{"id":2422,"date":"2019-10-06T01:29:23","date_gmt":"2019-10-05T23:29:23","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=2422"},"modified":"2024-12-16T16:03:50","modified_gmt":"2024-12-16T15:03:50","slug":"cancer-de-mama","status":"publish","type":"page","link":"https:\/\/idibell.cat\/recerca\/area-de-cancer\/programa-de-mecanismes-moleculars-i-terapia-experimental-en-oncologia-oncobell\/cancer-de-mama\/","title":{"rendered":"C\u00e0ncer de Mama"},"content":{"rendered":"\n<h1>\n\t\tC\u00e0ncer de mama\n\t<\/h1>\n<h3>\n\t\tResum\n\t<\/h3>\n\t<p>El grup de recerca de c\u00e0ncer de mama t\u00e9 com a objectiu comprendre millor el desenvolupament del c\u00e0ncer de mama, l&#8217;origen dels subtipus de malalties i la progressi\u00f3 i les vulnerabilitats de la malaltia. Els projectes de recerca comprenen els principals subtipus de malalties aix\u00ed com el c\u00e0ncer de mama amb mutaci\u00f3 BRCA1\/2. El grup tamb\u00e9 treballa per desenvolupar nous enfocaments preventius espec\u00edfics i per millorar la qualitat de vida dels pacients. Es tracta d&#8217;un equip multidisciplinari que combina l\u00b4experi\u00e8ncia i el coneixement d\u00b4investigadors cl\u00ednics i translacionals.<\/p>\n<h2>320<\/h2>\n<h2>Publicacions<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/04\/breast_carcinoma_in_a_lymph_node.jpg\" alt=\"breast_carcinoma_in_a_lymph_node\" itemprop=\"image\" height=\"300\" width=\"600\" title=\"breast_carcinoma_in_a_lymph_node\" onerror=\"this.style.display='none'\"  \/>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\">L\u00ednies estrat\u00e8giques<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-0\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\t\u2022 C\u00e0ncer de mama HER2 positiu (S Pern\u00e0s)<br \/>\n\u2022 C\u00e0ncer de mama ER positiu (M Gil)<br \/>\n\u2022 C\u00e0ncer de mama metast\u00e0tic i qualitat de vida (C Fal\u00b7lo)<br \/>\n\u2022 Biomarcadors circulants (R Villanueva)<br \/>\n\u2022 Base gen\u00e8tica del risc de c\u00e0ncer de mama i prevenci\u00f3 dirigida (MA Pujana)<br \/>\n\u2022 Resist\u00e8ncia terap\u00e8utica i progressi\u00f3 del c\u00e0ncer (diversos IP)<br \/>\n\u2022 Desenvolupament precl\u00ednic de noves ter\u00e0pies (diversos IP)\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\">Publicacions seleccionades<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-1\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>Villacampa,G;Tung,NM;Pernas,S;Par\u00e9,L;Bueno Mui\u00f1o,C;Echavarr\u00eda,I;L\u00f3pez Tarruella,S et al, <strong>Association of HER2DX with pathological complete response and survival outcomes in HER2-positive breast cancer<\/strong>, Ann. Oncol., 2023;34(9):doi:10.1016\/j.annonc.2023.05.012<\/li>\n<li>Oliveira,M;Falato,C;Cejalvo,JM;Vila,MM;Tolosa,P;Salvador Bo,FJ;Cruz,J et al, <strong>Patritumab deruxtecan in untreated hormone receptor-positive\/HER2-negative early breast cancer: final results from part A of the window-of- opportunity SOLTI TOT-HER3 pre-operative study<\/strong>, Ann. Oncol., 2023;34(8):670-680, doi:10.1016\/j.annonc.2023.05.004<\/li>\n<li>Patel,PS;Algouneh,A;Krishnan,R;Reynolds,JJ;Nixon,KCJ;Hao,J;Lee,J et al, <strong>Excessive transcription-replication conflicts are a vulnerability of BRCA1-mutant cancers<\/strong>., Nucleic Acids Res., 2023;51(9):4341-4362, doi:10.1093\/nar\/gkad172<\/li>\n<li>Krishnan,R;Lapierre,M;Gautreau,B;Nixon,KCJ;El Ghamrasni,S;Patel,PS;Hao,J et al, <strong>RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells<\/strong>, Nucleic Acids Res., 2023;51(19):10484-10505 doi:10.1093\/nar\/gkad733,<\/li>\n<li>Ciscar,M;Trinidad,EM;Perez Chacon,G;Alsaleem,M;Jimenez,M;Jimenez Santos,MJ;Perez Montoyo,H et al, <strong>RANK is a poor prognosis marker and a therapeutic target in ER-negative postmenopausal breast cancer<\/strong>., EMBO Mol. Med. 2023;15(4):doi:10.15252\/emmm.202216715<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\">Projectes seleccionats<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-2\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>LCX21020. <strong>Becas de posdoctorado Junior Leader Incoming<\/strong>. FUNDACI\u00d3 &#8220;LA CAIXA&#8221;. Budget: 297.900\u20ac. 2022-2025. PI: GENESTAR PUJANA, MIGUEL ANGEL.<\/li>\n<li>2023-595-1. <strong>A PHASE 3, OPEN-LABEL, RANDOMIZED, TWO-PART STUDY COMPARING GEDATOLISIB IN COMBINATION WITH PALBOCICLIB AND FULVESTRANT TO STANDARD-OF-CARE THERAPIES IN PATIENTS WITH HR-POSITIVE, HER2-NEGATIVE ADVANCED BREAST CANCER PREVIOUSLY TREATED WITH A CDK4\/6 INHIBITOR IN COMBINATION WITH NON-STEROIDAL AROMATASE INHIBITOR THERAPY (VIKTORIA-1)<\/strong>. CELCUITY INC. Budget: 253.918\u20ac. 2023- . PI: Stradella Trucco, Agostina.<\/li>\n<li>2022-061-1. <strong>Ensayo multic\u00e9ntrico, aleatorizado, doble ciego y controlado con placebo, con un periodo de preinclusi\u00f3n con un solo grupo, para evaluar la seguridad y la eficacia de un colirio de tiosulfato de sodio (BYON5667) para reducir la toxicidad ocular en pacientes oncol\u00f3gicos tratados con SYD985.<\/strong> BYONDIS B.V.;Byondis B.V. (formerly Synthon Biopharmaceuticals B.V.) . Budget: 221.291\u20ac. 2022- . PI: Stradella Trucco, Agostina.<\/li>\n<li>2021-037-1. <strong>SERENA-4: Ensayo de fase III aleatorizado, multic\u00e9ntrico, doble ciego, de AZD9833 (un SERD, Degradador selectivo del RE, oral) m\u00e1s palbociclib en comparaci\u00f3n con anastrozol m\u00e1s palbociclib para el tratamiento de pacientes con c\u00e1ncer de mama avanzado con receptores estrog\u00e9nicos positivos y HER2 negativo que no han recibido ning\u00fan tratamiento sist\u00e9mico para la enfermedad avanzada.<\/strong> Astrazeneca Farmac\u00e9utica Spain, S.A. Budget: 218.253\u20ac. 2021- . PI: OBADIA GIL, VERONICA LUISA.<\/li>\n<li>FIS22070. <strong>CONTRATOS MIGUEL SERVET<\/strong>. Instituto de Salud Carlos III (ISCIII). Budget: 202.500\u20ac. 2023-2028. PI: ANTOLIN HERNANDEZ, ALBERT.<\/li>\n\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-3\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-3\">Transfer\u00e8ncia de tecnologia<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-3\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\tPAT077-&#8220;Dna Damage Repair Deficit In Cancer Cells&#8221;<br \/>\nIP: Miguel Angel Pujana<br \/>\nOWNERSHIP: 25%IDIBELL-ICO, 75% UNIVERSITY OF CALIFORNIA (UCSF)<br \/>\nREQUEST No.: US63\/038,747<br \/>\nPRIORITY COUNTRY: USA<br \/>\nPRIORITY DATE: 12\/06\/2020<br \/>\nPCT APPLICATION: WO2021\/252945 (11\/06\/2021)\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-4\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-4\">M\u00e9s informaci\u00f3<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-4\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\t<p>El grup compta amb una \u00e0mplia experi\u00e8ncia en enfocaments bioinform\u00e0tics i biologia de sistemes, combinats amb estudis experimentals in vitro i in vivo, destinats a comprendre millor el desenvolupament i la progressi\u00f3 del c\u00e0ncer de mama. En els \u00faltims 5 anys, l&#8217;equip ha publicat 50 publicacions peri\u00f2diques que inclouen diversos manuscrits en revistes de primer ordre. L&#8217;equip tamb\u00e9 ha estat guardonat amb diverses subvencions nacionals i internacionals i ha establert fortes col\u00b7laboracions amb l\u00edders nacionals i internacionals en aquest \u00e0mbit.<\/p>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2024\/12\/Sonia-Pernas-Simon24-150x150.jpg\" alt=\"Sonia-Pernas-Simon24\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Sonia-Pernas-Simon24\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tPernas Simon, Sonia\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:spernas@idibell.cat\" title=\"spernas@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tspernas@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2022\/11\/Ruth-Rodriguez-Barrueco22-150x150.jpg\" alt=\"Ruth-Rodriguez-Barrueco22\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Ruth-Rodriguez-Barrueco22\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tRodriguez Barrueco, Ruth\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:rrodriguezb@idibell.cat\" title=\"rrodriguezb@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\trrodriguezb@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tInvestigadors principals\n\t<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2024\/12\/Sonia-Pernas-Simon24-150x150.jpg\" alt=\"Sonia-Pernas-Simon24\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Sonia-Pernas-Simon24\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tPernas Simon, Sonia\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:spernas@idibell.cat\" title=\"spernas@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tspernas@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2022\/11\/Ruth-Rodriguez-Barrueco22-150x150.jpg\" alt=\"Ruth-Rodriguez-Barrueco22\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Ruth-Rodriguez-Barrueco22\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tRodriguez Barrueco, Ruth\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:rrodriguezb@idibell.cat\" title=\"rrodriguezb@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\trrodriguezb@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2021\/06\/Amparo-Garcia-Tejedor-150x150.jpg\" alt=\"Amparo-Garcia-Tejedor\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Amparo-Garcia-Tejedor\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tGarc\u00eda Tejedor, Amparo\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:agarciat@idibell.cat\" title=\"agarciat@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tagarciat@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\tENLLA\u00c7OS RELACIONATS\n\t<\/h4>\n<h4>\n\t\t<a href=\"http:\/\/ico.gencat.cat\/ca\/recerca\/Programa-ProCURE\/\" title=\"ProCURE\" target=\"_blank\" rel=\"noopener\">\n\t\tProCURE\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/twitter.com\/ProcureICO\" title=\"@ProcureICO\" target=\"_blank\" rel=\"noopener\">\n\t\t@ProcureICO\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/twitter.com\/SoniaPernas\" title=\"@SoniaPernas\" target=\"_blank\" rel=\"noopener\">\n\t\t@SoniaPernas\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/twitter.com\/AmpaGarTej\" title=\"@AmpaGarTej\" target=\"_blank\" rel=\"noopener\">\n\t\t@AmpaGarTej\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"http:\/\/cimba.ccge.medschl.cam.ac.uk\/\" title=\"CIMBA\" target=\"_blank\" rel=\"noopener\">\n\t\tCIMBA\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tEquip\n\t<\/h2>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-0\" data-index=\"0\" aria-selected=\"true\" aria-controls=\"fl-tabs--panel-0\" aria-expanded=\"true\" role=\"tab\" tabindex=\"0\">\t\t\t\tCaps de grup\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-1\" data-index=\"1\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-1\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es principals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-2\" data-index=\"2\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-2\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es cl\u00ednics\/ques\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-3\" data-index=\"3\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-3\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es predoctorals\t\t\t\t<\/a>\n\t\t\t\t\t\tCaps de grup\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Pernas Simon, Sonia<\/li>\n<li>Rodriguez Barrueco, Ruth<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es principals\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Garc\u00eda Tejedor, Amparo<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es cl\u00ednics\/ques\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Gil Gil, Juan Miguel<\/li>\n<li>Fernandez Ortega, Adela<\/li>\n<li>Falo Zamora, Catalina<\/li>\n<li>Pla Farn\u00f3s, Mar\u00eda Jes\u00fas<\/li>\n<li>Obadia Gil, Veronica Luisa<\/li>\n<li>Petit Montserrat, Anna<\/li>\n<li>Fullana Grimalt, Bartomeu<\/li>\n<li>Recalde Penabad, Sabela<\/li>\n<li>Stradella Trucco, Agostina<\/li>\n<li>V\u00e1zquez Fern\u00e1ndez, Silvia<\/li>\n<li>Villanueva V\u00e1zquez, Rafael<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es predoctorals\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Mig\u00f3 Aran J\u00falia<\/li>\n<li>Rodr\u00edguez Barrante, Aintzane<\/li>\n<li>Bonilla Amadeo, Ricard<\/li>\n<\/ul>\n<h2>\n\t\tNot\u00edcies relacionades\n\t<\/h2>\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/26278\" content=\"Els aven\u00e7os en biologia qu\u00edmica requereixen multidisciplinarietat i treball en equip\" \/><meta itemprop=\"datePublished\" content=\"2024-09-20\" \/><meta itemprop=\"dateModified\" content=\"2024-11-21\" 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