{"id":18214,"date":"2021-06-30T08:07:39","date_gmt":"2021-06-30T06:07:39","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=18214"},"modified":"2024-11-11T16:41:20","modified_gmt":"2024-11-11T15:41:20","slug":"trastorns-del-neurodesenvolupament","status":"publish","type":"page","link":"https:\/\/idibell.cat\/recerca\/area-de-neurociencies\/programa-de-neurociencies\/trastorns-del-neurodesenvolupament\/","title":{"rendered":"Trastorns del neurodesenvolupament"},"content":{"rendered":"\n<h1>\n\t\tTrastorns del neurodesenvolupament \n\t<\/h1>\n<h3>\n\t\tResum\n\t<\/h3>\n\t<p>El desenvolupament de sistema nervi\u00f3s central est\u00e0 estrictament modulat per factors gen\u00e8tics i ambientals d&#8217;una manera espai-temporal. Fins i tot les alteracions lleus en els gens i \/ o els senyals ambientals durant els per\u00edodes cr\u00edtics del desenvolupament pre i postnatal, condueixen a anomalies morfol\u00f2giques i funcionals que comprometran el comportament normal i la funci\u00f3 cognitiva. Mitjan\u00e7ant la identificaci\u00f3 de factors de risc i la investigaci\u00f3 del seu paper en el desenvolupament de el sistema nervi\u00f3s central, utilitzant tecnologies in vitro i in vivo d&#8217;avantguarda, tenim com a objectiu dissenyar estrat\u00e8gies noves i m\u00e9s efectives per a la intervenci\u00f3 terap\u00e8utica.<\/p>\n<h2>85<\/h2>\n<h2>Publicacions<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2021\/06\/Neurodevelopmental-disorders2.jpg\" alt=\"Neurodevelopmental-disorders2\" itemprop=\"image\" height=\"300\" width=\"600\" title=\"Neurodevelopmental-disorders2\" onerror=\"this.style.display='none'\"  \/>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\">L\u00ednies estrat\u00e8giques<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\"><i>Expand<\/i><\/a>\n\t\t\t\t\t&#8211; Neurogen\u00f2mica funcional<br \/>\n&#8211; Estrat\u00e8gies biomim\u00e8tiques per dirigir el desenvolupament i regeneraci\u00f3 neural<br \/>\n&#8211; Modelat hum\u00e0 de trastorns neurol\u00f2gics\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\">Publicacions seleccionades<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>Alvarez,Z;Ortega,JA;Sato,K;Sasselli,IR;Kolberg Edelbrock,AN;Qiu,RM;Marshall,KA et al, <strong>Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons<\/strong>, Cell Stem Cell, 2023;30(2):219-doi:10.1016\/j.stem.2022.12.010<\/li>\n<li>SMITH, C. S., \u00c1LVAREZ, Z., QIU, R., SASSELLI, I. R., CLEMONS, T., ORTEGA, J. A., VILELA-PICOS, M., WELLMAN, H., KISKINIS, E. &amp; STUPP, S. I. 2023. <strong>Enhanced Neuron Growth and Electrical Activity by a Supramolecular Netrin-1 Mimetic Nanofiber<\/strong>. ACS Nano, 17, 19887-19902<\/li>\n<li>Ortega JA, Sasselli IR, Boccitto M, Fleming AC, Fortuna TR, Li Y, Sato K, Clemons TD, Mckenna ED, Nguyen TP, Anderson EN, Asin J, Ichida JK, Pandey UB, Wolin SL, Stupp SI, Kiskinis E. <strong>CLIP-Seq analysis enables the design of protective ribosomal RNA bait oligonucleotides against C9ORF72 ALS\/FTD poly-GR pathophysiology<\/strong>. Sci Adv. 2023 Nov 10;9(45):eadf7997. doi: 10.1126\/sciadv.adf7997<\/li>\n<li>Musokhranova,U;Grau,C;Vergara,C;Rodr\u00edguez Pascau,L;Xiol,C;Castells,AA;Alc\u00e1ntara,S et al, <strong>Mitochondrial modulation with leriglitazone as a potential treatment for Rett syndrome<\/strong>., J. Transl. Med., 2023;21(1):756-756, doi:10.1186\/s12967-023-04622-5<\/li>\n<li>Garcia Gonzalez,L;Marti Sarrias,A;Puertas,MC;Bayon Gil,A;Resa Infante,P;Martinez Picado,J;Navarro,A et al, <strong>Understanding the neurological implications of acute and long COVID using brain organoids, Dis. Model<\/strong>. Mech., 2023;16(7):doi:10.1242\/dmm.050049<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\">Projectes seleccionats<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>PUB22026. <strong>INVESTIGO 2022<\/strong>. SERVICIO PUBLICO DE EMPLEO ESTATAL SEPE. Budget: 66.217,68\u20ac. 2022 &#8211; . PI: Ortega Cano, Juan Alberto.<\/li>\n<li>INT23001. <strong>theALSmatrisome: Defining the contribution of ALS-associated alterations in motor neuron microenvironment to disease pathogenesis<\/strong>. ASSOCIATION FRAN\u00c7AISE CONTRE LES MYOPATHIES (FRENCH MUSCULAR DYSTROPHY ASSOCIATION) AFM-T\u00c9L\u00c9THON.\u00a0Budget: 30.000,00\u20ac. 2023-2025. PI: Ortega Cano, Juan Alberto.<\/li>\n<\/ul>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2022\/11\/Soledad-Alcantara22-150x150.jpg\" alt=\"Soledad-Alcantara22\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Soledad-Alcantara22\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tAlc\u00e1ntara Horrillo, Soledad\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:isalcantara@idibell.cat\" title=\"salcantara@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tsalcantara@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tInvestigadors principals\n\t<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2022\/11\/Soledad-Alcantara22-150x150.jpg\" alt=\"Soledad-Alcantara22\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Soledad-Alcantara22\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tAlc\u00e1ntara Horrillo, Soledad\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:salcantara@idibell.cat\" title=\"salcantara@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tsalcantara@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2021\/06\/Sandra-Acosta-Verdugo-150x150.jpg\" alt=\"Sandra-Acosta-Verdugo\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Sandra-Acosta-Verdugo\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tAcosta Verdugo, Sandra\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2021\/06\/J-Alberto-Ortega-Cano-150x150.jpg\" alt=\"J-Alberto-Ortega-Cano\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"J-Alberto-Ortega-Cano\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tOrtega Cano, Alberto\n\t<\/h4>\n<h4>\n\t\tENLLA\u00c7OS RELACIONATS\n\t<\/h4>\n<h4>\n\t\t<a href=\"http:\/\/www.neurociencies.ub.edu\/neurodevelopmental-disorders\/\" title=\"Institut de Neuroci\u00e8ncies UB\" target=\"_blank\" rel=\"noopener\">\n\t\tInstitut de Neuroci\u00e8ncies UB\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/www.ub.edu\/portal\/web\/dp-patologia-terapeutica\/laboratori-de-desenvolupament-neural-ndlab-\" title=\"Soledad Alc\u00e1ntara - NDLab\" target=\"_blank\" rel=\"noopener\">\n\t\tSoledad Alc\u00e1ntara &#8211; NDLab\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"http:\/\/www.acostalab.cat\/\" title=\"Acosta Lab\" target=\"_blank\" rel=\"noopener\">\n\t\tAcosta Lab\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/twitter.com\/sacostav\" title=\"@sacostav\" target=\"_blank\" rel=\"noopener\">\n\t\t@sacostav\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tEquip\n\t<\/h2>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-0\" data-index=\"0\" aria-selected=\"true\" aria-controls=\"fl-tabs--panel-0\" aria-expanded=\"true\" role=\"tab\" tabindex=\"0\">\t\t\t\tCaps de grup\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-1\" data-index=\"1\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-1\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es principals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-2\" data-index=\"2\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-2\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es postdoctorals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-3\" data-index=\"3\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-3\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadores\/as predoctorales\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-4\" data-index=\"4\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-4\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tSuport cient\u00edfic\t\t\t\t<\/a>\n\t\t\t\t\t\tCaps de grup\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Alc\u00e1ntara Horrillo, Soledad<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es principals\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Acosta Verdugo, Sandra<\/li>\n<li>Ortega Cano, Alberto<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es postdoctorals\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Garc\u00eda Gonz\u00e1lez, Laura<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadores\/as predoctorales\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Soriano Esque, Jos\u00e9 Pablo<\/li>\n<li>Soares de Aguiar, Gisele Priscila<\/li>\n<li>Mart\u00ed Sarrias, Andrea<\/li>\n<li>Turpin Moreno, Isabel<\/li>\n<\/ul>\n\t\t\t\t\t\tSuport cient\u00edfic\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Cuenca Medina, Marta<\/li>\n<\/ul>\n<h2>\n\t\tNot\u00edcies relacionades\n\t<\/h2>\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/26466\" content=\"BioCl\u00faster, gamificaci\u00f3 i innovaci\u00f3 en salut: la participaci\u00f3 de l'IDIBELL a l'Smart City Expo World Congress 2024\" \/><meta itemprop=\"datePublished\" content=\"2024-11-07\" \/><meta itemprop=\"dateModified\" 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Sandra Acosta exhibits en l&#8217;exposici\u00f3 Cervell(s) del CCCB\" \/><meta itemprop=\"datePublished\" content=\"2022-10-26\" \/><meta itemprop=\"dateModified\" content=\"2022-10-26\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/wp-content\/uploads\/2023\/03\/cropped-Marca-B.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/wp-content\/uploads\/2022\/10\/NO97-Expo-CCCB_Cervells-Imatge-noti.jpg\" \/><meta itemprop=\"width\" content=\"1366\" \/><meta itemprop=\"height\" content=\"768\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/2022\/10\/organoides-del-grup-de-recerca-de-la-dra-sandra-acosta-exhibits-en-lexposicio-cervells-del-cccb\/\" title=\"Organoides del grup de recerca de la Dra. Sandra Acosta exhibits en l&#8217;exposici\u00f3 Cervell(s) del CCCB\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/2022\/10\/organoides-del-grup-de-recerca-de-la-dra-sandra-acosta-exhibits-en-lexposicio-cervells-del-cccb\/\" title=\"Organoides del grup de recerca de la Dra. Sandra Acosta exhibits en l&#8217;exposici\u00f3 Cervell(s) del CCCB\">Organoides del grup de recerca de la Dra. Sandra Acosta exhibits en l&#8217;exposici\u00f3 Cervell(s) del CCCB<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/author\/comunicacio\/\">comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t26\/10\/2022\t\t\t\t\t\t\t\n\t\t<!-- .pp-content-posts -->\n\n","protected":false},"excerpt":{"rendered":"<p>Trastorns del neurodesenvolupament Resum El desenvolupament de sistema nervi\u00f3s central est\u00e0 estrictament modulat per factors gen\u00e8tics i ambientals d&#8217;una manera espai-temporal. Fins i tot les alteracions lleus en els gens i \/ o els senyals ambientals durant els per\u00edodes cr\u00edtics del desenvolupament pre i postnatal, condueixen a anomalies morfol\u00f2giques i funcionals que comprometran el comportament [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":503,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-18214","page","type-page","status-publish","hentry"],"publishpress_future_action":{"enabled":false,"date":"2025-01-25 07:42:13","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages\/18214","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=18214"}],"version-history":[{"count":11,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages\/18214\/revisions"}],"predecessor-version":[{"id":26487,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages\/18214\/revisions\/26487"}],"up":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages\/503"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=18214"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}