{"id":2422,"date":"2019-10-06T01:29:23","date_gmt":"2019-10-05T23:29:23","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=2422"},"modified":"2024-03-12T10:54:56","modified_gmt":"2024-03-12T09:54:56","slug":"cancer-de-mama","status":"publish","type":"page","link":"https:\/\/idibell.cat\/recerca\/area-de-cancer\/programa-de-mecanismes-molleculars-i-terapia-experimental-en-oncologia-oncobell\/cancer-de-mama\/","title":{"rendered":"C\u00e0ncer de Mama"},"content":{"rendered":"\n
El grup de recerca de c\u00e0ncer de mama t\u00e9 com a objectiu comprendre millor el desenvolupament del c\u00e0ncer de mama, l’origen dels subtipus de malalties i la progressi\u00f3 i les vulnerabilitats de la malaltia. Els projectes de recerca comprenen els principals subtipus de malalties aix\u00ed com el c\u00e0ncer de mama amb mutaci\u00f3 BRCA1\/2. El grup tamb\u00e9 treballa per desenvolupar nous enfocaments preventius espec\u00edfics i per millorar la qualitat de vida dels pacients. Es tracta d’un equip multidisciplinari que combina l\u00b4experi\u00e8ncia i el coneixement d\u00b4investigadors cl\u00ednics i translacionals.<\/p>\n
Modi S, Jacot W, Yamashita T, Sohn J, Vidal M, Tokunaga E, Tsurutani J, Ueno NT, Prat A, Chae YS, Lee KS, Niikura N, Park YH, Xu B, Wang X, Gil M, Li W, Pierga JY, Im SA, Moore HCF, Rugo HS, Yerushalmi R, Zagouri F, Gombos A, Kim SB, Liu Q, Luo T, Saura C, Schmid P, Sun T, Gambhire D, Yung L, Wang Y, Singh J, Vitazka P, Meinhardt G, Harbeck N, Cameron DA. Trastuzumab Deruxtecan in Previously Treated HER2-Low Advanced Breast Cancer<\/strong>. N. Engl. J. Med. 2022;387(1):9-20. doi:10.1056\/NEJMoa2203690.<\/p>\n Langille E, Al Zahrani KN, Ma Z, Liang M, Uuskula Reimand L, Espin R, Teng K, Malik A, Bergholtz H, El Ghamrasni S, Afiuni Zadeh S, Tsai R, Alvi S, Elia A, Lu Y, Oh RH, Kozma KJ, Trcka D, Narimatsu M, Liu JC, Nguyen T, Barutcu S, Loganathan SK, Bremner R, Bader GD, Egan SE, Cescon DW, Sorlie T, Wrana JL, Jackson HW, Wilson MD, Witkiewicz AK, Knudsen ES, Pujana MA, Wahl GM, Schramek D. Loss of epigenetic regulation disrupts lineage integrity, induces aberrant alveogenesis and promotes breast cancer<\/strong>. Cancer Discov. 2022;doi:10.1158\/2159-8290.CD-21-0865.<\/p>\n Mateo F, He Z, Mei L, de Garibay GR, Herranz C, Garc\u00eda N, Lorentzian A, Baiges A, Blommaert E, G\u00f3mez A, Mirallas O, Garrido Utrilla A, Palomero L, Esp\u00edn R, Extremera AI, Soler Mons\u00f3 MT, Petit A, Li R, Brunet J, Chen K, Tan S, Eaves CJ, McCloskey C, Hakem R, Khokha R, Lange PF, L\u00e1zaro C, Maxwell CA, Pujana MA. Modification of BRCA1-associated breast cancer risk by HMMR overexpression<\/strong>. Nat. Commun. 2022;13(1):1895-1895. doi:10.1038\/s41467-022-29335-z.<\/p>\n He Z, Ghorayeb R, Tan S, Chen K, Lorentzian AC, Bottyan J, Aalam SMM, Pujana MA, Lange PF, Kannan N, Eaves CJ, Maxwell CA. Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation<\/strong>. Nat. Commun. 2022;13(1):2200-2200. doi:10.1038\/s41467-022-29885-2.<\/p>\n Guix I, Liu Q, Pujana MA, Ha P, Piulats J, Linares I, Guedea F, Mao JH, Lazar A, Chapman J, Yom SS, Ashworth A, Barcellos Hoff MH. Validation of anti-correlated TGF\u00df signaling and alternative end-joining DNA repair signatures that predict response to genotoxic cancer therapy<\/strong>. Clin. Cancer Res. 2022;28(7):1372-1382. doi:10.1158\/1078-0432.CCR-21-2846.<\/p>\n\t\t\t\t\tProjectes seleccionats<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t LCX21020. Becas de posdoctorado Junior Leader Incoming<\/strong>. FUNDACI\u00d3 “LA CAIXA”. Budget: 297900. 2022-2025. PI: Pujana PUJANA, Miguel \u00c1ngel.<\/p>\n 19FIS022. Atlas de moduladores moleculares del c\u00e1ncer y validaci\u00f3n en el subtipo receptor estr\u00f3genopositivo de c\u00e1ncer de mama<\/strong>. Instituto de Salud Carlos III (ISCIII). Budget: 233832,5. 2019-2022. PI: Pujana PUJANA, Miguel \u00c1ngel.<\/p>\n FIS21092. BASE BIOL\u00d3GICA DE LA MODIFICACI\u00d3N DEL RIESGO DE C\u00c1NCER DE MAMA: HACIA LA MEJORA DE LA PREVENCI\u00d3N<\/strong>. Instituto de Salud Carlos III (ISCIII). Budget: 196020. 2022-2024. PI: Pujana PUJANA, Miguel \u00c1ngel.<\/p>\n 20ACL092. ESTUDIO DE FASE III, MULTIC\u00c9NTRICO, ALEATORIZADO (1:1), DOBLE CIEGO, CONTROLADO CON PLACEBO, DE DOS PARTES PARA EVALUAR LA EFICACIA Y SEGURIDAD DE ALPELISIB (BYL719) EN COMBINACI\u00d3N CON TRASTUZUMAB Y PERTUZUMAB COMO TERAPIA DE MANTENIMIENTO EN PACIENTES CON C\u00c1NCER DE MAMA AVANZADO HER2 POSITIVO CON UNA MUTACI\u00d3N DE PIK3CA<\/strong>. Novartis Farmac\u00e9utica, S.A.. Budget: 152413,02. 2020- . PI: Pernas Sim\u00f3n, Sonia.<\/p>\n 21ACL065. TENACIDAD:<\/strong> UN ESTUDIO DE FASE 2, MULTIC\u00c9NTRICO, ABIERTO, DE BRAZO \u00daNICO SOBRE LA MONOTERAPIA DE AL101 EN PACIENTES CON C\u00c1NCER DE MAMA TRIPLE NEGATIVO CON ACTIVACI\u00d3N DE NOTCH<\/strong>. PRECISION FOR MEDICINE, LLC. Budget: 123322,3. 2021- . PI: Pernas Sim\u00f3n, Sonia.<\/p>\n\t\t\t\t\tTransfer\u00e8ncia de tecnologia<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\tPAT077-“Dna Damage Repair Deficit In Cancer Cells” El grup compta amb una \u00e0mplia experi\u00e8ncia en enfocaments bioinform\u00e0tics i biologia de sistemes, combinats amb estudis experimentals in vitro i in vivo, destinats a comprendre millor el desenvolupament i la progressi\u00f3 del c\u00e0ncer de mama. En els \u00faltims 5 anys, l’equip ha publicat 50 publicacions peri\u00f2diques que inclouen diversos manuscrits en revistes de primer ordre. L’equip tamb\u00e9 ha estat guardonat amb diverses subvencions nacionals i internacionals i ha establert fortes col\u00b7laboracions amb l\u00edders nacionals i internacionals en aquest \u00e0mbit.<\/p>\n\t\t\t\t\n C\u00e0ncer de mama Resum El grup de recerca de c\u00e0ncer de mama t\u00e9 com a objectiu comprendre millor el desenvolupament del c\u00e0ncer de mama, l’origen dels subtipus de malalties i la progressi\u00f3 i les vulnerabilitats de la malaltia. Els projectes de recerca comprenen els principals subtipus de malalties aix\u00ed com el c\u00e0ncer de mama amb […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":448,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"publishpress_future_action":{"enabled":false,"date":"2024-05-10 11:13:54","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages\/2422"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=2422"}],"version-history":[{"count":6,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages\/2422\/revisions"}],"predecessor-version":[{"id":25209,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages\/2422\/revisions\/25209"}],"up":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages\/448"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=2422"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nIP: Miguel Angel Pujana
\nOWNERSHIP: 25%IDIBELL-ICO, 75% UNIVERSITY OF CALIFORNIA (UCSF)
\nREQUEST No.: US63\/038,747
\nPRIORITY COUNTRY: USA
\nPRIORITY DATE: 12\/06\/2020
\nPCT APPLICATION: WO2021\/252945 (11\/06\/2021)\n\t\t\t\t\tM\u00e9s informaci\u00f3<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t\n\t\tGenestar Pujana, Miguel Angel\n\t<\/h4>\n
\n\t\t\n\t\tmgenestar@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n
\n\t\tInvestigadors principals\n\t<\/h2>\n\t\t\t\t\n
\n\t\tGenestar Pujana, Miguel Angel\n\t<\/h4>\n
\n\t\t\n\t\tmgenestar@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\n
\n\t\tGarc\u00eda Tejedor, Amparo\n\t<\/h4>\n
\n\t\t\n\t\tagarciat@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\n
\n\t\tObadia Gil, Veronica Luisa\n\t<\/h4>\n\t\t\t\t\n
\n\t\tFernandez Ortega, Adela\n\t<\/h4>\n
\n\t\t\n\t\tafernandezo@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\n
\n\t\tPla Farn\u00f3s, Mar\u00eda Jes\u00fas\n\t<\/h4>\n\t\t\t\t\n
\n\t\tPernas Simon, Sonia\n\t<\/h4>\n
\n\t\t\n\t\tspernas@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\n
\n\t\tFalo Zamora, Catalina\n\t<\/h4>\n
\n\t\t\n\t\tcfalo@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\n
\n\t\tGil Gil, Juan Miguel\n\t<\/h4>\n
\n\t\t\n\t\tjmgil@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\n
\n\t\tAntolin Hernandez, Albert\n\t<\/h4>\n
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\n\t\tENLLA\u00c7OS RELACIONATS\n\t<\/h4>\n
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\n\t\t\n\t\t@ProcureICO\n\t\t<\/a>\n\t<\/h4>\n
\n\t\t\n\t\t@PujanaLab\n\t\t<\/a>\n\t<\/h4>\n
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\n\t\t\n\t\t@AmpaGarTej\n\t\t<\/a>\n\t<\/h4>\n
\n\t\t\n\t\tCIMBA\n\t\t<\/a>\n\t<\/h4>\n
\n\t\tEquip\n\t<\/h2>\n\t\t\t\t\t\t\t\t\t\t\t\tCaps de grup\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadors\/es principals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadors\/es cl\u00ednics\/ques\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadors\/es postdoctorals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadors\/es predoctorals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tSuport cient\u00edfic\t\t\t\t<\/a>\n\t\t\t\t\t\tCaps de grup\n\t\t\t\t\t\t\t\t\t\t\t
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\n\t\tNot\u00edcies relacionades\n\t<\/h2>\n\t\t\n\t\t\t\t<\/a>\n\t\t\tUn f\u00e0rmac anticancer\u00f3s obre una nova via de tractament del Parkinson<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t09\/02\/2024\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tDescobreixen alteracions del sistema immunol\u00f2gic sanguini que augmenten el risc de c\u00e0ncer<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t06\/02\/2024\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tS’obre una nova via per combatre el c\u00e0ncer a trav\u00e9s del gen MYC<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t19\/12\/2023\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tL’AELAM fa un donatiu de 15.000 euros per a la recerca en Limfangioleiomiomatosi<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t03\/11\/2023\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tNou acord de col\u00b7laboraci\u00f3 amb l’ICR i Vivan Therapeutics per dissenyar nous tractaments personalitzats contra el c\u00e0ncer<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t13\/07\/2023\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tUna ajuda de la Fundaci\u00f3 “la Caixa” permet a Albert Antol\u00edn instal\u00b7lar la seva recerca a l’IDIBELL<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t23\/03\/2023\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tL’IDIBELL ha organitzat una trobada de donants i associacions solid\u00e0ries amb el c\u00e0ncer de mama<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t29\/09\/2022\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tUn nou tractament \u00e9s efica\u00e7 en el c\u00e0ncer de mama avan\u00e7at amb baix HER2<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t05\/06\/2022\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tIdentifiquen la base biol\u00f2gica responsable del desenvolupament de c\u00e0ncer de mama en pacients portadores de mutacions en BRCA1<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t07\/04\/2022\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tEl cribratge molecular en pacients amb c\u00e0ncer de mama avan\u00e7at permet prendre decisions terap\u00e8utiques personalitzades<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t13\/01\/2022\t\t\t\t\t\t\t\n\t\t\n\n","protected":false},"excerpt":{"rendered":"