{"id":1783,"date":"2019-09-19T11:25:21","date_gmt":"2019-09-19T09:25:21","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=1783"},"modified":"2024-12-17T13:33:41","modified_gmt":"2024-12-17T12:33:41","slug":"tgf-beta-i-cancer","status":"publish","type":"page","link":"https:\/\/idibell.cat\/recerca\/area-de-cancer\/programa-de-mecanismes-moleculars-i-terapia-experimental-en-oncologia-oncobell\/tgf-beta-i-cancer\/","title":{"rendered":"TGF-Beta i C\u00e0ncer"},"content":{"rendered":"\n<h1>\n\t\tTGF-beta i c\u00e0ncer\n\t<\/h1>\n<h3>\n\t\tResum\n\t<\/h3>\n\t<p>El grup est\u00e0 format per dos investigadors principals, les l\u00ednies de recerca dels quals tenen com a nexe com\u00fa avan\u00e7ar en el coneixement dels mecanismes moleculars que influeixen en la plasticitat de les c\u00e8l\u00b7lules tumorals i en les interaccions tumor-estroma. El grup t\u00e9 un inter\u00e8s especial en el paper del factor de creixement transformador (TGF)-\u03b2 en la regulaci\u00f3 d&#8217;aquests processos, aix\u00ed com en desxifrar la rellev\u00e0ncia d&#8217;altres vies de senyalitzaci\u00f3, com la senyalitzaci\u00f3 del factor de creixement epid\u00e8rmic (EGF) o del interfer\u00f3 (IFN). La investigaci\u00f3 se centra principalment en el c\u00e0ncer de fetge, p\u00e0ncrees i pell, per\u00f2 tamb\u00e9 s&#8217;estan treballant models addicionals en col\u00b7laboraci\u00f3 amb altres grups.<\/p>\n<h2>268<\/h2>\n<h2>Publicacions<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/04\/110-tgfbetacancer-fabregat-def.jpg\" alt=\"110-tgfbetacancer-fabregat-def\" itemprop=\"image\" height=\"300\" width=\"600\" title=\"110-tgfbetacancer-fabregat-def\" onerror=\"this.style.display='none'\"  \/>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\">L\u00ednies estrat\u00e8giques<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-0\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>Mecanismes moleculars implicats en la migraci\u00f3, plasticitat, invasi\u00f3 i met\u00e0stasi de c\u00e8l\u00b7lules tumorals. Paper del TGF-beta, EGF i IFN en aquests processos.<\/li>\n<li>Exosomes i microRNA com a promotors del n\u00ednxol metast\u00e0tic: relaci\u00f3 amb la via del TGF-beta.<\/li>\n<li>Paper de la fam\u00edlia NADPH oxidasa (NOX) com a mediador dels efectes del TGF-beta. L&#8217;eix TGF-beta\/NOX4 com a regulador del metabolisme i del balan\u00e7 redox cel\u00b7lular.<\/li>\n<li>An\u00e0lisi de la interacci\u00f3 tumor-stroma en la iniciaci\u00f3 i progressi\u00f3 tumoral.<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\">Publicacions seleccionades<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-1\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>Espinosa Sotelo,R;Fuste,NP;Penuelas Haro,I;Alay,A;Pons,G;Almodovar,X;Albaladejo,J et al, <strong>Dissecting the role of the NADPH oxidase NOX4 in TGF-beta signaling in hepatocellular carcinoma<\/strong>, Redox Biol., 2023;65102818-102818, doi:10.1016\/j.redox.2023.102818<\/li>\n<li>Cazzagon,N;Gonzalez Sanchez,E;El Mourabit,H; Wendum,D; Rainteau,D; Humbert,L; Corpechot,C et al, <strong>Protective potential of the gallbladder in primary sclerosing cholangitis<\/strong>., JHEP Rep., 2023;5(4):100649-100649, doi:10.1016\/j.jhepr.2022.100649,<\/li>\n<li>Calvisi,DF;Boulter,L;Vaquero,J;Saborowski,A;Fabris,L;Rodrigues,PM;Coulouarn,C et al, <strong>Criteria for preclinical models of cholangiocarcinoma: scientific and medical relevance<\/strong>, Nat. Rev. Gastroenterol. Hepatol., 2023;20(7):462-480, doi:10.1038\/s41575-022-00739-y,<\/li>\n<li>Ramos,R;Cabr\u00e9,E;Vinyals,A;Lorenzo,D;Ferreres,JR;Varela,M;Gom\u00e1,M et al, <strong>Orthotopic murine xenograft model of uveal melanoma with spontaneous liver metastasis<\/strong>., Melanoma Res., 2023;33(1):1-11, doi:10.1097\/CMR.0000000000000860,<\/li>\n<li>Wiedmann,L;Rigotti,FD;Vaquero Siguero,N;Donato,E;Espinet,E;Moll,I;Alsina Sanchis,E et al, <strong>HAPLN1 potentiates peritoneal metastasis in pancreatic cancer<\/strong>, Nat. Commun., 2023;14(1):2353-2353, doi:10.1038\/s41467-023-38064-w,<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\">Projectes seleccionats<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-2\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>MCI21045. <strong>Descifrando el papel de la NADPH oxidasa NOX4 en el carcinoma hepatocelular: relevancia en c\u00e9lulas tumorales y estroma y relaci\u00f3n con la v\u00eda del TGF-beta.<\/strong> Ministerio de Ciencia e Innovaci\u00f3n. Budget: 344.850\u20ac. 2022-2025. PI: FABREGAT ROMERO, MARIA ISABEL.<\/li>\n<li>ERA21007. <strong>Targeting ROBOs and SLIT guidance cues in the immunosuppressive stromal context of pancreatic cancer (TRanSLIT)<\/strong>. Asociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer (AECC)\/Instituto de Salud Carlos III (ISCIII). Budget: 302.600\u20ac. 2022-2025. PI: Espinet Hern\u00e1ndez, Elisa Maria.<\/li>\n<li>AEC21009. <strong>Towards a precision medicine using TGF-\u00df inhibitors in hepatocellular carcinoma and cholangiocarcinoma<\/strong>. Asociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer (AECC). Budget: 299.813,75\u20ac. 2021-2024. PI: FABREGAT ROMERO, MARIA ISABEL.<\/li>\n<li>21PSJ005. <strong>Dissecting the role of the hepatocyte Epidermal Growth Factor Receptor (EGFR) pathway in the cellular interactome within the liver fibrotic niche<\/strong>. FUNDACI\u00d3N RAM\u00d3N ARECES. Budget: 112.000\u20ac. 2021-2024. PI: FABREGAT ROMERO, MARIA ISABEL.<\/li>\n<li>2022-040-1. <strong>PRIMER ESTUDIO DE FASE I EN HUMANOS, SIN ENMASCARAMIENTO, DE AUMENTO ESCALONADO DE LA DOSIS PARA EVALUAR LA SEGURIDAD, LA FARMACOCIN\u00c9TICA, LA FARMACODIN\u00c1MICA Y EL PERFIL DE ACTIVIDAD CL\u00cdNICA PRELIMINAR DEL AGENTE RO7119929 (AGONISTA DE TLR7) EN MONOTERAPIA ADMINISTRADO POR V\u00cdA ORAL A PARTICIPANTES CON CARCINOMA HEPATOCELULAR AVANZADO IRRESECABLE O METAST\u00c1SICO, C\u00c1NCER DEL TRACTO BILIAR O TUMORES S\u00d3LIDOS CON MET\u00c1STASIS HEP\u00c1TICAS<\/strong>. FORTREA INC. Budget: 193.971\u20ac. 2022- . PI: Calvo Campos, Mariona.<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-3\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-3\">Transfer\u00e8ncia de tecnologia<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-3\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\tLicense: ANTINOX<br \/>\nPI: Dra. Isabel Fabregat\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-4\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-4\">M\u00e9s informaci\u00f3<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-4\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>Coordinaci\u00f3 del consorci europeu IT-LIVER (inhibici\u00f3 de TGF-\u03b2 en malalties del fetge) &#8211; programa de Marie Curie ITN.<\/li>\n<li>Projectes nacionals (Pla Estatal, FIS), fundacions privades (Marat\u00f3 TV3 i AECC) i projectes amb empreses farmac\u00e8utiques (Digna &#8211; Espanya, 4SC AG-Alemanya)<\/li>\n<\/ul>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2022\/11\/Isabel-Fabregat22-150x150.jpg\" alt=\"Isabel-Fabregat22\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Isabel-Fabregat22\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tFabregat Romero, Maria Isabel\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:ifabregat@idibell.cat\" title=\"ifabregat@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tifabregat@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tInvestigadors principals\n\t<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2022\/11\/Isabel-Fabregat22-150x150.jpg\" alt=\"Isabel-Fabregat22\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Isabel-Fabregat22\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tFabregat Romero, Maria Isabel\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:ifabregat@idibell.cat\" title=\"ifabregat@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tifabregat@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2022\/06\/Elisa-Espinet-150x150.jpg\" alt=\"Elisa-Espinet\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Elisa-Espinet\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tEspinet, Elisa\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:eespinet@idibell.cat\" title=\"eespinet@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\teespinet@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\tENLLA\u00c7OS RELACIONATS\n\t<\/h4>\n<h4>\n\t\t<a href=\"http:\/\/www.it-liver.eu\/\" title=\"IT-liver\" target=\"_blank\" rel=\"noopener\">\n\t\tIT-liver\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/www.facebook.com\/IT-Liver-141184969424873\/\" title=\"Facebook IT-Liver\" target=\"_blank\" rel=\"noopener\">\n\t\tFacebook IT-Liver\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/twitter.com\/IsabelFabregat\" title=\"@IsabelFabregat\" target=\"_blank\" rel=\"noopener\">\n\t\t@IsabelFabregat\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tEquip\n\t<\/h2>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-0\" data-index=\"0\" aria-selected=\"true\" aria-controls=\"fl-tabs--panel-0\" aria-expanded=\"true\" role=\"tab\" tabindex=\"0\">\t\t\t\tCaps de grup\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-1\" data-index=\"1\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-1\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es principals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-2\" data-index=\"2\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-2\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es cl\u00ednics\/ques\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-3\" data-index=\"3\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-3\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es postdoctorals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-4\" data-index=\"4\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-4\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadors\/es predoctorals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-5\" data-index=\"5\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-5\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tSuport cient\u00edfic\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-6\" data-index=\"6\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-6\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tCol\u00b7laboradors\/es\t\t\t\t<\/a>\n\t\t\t\t\t\tCaps de grup\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Fabregat Romero, Mar\u00eda Isabel<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es principals\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Espinet, Elisa<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es cl\u00ednics\/ques\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Calvo Campos, Mariona<\/li>\n<li>Ramos Rubio, Emili<\/li>\n<li>Serrano Pinol, Teresa<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es postdoctorals\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Pe\u00f1uelas Haro, Irene<\/li>\n<li>Pel\u00e1ez Llaneza, Nicol\u00e1s<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es predoctorals\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Amengual Segura, Josep<\/li>\n<li>\u00a0Cantos Cortes Ana<\/li>\n<li>Gonfaus Ortiz, Gemma<\/li>\n<li>Jimenez Arriola, Martin<\/li>\n<li>Acu\u00f1a Pincay, Cristhian Ariel<\/li>\n<\/ul>\n\t\t\t\t\t\tSuport cient\u00edfic\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Bertran Rodriguez, Esther<\/li>\n<\/ul>\n\t\t\t\t\t\tCol\u00b7laboradors\/es\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Vaquero Rodr\u00edguez, Javier<\/li>\n<li>Gonzalez Sanchez, Maria Esther<\/li>\n<\/ul>\n<h2>\n\t\tNot\u00edcies relacionades\n\t<\/h2>\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/26709\" content=\"Nous aven\u00e7os en la investigaci\u00f3 sobre la met\u00e0stasi en diferents tipus de melanoma\" \/><meta itemprop=\"datePublished\" content=\"2024-12-09\" \/><meta itemprop=\"dateModified\" content=\"2024-12-09\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" 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