{"id":2579,"date":"2019-10-06T21:21:19","date_gmt":"2019-10-06T19:21:19","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=2579"},"modified":"2025-01-28T15:39:32","modified_gmt":"2025-01-28T14:39:32","slug":"nutricio-metabolisme-i-terapia-genica","status":"publish","type":"page","link":"https:\/\/idibell.cat\/recerca\/area-de-medicina-translacional\/programa-de-diabetis-i-metabolisme\/nutricio-metabolisme-i-terapia-genica\/","title":{"rendered":"Nutrici\u00f3, Metabolisme i Ter\u00e0pia G\u00e8nica"},"content":{"rendered":"\n<h1>\n\t\tNutrici\u00f3, metabolisme i ter\u00e0pia g\u00e8nica\n\t<\/h1>\n<h3>\n\t\tResum\n\t<\/h3>\n\tEl grup se centra en estudiar les implicacions metab\u00f2liques de malalties cr\u00f2niques com l&#8217;obesitat, la diabetis i el c\u00e0ncer. Mitjan\u00e7ant la ter\u00e0pia g\u00e8nica, el grup t\u00e9 com a objectiu modificar el genoma o la regulaci\u00f3 gen\u00f2mica d&#8217;un pacient mitjan\u00e7ant diverses estrat\u00e8gies, amb la finalitat de reempla\u00e7ar una escassetat causada per una mutaci\u00f3, desregulaci\u00f3 gen\u00e8tica o mal funcionament d&#8217;una via de senyalitzaci\u00f3 cel\u00b7lular.<br \/>\nA trav\u00e9s d&#8217;aquest enfocament, aquest grup estudia el metabolisme cel\u00b7lular, definint els mecanismes que utilitzen les c\u00e8l\u00b7lules per adaptar-se a diferents condicions (estr\u00e8s per falta de nutrients, esfor\u00e7 f\u00edsic, etc.), que utilitza com a base per a proposar noves estrat\u00e8gies en el tractament. de malalties com la diabetis i el c\u00e0ncer, o en pacients amb dany hep\u00e0tic o en pacients sotmesos a cirurgies d&#8217;alt risc.\n<h2>390<\/h2>\n<h2>Publicacions<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/04\/srynge.jpg\" alt=\"srynge\" itemprop=\"image\" height=\"300\" width=\"600\" title=\"srynge\" onerror=\"this.style.display='none'\"  \/>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\">L\u00ednies estrat\u00e8giques<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-0\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\t&#8211; Estudi de el paper de PEPCK-M i la fisiologia mitocondrial en el metabolisme del c\u00e0ncer<br \/>\n&#8211; Plasticitat metab\u00f2lica en obesitat i diabetis tipus 2<br \/>\n&#8211; Aplicaci\u00f3 d&#8217;enfocaments gen\u00e8tics i metabol\u00f2mics basats en is\u00f2tops estables per investigar el metabolisme dels tumors in vivo i descobrir dianes metab\u00f2liques per al tractament del c\u00e0ncer.<br \/>\n&#8211; Caracteritzaci\u00f3 de l&#8217;estructura gen\u00f2mica i funcional dels gens codificants pfkfb3 i pfkfb4 de l&#8217;enzim PFK2 (6-fosfofructo-2- quinasa \/ fructosa 2,6-bisfosfatasa).<br \/>\n&#8211; Estudi de la influ\u00e8ncia de diferents ajudes ergog\u00e8niques sobre el rendiment f\u00edsic<br \/>\n&#8211; Avaluaci\u00f3 de la influ\u00e8ncia de la ingesta aguda de greixos, pr\u00e8via a l&#8217;exercici, sobre l&#8217;adaptaci\u00f3 a l&#8217;esfor\u00e7 i el rendiment en esfor\u00e7os de llarga durada.\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\">Publicacions seleccionades<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-1\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>Kreuzaler,P;Inglese,P;Ghanate,A;Gjelaj,E;Wu,VC;Panina,Y;Mendez Lucas,A et al, <strong>Vitamin B<sub>5<\/sub> supports MYC oncogenic metabolism and tumor progression in breast cancer<\/strong>, Nat. Metab., 2023;5(11):doi:10.1038\/s42255-023-00915-7<\/li>\n<li>Jansen,KM;Dahdah,N;Gama Perez,P;Schots,PC;Larsen,TS;Garcia Roves,PM, <strong>Impact of GLP-1 receptor agonist versus omega-3 fatty acids supplement on obesity-induced alterations of mitochondrial respiration<\/strong>, Front. Endocrinol., 2023;141098391-1098391, doi:10.3389\/fendo.2023.1098391<\/li>\n<li>Pimenta Lopes,C;S\u00e1nchez Diego,C;Deber,A;Egea Cort\u00e9s,A;Valer,JA;Alcal\u00e1,A;M\u00e9ndez Lucas,A et al, <strong>Inhibition of C5AR1 impairs osteoclast mobilization and prevents bone loss<\/strong>., Mol. Ther., 2023;31(8):2507-2523, doi:10.1016\/j.ymthe.2023.04.022<\/li>\n<li>Playa Albinyana,H;Arenas,F;Royo,R;Gir\u00f3,A;L\u00f3pez Oreja,I;Aymerich,M;L\u00f3pez Guerra,M et al, <strong>Chronic lymphocytic leukemia patient-derived xenografts recapitulate clonal evolution to Richter transformation<\/strong>., Leukemia, 2023;doi:10.1038\/s41375-023-02095-5<\/li>\n<li>Jansen,KM;Dahdah,N;Gama Perez,P;Schots,PC;Larsen,TS;Garcia Roves,PM, <strong>Impact of GLP-1 receptor agonist versus omega-3 fatty acids supplement on obesity-induced alterations of mitochondrial respiration<\/strong>, Front. Endocrinol., 2023;141098391-1098391, doi:10.3389\/fendo.2023.1098391<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\">Projectes actius<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-2\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\t<h3>Estudio integrativo y traslacional de la desregulaci\u00f3n metab\u00f3lica debida a la obesidad. Repercusiones sobre la plasticidad del tejido adiposo blanco<\/h3>\n<p>Garcia-Roves Gonzalez, Pablo Miguel (Investigador principal (IP))<\/p>\n<p>Ref.: PI15\/00701<\/p>\n<p>Entitat finan\u00e7adora:<\/p>\n<ul>\n<li>FIS-INSTITUTO DE SALUD CARLOS III<\/li>\n<\/ul>\n<p>2016-01-01 &#8211; 2018-12-31<\/p>\n<hr \/>\n<h3>ESTANCIA BREVE BECA FPI BES-2007-16437<\/h3>\n<p>Bartrons Bach, Ramon (Investigador principal (IP))<\/p>\n<p>Ref.: EEBB-2011-44136<\/p>\n<p>Entitat finan\u00e7adora:<\/p>\n<ul>\n<li>MINISTERIO DE EDUCACI\u00d3N Y CIENCIA<\/li>\n<\/ul>\n<p>2011-01-01 &#8211; 2011-12-31<\/p>\n<hr \/>\n<h3>Regulaci\u00f3n y funci\u00f3n de los genes pfkfb3,pfkfb4 y TIGAR<\/h3>\n<p>Bartrons Bach, Ramon (Investigador principal (IP))<\/p>\n<p>Ref.: BUF2009-07380<\/p>\n<p>Entitat finan\u00e7adora:<\/p>\n<ul>\n<li>MINISTERIO DE EDUCACI\u00d3N Y CIENCIA<\/li>\n<\/ul>\n<p>2010-01-01 &#8211; 2012-12-31<\/p>\n<hr \/>\n<h3>FPI &#8211; BES-2007-16437<\/h3>\n<p>Bartrons Bach, Ramon (Investigador principal (IP))<\/p>\n<p>Ref.: FPI-BES-2007-16437<\/p>\n<p>Entitat finan\u00e7adora:<\/p>\n<ul>\n<li>MINISTERIO DE EDUCACI\u00d3N Y CIENCIA<\/li>\n<\/ul>\n<p>2009-07-02 &#8211; 2011-07-01<\/p>\n<hr \/>\n<h3>Conv. Mutua Madrile\u00f1a &#8212; DR. JAVIERRE<\/h3>\n<p>Javierre Garces, Casimiro (Investigador principal (IP))<\/p>\n<p>Ref.: 07PRV009<\/p>\n<p>Entitat finan\u00e7adora:<\/p>\n<ul>\n<li>FUNDACI\u00d3 MUTUA MADRILE\u00d1A<\/li>\n<\/ul>\n<p>2007-05-04 &#8211; 2010-05-03<\/p>\n<hr \/>\n<h3>BFU2006-02412<\/h3>\n<p>Bartrons Bach, Ramon (Investigador principal (IP))<\/p>\n<p>Ref.: BFU2006-02412<\/p>\n<p>Entitat finan\u00e7adora:<\/p>\n<ul>\n<li>MINISTERIO DE EDUCACI\u00d3N Y CIENCIA<\/li>\n<\/ul>\n<p>2007-01-01 &#8211; 2009-09-30<\/p>\n<hr \/>\n<h3>Inv. Efectes aspirina &#8212; Dr. Bartrons<\/h3>\n<p>Bartrons Bach, Ramon (Investigador principal (IP))<\/p>\n<p>Ref.: 94VAR026<\/p>\n<hr \/>\n<h3>MTV3<\/h3>\n<p>Bartrons Bach, Ramon (Investigador principal (IP))<\/p>\n<p>Ref.: MTV3<\/p>\n<p>Entitat finan\u00e7adora:<\/p>\n<ul>\n<li>MARATO TV3<\/li>\n<\/ul>\n<p>2006-01-01 &#8211; 2009-12-31<\/p>\n<hr \/>\n<h3>NOVES ESTRAT\u00c8GIES DE TERAPIA G\u00c8NICA PER AL TRACTAMENT DE LA MALALTIA INFLAMATORIA INTESTINAL: LA SILENCIACI\u00d3 DE L\u00b4EXPRESSI\u00d3 DE TNFalfa I LA SOBREEXPRESSI\u00d3 D\u00b4INTERLEUQUINA-10<\/h3>\n<p>Perales Losa, Jose Carlos (Investigador principal (IP))<\/p>\n<p>Ref.: 31633<\/p>\n<p>2006-01-01 &#8211; 2009-12-31<\/p>\n<p><a href=\"http:\/\/imarinaid.com\/04-270085\">See full list<\/a><\/p>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/11\/Pablo-Garcia-Roves-Gonzalez-150x150.jpg\" alt=\"Pablo-Garcia-Roves-Gonzalez\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Pablo-Garcia-Roves-Gonzalez\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tGarcia-Roves Gonzalez, Pablo\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:pgarciaroves@idibell.cat\" title=\"pgarciaroves@idibell.cat\"  target=\"_blank\"  rel=\"noopener\">\n\t\tpgarciaroves@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tInvestigadors principals\n\t<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/11\/Pablo-Garcia-Roves-Gonzalez-150x150.jpg\" alt=\"Pablo-Garcia-Roves-Gonzalez\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Pablo-Garcia-Roves-Gonzalez\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tGarcia-Roves Gonzalez, Pablo\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:pgarciaroves@idibell.cat\" title=\"pgarciaroves@idibell.cat\"  target=\"_blank\"  rel=\"noopener\">\n\t\tpgarciaroves@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/11\/Jose-Carlos-Perales-Losa.jpg\" alt=\"Jose-Carlos-Perales-Losa\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Jose-Carlos-Perales-Losa\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tPerales Losa, Jose Carlos\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:jperales@idibell.cat\" title=\"jperales@idibell.cat\"  target=\"_blank\"  rel=\"noopener\">\n\t\tjperales@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2021\/01\/Andres-Mendez-Lucas-150x150.jpg\" alt=\"Andres-Mendez-Lucas\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Andres-Mendez-Lucas\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tMendez Lucas, Andres\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2022\/06\/Anna-Manzano-Cuesta-150x150.jpg\" alt=\"Anna-Manzano-Cuesta\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Anna-Manzano-Cuesta\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tManzano Cuesta, Anna\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:amanzano@idibell.cat\" title=\"amanzano@idibell.cat\"  target=\"_blank\"  rel=\"noopener\">\n\t\tamanzano@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\tENLLA\u00c7OS RELACIONATS\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/twitter.com\/m_roves\" title=\"@m_roves\"  target=\"_blank\"  rel=\"noopener\">\n\t\t@m_roves\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/twitter.com\/Aml_Metab\" title=\"@Aml_Metab\"  target=\"_blank\"  rel=\"noopener\">\n\t\t@Aml_Metab\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tEquip\n\t<\/h2>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-0\" data-index=\"0\" aria-selected=\"true\" aria-controls=\"fl-tabs--panel-0\" aria-expanded=\"true\" role=\"tab\" tabindex=\"0\">\t\t\t\tCaps de grup\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-1\" data-index=\"1\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-1\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es principals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-2\" data-index=\"2\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-2\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es cl\u00ednics\/ques\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-3\" data-index=\"3\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-3\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es postdoctorals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-4\" data-index=\"4\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-4\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es predoctorals\t\t\t\t<\/a>\n\t\t\t\t\t\tCaps de grup\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Garcia-Roves Gonzalez, Pablo<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es principals\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Perales Losa, Jose Carlos<\/li>\n<li>Mendez Lucas, Andres<\/li>\n<li>Manzano Cuesta, Anna<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es cl\u00ednics\/ques\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Javierre Garces, Casimiro<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es postdoctorals\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Gama Perez, Pau<\/li>\n<li>Palmieri, Flavio<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es predoctorals\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>De Benito Gomez, Lidia<\/li>\n<li>Tormo Fabios, Maria<\/li>\n<li>\u00c1lvarez Luis, Jorge<\/li>\n<li>Barrientos Salinas, Roberto Gustavo<\/li>\n<\/ul>\n<h2>\n\t\tNoticias relacionadas\n\t<\/h2>\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/24776\" content=\"Generen un model de ratol\u00ed que permetr\u00e0 estudiar la progressi\u00f3 d'un tipus de la leuc\u00e8mia i buscar tractaments m\u00e9s efica\u00e7os\" \/><meta itemprop=\"datePublished\" 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