2\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es cl\u00ednics\/ques\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-3\" data-index=\"3\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-3\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es postdoctorals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-4\" data-index=\"4\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-4\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es predoctorals\t\t\t\t<\/a>\n\t\t\t\t\t\tCaps de grup\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Ma\u00f1ez Mendiluce, Rafael<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es principals\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Sabater Riera, Joan<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es cl\u00ednics\/ques\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Corral Ansa, Luisa<\/li>\n<li>Esteve Urbano, Francesc<\/li>\n<li>Fuset Cabanes, M\u00aa Paz<\/li>\n<li>Moreno Gonz\u00e1lez, Gabriel Jesus<\/li>\n<li>Ochagavia Calvo, Ana<\/li>\n<li>Oliver Juan, Eva<\/li>\n<li>P\u00e9rez Fern\u00e1ndez, Xos\u00e9 Luis<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es postdoctorals\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Olivera Ardid, Sara<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es predoctorals\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Soley Corderas, Ricard<\/li>\n<li>Gumucio Sanguino, Victor Daniel<\/li>\n<\/ul>\n<h2>\n\t\tNot\u00edcies relacionades\n\t<\/h2>\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/20528\" content=\"Dos anticossos que tenim de forma natural s\u00f3n els responsables del deteriorament dels implants card\u00edacs valvulars d&#8217;origen animal\" \/><meta itemprop=\"datePublished\" content=\"2022-02-17\" \/><meta itemprop=\"dateModified\" content=\"2022-02-17\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/wp-content\/uploads\/2023\/03\/cropped-Marca-B.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/wp-content\/uploads\/2022\/02\/NP03-R-Manez_Nat-Med-Imatge.jpg\" \/><meta 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