{"id":2696,"date":"2019-10-07T16:08:26","date_gmt":"2019-10-07T14:08:26","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=2696"},"modified":"2025-01-13T09:03:04","modified_gmt":"2025-01-13T08:03:04","slug":"processos-immune-inflamatoris-i-terapia-genica","status":"publish","type":"page","link":"https:\/\/idibell.cat\/recerca\/area-de-medicina-translacional\/programa-de-gens-malaltia-i-terapia\/processos-immune-inflamatoris-i-terapia-genica\/","title":{"rendered":"Processos Immune-inflamatoris i Ter\u00e0pia G\u00e8nica"},"content":{"rendered":"\n<h1>\n\t\tProcessos immune-inflamatoris i ter\u00e0pia g\u00e8nica\n\t<\/h1>\n<h3>\n\t\tResum\n\t<\/h3>\n\t<p>El grup de recerca en processos immune-inflamatoris i ter\u00e0pia g\u00e9nica realitza recerca translacional amb un enfocament primari sobre les bases moleculars dels processos immune-inflamatoris i malalties complexes relacionades. El seu objectiu \u00e9s promoure recerca rellevant i d&#8217;excel\u00b7l\u00e8ncia en la inflamaci\u00f3 i proporcionar un entorn \u00f2ptim de formaci\u00f3 per a joves investigadors.<\/p>\n<h2>88<\/h2>\n<h2>Publicacions<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/04\/902_aran.png\" alt=\"902_aran\" itemprop=\"image\" height=\"300\" width=\"600\" title=\"902_aran\" onerror=\"this.style.display='none'\"  \/>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\">L\u00ednies estrat\u00e8giques<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-0\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\tIdentificaci\u00f3 i caracteritzaci\u00f3 de noves prote\u00efnes immunomoduladores i avaluaci\u00f3 de la seva rellev\u00e0ncia i potencial terap\u00e8utic en malalties inflamat\u00f2ries\u00a0 immunomediades.<br \/>\nAn\u00e0lisi de nous biomarcadors diagn\u00f2stics \/ pron\u00f2stics en patologies inflamat\u00f2ries agudes i cr\u00f2niques<br \/>\nEstr\u00e8s oxidatiu en c\u00e8l\u00b7lules epitelials de les vies respirat\u00f2ries.<br \/>\nMecanismes moleculars inflamatoris.<br \/>\nBases moleculars de malalties urogenitals i infertilitat masculina. La resposta immune com a potencial factor etiol\u00f2gic de malalties complexes.\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\">Publicacions seleccionades<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-1\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>Ferre-Giraldo A, Castells M, S\u00e1nchez-Herrero JF, L\u00f3pez-Rodrigo O, de Rocco-Ponce M, Bassas L, Vigu\u00e9s F, Sumoy L, Larriba S. <strong>Semen sEV tRF-based models increase non-invasive prediction accuracy of clinically significant prostate cancer among patients with moderately altered PSA levels<\/strong>. Int J Mol Sci. 2024 Sep 20;25(18):10122. doi: 10.3390\/ijms251810122<\/li>\n<li>Larriba,S;S\u00e1nchez Herrero,JF;Pluvinet,R;L\u00f3pez Rodrigo,O;Bassas,L;Sumoy,L, <strong>Seminal extracellular vesicle sncRNA sequencing reveals altered miRNA\/isomiR profiles as sperm retrieval biomarkers for azoospermia<\/strong>, Andrology, 2023;12(1):137-156, doi:10.1111\/andr.13461<\/li>\n<li>Serrano,I;Luque,A;Ruiz Cerulla,A;Navas,S;Blom,AM;de C\u00f3rdoba,SR;Fern\u00e1ndez,FJ et al, <strong>C4BP(\u00df-)-mediated immunomodulation attenuates inflammation in DSS-induced murine colitis and in myeloid cells from IBD patients<\/strong>, Pharmacol. Res., 2023;197106948-106948, doi:10.1016\/j.phrs.2023.106948,<\/li>\n<li>Serrano I, Luque A, Mitjavila F, Blom AM, Rodr\u00edguez de C\u00f3rdoba S, Vega MC, Torras J, Aran JM. <strong>The Hidden Side of Complement Regulator C4BP: Dissection and Evaluation of Its Immunomodulatory Activity<\/strong>. Front. Immunol. 2022;13883743-883743. doi:10.3389\/fimmu.2022.883743.<\/li>\n<li>Checa J, Martinez Gonzalez I, Maqueda M, Mosquera JL, Aran JM.<strong> Genome-Wide RNAi Screening Identifies Novel Pathways\/Genes Involved in Oxidative Stress and Repurposable Drugs to Preserve Cystic Fibrosis Airway Epithelial Cell Integrity<\/strong>. Antioxidants. 2021;10(12):doi:10.3390\/antiox10121936.<\/li>\n<li>Hueso M, Mall\u00e9n A, Su\u00f1\u00e9 Pou M, Aran JM, Su\u00f1\u00e9 Negre JM, Navarro E. <strong>ncRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery.<\/strong> Int J Mol Sci. 2021;22(21):doi:10.3390\/ijms222111596.<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\">Projectes seleccionats<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-2\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>FIS23037. <strong>Caracterizaci\u00f3n de Heptammune, un nuevo inmunomodulador biol\u00f3gico para controlar la hiperinflamaci\u00f3n y la inmunidad entrenada desadaptada en enfermedades autoinmunes<\/strong>. Instituto de Salud Carlos III (ISCIII). Budget: 252.500\u20ac. 2024-2026. PI: ARAN PERRAMON, JOSEP M\u00aa.<\/li>\n<li>21FIS019. <strong>Caracterizaci\u00f3n, potencial diagn\u00f3stico y terape\u00fatico de un nuevo inmunomodulador biol\u00f3gico para el tratamiento de enfermedades autoinmunes<\/strong>. Instituto de Salud Carlos III (ISCIII). Budget: 171.820\u20ac. 2021-2025. PI: ARAN PERRAMON, JOSEP M\u00aa.<\/li>\n<li>21FIS011. <strong>Desarrollo de un nuevo biol\u00f3gico restaurador de la tolerancia inmunitaria. Aplicaci\u00f3n al tratamiento de la enfermedad inflamatoria intestinal<\/strong>. Instituto de Salud Carlos III (ISCIII). Budget: 115.500\u20ac. 2021-2023. PI: ARAN PERRAMON, JOSEP M\u00aa.<\/li>\n<li>AGA22021. <strong>PurPose Biotherapeutics: first-in-class metabolic modulators against autoimmune diseases<\/strong>. AGENCIA GESTIO D&#8217;AJUTS UNIV. I RECERCA. Budget: 84.000,06\u20ac. 2022-2024. PI: ARAN PERRAMON, JOSEP M\u00aa.<\/li>\n<li>LCX22001. <strong>PRP6-HO7: a first-in-class biologic immunomodulator against autoimmune diseases<\/strong>. FUNDACI\u00d3 &#8220;LA CAIXA&#8221;. Budget: 70.000\u20ac. 2022-2024. PI: ARAN PERRAMON, JOSEP M\u00aa.<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-3\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-3\">Transfer\u00e8ncia de tecnologia<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-3\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\tPAT10- &#8220;Compositions and methods for immunomodulation&#8221;<br \/>\nIP: Josep Maria Aran<br \/>\nOWNERSHIP:100% IDIBELL<br \/>\nREQUEST No.: EP11382240<br \/>\nPRIORITY COUNTRY: European Union<br \/>\nPRIORITY DATE: 15\/07\/11<br \/>\nPCT APPLICATION: PCT\/EP2012\/063932 (16\/07\/12)\nPAT057-Predictive methods of atherosclerosis and stenosis<br \/>\nEP16382025<br \/>\nIP: Josep Maria Aran, Ana Luque\nPAT62- &#8220;C4BP-based compounds for treating immunological diseases&#8221;<br \/>\nOWNERSHIP:100% IDIBELL<br \/>\nREQUEST No.: EP17382187<br \/>\nPRIORITY COUNTRY: European Union<br \/>\nPRIORITY DATE: 06\/04\/17<br \/>\nPCT APPLICATION: PCT\/EP2018\/058773 (06\/07\/18)\nPAT76- &#8220;Compounds for immunomodulation&#8221;<br \/>\nINVENTORS: Aran, J.M., Luque, A., Serrano, I.<br \/>\nOWNERSHIP:100% IDIBELL<br \/>\nREQUEST No.: EP19382910<br \/>\nPRIORITY COUNTRY: European Union<br \/>\nPRIORITY DATE: 17\/10\/19\nLicense: ISR-TEST: Test r\u00e0pid pel diagn\u00f2stic del risc d&#8217;ICTUS<br \/>\nPI: Dr. Josep Maria Aran\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2019\/10\/aran-perramon-jose-maria-150x150.jpg\" alt=\"Aran Perramon, Jose Maria\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"aran-perramon-jose-maria\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tAran Perramon, Jose Maria\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:jaran@idibell.cat\" title=\"jaran@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tjaran@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tInvestigadors principals\n\t<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2019\/10\/aran-perramon-jose-maria-150x150.jpg\" alt=\"Aran Perramon, Jose Maria\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"aran-perramon-jose-maria\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tAran Perramon, Jose Maria\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:jaran@idibell.cat\" title=\"jaran@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tjaran@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2022\/11\/Sara-Larriba-22-150x150.jpg\" alt=\"Sara-Larriba-22\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Sara-Larriba-22\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tLarriba Bartolome, Sara\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:slarriba@idibell.cat\" title=\"slarriba@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tslarriba@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tEquip\n\t<\/h2>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-0\" data-index=\"0\" aria-selected=\"true\" aria-controls=\"fl-tabs--panel-0\" aria-expanded=\"true\" role=\"tab\" tabindex=\"0\">\t\t\t\tCaps de grup\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-1\" data-index=\"1\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-1\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es principals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-2\" data-index=\"2\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-2\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es postdoctorals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-3\" data-index=\"3\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-3\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tSuport cient\u00edfic\t\t\t\t<\/a>\n\t\t\t\t\t\tCaps de grup\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Aran Perramon, Jose Maria<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es principals\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Larriba Bartolome, Sara<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es postdoctorals\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Luque Gomez, Ana<\/li>\n<li>Serrano Santacruz, Inmaculada<\/li>\n<\/ul>\n\t\t\t\t\t\tSuport cient\u00edfic\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Ferre Giraldo, Adriana<\/li>\n<\/ul>\n<h2>\n\t\tNot\u00edcies relacionades\n\t<\/h2>\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/26411\" content=\"Identifiquen biomarcadors en mostres de semen que podrien ajudar a reduir el sobrediagn\u00f2stic en el cribratge de c\u00e0ncer de pr\u00f2stata\" \/><meta itemprop=\"datePublished\" content=\"2024-10-25\" \/><meta itemprop=\"dateModified\" content=\"2025-01-09\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/wp-content\/uploads\/2023\/03\/cropped-Marca-B.png\"\/><meta 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