{"id":2682,"date":"2019-10-07T15:10:19","date_gmt":"2019-10-07T13:10:19","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=2682"},"modified":"2024-06-11T10:12:13","modified_gmt":"2024-06-11T08:12:13","slug":"models-de-malaltia-en-c-elegans","status":"publish","type":"page","link":"https:\/\/idibell.cat\/recerca\/area-de-medicina-translacional\/programa-de-gens-malaltia-i-terapia\/models-de-malaltia-en-c-elegans\/","title":{"rendered":"Models de malaltia en C.elegans"},"content":{"rendered":"\n<h1>\n\t\tModels de malaltia en C.elegans\n\t<\/h1>\n<h3>\n\t\tResum\n\t<\/h3>\n\t<p>Utilitzem l&#8217;organisme model Caernorhabditis elegans per modelar malalties humanes. El nostre grup ha investigat gens involucrats en el processament d&#8217;ARN que estan alterats en malalties rares o c\u00e0ncer. Gr\u00e0cies a les tecnologies CRISPR, estem avan\u00e7ant cap a la medicina personalitzada en imitar mutacions humanes en <em>C. elegans<\/em>. A m\u00e9s, estem aprofitant la viabilitat de <em>C. elegans<\/em> per a l&#8217;edici\u00f3 gen\u00f2mica CRISPR per desenvolupar metodologies m\u00e9s eficients i vers\u00e0tils per a editar el loci gen\u00e8tic.<\/p>\n<h2>34<\/h2>\n<h2>Publicacions<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/07\/Modeling-human-diseases-in-C-elegans2.png\" alt=\"Modeling-human-diseases-in-C-elegans2\" itemprop=\"image\" height=\"300\" width=\"600\" title=\"Modeling-human-diseases-in-C-elegans2\" onerror=\"this.style.display='none'\"  \/>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\">L\u00ednies estrat\u00e8giques<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\"><i>Expand<\/i><\/a>\n\t\t\t\t\tProcessament d&#8217;ARN i malaltia<br \/>\nModelatge de c\u00e0ncer<br \/>\nEdici\u00f3 gen\u00f2mica CRISPR\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\">Publicacions seleccionades<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>Serrano,I;Luque,A;Ruiz Cerulla,A;Navas,S;Blom,AM;de C\u00f3rdoba,SR;Fern\u00e1ndez,FJ et al, <strong>C4BP(\u00df-)-mediated immunomodulation attenuates inflammation in DSS-induced murine colitis and in myeloid cells from IBD patients<\/strong>, Pharmacol. Res., 2023;197106948-106948, doi:10.1016\/j.phrs.2023.106948<\/li>\n<li>Vicencio J, S\u00e1nchez Bola\u00f1os C, Moreno S\u00e1nchez I, Brena D, Vejnar CE, Kukhtar D, Ruiz L\u00f3pez M, Cots Ponjoan M, Rubio A, Melero NR, Crespo Cuadrado J, Carolis C, P\u00e9rez Pulido AJ, Gir\u00e1ldez AJ, Kleinstiver BP, Cer\u00f3n J, Moreno Mateos MA. <strong>Genome editing in animals with minimal PAM CRISPR-Cas9 enzymes.<\/strong> Nat. Commun. 2022;13(1):2601-2601. doi:10.1038\/s41467-022-30228-4.<\/li>\n<li>Mart\u00ednez Fern\u00e1ndez C, Bergamino M, Schiavi A, Brena D, Ventura N, Honnen S, Villanueva A, Nadal E, Cer\u00f3n J. <strong>Insights into cisplatin-induced neurotoxicity and mitochondrial dysfunction in Caenorhabditis elegans.<\/strong> Dis. Model. Mech. 2022;15(3):doi:10.1242\/dmm.049161.<\/li>\n<li>Jungtrakoon Thamtarana P, Marucci A, Pannone L, Bonnefond A, Pezzilli S, Biagini T, Buranasupkajorn P, Hastings T, Mendonca C, Marselli L, Di Paola R, Abubakar Z, Mercuri L, Alberico F, Flex E, Cer\u00f2n J, Porta Riva M, Ludovico O, Carella M, Martinelli S, Marchetti P, Mazza T, Froguel P, Trischitta V, Doria A, Prudente S. <strong>Gain of function of Malate Dehydrogenase 2 (MDH2) and familial hyperglycemia.<\/strong> J. Clin. Endocrinol. Metab. 2022;107(3):668-684. doi:10.1210\/clinem\/dgab790.<\/li>\n<li>Saura Esteller J, Sanchez Vera I, Nunez Vazquez S, Jabalquinto Carrasco J, Cosialls AM, Mendive Tapia L, Kukhtar D, Martinez Bueno MD, Lavilla R, Ceron J, Artal Sanz M, Pons G, Iglesias Serret D, Gil J. <strong>Fluorizoline-induced apoptosis requires prohibitins in nematodes and human cells.<\/strong> Apoptosis. 2021;26(1-2):83-95. doi:10.1007\/s10495-020-01651-z.<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\">Projectes seleccionats<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>21FIS019. <strong>Caracterizaci\u00f3n, potencial diagn\u00f3stico y terape\u00fatico de un nuevo inmunomodulador biol\u00f3gico para el tratamiento de enfermedades autoinmunes<\/strong>. Instituto de Salud Carlos III (ISCIII). Budget: 171.820\u20ac. 2021-2023. PI: Aran Perramon, Josep M\u00aa.<\/li>\n<li>AGA21005. <strong>PROGRAMA BEATRIU DE PINOS 2020<\/strong>. AGENCIA GESTIO D&#8217;AJUTS UNIV. I RECERCA. Budget: 144.300\u20ac. 2022-2025. PI: Aran Perramon, Josep M\u00aa.<\/li>\n<li>21FIS011. <strong>Desarrollo de un nuevo biol\u00f3gico restaurador de la tolerancia inmunitaria. Aplicaci\u00f3n al tratamiento de la enfermedad inflamatoria intestinal<\/strong>. Instituto de Salud Carlos III (ISCIII). Budget: 115.500\u20ac. 2021-2023. PI: Aran Perramon, Josep M\u00aa.<\/li>\n<li>FIS21142. <strong>CONTRATOS SARA BORRELL<\/strong>. Instituto de Salud Carlos III (ISCIII). Budget: 95.000\u20ac. 2022-2022. PI: Aran Perramon, Josep M\u00aa.<\/li>\n<li>AGA22021. <strong>PurPose Biotherapeutics: first-in-class metabolic modulators against autoimmune diseases<\/strong>. AGENCIA GESTIO D&#8217;AJUTS UNIV. I RECERCA. Budget: 84.000,06\u20ac. 2022-2024. PI: Aran Perramon, Josep M\u00aa.<\/li>\n<\/ul>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2022\/11\/Julian-Ceron22-150x150.jpg\" alt=\"Juli\u00e1n-Cer\u00f3n22\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Juli\u00e1n-Cer\u00f3n22\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tCer\u00f3n Madrigal, Juli\u00e1n\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:jceron@idibell.cat\" title=\"jceron@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tjceron@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tInvestigadors principals\n\t<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2022\/11\/Julian-Ceron22-150x150.jpg\" alt=\"Juli\u00e1n-Cer\u00f3n22\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Juli\u00e1n-Cer\u00f3n22\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tCer\u00f3n Madrigal, Juli\u00e1n\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:vmoreno@idibell.cat\" title=\"jceron@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tjceron@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\tENLLA\u00c7OS RELACIONATS\n\t<\/h4>\n<h4>\n\t\t<a href=\"http:\/\/www.ceronlab.com\/\" title=\"Ceronlab\" target=\"_blank\" rel=\"noopener\">\n\t\tCeronlab\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/twitter.com\/CeronLab\" title=\"@CeronLab\" target=\"_blank\" rel=\"noopener\">\n\t\t@CeronLab\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tEquip\n\t<\/h2>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-0\" data-index=\"0\" aria-selected=\"true\" aria-controls=\"fl-tabs--panel-0\" aria-expanded=\"true\" role=\"tab\" tabindex=\"0\">\t\t\t\tCaps de grup\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-1\" data-index=\"1\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-1\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es postdoctorals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-2\" data-index=\"2\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-2\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tSuport cient\u00edfic\t\t\t\t<\/a>\n\t\t\t\t\t\tCaps de grup\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Cer\u00f3n Madrigal, Juli\u00e1n<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es postdoctorals\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Aristizabal Corrales, David<\/li>\n<\/ul>\n\t\t\t\t\t\tSuport cient\u00edfic\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Olaso Llorca, Alba<\/li>\n<\/ul>\n<h2>\n\t\tNot\u00edcies relacionades\n\t<\/h2>\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/21375\" content=\"Estableixen un nou sistema d'edici\u00f3 gen\u00e8tica en animals\" \/><meta itemprop=\"datePublished\" content=\"2022-05-12\" \/><meta itemprop=\"dateModified\" content=\"2022-05-12\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" 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href=\"https:\/\/idibell.cat\/2019\/02\/el-nou-metode-nested-crispr-permet-editar-eficientment-el-genoma-amb-fragments-llargs-dadn\/\" title=\"El nou m\u00e8tode Nested CRISPR permet editar eficientment el genoma amb fragments llargs d'ADN\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/2019\/02\/el-nou-metode-nested-crispr-permet-editar-eficientment-el-genoma-amb-fragments-llargs-dadn\/\" title=\"El nou m\u00e8tode Nested CRISPR permet editar eficientment el genoma amb fragments llargs d'ADN\">El nou m\u00e8tode Nested CRISPR permet editar eficientment el genoma amb fragments llargs d&#8217;ADN<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/author\/erigin\/\">Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t07\/02\/2019\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/7621\" content=\"El canvi d'un sol amino\u00e0cid mitjan\u00e7ant la t\u00e8cnica de CRISPR fa que un animal sigui resistent a la quimioter\u00e0pia basada en cisplat\u00ed\" \/><meta itemprop=\"datePublished\" content=\"2018-06-22\" \/><meta itemprop=\"dateModified\" content=\"2020-05-13\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/wp-content\/uploads\/2023\/03\/cropped-Marca-B.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/author\/erigin\/\" \/><meta itemprop=\"name\" content=\"Idibell\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/05\/gusano-2.jpg\" \/><meta itemprop=\"width\" content=\"1388\" \/><meta itemprop=\"height\" content=\"828\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/2018\/06\/el-canvi-dun-sol-aminoacid-mitjancant-la-tecnica-de-crispr-fa-que-un-animal-sigui-resistent-a-la-quimioterapia-basada-en-cisplati\/\" title=\"El canvi d'un 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content=\"https:\/\/idibell.cat\/wp-content\/uploads\/2023\/03\/cropped-Marca-B.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/author\/erigin\/\" \/><meta itemprop=\"name\" content=\"Idibell\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/05\/20170801_Ceron_Fdez_INPhINIT.jpg\" \/><meta itemprop=\"width\" content=\"350\" \/><meta itemprop=\"height\" content=\"214\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/2017\/07\/lidibell-acull-tres-joves-investigadors-amb-beca-inphinit\/\" title=\"L'IDIBELL acull tres joves investigadors amb beca INPhINIT\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/2017\/07\/lidibell-acull-tres-joves-investigadors-amb-beca-inphinit\/\" title=\"L'IDIBELL acull tres joves investigadors amb beca INPhINIT\">L&#8217;IDIBELL acull tres joves investigadors amb beca INPhINIT<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/author\/erigin\/\">Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t31\/07\/2017\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/7923\" content=\"L&#8217;ONCE i l&#8217;IDIBELL col\u00b7laboren en un projecte sobre Retinosi Pigment\u00e0ria\" \/><meta itemprop=\"datePublished\" content=\"2016-09-26\" \/><meta itemprop=\"dateModified\" content=\"2020-05-29\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/wp-content\/uploads\/2023\/03\/cropped-Marca-B.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/author\/erigin\/\" \/><meta itemprop=\"name\" content=\"Idibell\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/05\/20160926_Ceron_ONCE.jpg\" \/><meta itemprop=\"width\" content=\"1200\" \/><meta itemprop=\"height\" content=\"799\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/2016\/09\/lonce-i-lidibell-col%c2%b7laboren-en-un-projecte-sobre-retinosi-pigmentaria\/\" title=\"L&#8217;ONCE i l&#8217;IDIBELL col\u00b7laboren en un projecte sobre Retinosi Pigment\u00e0ria\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/2016\/09\/lonce-i-lidibell-col%c2%b7laboren-en-un-projecte-sobre-retinosi-pigmentaria\/\" title=\"L&#8217;ONCE i l&#8217;IDIBELL col\u00b7laboren en un projecte sobre Retinosi Pigment\u00e0ria\">L&#8217;ONCE i l&#8217;IDIBELL col\u00b7laboren en un projecte sobre Retinosi Pigment\u00e0ria<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/author\/erigin\/\">Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t26\/09\/2016\t\t\t\t\t\t\t\n\t\t<!-- .pp-content-posts -->\n\n","protected":false},"excerpt":{"rendered":"<p>Models de malaltia en C.elegans Resum Utilitzem l&#8217;organisme model Caernorhabditis elegans per modelar malalties humanes. El nostre grup ha investigat gens involucrats en el processament d&#8217;ARN que estan alterats en malalties rares o c\u00e0ncer. Gr\u00e0cies a les tecnologies CRISPR, estem avan\u00e7ant cap a la medicina personalitzada en imitar mutacions humanes en C. elegans. A m\u00e9s, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":552,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-2682","page","type-page","status-publish","hentry"],"publishpress_future_action":{"enabled":false,"date":"2024-11-29 09:37:23","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages\/2682","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=2682"}],"version-history":[{"count":7,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages\/2682\/revisions"}],"predecessor-version":[{"id":25939,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages\/2682\/revisions\/25939"}],"up":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages\/552"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=2682"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}