{"id":1930,"date":"2019-09-27T17:56:02","date_gmt":"2019-09-27T15:56:02","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=1930"},"modified":"2024-05-29T13:54:17","modified_gmt":"2024-05-29T11:54:17","slug":"cancer-ginecologic","status":"publish","type":"page","link":"https:\/\/idibell.cat\/recerca\/area-de-cancer\/programa-de-mecanismes-moleculars-i-terapia-experimental-en-oncologia-oncobell\/cancer-ginecologic\/","title":{"rendered":"C\u00e0ncer Ginecol\u00f2gic"},"content":{"rendered":"\n<h1>\n\t\tC\u00e0ncer ginecol\u00f2gic\n\t<\/h1>\n<h3>\n\t\tResum\n\t<\/h3>\n\t<p>El grup de C\u00e0ncer ginecol\u00f2gic \u00e9s un equip multidisciplinari format per ginec\u00f2legs, onc\u00f2legs, pat\u00f2legs i investigadors b\u00e0sics. El grup compta amb tres l\u00edders, Xavier Matias-Guiu, tamb\u00e9 l\u00edder del grup CIBER (CB16 \/ 12\/00231, conjuntament amb IRBLLEIDA), Jordi Ponce, Mireia Martin-Satu\u00e9, David Llobet i Ruth Rodriguez-Barrueco. El grup acaba d&#8217;iniciar el treball col\u00b7laboratiu en diferents \u00e0rees del c\u00e0ncer ginecol\u00f2gic.<\/p>\n<p>&nbsp;<\/p>\n<h2>867<\/h2>\n<h2>Publicacions<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/04\/mucinous_lmp_ovarian_tumour_intermed_mag.jpg\" alt=\"mucinous_lmp_ovarian_tumour_intermed_mag\" itemprop=\"image\" height=\"300\" width=\"600\" title=\"mucinous_lmp_ovarian_tumour_intermed_mag\" onerror=\"this.style.display='none'\"  \/>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\">L\u00ednies estrat\u00e8giques<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\"><i>Expand<\/i><\/a>\n\t\t\t\t\tOncologia ginecol\u00f2gica cl\u00ednica i quir\u00fargica<br \/>\nSenyalitzaci\u00f3 purin\u00e8rgica en c\u00e8l\u00b7lules endometrials normals, endometriosi i c\u00e0ncer d&#8217;endometri<br \/>\nTractaments selectius i immunoter\u00e0pia en c\u00e0ncer ginecol\u00f2gic\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\">Publicacions seleccionades<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>Kim,TW;Bedard,PL;Lorusso,P;Gordon,MS;Bendell,J;Oh,D;Ahn,MJ et al, <strong>Anti-TIGIT Antibody Tiragolumab Alone or With Atezolizumab in Patients With Advanced Solid Tumors A Phase 1a\/1b Nonrandomized Controlled Trial<\/strong>, JAMA Oncol., 2023;9(11):1574-1582, doi:10.1001\/jamaoncol.2023.3867<\/li>\n<li>Crosas Molist,E;Graziani,V;Maiques,O;Pandya,P;Monger,J;Samain,R;George,SL et al, <strong>AMPK is a mechano-metabolic sensor linking cell adhesion and mitochondrial dynamics to Myosin-dependent cell migration<\/strong>., Nat. Commun., 2023;14(1):2740-2740, doi:10.1038\/s41467-023-38292-0<\/li>\n<li>Samain,R;Maiques,O;Monger,J;Lam,H;Candido,J;George,S;Ferrari,N et al, <strong>CD73 controls Myosin II-driven invasion, metastasis, and immunosuppression in amoeboid pancreatic cancer cells<\/strong>, Sci. Adv., 2023;9(42):doi:10.1126\/sciadv.adi0244<\/li>\n<li>Costas,L;Onieva,I;Pelegrina,B;Marin,F;Carmona,A;L\u00f3pez Querol,M;Frias Gomez,J et al, <strong>Evaluation of Somatic Mutations in Urine Samples as a Noninvasive Method for the Detection and Molecular Classification of Endometrial Cancer<\/strong>, Clin. Cancer Res., 2023;29(18):3681-3690, doi:10.1158\/1078-0432.CCR-23-0367<\/li>\n<li>Espinosa Sotelo,R;Fuste,NP;Penuelas Haro,I;Alay,A;Pons,G;Almodovar,X;Albaladejo,J et al, <strong>Dissecting the role of the NADPH oxidase NOX4 in TGF-beta signaling in hepatocellular carcinoma<\/strong>, Redox Biol., 2023;65102818-102818, doi:10.1016\/j.redox.2023.102818<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\">Projectes seleccionats<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>17ACL120. <strong>A PHASE IA\/B OPEN-LABEL, DOSE-ESCALATION STUDY OF THE SAFETY AND PHARACOKINETICS OF MTIG7192A AS A SINGLE AGENT AND INCOMBINATION WITH ATEZOLIZUMAB IN PATIENTS WITH LOCALLY ADVANCED OR METASTATIC TUMORS<\/strong>. Genentech, Inc.. Budget: 619.866\u20ac. 2017- . PI: Gil Martin, Marta.<\/li>\n<li>19ACL209. <strong>ESTUDIO DE FASE 1, ABIERTO, MULTIC\u00c9NTRICO Y DE VARIOS GRUPOS DE MK-4830 EN MONOTERAPIA Y EN COMBINACI\u00d3N CON PEMBROLIZUMAB EN PARTICIPANTES CON TUMORES S\u00d3LIDOS AVANZADOS<\/strong>. MERCK SHARP &amp; DOHME ESPA\u00d1A S.A. Budget: 521.875\u20ac. 2019- . PI: Gil Martin, Marta.<\/li>\n<li>19PSJ014. <strong>TARGETING THE AUTORESISTOME AS A NEW THERAPEUTIC STRATEGY IN ENDOMETRIAL CANCER<\/strong>. Asociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer (AECC). Budget: 299.849,22\u20ac. 2019-2023. PI: LLOBET NAVAS, DAVID.<\/li>\n<li>2023-151-1. <strong>ESTUDIO TIPO CESTA DE FASE 1B\/2, MULTIC\u00c9NTRICO Y ABIERTO QUE EVAL\u00daA LA SEGURIDAD Y EFICACIA DE BEMARITUZUMAB EN MONOTERAPIA EN TUMORES S\u00d3LIDOS CON SOBREEXPRESI\u00d3N DE FGFR2B (FORTITUDE-301)<\/strong>. Amgen, S.A.. Budget: 240.251\u20ac. 2023- . PI: Gil Martin, Marta.<\/li>\n<li>18ACL156. <strong>ESTUDIO DE FASE I, ABIERTO, MULTIC\u00c9NTRICO, DE B\u00daSQUEDA DE DOSIS DE TNO155 ORAL EN PACIENTES ADULTOS CON TUMORES S\u00d3LIDOS AVANZADOS<\/strong>. Novartis Farmac\u00e9utica, S.A.. Budget: 233.522\u20ac. 2018- . PI: Gil Martin, Marta.<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-3\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-3\">M\u00e9s informaci\u00f3<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-3\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-3\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<p>El grup compta amb projectes actius finan\u00e7ats per ISCIII, MINECO i organismes privats (Merck-Serono, MSD), i un bon historial de publicacions en revistes de revisi\u00f3 per parells.<\/p>\n<p>&nbsp;<\/p>\n<strong>CULTIVOS 3D PERSONALIZADOS PARA SELECCI\u00d3N DE TRATAMIENTO PARA PACIENTES DE C\u00c1NCER EN MEDICINA DE PRECISI\u00d3N (PROYECTO 3D-ID)<\/strong><br \/>\nPI: Matias-Guiu, Xavier<br \/>\nConvocatoria Retos Colaboraci\u00f3n, expediente: RTC-2017- 6573-1<br \/>\nCoordinador: STEMTEK THERAPEUTICS, S.L.<br \/>\nMinisterio de Ciencia, Innovaci\u00f3n y Universidades, perteneciente a la Agencia Estatal de Investigaci\u00f3n (AEI).<br \/>\nCofinanciado por el Fondo Europeo de Desarrollo Regional. FEDER, una manera de hacer Europa. Promover el desarrollo tecnol\u00f3gico, la innovaci\u00f3n y una investigaci\u00f3n de calidad.\n<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/es\/\/..\/..\/..\/wp-content\/uploads\/2019\/09\/gobierno-de-espa\u00f1a-300x63.jpg\" alt=\"\" width=\"300\" height=\"63\" \/><br \/>\n<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/es\/\/..\/..\/..\/wp-content\/uploads\/2019\/09\/union-europea-300x78.png\" alt=\"\" width=\"300\" height=\"78\" \/>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/11\/Xavier-Matias-Guiu-150x150.jpg\" alt=\"Xavier-Matias-Guiu\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Xavier-Matias-Guiu\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tMatias-Guiu Guia, Xavier\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:xmatias@idibell.cat\" title=\"xmatias@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\txmatias@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tInvestigadors principals\n\t<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/11\/Xavier-Matias-Guiu-150x150.jpg\" alt=\"Xavier-Matias-Guiu\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Xavier-Matias-Guiu\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tMatias-Guiu Guia, Xavier\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:xmatias@idibell.cat\" title=\"xmatias@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\txmatias@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2023\/03\/Mireia-Martin-Satue-circle-150x150.jpg\" alt=\"Mireia-Martin-Satue-circle\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Mireia-Martin-Satue-circle\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tMart\u00edn Satu\u00e9, Mireia\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:mmartin@idibell.cat\" title=\"mmartin@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tmmartin@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:vmoreno@idibell.cat\" title=\"\" target=\"_blank\" rel=\"noopener\">\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/11\/Jordi-Ponce-Sebastia-150x150.jpg\" alt=\"Jordi-Ponce-Sebastia\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Jordi-Ponce-Sebastia\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tPonce Sebastia, Jordi\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:jponce@idibell.cat\" title=\"jponce@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tjponce@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2022\/11\/David-Llobet22-150x150.jpg\" alt=\"David-Llobet22\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"David-Llobet22\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tLlobet Navas, David\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:dllobet@idibell.cat\" title=\"dllobet@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tdllobet@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2019\/05\/avatar_idibell_0-150x150.jpeg\" alt=\"avatar_idibell_0\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"avatar_idibell_0\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tGil Martin, Marta\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:mgil@idibell.cat\" title=\"mgil@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tmgil@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2022\/11\/Ruth-Rodriguez-Barrueco22-150x150.jpg\" alt=\"Ruth-Rodriguez-Barrueco22\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Ruth-Rodriguez-Barrueco22\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tRodriguez Barrueco, Ruth\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:rrodriguezb@idibell.cat\" title=\"rrodriguezb@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\trrodriguezb@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2019\/05\/avatar_idibell_0-150x150.jpeg\" alt=\"avatar_idibell_0\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"avatar_idibell_0\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tPardo Burdalo, Beatriz\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:bpardo@idibell.cat\" title=\"bpardo@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tbpardo@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\tENLLA\u00c7OS RELACIONATS\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/twitter.com\/xmatiasguiu\" title=\"@xmatiasguiu\" target=\"_blank\" rel=\"noopener\">\n\t\t@xmatiasguiu\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/twitter.com\/DLN_Lab\" title=\"@DLN_Lab\" target=\"_blank\" rel=\"noopener\">\n\t\t@DLN_Lab\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/twitter.com\/RRdguezBarrueco\" title=\"@RRdguezBarrueco\" target=\"_blank\" rel=\"noopener\">\n\t\t@RRdguezBarrueco\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tEquip\n\t<\/h2>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-0\" data-index=\"0\" aria-selected=\"true\" aria-controls=\"fl-tabs--panel-0\" aria-expanded=\"true\" role=\"tab\" tabindex=\"0\">\t\t\t\tCaps de grup\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-1\" data-index=\"1\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-1\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es principals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-2\" data-index=\"2\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-2\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es cl\u00ednics\/ques\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-3\" data-index=\"3\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-3\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es postdoctorals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-4\" data-index=\"4\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-4\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es predoctorals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-5\" data-index=\"5\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-5\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tSuport cient\u00edfic\t\t\t\t<\/a>\n\t\t\t\t\t\tCaps de grup\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Matias-Guiu Guia, Xavier<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es principals\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Ponce Sebastia, Jordi<\/li>\n<li>Gil Martin, Marta<\/li>\n<li>Pardo Burdalo, Beatriz<\/li>\n<li>Mart\u00edn Satu\u00e9, Mireia<\/li>\n<li>Llobet Navas, David<\/li>\n<li>Rodriguez Barrueco, Ruth<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es cl\u00ednics\/ques\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Marti Cardona, Maria Dolores<\/li>\n<li>Barahona Orpinell, Marc<\/li>\n<li>Varela Rodriguez, Maria del Mar<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es postdoctorals\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Devis Jauregui, Laura<\/li>\n<li>Marin Borras, Susana<\/li>\n<li>Bonifaci Cano, Nuria<\/li>\n<li>Trapero Candela, Carla<\/li>\n<li>Gassner, Katja<\/li>\n<li>Coll Iglesias, Laura<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es predoctorals\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Guerra Fernandez, Maria Esther<\/li>\n<li>Vidal Bel, August<\/li>\n<li>Taco Sanchez, Mar\u00eda del Rosario<\/li>\n<li>Mig\u00f3 Aran J\u00falia<\/li>\n<li>Rodr\u00edguez Barrante, Aintzane<\/li>\n<li>Soler, Sole, Eva<\/li>\n<\/ul>\n\t\t\t\t\t\tSuport cient\u00edfic\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Bonilla Amadeo, Ricard<\/li>\n<li>Llobet Nav\u00e0s, Francisco Javier<\/li>\n<li>Rodriguez Vazquez, Axel<\/li>\n<\/ul>\n<h2>\n\t\tNot\u00edcies relacionades\n\t<\/h2>\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/22537\" content=\"Nous models de ratol\u00ed obren vies de recerca per a tractaments personalitzats en c\u00e0ncer d'endometri\" \/><meta itemprop=\"datePublished\" content=\"2022-11-29\" \/><meta itemprop=\"dateModified\" content=\"2022-11-29\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/wp-content\/uploads\/2023\/03\/cropped-Marca-B.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/wp-content\/uploads\/2022\/11\/NP28-D-Llobet_Adv-Scie-ImatgeB.jpg\" \/><meta itemprop=\"width\" content=\"1366\" \/><meta itemprop=\"height\" 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grup de C\u00e0ncer ginecol\u00f2gic \u00e9s un equip multidisciplinari format per ginec\u00f2legs, onc\u00f2legs, pat\u00f2legs i investigadors b\u00e0sics. El grup compta amb tres l\u00edders, Xavier Matias-Guiu, tamb\u00e9 l\u00edder del grup CIBER (CB16 \/ 12\/00231, conjuntament amb IRBLLEIDA), Jordi Ponce, Mireia Martin-Satu\u00e9, David Llobet i Ruth Rodriguez-Barrueco. 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