{"id":1916,"date":"2019-09-26T19:49:29","date_gmt":"2019-09-26T17:49:29","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=1916"},"modified":"2024-06-19T14:25:24","modified_gmt":"2024-06-19T12:25:24","slug":"neuro-oncologia","status":"publish","type":"page","link":"https:\/\/idibell.cat\/recerca\/area-de-cancer\/programa-de-mecanismes-moleculars-i-terapia-experimental-en-oncologia-oncobell\/neuro-oncologia\/","title":{"rendered":"Neurooncologia"},"content":{"rendered":"\n<h1>\n\t\tNeuro-oncologia\n\t<\/h1>\n<h3>\n\t\tResum\n\t<\/h3>\n\t<p>El grup de Neuro-oncologia se centra en l&#8217;estudi dels tractaments de tumors cerebrals i les complicacions neurol\u00f2giques relacionades amb el c\u00e0ncer i els tractaments contra el c\u00e0ncer. L&#8217;objectiu del grup \u00e9s crear i refor\u00e7ar una xarxa de recerca entre investigadors cl\u00ednics i precl\u00ednics tant dins com fora de la instituci\u00f3,\u00a0 per proporcionar noves opcions terap\u00e8utiques per a pacients, millorar les eines de diagn\u00f2stic i contribuir a augmentar els coneixements en aquests camps.<\/p>\n<h2>379<\/h2>\n<h2>Publicacions<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/04\/119-neurooncologia-jbruna-def.jpg\" alt=\"119-neurooncologia-jbruna-def\" itemprop=\"image\" height=\"300\" width=\"600\" title=\"119-neurooncologia-jbruna-def\" onerror=\"this.style.display='none'\"  \/>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\">L\u00ednies estrat\u00e8giques<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\"><i>Expand<\/i><\/a>\n\t\t\t\t\tAvaluaci\u00f3 de nous f\u00e0rmacs i nous enfocaments de tractament contra gliomes i meningiomes (Jordi Bruna, Carles Mesia, Ana Lucas, Carles Maj\u00f3s, Gerard Plans)<br \/>\nNeuropaties perif\u00e8riques indu\u00efdes per quimioter\u00e0pia (Jordi Bruna, Roser Velasco)<br \/>\nC\u00e0ncer i cognici\u00f3 (Marta Sim\u00f3)<br \/>\nMet\u00e0stasis leptomen\u00edngees (Jordi Bruna)<br \/>\nFactors pron\u00f2stics de superviv\u00e8ncia implicats en els tumors del sistema nervi\u00f3s central (Noem\u00ed Vidal, Jordi Bruna, Carles Maj\u00f3s. Albert Pons, Gerard Plans)<br \/>\nPrevenci\u00f3 i tractament personalitzat de met\u00e0stasis cerebrals: desenvolupament de noves ter\u00e0pies basades en la prevenci\u00f3 i pron\u00f2stic de biomarcadors (Carles Mesia, Noem\u00ed Vidal, Gerard Plans, Ana Lucas)<br \/>\nValoraci\u00f3 quantitativa de t\u00e8cniques avan\u00e7ades de RM en neurooncologia cl\u00ednica (Carles Majos, Albert Pons)\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\">Publicacions seleccionades<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>Nadal,E;Rodr\u00edguez Abreu,D;Sim\u00f3,M;Massut\u00ed,B;Juan,O;Huidobro,G;L\u00f3pez,R et al, <strong>Phase II Trial of Atezolizumab Combined With Carboplatin and Pemetrexed for Patients With Advanced Nonsquamous Non-Small-Cell Lung Cancer With Untreated Brain Metastases (Atezo-Brain, GECP17\/05)<\/strong>, J. Clin. Oncol., 2023;41(28):4478-4485, doi:10.1200\/JCO.22.02561<\/li>\n<li>Velasco,R;Argyriou,AA;Marco,C;Mariotto,S;Stradella,A;Hern\u00e1ndez,J;Pernas,S et al, <strong>Serum neurofilament levels correlate with electrodiagnostic evidence of axonal loss in paclitaxel-induced peripheral neurotoxicity<\/strong>., J. Neurol., 2023;270(1):531-537, doi:10.1007\/s00415-022-11377-4<\/li>\n<li>Maj\u00f3s,C;Pons Escoda,A;Naval,P;Guell,A;Lucas,A;Vidal,N;Cos,M et al, <strong>Proton MR spectroscopy shows improved performance to segregate high-grade astrocytoma subgroups when defined with the new 2021 World Health Organization classification of central nervous system tumors<\/strong>, Eur. Radiol., 2023;doi:10.1007\/s00330-023-10138-9<\/li>\n<li>Alemany,M;Todeschini,FA;Vidal,N;Pons,A;Plans,G;Vilarino,N;Maci\u00e0,M et al, <strong>The impact of health system crises on glioblastoma management and outcomes, Neuro-Oncology<\/strong>, 2023;25(3):609-611, doi:10.1093\/neuonc\/noac266<\/li>\n<li>Pons Escoda,A;Garcia Ruiz,A;Garcia Hidalgo,C;Gil Solsona,R;Naval Baudin,P;Martin Noguerol,T;Fernandez Coello,A et al, <strong>MR dynamic-susceptibility-contrast perfusion metrics in the presurgical discrimination of adult solitary intra-axial cerebellar tumors<\/strong>, Eur. Radiol., 2023;33(12):9120-9129, doi:10.1007\/s00330-023-09892-7,<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\">Projectes seleccionats<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>FIS21056. <strong>Comprensi\u00f3n y modulaci\u00f3n de los mecanismos de respuesta senescente en la neuropat\u00eda inducida por platinos<\/strong>. Instituto de Salud Carlos III (ISCIII). Budget: 165.770\u20ac. 2022-2024. PI: Bruna Escuer, Jordi.<\/li>\n<li>21FIS037. <strong>Valoraci\u00f3n pron\u00f3stica de los gliomas cerebrales mediante Espectroscpia por RM (MRS-PROG)<\/strong>. Instituto de Salud Carlos III (ISCIII). Budget: 58.080\u20ac. 2021-2023. PI: MAJOS TORRO, CARLOS.<\/li>\n<li>19FIS035. <strong>C\u00e1ncer de pulm\u00f3n y toxicidad cognitiva: marcadores serol\u00f3gicos y de neuroimagen de disrupci\u00f3n de la barrera hemato-encef\u00e1lica. Instituto de Salud Carlos III (ISCIII)<\/strong>. Budget: 93.170\u20ac. 2019-2023. PI: Sim\u00f3 Parra, Marta.<\/li>\n<li>21FIS039. <strong>Neurotoxicidad inducida por quimioterapia y estado nutricional: biomarcadores cl\u00ednicos, s\u00e9ricos, radiol\u00f3gicos y neurofisol\u00f3gicos asociados al desarrollo y la regeneraci\u00f3n nerviosa<\/strong>. Instituto de Salud Carlos III (ISCIII). Budget: 93.170\u20ac. 2021-2024. PI: VELASCO FARGAS, ROSER.<\/li>\n<li>2022-231-1. <strong>Estudio de fase II, multic\u00e9ntrico, aleatorizado, con doble enmascaramiento, de grupos paralelos y controlado con placebo para evaluar la eficacia y la seguridad de ATX01 (Clorhidrato de Amitriptilina t\u00f3pica al 10 % y al 15 % p\/p) en comparaci\u00f3n con placebo en pacientes adultos que han sobrevivido a un c\u00e1ncer y presentan neuropat\u00eda perif\u00e9rica inducida por quimioterapia -NPIQ<\/strong>. WORLDWIDE CLINICAL TRIALS, INC. Budget: 58.375,75\u20ac. 2022- . PI: Bruna Escuer, Jordi.<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-3\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-3\">M\u00e9s informaci\u00f3<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-3\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-3\"><i>Expand<\/i><\/a>\n\t\t\t\t\tIdentificaci\u00f3 de marcadors de risc predictiu cl\u00ednic i neurofisiol\u00f2gic per desenvolupar neuropatia indu\u00efda per oxaliplat\u00ed<br \/>\nNoves demostracions sobre l&#8217;efic\u00e0cia del nou antagonista del receptor sigma-1 per prevenir la neuropatia aguda de oxaliplat\u00ed en un estudi aleatoritzat de fase 2<br \/>\nDocumentaci\u00f3 dels canvis longitudinals del cervell associats amb la irradiaci\u00f3 cerebral profil\u00e0ctica i la quimioter\u00e0pia en pacients amb c\u00e0ncer de pulm\u00f3 de c\u00e8l\u00b7lules petites<br \/>\nIdentificaci\u00f3 d&#8217;un tret com\u00fa en glioblastomes: la defici\u00e8ncia intr\u00ednseca de la endonucleasa DFF40 \/ CAD que afecta la hidr\u00f2lisi de l&#8217;ADN durant la mort cel\u00b7lular caspasa-dependent\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2022\/10\/Jordi-Bruna22-150x150.jpg\" alt=\"Jordi-Bruna22\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Jordi-Bruna22\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tBruna Escuer, Jordi\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:jbruna@idibell.cat\" title=\"jbruna@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tjbruna@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tInvestigadors principals\n\t<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2022\/10\/Jordi-Bruna22-150x150.jpg\" alt=\"Jordi-Bruna22\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Jordi-Bruna22\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tBruna Escuer, Jordi\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:jbruna@idibell.cat\" title=\"jbruna@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tjbruna@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2021\/02\/Marta-Simo-150x150.jpg\" alt=\"Marta-Simo\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Marta-Simo\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tSimo Parra, Marta\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:msimo@idibell.cat\" title=\"msimo@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tmsimo@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/11\/Carlos-Mesia-Barroso-150x150.jpg\" alt=\"Carlos-Mesia-Barroso\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Carlos-Mesia-Barroso\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tMesia Barroso, Carlos\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:cmesia@idibell.cat\" title=\"cmesia@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tcmesia@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2021\/05\/Anna-Lucas-Calduch-150x150.jpg\" alt=\"Anna-Lucas-Calduch\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Anna-Lucas-Calduch\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tLucas Calduch, Anna Maria\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:alucas@idibell.cat\" title=\"alucas@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\talucas@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/11\/Roser-Velasco-Fargas-150x150.jpg\" alt=\"Roser-Velasco-Fargas\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Roser-Velasco-Fargas\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tVelasco Fargas, Roser\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:rvelasco@idibell.cat\" title=\"rvelasco@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\trvelasco@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2021\/05\/Carles-Majos-Torro-150x150.jpg\" alt=\"Carles-Majos-Torro\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Carles-Majos-Torro\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tMajos Torro, Carlos\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:cmajos@idibell.cat\" title=\"cmajos@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tcmajos@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\tENLLA\u00c7OS RELACIONATS\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/twitter.com\/VelascoRoser\" title=\"@VelascoRoser\" target=\"_self\" rel=\"noopener\">\n\t\t@VelascoRoser\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tEquip\n\t<\/h2>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-0\" data-index=\"0\" aria-selected=\"true\" aria-controls=\"fl-tabs--panel-0\" aria-expanded=\"true\" role=\"tab\" tabindex=\"0\">\t\t\t\tCaps de grup\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-1\" data-index=\"1\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-1\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es principals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-2\" data-index=\"2\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-2\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es cl\u00ednics\/ques\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-3\" data-index=\"3\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-3\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es predoctorals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-4\" data-index=\"4\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-4\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tSuport de gesti\u00f3\t\t\t\t<\/a>\n\t\t\t\t\t\tCaps de grup\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Bruna Escuer, Jordi<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es principals\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Velasco Fargas, Roser<\/li>\n<li>Mesia Barroso, Carlos<\/li>\n<li>Simo Parra, Marta<\/li>\n<li>Majos Torro, Carlos<\/li>\n<li>Lucas Calduch, Anna Maria<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es cl\u00ednics\/ques\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Fern\u00e1ndez Coello, Alejandro<\/li>\n<li>Vidal Sarro, Noemi<\/li>\n<li>Plans Ahicart, Gerard<\/li>\n<li>Pons Escoda, Albert<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es predoctorals\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Alemany\u00a0 Mart\u00ed, Montserrat<\/li>\n<li>Septien Rivera, Sara<\/li>\n<\/ul>\n\t\t\t\t\t\tSuport de gesti\u00f3\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Sala Corominas, Ros\u00f3<\/li>\n<\/ul>\n<h2>\n\t\tNot\u00edcies relacionades\n\t<\/h2>\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" 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content=\"2018-09-13\" \/><meta itemprop=\"dateModified\" content=\"2021-07-28\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/wp-content\/uploads\/2023\/03\/cropped-Marca-B.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/author\/erigin\/\" \/><meta itemprop=\"name\" content=\"Idibell\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/05\/elcancerdetuatu2.jpg\" \/><meta itemprop=\"width\" content=\"700\" \/><meta itemprop=\"height\" content=\"409\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/2018\/09\/el-cancer-de-tu-a-tu-pacients-metges-investigadors-i-activistes-de-la-lluita-contra-el-cancer-dialoguen-i-sobren-a-la-ciutadania\/\" title=\"El c\u00e0ncer de tu a tu: Pacients, metges, investigadors i activistes de la lluita contra 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tractaments contra el c\u00e0ncer. 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