{"id":2455,"date":"2019-10-06T05:02:30","date_gmt":"2019-10-06T03:02:30","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=2455"},"modified":"2024-11-19T17:22:22","modified_gmt":"2024-11-19T16:22:22","slug":"senyalitzacio-molecular","status":"publish","type":"page","link":"https:\/\/idibell.cat\/recerca\/area-de-cancer\/programa-de-mecanismes-moleculars-i-terapia-experimental-en-oncologia-oncobell\/senyalitzacio-molecular\/","title":{"rendered":"Senyalitzaci\u00f3 molecular"},"content":{"rendered":"\n<h1>\n\t\tSenyalitzaci\u00f3 molecular en c\u00e0ncer\n\t<\/h1>\n<h3>\n\t\tResum\n\t<\/h3>\n\t<p>Les cascades de senyalitzaci\u00f3 molecular que es produeixen a nivell cel\u00b7lular s\u00f3n essencials per respondre als canvis en el seu entorn o per alterar la seva home\u00f2stasi, per exemple, en el nivell de proliferaci\u00f3, moviment, creixement o metabolisme cel\u00b7lular. Entendre el mecanisme de la transducci\u00f3 de senyals permet explicar com es controlen les alteracions que es produeixen en moltes patologies. Aix\u00ed, els canvis en la senyalitzaci\u00f3 es poden utilitzar per detectar la pres\u00e8ncia de moltes malalties i les mol\u00e8cules de senyalitzaci\u00f3 poden esdevenir dianes terap\u00e8utiques. A m\u00e9s, aquestes vies de senyalitzaci\u00f3 es veuen afectades en resposta a les ter\u00e0pies que s&#8217;utilitzen per tractar, per exemple, el c\u00e0ncer, i participen en la generaci\u00f3 de resist\u00e8ncia als medicaments.<\/p>\n<h2>176<\/h2>\n<h2>Publicacions<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/04\/southern_blot_membrane.jpg\" alt=\"southern_blot_membrane\" itemprop=\"image\" height=\"300\" width=\"600\" title=\"southern_blot_membrane\" onerror=\"this.style.display='none'\"  \/>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\">L\u00ednies estrat\u00e8giques<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\"><i>Expand<\/i><\/a>\n\t\t\t\t\tRol de diferents vies de senyalitzaci\u00f3 en processos fisiol\u00f2gics: com membres de les fam\u00edlies de TGFbeta i EGFR controlen l&#8217;angiog\u00e8nesi, o el paper de diferents ubiquitin-ligases que regulen la funci\u00f3 de les prote\u00efnes de senyalitzaci\u00f3.<br \/>\nC\u00e0ncer epitelial ov\u00e0ric: paper de diferents tirosina quinases receptores (com els receptors PDGF o c-Kit) i els receptors de citocines (com CXCR4) en el desenvolupament i la met\u00e0stasi d&#8217;aquest tipus de c\u00e0ncer.<br \/>\nParticipaci\u00f3 de diferents vies de senyalitzaci\u00f3 i canvis metab\u00f2lics en la creaci\u00f3 de resist\u00e8ncia a la quimioter\u00e0pia en els c\u00e0ncers d&#8217;ovari, testicular i epitelial.<br \/>\nModificaci\u00f3 del pH cel\u00b7lular utilitzant subst\u00e0ncies anionof\u00f2riques com una nova estrat\u00e8gia terap\u00e8utica per al tractament de c\u00e0ncer de pulm\u00f3.<br \/>\nDesenvolupament precl\u00ednic de nous f\u00e0rmacs contra el c\u00e0ncer contra objectius terap\u00e8utics relacionats amb la resist\u00e8ncia al tractament.<br \/>\nAvaluaci\u00f3 de nous sistemes d&#8217;administraci\u00f3 de f\u00e0rmacs per al tractament de c\u00e0ncer mitjan\u00e7ant la nanoencapsulaci\u00f3 de compostos antitumorals.\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\">Publicacions seleccionades<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>Genet,G;Genet,N;Paila,U;Cain,SR;Cwiek,A;Chavkin,NW;Serbulea,V et al, <strong>Induced Endothelial Cell CycleArrest Prevents Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia<\/strong>., Circulation, 2023;doi:10.1161\/CIRCULATIONAHA.122.062952<\/li>\n<li>Cerd\u00e1,P;Castillo,SD;Aguilera,C;Iriarte,A;Rocamora,JL;Larrinaga,AM;Vi\u00f1als,F et al, <strong>New genetic drivers in hemorrhagic hereditary telangiectasia<\/strong>, Eur. J. Intern. Med., 2023;11999-108, doi:10.1016\/j.ejim.2023.08.024<\/li>\n<li>Villanueva,B;Cerd\u00e0,P;Torres Iglesias,R;Rocamora,JL;Figueras,A;Vi\u00f1als,F;Riera Mestre,A, <strong>Potential angiogenic biomarkers in hereditary hemorrhagic telangiectasia and other vascular diseases<\/strong>., Eur. J. Intern. Med., 2023;11510-17, doi:10.1016\/j.ejim.2023.05.020<\/li>\n<li>Gendrau Sanclemente,N;Figueras,A;Gracova,K;Lahiguera,A;Alsina Sanch\u00eds,E;Marin Jim\u00e9nez,JA;Vidal,A et al, <strong>Ovarian cancer relies on the PDGFR\u00df-fibronectin axis for tumorsphere formation and metastatic spread<\/strong>, Mol. Oncol., 2023;18(1):136-155, doi:10.1002\/1878-0261.13556<\/li>\n<li>Carrillo,DA;Arias Betancur,A;Carreira Barral,I;Fontova,P;Soto Cerrato,V;Garc\u00eda Valverde,M;P\u00e9rez Tom\u00e1s,R et al, <strong>Small molecule anion carriers facilitate lactate transport in model liposomes and cells, iScience<\/strong>, 2023;26(10):107898-107898, doi:10.1016\/j.isci.2023.107898<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\">Projectes seleccionats<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>MCI21003. <strong>EL PERFIL METAB\u00d3LICO COMO UNA OPORTUNIDAD TERAP\u00c9UTICA EN EL C\u00c1NCER EPITELIAL DE OVARIO. IMPLICACIONES EN MET\u00c1STASIS Y RESISTENCIA A LOS TRATAMIENTOS (MELATHE)<\/strong>. Ministerio de Ciencia e Innovaci\u00f3n. Budget: 217.800\u20ac. 2021-2024. PI: Vi\u00f1als Canals, Francesc.<\/li>\n<li>FIS22046. <strong>Desarrollo de estrategias terap\u00e9uticas para disminuir la resistencia a tratamientos convencionales en c\u00e1ncer de pulm\u00f3n<\/strong>. Instituto de Salud Carlos III (ISCIII). Budget: 141.570\u20ac. 2023-2025. PI: Soto Cerrato, Vanessa.<\/li>\n<li>19MEC005. <strong>AYUDAS PARA CONTRATOS PREDOCTORALES PARA LA FORMACI\u00d3N DE DOCTORES 2018<\/strong>. Ministerio de Ciencia e Innovaci\u00f3n. Budget: 88.250\u20ac. 2019-2023. PI: Vi\u00f1als Canals, Francesc.<\/li>\n<li>AGA22047. <strong>Gen\u00e8tica, Ter\u00e0pia i Resist\u00e8ncia en Tumors Epitelials i Germinals. AGENCIA GESTIO D&#8217;AJUTS UNIV. I RECERCA<\/strong>. Budget: 60.000\u20ac. 2022-2025. PI: Vi\u00f1als Canals, Francesc.<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-3\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-3\">Transfer\u00e8ncia de tecnologia<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-3\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-3\"><i>Expand<\/i><\/a>\n\t\t\t\t\tPAT086- &#8220;Asenapine for use in cancer&#8221;<br \/>\nIP: Vanessa Soto<br \/>\nOWNERSHIP:20% IDIBELL, 40%NOSTRUM, 20%UB 20%UNIVERSIDAD de BURGOS<br \/>\nREQUEST No.: EP21382721.5<br \/>\nPRIORITY COUNTRY: European Union<br \/>\nPRIORITY DATE: 30\/07\/21\nPAT089: COMPUESTO QUE TIENE ACTIVIDAD TRANSPORTADORA DE<br \/>\nLACTATO<br \/>\nIP: Vanessa Soto, Ricardo P\u00e9rez Tomas<br \/>\nP202330370\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-4\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-4\">M\u00e9s informaci\u00f3<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-4\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-4\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<p><em>Proyectos financiados por el Instituto de Salud Carlos III (ISCIII) y cofinanciados por el Fondo Europeo de Desarrollo Regional (FEDER):<\/em><\/p>\n<strong>Estudio precl\u00ednico y traslacional de nuevos agentes anticancerosos derivados de tambjaminas para el tratamiento del c\u00e1ncer de pulm\u00f3n humano<br \/>\n<\/strong>PI13\/00089. 01\/2014-12\/2016. 57.500 \u20ac. IP: Ricardo P\u00e9rez Tom\u00e1s.<br \/>\nIdentificar nuevas mol\u00e9culas m\u00e1s eficaces para combatir el c\u00e1ncer de pulm\u00f3n, bajo diversas perspectivas como son la qu\u00edmica m\u00e9dica, formulaci\u00f3n de nuevos f\u00e1rmacos, simulaci\u00f3n computacional, biolog\u00eda celular in vitro y t\u00e9cnicas bioqu\u00edmicas, transcript\u00f3mica y an\u00e1lisis de prote\u00f3mica, as\u00ed como en investigaci\u00f3n traslacional en modelos de xenotrasplante, permitir\u00e1 que seamos capaces de completar con \u00e9xito los estudios precl\u00ednicos de una prometedora nueva familia de compuestos anticancerosos. La desregulaci\u00f3n del pH es una caracter\u00edstica com\u00fan que confiere ventajas adaptativas a las c\u00e9lulas cancerosas. Proponemos que mol\u00e9culas que selectivamente poseen la capacidad de disminuir el pH intracelular ser\u00edan de gran inter\u00e9s como nuevos agentes quimioterap\u00e9uticos para el tratamiento del c\u00e1ncer de pulm\u00f3n. Evaluar la seguridad y eficacia de estos compuestos in vivo, desarrollar una innovadora nanoformulaci\u00f3n farmacol\u00f3gica con el fin de mejorar la selectividad y la eficacia, as\u00ed como ensayar una nueva y prometedora v\u00eda de administraci\u00f3n del f\u00e1rmaco.\n<p>&nbsp;<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/i.imgur.com\/7mUdUAq.png\" alt=\"\" \/><\/p>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2019\/10\/vi\u00f1als-canals-francesc-150x150.jpg\" alt=\"Vinyals Canals, Francesc\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"vi\u00f1als-canals,-francesc\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tVi\u00f1als Canals, Francesc\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:fvinyals@idibell.cat\" title=\"fvinyals@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tfvinyals@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tInvestigadors principals\n\t<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2019\/10\/vi\u00f1als-canals-francesc-150x150.jpg\" alt=\"Vinyals Canals, Francesc\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"vi\u00f1als-canals,-francesc\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tVi\u00f1als Canals, Francesc\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:fvinyals@idibell.cat\" title=\"fvinyals@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tfvinyals@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/11\/Vanessa-Soto-Cerrato1-150x150.jpg\" alt=\"Vanessa-Soto-Cerrato1\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Vanessa-Soto-Cerrato1\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tSoto Cerrato, Vanessa\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:vsoto@idibell.cat\" title=\"vsoto@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tvsoto@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/11\/Ricardo-Perez-Tomas1-150x150.jpg\" alt=\"Ricardo-Perez-Tomas1\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Ricardo-Perez-Tomas1\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tPerez Tomas, Ricardo\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:rperez@idibell.cat\" title=\"rperez@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\trperez@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2024\/02\/Miquel-A\u2560Cngel-Pujana-_0001_2-1-150x150.jpg\" alt=\"Miquel A\u2560\u00c7ngel Pujana _0001_2-1\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Miquel A\u2560\u00c7ngel Pujana _0001_2-1\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tGenestar Pujana, Miguel \u00c1ngel\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:rperez@idibell.cat\" title=\"mgenestar@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tmgenestar@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\tENLLA\u00c7OS RELACIONATS\n\t<\/h4>\n<h4>\n\t\t<a href=\"http:\/\/ico.gencat.cat\/ca\/recerca\/Programa-ProCURE\/\" title=\"ProCURE\" target=\"_blank\" rel=\"noopener\">\n\t\tProCURE\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tEquip\n\t<\/h2>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-0\" data-index=\"0\" aria-selected=\"true\" aria-controls=\"fl-tabs--panel-0\" aria-expanded=\"true\" role=\"tab\" tabindex=\"0\">\t\t\t\tCaps de grup\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-1\" data-index=\"1\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-1\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es principals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-2\" data-index=\"2\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-2\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es postdoctorals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-3\" data-index=\"3\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-3\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es predoctorals\t\t\t\t<\/a>\n\t\t\t\t\t\tCaps de grup\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Vi\u00f1als Canals, Francesc<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es principals\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Soto Cerrato, Vanessa<\/li>\n<li>Perez Tomas, Ricardo<\/li>\n<li>Genestar Pujana, Miguel \u00c1ngel<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es postdoctorals\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Figueras Amat, Agnes<\/li>\n<li>Fontova Pale, Pere<\/li>\n<li>Mateo Gonzalez, Francesca<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es predoctorals\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Gendrau Sanclemente, N\u00faria<\/li>\n<li>Medina Jover, Ferran<\/li>\n<li>Benitez Garcia, Cristina<\/li>\n<li>Torres Garc\u00eda, Ana Aurora<\/li>\n<li>Dai, Tianuy<\/li>\n<li>Shabbir, Arzoo<\/li>\n<li>Espin Garcia, Roderic<\/li>\n<li>Ruiz Auladell, Lara<\/li>\n<\/ul>\n<h2>\n\t\tNot\u00edcies relacionades\n\t<\/h2>\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/24867\" content=\"Presenten un virus oncol\u00edtic dirigit a c\u00e8l\u00b7lules NK amb gran potencial antitumoral\" \/><meta itemprop=\"datePublished\" content=\"2024-01-12\" \/><meta itemprop=\"dateModified\" content=\"2024-01-12\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/wp-content\/uploads\/2023\/03\/cropped-Marca-B.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/wp-content\/uploads\/2024\/01\/NO001-Adenovirus-oncolitic-169-g-1.jpg\" \/><meta itemprop=\"width\" content=\"1366\" 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