{"id":2764,"date":"2019-10-07T23:45:16","date_gmt":"2019-10-07T21:45:16","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=2764"},"modified":"2024-12-17T12:42:40","modified_gmt":"2024-12-17T11:42:40","slug":"malalties-sistemiques-vasculars-i-envelliment","status":"publish","type":"page","link":"https:\/\/idibell.cat\/recerca\/area-de-medicina-translacional\/programa-de-malalties-cardiovasculars-respiratories-sistemiques-i-denvelliment-cel%c2%b7lular\/malalties-sistemiques-vasculars-i-envelliment\/","title":{"rendered":"Malalties Sist\u00e8miques, Vasculars i Envelliment"},"content":{"rendered":"\n

\n\t\tMalalties sist\u00e8miques, vasculars i envelliment\n\t<\/h1>\n

\n\t\tResum\n\t<\/h3>\n\t

El grup de malalties sist\u00e8miques, vasculars i envelliment estudia l’impacte i el tractament de les malalties sist\u00e8miques (\u00e9s a dir, malalties que afecten m\u00e9s d’un \u00f2rgan) des de la perspectiva cl\u00ednica i epidemiol\u00f2gica fins a l’entorn del laboratori. La seva \u00e0rea d’experi\u00e8ncia inclou els camps de les malalties autoimmunes sist\u00e8miques, la malaltia tromboemb\u00f2lica venosa, l’envelliment (principalment insufici\u00e8ncia card\u00edaca cr\u00f2nica) i les telangiect\u00e0sies heredit\u00e0ries hemorr\u00e0giques i altres malalties rares vasculars. Pel que fa a les malalties rares, aquest grup tamb\u00e9 estudia aquestes malalties des de la investigaci\u00f3 b\u00e0sica, amb models cel\u00b7lulars i animals. De fet, practiquem una veritable investigaci\u00f3 translacional, transferint els coneixements d’un entorn de laboratori a un de cl\u00ednic, evitant qualsevol escletxa en la transici\u00f3 entre ambd\u00f3s entorns.<\/p>\n

1452<\/h2>\n

Publicacions<\/h2>\n\t\t\t\t\"10825875005_5e6b57688a_b\"\n\t\t\t\t\tL\u00ednies estrat\u00e8giques<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\tMalalties autoimmunes, autoimflamat\u00f2ries i sist\u00e8miques
\nCronicitat i envelliment
\nMalaltia tromboemb\u00f2lica venosa
\nTelangi\u00e8ctasi hemorr\u00e0gica heredit\u00e0ria i altres malalties rares vasculars
\nMalalties minorit\u00e0ries vasculars i de dip\u00f2sit
\nImmunopaties de l’adult
\nAl\u00b7lergologia
\nFactors de risc cardio-vasculars i aterosclerosi
\nDislip\u00e8mies complexes
\nAngiog\u00e8nesi i remodelaci\u00f3 de vasos sanguinis
\nExtravasaci\u00f3 i inflamaci\u00f3 de leuc\u00f2cits\n\t\t\t\t\t
Publicacions seleccionades<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t

Arribas V, Onetti Y, Ramiro-Pareta M, Villacampa P, Beck H, Alberola M, Esteve-Codina A, Merkel A, Sperandio M, Mart\u00ednez-Estrada OM, Schmid B, Montanez E. Endothelial TDP-43 controls sprouting angiogenesis and vascular barrier integrity, and its deletion triggers neuroinflammation<\/strong>. JCI Insight. 2024 Feb 1:e177819. doi: 10.1172\/jci.insight.177819. Epub ahead of print. PMID: 38300714.<\/p>\n

Cand\u00e1s-Est\u00e9banez B, Fern\u00e1ndez-Cid\u00f3n B, Corbella E, Teb\u00e9 C, Fanlo-Maresma M, Esteve-Luque V, Salas-Salvad\u00f3 J, Fit\u00f3 M, Riera-Mestre A, Ros E, Pint\u00f3 X. The Impact of the Mediterranean Diet and Lifestyle Intervention on Lipoprotein Subclass Profiles among Metabolic Syndrome Patients: Findings of a Randomized Controlled Trial.<\/strong> Int J Mol Sci. 2024 Jan 22;25(2):1338. doi: 10.3390\/ijms25021338. PMID: 38279337; PMCID: PMC10817060.<\/p>\n

Genet G, Genet N, Paila U, Cain SR, Cwiek A, Chavkin NW, Serbulea V, Figueras A, Cerd\u00e0 P, McDonnell SP, Sankaranarayanan D, Huba M, Nelson EA, Riera-Mestre A, Hirschi KK. Induced Endothelial Cell CycleArrest Prevents Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia<\/strong>. Circulation. 2023 Dec 21. doi: 10.1161\/CIRCULATIONAHA.122.062952. Epub ahead of print. PMID: 38126211.<\/p>\n

Bastard P, Vazquez S, Liu J, Laurie MT, Wang CY, Gervais A, Le Voyer T, Bizien L, Zamecnik C, Philippot Q, Rosain J, Catherinot E, Willmore A, Mitchell AM, Bair R, Gar\u00e7on P, Kenney H, Fekkar A, Salagianni M, Poulakou G, Siouti E, Sahanic S, Tancevski I, Weiss G, Nagl L, Manry J, Duvlis S, Arroyo S\u00e1nchez D, Paz Artal E, Rubio L, Perani C, Bezzi M, Sottini A, Quaresima V, Roussel L, Vinh DC, Reyes LF, Garzaro M, Hatipoglu N, Boutboul D, Tandjaoui Lambiotte Y, Borghesi A, Aliberti A, Cassaniti I, Venet F, Monneret G, Halwani R, Sharif Askari NS, Danielson J, Burrel S, Morbieu C, Stepanovskyy Y, Bondarenko A, Volokha A, Boyarchuk O, Gagro A, Neuville M, Neven B, Hernu R, Bal A, Novelli A, Novelli G, Saker K, Ailioaie O, Antol\u00ed A, Jeziorski E, Rocamora Blanch G, Teixeira C, Delaunay C, Lhuillier M, Le Turnier P, Zhang Y, Mahevas M, Pan Hammarstr\u00f6m Q, Abolhassani H, Bompoil T, Dorgham K, COVID HGE consortium \u2020, French COVID study group \u2020, COMET consortium \u2020, Gorochov G, Laouenan C, Rodr\u00edguez Gallego C, NGLFP, Renia L, Pujol A, Belot A, Raffi F, Allende LM, Martinez Picado J, Ozcelik T, Keles S, Imberti L, Notarangelo LD, Troya J, Solanich X, Zhang SY, Puel A, Wilson MR, Trouillet Assant S, Abel L, Jouanguy E, Ye CJ, Cobat A, Thompson LM, Andreakos E, Zhang Q, Anderson MS, Casanova JL, DeRisi JL. Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs<\/strong>. Sci. Immunol. 2022;doi:10.1126\/sciimmunol.abp8966.<\/p>\n

Corsonello A, Soraci L, \u00c4rnl\u00f6v J, Carlsson AC, Roller Wirnsberger R, Wirnsberger G, Mattace Raso F, Tap L, Formiga F, Moreno Gonz\u00e1lez R, Kostka T, Guligowska A, Artzi Medvedik R, Melzer I, Weingart C, Sieber C, Lattanzio F, Screening for among Older People across Europe (SCOPE) study investigators CKD. The relevance of geriatric assessments on the association between chronic kidney disease stages and mortality among older people: a secondary analysis of a multicentre cohort study.<\/strong> Age Ageing. 2022;51(7):doi:10.1093\/ageing\/afac168.<\/p>\n\t\t\t\t\tProjectes seleccionats<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t

PI23\/00651. Papel de los autoanticuerpos que neutralizan interferones de tipo I en el lupus eritematoso sist\u00e9mico<\/strong>. AES2023. Budget: 202.500,00 \u20ac. 2024-2026. PI:\u00a0 Solanich Moreno, Xavier<\/p>\n

PID2022-141840OB-I00. Deciphering the role of TDP-43 in angiogenesis, vascular barrier and homostasis of blood vessels under both physiological and pathological conditions.<\/strong> (NeuVasTDP43). Budget: 200.000\u20ac. 2023-2026. PI: Monta\u00f1ez Miralles, Eloi.<\/p>\n

CNS2023-144390. Caracterizaci\u00f3n de un nuevo modelo animal de fibrosis retinal mediada por pericitos.<\/strong> Consolidaci\u00f3n Investigadora 2023 (MCINN). Budget: 199.890,34 \u20ac 2023-2025. PI:\u00a0 Villacampa Alcubierre, Pilar.<\/p>\n

PI23\/00164. Nuevo conocimiento en el desarrollo de malformaciones vasculares hep\u00e1ticas en los pacientes con Telangiectasia Hemorr\u00e1gica Hereditaria<\/strong> . Proyectos de investigaci\u00f3n en Salud (AES 2023).\u00a0 Budget: 167.500\u20ac. 2024-2027. PI: Riera Mestre, Antoni.<\/p>\n

2023-713-1. Desxifrar el paper de TDP-43 en la barrera vascular i l’estabilitat dels vasos sanguinis<\/strong>. La Marat\u00f3 TV3 2022. Budget: 120.000\u20ac. PI: Monta\u00f1ez Miralles, Eloi.<\/p>\n\t\t\t\t\"Riera\n

\n\t\tRiera Mestre, Antoni\n\t<\/h4>\n

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\n\t\tInvestigadors principals\n\t<\/h2>\n\t\t\t\t\"Riera\n

\n\t\tRiera Mestre, Antoni\n\t<\/h4>\n

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\n\t\tPint\u00f3 Sala, Xavier\n\t<\/h4>\n

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\n\t\tSolanich Moreno, Xavier\n\t<\/h4>\n

\n\t\t\n\t\txsolanich@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\"Eloi-Monta\u00f1ez-Miralles\"\n

\n\t\tMonta\u00f1ez Miralles, Eloi\n\t<\/h4>\n

\n\t\t\n\t\temontanez@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\"Francesc-Formiga-Perez\"\n

\n\t\tFormiga P\u00e9rez, Francesc\n\t<\/h4>\n

\n\t\t\n\t\tfformiga@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\"Pilar-Villacampa-Alcubierre\"\n

\n\t\tVillacampa Alcubierre, Pilar\n\t<\/h4>\n

\n\t\t\n\t\tpvillacampa@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\"Ramon\n

\n\t\tLleonart Bellfill, Ramon\n\t<\/h4>\n

\n\t\t\n\t\trlleonart@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\"Foto\n

\n\t\tCastro Castro, M\u00aa Jos\u00e9\n\t<\/h4>\n

\n\t\tENLLA\u00c7OS RELACIONATS\n\t<\/h4>\n

\n\t\t\n\t\tBloc Antoni Riera-Mestre\n\t\t<\/a>\n\t<\/h4>\n

\n\t\t\n\t\t@FormigaFrancesc\n\t\t<\/a>\n\t<\/h4>\n

\n\t\t\n\t\t@ramcat61\n\t\t<\/a>\n\t<\/h4>\n

\n\t\t\n\t\tIG InternaHub \n\t\t<\/a>\n\t<\/h4>\n

\n\t\t\n\t\tThreads InternaHub\n\t\t<\/a>\n\t<\/h4>\n

\n\t\tEquip\n\t<\/h2>\n\t\t\t\t\t\t\t\t\t\t\t\tCaps de grup\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadors\/es principals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadors\/es cl\u00ednics\/ques\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadors\/es postdoctorals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadors\/es predoctorals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tSuport cient\u00edfic\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tCol\u00b7laboradors\/es\t\t\t\t<\/a>\n\t\t\t\t\t\tCaps de grup\n\t\t\t\t\t\t\t\t\t\t\t