{"id":2340,"date":"2019-10-05T18:50:35","date_gmt":"2019-10-05T16:50:35","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=2340"},"modified":"2024-05-28T10:37:39","modified_gmt":"2024-05-28T08:37:39","slug":"envelliment-i-cancer","status":"publish","type":"page","link":"https:\/\/idibell.cat\/recerca\/area-de-cancer\/programa-de-mecanismes-moleculars-i-terapia-experimental-en-oncologia-oncobell\/envelliment-i-cancer\/","title":{"rendered":"Envelliment i c\u00e0ncer"},"content":{"rendered":"\n<h1>\n\t\tEnvelliment i c\u00e0ncer\n\t<\/h1>\n<h3>\n\t\tResum\n\t<\/h3>\n\tEls principals objectius d&#8217;aquest grup s\u00f3n analitzar els mecanismes implicats en la plasticitat de les c\u00e8l\u00b7lules canceroses i l&#8217;impacte d&#8217;aquesta plasticitat en la progressi\u00f3 de l&#8217;SCC cutani i la resposta a la ter\u00e0pia. Estem interessats en determinar els mecanismes moleculars que promouen la progressi\u00f3 i la met\u00e0stasi de l&#8217;SCC cutani (cSCC), mitjan\u00e7ant l&#8217;estudi de les vies que regulen la plasticitat de les c\u00e8l\u00b7lules canceroses i la funci\u00f3 de les c\u00e8l\u00b7lules mare de el c\u00e0ncer, aix\u00ed com en determinar l&#8217;impacte de la plasticitat de les c\u00e8l\u00b7lules canceroses en el microambient tumoral, per\u00f2 tamb\u00e9 com el microambient tumoral impacta en la plasticitat de les c\u00e8l\u00b7lules canceroses, la progressi\u00f3 de cSCC i la resposta a la ter\u00e0pia. L&#8217;objectiu final d&#8217;aquests estudis \u00e9s definir les bases moleculars de nous tractaments terap\u00e8utics que bloquegin la recurr\u00e8ncia i met\u00e0stasi de cSCC i superin la resist\u00e8ncia intr\u00ednseca i adquirida a la ter\u00e0pia.<br \/>\nEl laboratori de la Dra. Mu\u00f1oz ha generat models de ratol\u00ed de cSCC (cSCC-PDXs, entre d&#8217;altres) que s&#8217;han utilitzat com a models precl\u00ednics per avaluar l&#8217;efic\u00e0cia antitumoral de diferents f\u00e0rmacs, i per estudiar ter\u00e0pies combinades per superar prim\u00e0ries i \/ o adquirides . resist\u00e8ncia a aquests f\u00e0rmacs.<br \/>\nEl nostre grup est\u00e0 compost per investigadors traslacionals i cl\u00ednics (cirurgians i pat\u00f2legs) de l&#8217;Hospital de Bellvitge (HUB, soci de l&#8217;IDIBELL), i col\u00b7labora amb Onc\u00f2legs de l&#8217;ICO \/ IDIBELL. Aquesta estreta interacci\u00f3 entre els investigadors b\u00e0sics i cl\u00ednics proporciona una perspectiva sobre les q\u00fcestions cr\u00edtiques associades amb les patologies de HNSCC i cSCC.\n<h2>156<\/h2>\n<h2>Publicacions<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/04\/606_munoz.jpg\" alt=\"606_munoz\" itemprop=\"image\" height=\"300\" width=\"600\" title=\"606_munoz\" onerror=\"this.style.display='none'\"  \/>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\">L\u00ednies estrat\u00e8giques<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\"><i>Expand<\/i><\/a>\n\t\t\t\t\t1. Estudiar els mecanismes implicats en la regulaci\u00f3 de la plasticitat de les c\u00e8l\u00b7lules canceroses durant la progressi\u00f3 de cSCC i determinar la rellev\u00e0ncia dels factors derivats del microambient tumoral en la promoci\u00f3 de la plasticitat de les c\u00e8l\u00b7lules canceroses i la progressi\u00f3 tumoral.<br \/>\n2. Investigar la base molecular de la resist\u00e8ncia a la ter\u00e0pia ICB en HNSCC i cSCC, per\u00f2 tamb\u00e9 a ter\u00e0pies basades en inhibidors de EGFR en HNSCC.<br \/>\n3. Identificar biomarcadors que prediuen la progressi\u00f3 de CSCC i la resist\u00e8ncia a ICB en HNSCC i cSCC i la resist\u00e8ncia a inhibidors de EGFR en HNSCC.\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\">Publicacions seleccionades<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>Drakaki,A;Powles,T;Bamias,A;Martin Liberal,J;Shin,SJ;Friedlander,T;Tosi,D et al, <strong>Atezolizumab plus Magrolimab, Niraparib, or Tocilizumab versus Atezolizumab Monotherapy in Platinum-Refractory Metastatic Urothelial Carcinoma: A Phase Ib\/II Open-Label, Multicenter, Randomized Umbrella Study (MORPHEUS Urothelial Carcinoma)<\/strong>., Clin. Cancer Res., 2023;29(21):4373-4384, doi:10.1158\/1078-0432.CCR-23-0798<\/li>\n<li>Soto Castillo,JJ;Llavata Marti,L;Fort Culillas,R;Andreu Cobo,P;Moreno,R;Codony,C;del Muro,XG et al, <strong>SWI\/SNF Complex Alterations in Tumors with Rhabdoid Features: Novel Therapeutic Approaches and Opportunities for Adoptive Cell Therapy<\/strong>, Int. J. Mol. Sci., 2023;24(13):doi:10.3390\/ijms241311143<\/li>\n<li>Creus Bachiller,E;Fern\u00e1ndez Rodr\u00edguez,J;Magall\u00f3n Lorenz,M;Ortega Bertran,S;Navas Rutete,S;Romagosa,C;Silva,TM et al, <strong>Expanding a precision medicine platform for malignant peripheral nerve sheath tumors: New patient-derived orthotopic xenografts, cell lines and tumor entities<\/strong>, Mol. Oncol., 2023;doi:10.1002\/1878-0261.13534<\/li>\n<li>Manzano,JL;Martin Liberal,J;Fernandez Morales,LA;Benitez,G;Martinez,JM;Quindos,M;Garcia Castano,A et al, <strong>Adjuvant dabrafenib and trametinib for patients with resected BRAF-mutated melanoma: DESCRIBE-AD real-world retrospective observational study<\/strong>, Melanoma Res., 2023;33(5):388-397, doi:10.1097\/CMR.0000000000000888<\/li>\n<li>Mill\u00e1n Esteban,D;Garc\u00eda Casado,Z;Maci\u00e0,A;de la Rosa,I;Torrecilla Llossera,C;Pen\u00edn,RM;Manrique Silva,E et al, <strong>Molecular Profile of Subungual Melanoma: a MelaNostrum Consortium Study of 68 Cases Reporting BRAF, NRAS, KIT, and TERT promoter status<\/strong>., Dermatology, 2023;240(1):164-169, doi:10.1159\/000534955<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\">Projectes seleccionats<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>MCI21004. <strong>Estudio de nuevas estrategias terap\u00e9uticas para suprimir la resistencia a terapias basadas en el bloqueo de los puntos de control inmunitarios (ICB) en cSCC y HNSCCs avanzados<\/strong>. Ministerio de Ciencia e Innovaci\u00f3n. Budget: 223.850\u20ac. 2021-2024. PI: MU\u00d1OZ MORUNO, PURIFICACION.<\/li>\n<li>FIS21126. <strong>Tratamiento con TILs en tumores avanzados con alteraciones del complejo SWI\/SNF: El estudio TILTS<\/strong>. Instituto de Salud Carlos III (ISCIII). Budget: 1.081.914,72\u20ac. 2022-2025. PI: MARTIN LIBERAL, JUAN JESUS.<\/li>\n<li>AGA22038. <strong>Nuevas terapias para el tratamiento de c\u00e1ncer de piel<\/strong><br \/>\n<strong>Novel therapies for skin cancer treatment<\/strong>. AGENCIA GESTIO D&#8217;AJUTS UNIV. I RECERCA. Budget: 40.000\u20ac. 2022-2025. PI: MU\u00d1OZ MORUNO, PURIFICACION; MARTIN LIBERAL, JUAN JESUS.<\/li>\n<li>PSJ22017. <strong>INFLUENCIA DE LA PLASTICIDAD DE LAS C\u00c9LULAS TUMORALES EN LA RESPUESTA AL TRATAMIENTO ADYUVANTE CON ANTI-PD-1 EN MELANOMA ESTAD\u00cdO IIIC\/D RESECADO<\/strong>. Grupo Espa\u00f1ol Multidisciplinar de Melanoma (GEM). Budget: 20.000\u20ac. 2022-2024. PI: MARTIN LIBERAL, JUAN JESUS; MU\u00d1OZ MORUNO, PURIFICACION.<\/li>\n<li>2023-020-1. <strong>Adjuvant encorafenib &amp; binimetinib vs. placebo in fully resected stage IIB\/C BRAF V600E\/K mutated melanoma: a randomized triple-blind phase III study in collaboration with the EORTC Melanoma Group<\/strong>. Pierre Fabre M\u00e9dicamen. Budget: 510.984\u20ac. 2022- . PI: MARTIN LIBERAL, JUAN JESUS.<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-3\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-3\">M\u00e9s informaci\u00f3<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-3\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-3\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<p><strong>Selected theses:<\/strong><\/p>\n<h3>Mecanismos moleculares que regulan el crecimiento, la met\u00e1stasis y la resistencia a terapias del carcinoma escamoso de piel<\/h3>\n<p>Mu\u00f1oz Moruno, Purificacion (Director)<\/p>\n<p>Phd Student:<\/p>\n<ul>\n<li>Adri\u00e0 Bernat Peguera<\/li>\n<\/ul>\n<p>2019, UB.<\/p>\n<hr \/>\n<h3>Estudio de los mecanismos moleculares que promueven la progresi\u00f3n del carcinoma escamoso de piel<\/h3>\n<p>Mu\u00f1oz Moruno, Purificacion (Director)<\/p>\n<p>Phd Student:<\/p>\n<ul>\n<li>Pilar Sim\u00f3n Extremera<\/li>\n<\/ul>\n<p>2017, UB.<\/p>\n<hr \/>\n<h3>Impact of cancer cell plasticity on tumor immune microenvironment and immunotherapy response<\/h3>\n<p>Mu\u00f1oz Moruno, Purificacion (Director)<\/p>\n<p>Phd Student:<\/p>\n<ul>\n<li>Laura Lorenzo Sanz<\/li>\n<\/ul>\n<p>2021, UB.<\/p>\n<hr \/>\n<h3>Theses in process:<\/h3>\n<p>Mu\u00f1oz Moruno, Purificacion (Director)<\/p>\n<p>Phd Students:<\/p>\n<ul>\n<li>Marta L\u00f3pez Cerda<\/li>\n<li>Joan Navarro Ventura<\/li>\n<li>Marta L\u00f3pez Cerda<\/li>\n<\/ul>\n<p>UB.<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/11\/Purificacion-Munoz-150x150.jpg\" alt=\"Purificacion-Mu\u00f1oz\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Purificacion-Mu\u00f1oz\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tMu\u00f1oz Moruno, Purificaci\u00f3n\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:p.munoz@idibell.cat\" title=\"p.munoz@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tp.munoz@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tInvestigadors principals\n\t<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/11\/Purificacion-Munoz-150x150.jpg\" alt=\"Purificacion-Mu\u00f1oz\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Purificacion-Mu\u00f1oz\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tMu\u00f1oz Moruno, Purificaci\u00f3n\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:p.munoz@idibell.cat\" title=\"p.munoz@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tp.munoz@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/11\/Joan-Vinals-Vinals-150x150.jpg\" alt=\"Joan-Vi\u00f1als-Vi\u00f1als\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Joan-Vi\u00f1als-Vi\u00f1als\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tVi\u00f1als Vi\u00f1als, Joan M.\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:jvinals@idibell.cat\" title=\"jvinals@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tjvinals@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2023\/04\/Juan-Martin-Liberal-150x150.jpg\" alt=\"Juan-Martin-Liberal\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Juan-Martin-Liberal\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tMartin Liberal, Juan Jes\u00fas\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:jmartinl@idibell.cat\" title=\"jmartinl@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tjmartinl@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\tENLLA\u00c7OS RELACIONATS\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/twitter.com\/purimunnoz\" title=\"@purimunnoz\" target=\"_blank\" rel=\"noopener\">\n\t\t@purimunnoz\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tEquip\n\t<\/h2>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-0\" data-index=\"0\" aria-selected=\"true\" aria-controls=\"fl-tabs--panel-0\" aria-expanded=\"true\" role=\"tab\" tabindex=\"0\">\t\t\t\tCaps de grup\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-1\" data-index=\"1\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-1\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\t Investigadors\/es principals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-2\" data-index=\"2\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-2\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es cl\u00ednics\/ques\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-3\" data-index=\"3\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-3\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es postdoctorals\t\t\t\t<\/a>\n\t\t\t\t\t\tCaps de grup\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Mu\u00f1oz Moruno, Purificaci\u00f3n<\/li>\n<\/ul>\n\t\t\t\t\t\t Investigadors\/es principals\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Vi\u00f1als Vi\u00f1als, Joan M.<\/li>\n<li>Martin Liberal, Juan Jes\u00fas<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es cl\u00ednics\/ques\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Penin Mosquera, Rosa Maria<\/li>\n<li>Perez Sidelnikova, Diana<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es postdoctorals\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Lorenzo Sanz, Laura<\/li>\n<li>Lopez Cerda, Marta<\/li>\n<\/ul>\n<h2>\n\t\tNot\u00edcies relacionades\n\t<\/h2>\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/16341\" content=\"Els models animals de xenograf recapitulen el comportament gen\u00e8tic dels tumors humans originals\" \/><meta itemprop=\"datePublished\" content=\"2021-01-28\" \/><meta itemprop=\"dateModified\" content=\"2021-02-02\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/wp-content\/uploads\/2023\/03\/cropped-Marca-B.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/wp-content\/uploads\/2021\/01\/NO01-NatGen-Imatge.jpg\" \/><meta itemprop=\"width\" content=\"1366\" \/><meta itemprop=\"height\" content=\"768\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/2021\/01\/els-models-animals-de-xenograf-recapitulen-el-comportament-genetic-dels-tumors-humans-originals\/\" title=\"Els models animals de xenograf recapitulen el comportament gen\u00e8tic dels tumors humans originals\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/2021\/01\/els-models-animals-de-xenograf-recapitulen-el-comportament-genetic-dels-tumors-humans-originals\/\" title=\"Els models animals de xenograf recapitulen el comportament gen\u00e8tic dels tumors humans originals\">Els models animals de xenograf recapitulen el comportament gen\u00e8tic dels tumors humans originals<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/author\/comunicacio\/\">comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t28\/01\/2021\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/16159\" content=\"La ter\u00e0pia combinada podria ser una soluci\u00f3 per als casos de c\u00e0ncer de c\u00e8l\u00b7lules escamoses de pell resistents a inhibidors d'EGFR\" \/><meta itemprop=\"datePublished\" content=\"2020-12-23\" \/><meta itemprop=\"dateModified\" content=\"2020-12-29\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/wp-content\/uploads\/2023\/03\/cropped-Marca-B.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/12\/NP50-P-Munoz_Clinical-Cancer-Research-Imatge.jpg\" \/><meta itemprop=\"width\" content=\"2000\" \/><meta itemprop=\"height\" content=\"1125\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/2020\/12\/la-terapia-combinada-podria-ser-una-solucio-per-als-casos-de-cancer-de-cellules-escamoses-de-pell-resistents-a-inhibidors-degfr\/\" title=\"La ter\u00e0pia combinada podria ser una soluci\u00f3 per als casos de c\u00e0ncer de c\u00e8l\u00b7lules escamoses de pell resistents a inhibidors d'EGFR\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/2020\/12\/la-terapia-combinada-podria-ser-una-solucio-per-als-casos-de-cancer-de-cellules-escamoses-de-pell-resistents-a-inhibidors-degfr\/\" title=\"La ter\u00e0pia combinada podria ser una soluci\u00f3 per als casos de c\u00e0ncer de 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content=\"Idibell\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/2019\/11\/la-investigadora-purificacion-munoz-rep-el-v-premi-marti-via\/\" title=\"La investigadora Purificaci\u00f3n Mu\u00f1oz rep el V premi Mart\u00ed Via\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/2019\/11\/la-investigadora-purificacion-munoz-rep-el-v-premi-marti-via\/\" title=\"La investigadora Purificaci\u00f3n Mu\u00f1oz rep el V premi Mart\u00ed Via\">La investigadora Purificaci\u00f3n Mu\u00f1oz rep el V premi Mart\u00ed Via<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/author\/erigin\/\">Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t29\/11\/2019\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/7499\" content=\"Identifiquen els mecanismes que promouen la 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content=\"https:\/\/idibell.cat\/wp-content\/uploads\/2023\/03\/cropped-Marca-B.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/author\/erigin\/\" \/><meta itemprop=\"name\" content=\"Idibell\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/wp-content\/uploads\/2012\/07\/estrella_mar_1-1.jpg\" \/><meta itemprop=\"width\" content=\"767\" \/><meta itemprop=\"height\" content=\"768\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/2012\/07\/sis-estudiants-viuran-lestiu-a-lidibell\/\" title=\"Sis estudiants viuran l'estiu a l'IDIBELL\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/2012\/07\/sis-estudiants-viuran-lestiu-a-lidibell\/\" title=\"Sis estudiants viuran l'estiu a l'IDIBELL\">Sis estudiants viuran l&#8217;estiu a l&#8217;IDIBELL<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/author\/erigin\/\">Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t02\/07\/2012\t\t\t\t\t\t\t\n\t\t<!-- .pp-content-posts -->\n\n","protected":false},"excerpt":{"rendered":"<p>Envelliment i c\u00e0ncer Resum Els principals objectius d&#8217;aquest grup s\u00f3n analitzar els mecanismes implicats en la plasticitat de les c\u00e8l\u00b7lules canceroses i l&#8217;impacte d&#8217;aquesta plasticitat en la progressi\u00f3 de l&#8217;SCC cutani i la resposta a la ter\u00e0pia. Estem interessats en determinar els mecanismes moleculars que promouen la progressi\u00f3 i la met\u00e0stasi de l&#8217;SCC cutani (cSCC), [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":448,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-2340","page","type-page","status-publish","hentry"],"publishpress_future_action":{"enabled":false,"date":"2024-12-02 02:56:29","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages\/2340","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=2340"}],"version-history":[{"count":6,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages\/2340\/revisions"}],"predecessor-version":[{"id":25754,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages\/2340\/revisions\/25754"}],"up":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages\/448"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=2340"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}