{"id":2091,"date":"2019-10-01T20:19:00","date_gmt":"2019-10-01T18:19:00","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=2091"},"modified":"2024-04-11T10:27:57","modified_gmt":"2024-04-11T08:27:57","slug":"neurofarmacologia-i-dolor","status":"publish","type":"page","link":"https:\/\/idibell.cat\/recerca\/area-de-neurociencies\/programa-de-neurociencies\/neurofarmacologia-i-dolor\/","title":{"rendered":"Neurofarmacologia i Dolor"},"content":{"rendered":"\n<h1>\n\t\tNeurofarmacologia i Dolor\n\t<\/h1>\n<h3>\n\t\tResum\n\t<\/h3>\n\t<p>El grup centra la seva recerca en la comprensi\u00f3 de la funci\u00f3 dels receptors de neurotransmissors en salut i malaltia. Per tant, el seu principal objectiu \u00e9s traduir els resultats del laboratori al pacient i la pr\u00e0ctica cl\u00ednica. En conseq\u00fc\u00e8ncia, busquen noves estrat\u00e8gies farmacol\u00f2giques per assolir una gesti\u00f3 efica\u00e7 de malalties neurol\u00f2giques, neuropsiqui\u00e0triques, inflamat\u00f2ries, autoimmunes i del dolor.<\/p>\n<h2>496<\/h2>\n<h2>Publicacions<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/03\/206-neurofarmacologiadolor-fciruela-def.jpg\" alt=\"206-neurofarmacologiadolor-fciruela-def\" itemprop=\"image\" height=\"300\" width=\"600\" title=\"206-neurofarmacologiadolor-fciruela-def\" onerror=\"this.style.display='none'\"  \/>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\">L\u00ednies estrat\u00e8giques<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\"><i>Expand<\/i><\/a>\n\t\t\t\t\tOligomeritzaci\u00f3 de receptors, canals i\u00f2nics i prote\u00efnes interaccionants en el marc de les malalties neuropsiqui\u00e0triques i dolor.<br \/>\nEstudi de la funcionalitat de les interaccions oligom\u00e8riques en models animals per establir les bases del tractament farmacol\u00f2gic combinat.<br \/>\nAvaluaci\u00f3 cl\u00ednica dels medicaments en les malalties neuropsiqui\u00e0triques i dolor amb m\u00e8todes de farmacoepidemiologia.\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\">Publicacions seleccionades<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<p>Alemany A, Millat Martinez P, Corbacho Monn\u00e9 M, Malchair P, Ouchi D, Ruiz Comellas A, Ram\u00edrez Morros A, Rodr\u00edguez Codina J, Amado Simon R, Videla S, Costes G, Capdevila J\u00e1uregui M, Torrano Soler P, San Jos\u00e9 A, Bonet Papell G, Puig J, Otero A, Ruibal Suarez JC, Zarauza Pellejero A, Llopis Roca F, Rodriguez Cortez O, Garcia V, Vidal Alaball J, Millan A, Contreras E, Grifols JR, Ancochea \u00c0, Galvan Femenia I, Piccolo Ferreira F, Bonet M, Cantoni J, Prat N, Ara J, Forcada Arcarons A, Farr\u00e9 M, Pradenas E, Blanco J, \u00c0ngel Rodriguez Arias M, Fern\u00e1ndez Rivas G, Marks M, Bassat Q, Blanco I, Baro B, Clotet B, Mitj\u00e0 O, CONV ERT G. <strong>High-titre methylene blue-treated convalescent plasma as an early treatment for outpatients with COVID-19: a randomised, placebo-controlled trial<\/strong>. Lancet Respir Med. 2022;10(3):278-288. doi:10.1016\/S2213-2600(21)00545-2.<\/p>\n<p>Millat Martinez P, Gharbharan A, Alemany A, Rokx C, Geurtsvankessel C, Papageourgiou G, van Geloven N, Jordans C, Groeneveld G, Swaneveld F, van der Schoot E, Corbacho Monn\u00e9 M, Ouchi D, Piccolo Ferreira F, Malchair P, Videla S, Garc\u00eda V, Ruiz Comellas A, Ram\u00edrez Morros A, Rodriguez Codina J, Amado Simon R, Grifols JR, Blanco J, Blanco I, Ara J, Bassat Q, Clotet B, Baro B, Troxel A, Zwaginga JJ, Mitj\u00e0 O, Rijnders B, CoV <strong>Early study G, COnV ert study G. Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients<\/strong>. Nat. Commun. 2022;13(1):2583-2583. doi:10.1038\/s41467-022-29911-3.<\/p>\n<p>Parameswaran J, Goicoechea L, Planas Serra L, Pastor A, Ruiz M, Calingasan NY, Guilera C, Aso E, Boada J, Pamplona R, Portero Ot\u00edn M, de la Torre R, Ferrer I, Casasnovas C, Pujol A, Fourcade S. <strong>Activating cannabinoid receptor 2 preserves axonal health through GSK-3\u00df\/NRF2 axis in adrenoleukodystrophy<\/strong>. Acta Neuropathol. 2022;144(2):241-258. doi:10.1007\/s00401-022-02451-2.<\/p>\n<p>Solis O, Beccari AR, Iaconis D, Talarico C, Ruiz Bedoya CA, Nwachukwu JC, Cimini A, Castelli V, Bertini R, Montopoli M, Cocetta V, Borocci S, Prandi IG, Flavahan K, Bahr M, Napiorkowski A, Chillemi G, Ooka M, Yang XP, Zhang SL, Xia MH, Zheng W, Bonaventura J, Pomper MG, Hooper JE, Morales M, Rosenberg AZ, Nettles KW, Jain SK, Allegretti M, Michaelides M. <strong>The SARS-CoV-2 spike protein binds and modulates estrogen receptors<\/strong>. Sci. Adv. 2022;8(48):doi:10.1126\/sciadv.add4150.<\/p>\n<p>Bonaventura J, Gomez JL, Carlton ML, Lam S, Sanchez Soto M, Morris PJ, Moaddel R, Kang HJ, Zanos P, Gould TD, Thomas CJ, Sibley DR, Zarate CA, Michaelides M. <strong>Target deconvolution studies of (2R,6R)-hydroxynorketamine: an elusive search<\/strong>. Mol. Psychiatr. 2022;doi:10.1038\/s41380-022-01673-w.<\/p>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\">Projectes seleccionats<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<p>21FIS041. <strong>Plataforma de Unidades de Investigaci\u00f3n Cl\u00ednica y Ensayos Cl\u00ednicos<\/strong>. Instituto de Salud Carlos III (ISCIII). Budget: 412500. 2021-2023. PI: Hereu Boher, Pilar.<\/p>\n<p>21DPS003. <strong>Subvencions per a la formaci\u00f3 de cient\u00edfics i tecn\u00f2legs: modalitat personal investigador en formaci\u00f3 (PIF-Salut)<\/strong>. Generalitat de Catalunya- Departament de Salut. Budget: 92623,53. 2021-2024. PI: Ciruela Alf\u00e9rez, Francisco.<\/p>\n<p>21INT002. <strong>Ecto-GPR37: a potential biomarker for Parkinson&#8217;s disease. MICHAEL J FOX FOUNDATION<\/strong>. Budget: 86218. 2021-2023. PI: Ciruela Alf\u00e9rez, Francisco.<\/p>\n<p>18CEE003. <strong>EUTRAIN: The EUropean TRAnsplantation and INnovation (EU-TRAIN) consortium for improving diagnosis and risk stratification in kidney transplant patients<\/strong>. COMISSI\u00d3 EUROPEA. Budget: 68463,44. 2018-2024. PI: Hereu Boher, Pilar.<\/p>\n<p>18ACL137. <strong>REPETITIVE LEVOSIMENDAN INFUSIONS FOR PATIENTS WITH ADVANCED CHRONIC HEART FAILURE (LEODOR)<\/strong>. Budget: 62592,72. 2018-2023. PI: Hereu Boher, Pilar.<\/p>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-3\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-3\">Transfer\u00e8ncia de tecnologia<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-3\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-3\"><i>Expand<\/i><\/a>\n\t\t\t\t\tPAT084_IP; Concepci\u00f3 Soler i Francisco Ciruela<br \/>\nEP23 382 389.7<br \/>\nTREX2 inhibitors\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-4\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-4\">M\u00e9s informaci\u00f3<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-4\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-4\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<p><i>Proyectos financiados por el Instituto de Salud Carlos III (ISCIII) y cofinanciados por el Fondo Europeo de Desarrollo Regional (FEDER):<\/i><\/p>\n<p>&nbsp;<\/p>\n<p><b>Modulaci\u00f3n molecular de los complejos extrasin\u00e1pticos de receptores NMDA como estrategia terap\u00e9utica para la enfermedad de Alzheimer<\/b><\/p>\n<p>PI13\/00135. 01\/2014-12\/2016. 33.500 \u20ac. IP: Xavier Altafaj.<\/p>\n<p>Desarrollo de herramientas moleculares que permitan desestabilizar los complejos proteicos de los Ex-NMDARs para reducir la neurodegeneraci\u00f3n asociada a la enfermedad de Alzheimer. Dise\u00f1ar y evaluar p\u00e9ptidos de disrupci\u00f3n de las interacciones moleculares de los NMDARs, para reducir la activaci\u00f3n y\/o niveles de los Ex-NMDARs y paliar la neurotoxicidad mediada por los mismos.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/03\/7mUdUAq.png\" alt=\"\" width=\"249\" height=\"150\" \/><\/p>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2022\/10\/Francisco-Ciruela22-150x150.jpg\" alt=\"Francisco-Ciruela22\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Francisco-Ciruela22\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tCiruela Alf\u00e9rez, Francisco\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:fciruela@idibell.cat\" title=\"fciruela@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tfciruela@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/11\/Ester-Aso-Perez2.jpg\" alt=\"Ester-Aso-Perez2\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Ester-Aso-Perez2\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tAso P\u00e9rez, Ester\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:easo@idibell.cat\" title=\"easo@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\teaso@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tInvestigadors principals\n\t<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2022\/10\/Francisco-Ciruela22-150x150.jpg\" alt=\"Francisco-Ciruela22\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Francisco-Ciruela22\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tCiruela Alf\u00e9rez, Francisco\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:fciruela@idibell.cat\" title=\"fciruela@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tfciruela@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2022\/06\/Africa-Flores-de-los-Heros-150x150.jpg\" alt=\"Africa-Flores-de-los-Heros\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Africa-Flores-de-los-Heros\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tFlores de los Heros, \u00c1frica\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/11\/Ester-Aso-Perez2.jpg\" alt=\"Ester-Aso-Perez2\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Ester-Aso-Perez2\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tAso P\u00e9rez, Ester\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:easo@idibell.cat\" title=\"easo@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\teaso@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2021\/06\/Victor-Fernandez-Duenas.jpg\" alt=\"Victor-Fernandez-Due\u00f1as\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Victor-Fernandez-Due\u00f1as\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tFern\u00e1ndez Due\u00f1as, V\u00edctor\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2023\/11\/Jordi-Bonaventura-Morera.jpg\" alt=\"Jordi-Bonaventura-Morera\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Jordi-Bonaventura-Morera\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tBonaventura Morera, Jordi\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:jbonaventura@idibell.cat\" title=\"jbonaventura@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tjbonaventura@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\tENLLA\u00c7OS RELACIONATS\n\t<\/h4>\n<h4>\n\t\t<a href=\"http:\/\/www.ub.edu\/neuropharmpain\" title=\"Grup de Neurofarmacologia i Dolor\" target=\"_blank\" rel=\"noopener\">\n\t\tGrup de Neurofarmacologia i Dolor\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/www.scren.es\/en\/scren.php\" title=\"Plataforma d&#039;Unitats d&#039;Investigaci\u00f3 Cl\u00ednica\" target=\"_blank\" rel=\"noopener\">\n\t\tPlataforma d&#8217;Unitats d&#8217;Investigaci\u00f3 Cl\u00ednica\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/twitter.com\/UBneuroscience\" title=\"@UBneuroscience\" target=\"_blank\" rel=\"noopener\">\n\t\t@UBneuroscience\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tEquip\n\t<\/h2>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-0\" data-index=\"0\" aria-selected=\"true\" aria-controls=\"fl-tabs--panel-0\" aria-expanded=\"true\" role=\"tab\" tabindex=\"0\">\t\t\t\tCap de grup\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-1\" data-index=\"1\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-1\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es principals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-2\" data-index=\"2\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-2\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es cl\u00ednics\/ques\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-3\" data-index=\"3\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-3\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es postdoctorals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-4\" data-index=\"4\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-4\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es predoctorals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-5\" data-index=\"5\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-5\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tSuport cient\u00edfic\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-6\" data-index=\"6\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-6\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es visitants\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-7\" data-index=\"7\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-7\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tCol\u00b7laboradors\/es\t\t\t\t<\/a>\n\t\t\t\t\t\tCap de grup\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Ciruela Alf\u00e9rez, Francisco<\/li>\n<li>Aso P\u00e9rez, Ester<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es principals\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Bonaventura Morera, Jordi<\/li>\n<li>Fern\u00e1ndez Due\u00f1as, V\u00edctor<\/li>\n<li>Flores de los Heros, \u00c1frica<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es cl\u00ednics\/ques\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Hereu Boher, Pilar<\/li>\n<li>Llop Rius, Roser<\/li>\n<li>Rodr\u00edguez Cumplido, Dolores<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es postdoctorals\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Fernandez Solanas, Alex<\/li>\n<li>Lopez Cano, Marc<\/li>\n<li>Salort Flaquer, Gl\u00f2ria<\/li>\n<li>Mart\u00edn Belmonte, Alejandro<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es predoctorals\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Argerich Bergad\u00e0, Josep<\/li>\n<li>S\u00e1nchez fern\u00e1ndez, Nuria<\/li>\n<li>G\u00f3mez Acero, Laura<\/li>\n<li>\u00a0\u00c1lvarez Montoya, Paula<\/li>\n<li>Carnaval, Thiago<\/li>\n<li>Rizzo, Arianna<\/li>\n<li>Sarasola Telleria, Laura Isabel<\/li>\n<\/ul>\n\t\t\t\t\t\tSuport cient\u00edfic\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Sanchez Rodriguez, Maria Salut<\/li>\n<li>Otero Gonzalez, Aurema De Los \u00c1ngeles<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es visitants\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Kristoffer Sahlholm<\/li>\n<li>Jiu Lin<\/li>\n<li>Ligresti, Alessia<\/li>\n<\/ul>\n\t\t\t\t\t\tCol\u00b7laboradors\/es\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Videla C\u00e9s, Sebasti\u00e1n<\/li>\n<\/ul>\n<h2>\n\t\tNot\u00edcies relacionades\n\t<\/h2>\n\t<meta itemscope itemprop=\"mainEntityOfPage\" 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