{"id":2764,"date":"2019-10-07T23:45:16","date_gmt":"2019-10-07T21:45:16","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=2764"},"modified":"2024-12-17T12:42:40","modified_gmt":"2024-12-17T11:42:40","slug":"malalties-sistemiques-vasculars-i-envelliment","status":"publish","type":"page","link":"https:\/\/idibell.cat\/recerca\/area-de-medicina-translacional\/programa-de-malalties-cardiovasculars-respiratories-sistemiques-i-denvelliment-cel%c2%b7lular\/malalties-sistemiques-vasculars-i-envelliment\/","title":{"rendered":"Malalties Sist\u00e8miques, Vasculars i Envelliment"},"content":{"rendered":"\n
El grup de malalties sist\u00e8miques, vasculars i envelliment estudia l’impacte i el tractament de les malalties sist\u00e8miques (\u00e9s a dir, malalties que afecten m\u00e9s d’un \u00f2rgan) des de la perspectiva cl\u00ednica i epidemiol\u00f2gica fins a l’entorn del laboratori. La seva \u00e0rea d’experi\u00e8ncia inclou els camps de les malalties autoimmunes sist\u00e8miques, la malaltia tromboemb\u00f2lica venosa, l’envelliment (principalment insufici\u00e8ncia card\u00edaca cr\u00f2nica) i les telangiect\u00e0sies heredit\u00e0ries hemorr\u00e0giques i altres malalties rares vasculars. Pel que fa a les malalties rares, aquest grup tamb\u00e9 estudia aquestes malalties des de la investigaci\u00f3 b\u00e0sica, amb models cel\u00b7lulars i animals. De fet, practiquem una veritable investigaci\u00f3 translacional, transferint els coneixements d’un entorn de laboratori a un de cl\u00ednic, evitant qualsevol escletxa en la transici\u00f3 entre ambd\u00f3s entorns.<\/p>\n
Arribas V, Onetti Y, Ramiro-Pareta M, Villacampa P, Beck H, Alberola M, Esteve-Codina A, Merkel A, Sperandio M, Mart\u00ednez-Estrada OM, Schmid B, Montanez E. Endothelial TDP-43 controls sprouting angiogenesis and vascular barrier integrity, and its deletion triggers neuroinflammation<\/strong>. JCI Insight. 2024 Feb 1:e177819. doi: 10.1172\/jci.insight.177819. Epub ahead of print. PMID: 38300714.<\/p>\n Cand\u00e1s-Est\u00e9banez B, Fern\u00e1ndez-Cid\u00f3n B, Corbella E, Teb\u00e9 C, Fanlo-Maresma M, Esteve-Luque V, Salas-Salvad\u00f3 J, Fit\u00f3 M, Riera-Mestre A, Ros E, Pint\u00f3 X. The Impact of the Mediterranean Diet and Lifestyle Intervention on Lipoprotein Subclass Profiles among Metabolic Syndrome Patients: Findings of a Randomized Controlled Trial.<\/strong> Int J Mol Sci. 2024 Jan 22;25(2):1338. doi: 10.3390\/ijms25021338. PMID: 38279337; PMCID: PMC10817060.<\/p>\n Genet G, Genet N, Paila U, Cain SR, Cwiek A, Chavkin NW, Serbulea V, Figueras A, Cerd\u00e0 P, McDonnell SP, Sankaranarayanan D, Huba M, Nelson EA, Riera-Mestre A, Hirschi KK. Induced Endothelial Cell CycleArrest Prevents Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia<\/strong>. Circulation. 2023 Dec 21. doi: 10.1161\/CIRCULATIONAHA.122.062952. Epub ahead of print. PMID: 38126211.<\/p>\n Bastard P, Vazquez S, Liu J, Laurie MT, Wang CY, Gervais A, Le Voyer T, Bizien L, Zamecnik C, Philippot Q, Rosain J, Catherinot E, Willmore A, Mitchell AM, Bair R, Gar\u00e7on P, Kenney H, Fekkar A, Salagianni M, Poulakou G, Siouti E, Sahanic S, Tancevski I, Weiss G, Nagl L, Manry J, Duvlis S, Arroyo S\u00e1nchez D, Paz Artal E, Rubio L, Perani C, Bezzi M, Sottini A, Quaresima V, Roussel L, Vinh DC, Reyes LF, Garzaro M, Hatipoglu N, Boutboul D, Tandjaoui Lambiotte Y, Borghesi A, Aliberti A, Cassaniti I, Venet F, Monneret G, Halwani R, Sharif Askari NS, Danielson J, Burrel S, Morbieu C, Stepanovskyy Y, Bondarenko A, Volokha A, Boyarchuk O, Gagro A, Neuville M, Neven B, Hernu R, Bal A, Novelli A, Novelli G, Saker K, Ailioaie O, Antol\u00ed A, Jeziorski E, Rocamora Blanch G, Teixeira C, Delaunay C, Lhuillier M, Le Turnier P, Zhang Y, Mahevas M, Pan Hammarstr\u00f6m Q, Abolhassani H, Bompoil T, Dorgham K, COVID HGE consortium \u2020, French COVID study group \u2020, COMET consortium \u2020, Gorochov G, Laouenan C, Rodr\u00edguez Gallego C, NGLFP, Renia L, Pujol A, Belot A, Raffi F, Allende LM, Martinez Picado J, Ozcelik T, Keles S, Imberti L, Notarangelo LD, Troya J, Solanich X, Zhang SY, Puel A, Wilson MR, Trouillet Assant S, Abel L, Jouanguy E, Ye CJ, Cobat A, Thompson LM, Andreakos E, Zhang Q, Anderson MS, Casanova JL, DeRisi JL. Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs<\/strong>. Sci. Immunol. 2022;doi:10.1126\/sciimmunol.abp8966.<\/p>\n Corsonello A, Soraci L, \u00c4rnl\u00f6v J, Carlsson AC, Roller Wirnsberger R, Wirnsberger G, Mattace Raso F, Tap L, Formiga F, Moreno Gonz\u00e1lez R, Kostka T, Guligowska A, Artzi Medvedik R, Melzer I, Weingart C, Sieber C, Lattanzio F, Screening for among Older People across Europe (SCOPE) study investigators CKD. The relevance of geriatric assessments on the association between chronic kidney disease stages and mortality among older people: a secondary analysis of a multicentre cohort study.<\/strong> Age Ageing. 2022;51(7):doi:10.1093\/ageing\/afac168.<\/p>\n\t\t\t\t\tProjectes seleccionats<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t PI23\/00651. Papel de los autoanticuerpos que neutralizan interferones de tipo I en el lupus eritematoso sist\u00e9mico<\/strong>. AES2023. Budget: 202.500,00 \u20ac. 2024-2026. PI:\u00a0 Solanich Moreno, Xavier<\/p>\n PID2022-141840OB-I00. Deciphering the role of TDP-43 in angiogenesis, vascular barrier and homostasis of blood vessels under both physiological and pathological conditions.<\/strong> (NeuVasTDP43). Budget: 200.000\u20ac. 2023-2026. PI: Monta\u00f1ez Miralles, Eloi.<\/p>\n CNS2023-144390. Caracterizaci\u00f3n de un nuevo modelo animal de fibrosis retinal mediada por pericitos.<\/strong> Consolidaci\u00f3n Investigadora 2023 (MCINN). Budget: 199.890,34 \u20ac 2023-2025. PI:\u00a0 Villacampa Alcubierre, Pilar.<\/p>\n PI23\/00164. Nuevo conocimiento en el desarrollo de malformaciones vasculares hep\u00e1ticas en los pacientes con Telangiectasia Hemorr\u00e1gica Hereditaria<\/strong> . Proyectos de investigaci\u00f3n en Salud (AES 2023).\u00a0 Budget: 167.500\u20ac. 2024-2027. PI: Riera Mestre, Antoni.<\/p>\n 2023-713-1. Desxifrar el paper de TDP-43 en la barrera vascular i l’estabilitat dels vasos sanguinis<\/strong>. La Marat\u00f3 TV3 2022. Budget: 120.000\u20ac. PI: Monta\u00f1ez Miralles, Eloi.<\/p>\n\t\t\t\t\n Malalties sist\u00e8miques, vasculars i envelliment Resum El grup de malalties sist\u00e8miques, vasculars i envelliment estudia l’impacte i el tractament de les malalties sist\u00e8miques (\u00e9s a dir, malalties que afecten m\u00e9s d’un \u00f2rgan) des de la perspectiva cl\u00ednica i epidemiol\u00f2gica fins a l’entorn del laboratori. La seva \u00e0rea d’experi\u00e8ncia inclou els camps de les malalties autoimmunes […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":568,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-2764","page","type-page","status-publish","hentry"],"publishpress_future_action":{"enabled":false,"date":"2025-01-29 04:46:48","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages\/2764","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=2764"}],"version-history":[{"count":11,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages\/2764\/revisions"}],"predecessor-version":[{"id":26802,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages\/2764\/revisions\/26802"}],"up":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages\/568"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=2764"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}\n\t\tRiera Mestre, Antoni\n\t<\/h4>\n
\n\t\t\n\t\tariera@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n
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\n\t\tRiera Mestre, Antoni\n\t<\/h4>\n
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\n\t\tPint\u00f3 Sala, Xavier\n\t<\/h4>\n
\n\t\t\n\t\txpinto@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\n
\n\t\tSolanich Moreno, Xavier\n\t<\/h4>\n
\n\t\t\n\t\txsolanich@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\n
\n\t\tMonta\u00f1ez Miralles, Eloi\n\t<\/h4>\n
\n\t\t\n\t\temontanez@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\n
\n\t\tFormiga P\u00e9rez, Francesc\n\t<\/h4>\n
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\n\t\tVillacampa Alcubierre, Pilar\n\t<\/h4>\n
\n\t\t\n\t\tpvillacampa@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\n
\n\t\tLleonart Bellfill, Ramon\n\t<\/h4>\n
\n\t\t\n\t\trlleonart@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\n
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\n\t\t\n\t\tBloc Antoni Riera-Mestre\n\t\t<\/a>\n\t<\/h4>\n
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\n\t\t\n\t\t@ramcat61\n\t\t<\/a>\n\t<\/h4>\n
\n\t\t\n\t\tIG InternaHub \n\t\t<\/a>\n\t<\/h4>\n
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\n\t\tEquip\n\t<\/h2>\n\t\t\t\t\t\t\t\t\t\t\t\tCaps de grup\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadors\/es principals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadors\/es cl\u00ednics\/ques\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadors\/es postdoctorals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadors\/es predoctorals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tSuport cient\u00edfic\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tCol\u00b7laboradors\/es\t\t\t\t<\/a>\n\t\t\t\t\t\tCaps de grup\n\t\t\t\t\t\t\t\t\t\t\t
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\n\t\tNot\u00edcies relacionades\n\t<\/h2>\n\t\t\n\t\t\t\t<\/a>\n\t\t\tBellvitge contribueix a una millora significativa en el tractament de l’angioedema hereditari<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t05\/07\/2024\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tLa integritat de la barrera hematoencef\u00e0lica dep\u00e8n d’una prote\u00efna que est\u00e0 alterada en algunes malalties neurodegeneratives<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t13\/03\/2024\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tDescobreixen un nou mecanisme que explica el desenvolupament de malformacions vasculars<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t11\/01\/2024\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tLa IV Jornada de Malalties Minorit\u00e0ries de Bellvitge reivindica el paper clau de les rean\u00e0lisis gen\u00e8tiques<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t24\/10\/2023\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tEl Dr. Riera-Mestre, escollit editor de la revista m\u00e9s prestigiosa en l’entorn de les malalties minorit\u00e0ries<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t23\/06\/2023\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tLa Generalitat reconeix 32 grups de l’IDIBELL com a Grups de Recerca Consolidats o Emergents<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t18\/04\/2023\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tLa tesi doctoral del Dr. Xavier Solanich, guardonada per la SCBMI<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t02\/06\/2022\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tLes vacunes contra el SARS-CoV-2 s\u00f3n segures i eficaces en les persones amb immunodefici\u00e8ncia<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t05\/05\/2022\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tTanquem un 2021 ple de ci\u00e8ncia!<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t30\/12\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tLa medicina personalitzada, un dels pilars de l’IDIBELL<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t16\/12\/2021\t\t\t\t\t\t\t\n\t\t\n\n","protected":false},"excerpt":{"rendered":"