Publicacions<\/h2>\n\t\t\t\t![\"110-tgfbetacancer-fabregat-def\"](\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/04\/110-tgfbetacancer-fabregat-def.jpg\" "\\"110-tgfbetacancer-fabregat-def\\"")
\n\t\t\t\t\tL\u00ednies estrat\u00e8giques<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t\n- Mecanismes moleculars implicats en la migraci\u00f3, plasticitat, invasi\u00f3 i met\u00e0stasi de c\u00e8l\u00b7lules tumorals. Paper del TGF-beta, EGF i IFN en aquests processos.<\/li>\n
- Exosomes i microRNA com a promotors del n\u00ednxol metast\u00e0tic: relaci\u00f3 amb la via del TGF-beta.<\/li>\n
- Paper de la fam\u00edlia NADPH oxidasa (NOX) com a mediador dels efectes del TGF-beta. L’eix TGF-beta\/NOX4 com a regulador del metabolisme i del balan\u00e7 redox cel\u00b7lular.<\/li>\n
- An\u00e0lisi de la interacci\u00f3 tumor-stroma en la iniciaci\u00f3 i progressi\u00f3 tumoral.<\/li>\n<\/ul>\n\t\t\t\t\tPublicacions seleccionades<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t
Penuelas Haro I, Espinosa Sotelo R, Crosas Molist E, Herranz Iturbide M, Caballero Diaz D, Alay A, Sole X, Ramos E, Serrano T, Martinez Chantar ML, Knaus UG, Cuezva JM, Zorzano A, Bertran E, Fabregat I. The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression<\/strong>. Hepatology. 2022;doi:10.1002\/hep.32702.<\/p>\nVaquero J, Pavy A, Gonzalez Sanchez E, Meredith M, Arbelaiz A, Fouassier L. Genetic alterations shaping tumor response to anti-EGFR therapies<\/strong>. Drug Resist Updat. 2022;64100863-100863. doi:10.1016\/j.drup.2022.100863.<\/p>\nEspinet E, Klein L, Pur\u00e9 E, Singh SK. Mechanisms of PDAC subtype heterogeneity and therapy response<\/strong>. Trends Cancer. 2022;8(12):1060-1071. doi:10.1016\/j.trecan.2022.08.005.<\/p>\nVinyals A, Ferreres JR, Calbet Llopart N, Ramos R, Tell Mart\u00ed G, Carrera C, Marcoval J, Puig S, Malvehy J, Puig Butille JA, Fabra \u00c0. Oncogenic properties via MAPK signaling of the SOX5-RAF1 fusion gene identified in a wild-type NRAS\/BRAF giant congenital nevus<\/strong>. Pigment Cell Melanoma Res. 2022;35(4):450-460. doi:10.1111\/pcmr.13044.<\/p>\nGoikoetxea Usandizaga N, Serrano Maci\u00e1 M, Delgado TC, Sim\u00f3n J, Fern\u00e1ndez Ramos D, Barriales D, Cornide ME, Jim\u00e9nez M, P\u00e9rez Redondo M, Lachiondo Ortega S, Rodr\u00edguez Agudo R, Bizkarguenaga M, Zalamea JD, Pasco ST, Caballero D\u00edaz D, Alfano B, Bravo M, Gonz\u00e1lez Recio I, Mercado G\u00f3mez M, Gil Pitarch C, Mabe J, Gracia Sancho J, Abecia L, Lorenzo \u00d3, Mart\u00edn Sanz P, Abrescia N, Sabio G, Rinc\u00f3n M, Anguita J, Mi\u00f1ambres E, Mart\u00edn C, Berenguer M, Fabregat I, Casado M, Peralta C, Varela Rey M, Mart\u00ednez Chantar ML. Mitochondrial bioenergetics boost macrophages activation promoting liver regeneration in metabolically compromised animals<\/strong>. Hepatology. 2022;75(3):550-566. doi:10.1002\/hep.32149.<\/p>\n\t\t\t\t\tProjectes seleccionats<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t19MEC012. Nuevas aproximaciones experimentales para analizar el papel de la NADPH oxidasa NOX4 en regeneraci\u00f3n y c\u00e1ncer hep\u00e1ticos. Relaci\u00f3n con la v\u00eda del TGF-beta<\/strong>. Ministerio de Ciencia e Innovaci\u00f3n. Budget: 338800. 2019-2022. PI: Fabregat Romero, Mar\u00eda Isabel.<\/p>\nAEC21009. Towards a precision medicine using TGF-\u00df inhibitors in hepatocellular carcinoma and cholangiocarcinoma<\/strong>. Asociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer (AECC). Budget: 299813,75. 2021-2024. PI: Fabregat Romero, Mar\u00eda Isabel.<\/p>\n20MEC015. Diseccionando el papel terap\u00e9utico de la NADPH oxidasa NOX4 en colangiocarcinoma por medio de secuenciaci\u00f3n masiva de RNA en c\u00e9lula \u00fanica (NOX4CHOL)<\/strong>. Ministerio de Ciencia e Innovaci\u00f3n. Budget: 181500. 2020-2023. PI: Vaquero Rodr\u00edguez, Javier.<\/p>\n20MEC023. DESARROLLO PRECL\u00cdNICO DE UN NUEVO ACTIVO MODULADOR DE LA FIBROSIS Y LA SENESCENCIA PARA EL TRATAMIENTO DE LA ENFERMEDAD DE H\u00cdGADO GRASO NO-ALCOH\u00d3LICO (HEPATOSEN)<\/strong>. Ministerio de Ciencia e Innovaci\u00f3n. Budget: 159287,29. 2020-2022. PI: Fabregat Romero, Mar\u00eda Isabel.<\/p>\n21PSJ005. Dissecting the role of the hepatocyte Epidermal Growth Factor Receptor (EGFR) pathway in the cellular interactome within the liver fibrotic niche<\/strong>. FUNDACI\u00d3N RAM\u00d3N ARECES. Budget: 112000. 2021-2024. PI: Fabregat Romero, Mar\u00eda Isabel.<\/p>\n\t\t\t\t\tTransfer\u00e8ncia de tecnologia<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\tLicense: ANTINOX
\nPI: Dra. Isabel Fabregat\n\t\t\t\t\tM\u00e9s informaci\u00f3<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t\n- Coordinaci\u00f3 del consorci europeu IT-LIVER (inhibici\u00f3 de TGF-\u03b2 en malalties del fetge) – programa de Marie Curie ITN.<\/li>\n
- Projectes nacionals (Pla Estatal, FIS), fundacions privades (Marat\u00f3 TV3 i AECC) i projectes amb empreses farmac\u00e8utiques (Digna – Espanya, 4SC AG-Alemanya)<\/li>\n<\/ul>\n\t\t\t\t
![\"Isabel-Fabregat22\"](\"https:\/\/idibell.cat\/wp-content\/uploads\/2022\/11\/Isabel-Fabregat22-150x150.jpg\" "\\"Isabel-Fabregat22\\"")
\n\n\t\tFabregat Romero, Maria Isabel\n\t<\/h4>\n\n\t\t\n\t\tifabregat@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\n\t\tInvestigadors principals\n\t<\/h2>\n\t\t\t\t\n\n\t\tFabregat Romero, Maria Isabel\n\t<\/h4>\n\n\t\t\n\t\tifabregat@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t![\"Angels-Fabra\"](\"https:\/\/idibell.cat\/wp-content\/uploads\/2020\/11\/Angels-Fabra-150x150.jpg\" "\\"Angels-Fabra\\"")
\n\n\t\tFabra Fres, Angels\n\t<\/h4>\n\n\t\t\n\t\tafabra@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t![\"Elisa-Espinet\"](\"https:\/\/idibell.cat\/wp-content\/uploads\/2022\/06\/Elisa-Espinet-150x150.jpg\" "\\"Elisa-Espinet\\"")
\n\n\t\tEspinet, Elisa\n\t<\/h4>\n\n\t\t\n\t\teespinet@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\n\t\tENLLA\u00c7OS RELACIONATS\n\t<\/h4>\n\n\t\t\n\t\tIT-liver\n\t\t<\/a>\n\t<\/h4>\n\n\t\t\n\t\tFacebook IT-Liver\n\t\t<\/a>\n\t<\/h4>\n\n\t\t\n\t\t@IsabelFabregat\n\t\t<\/a>\n\t<\/h4>\n\n\t\tEquip\n\t<\/h2>\n\t\t\t\t\t\t\t\t\t\t\t\tCaps de grup\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadors\/es principals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadors\/es cl\u00ednics\/ques\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadors\/es postdoctorals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadors\/es predoctorals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tSuport cient\u00edfic\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tCol\u00b7laboradors\/es\t\t\t\t<\/a>\n\t\t\t\t\t\tCaps de grup\n\t\t\t\t\t\t\t\t\t\t\t\n- Fabregat Romero, Mar\u00eda Isabel<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es principals\n\t\t\t\t\t\t\t\t\t\t\t
\n- Fabra Fres, Angels<\/li>\n
- Espinet, Elisa<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es cl\u00ednics\/ques\n\t\t\t\t\t\t\t\t\t\t\t
\n- Ferreres Riera, Josep Ram\u00f3n<\/li>\n
- Calvo Campos, Mariona<\/li>\n
- Ramos Rubio, Emili<\/li>\n
- Serrano Pinol, Teresa<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es postdoctorals\n\t\t\t\t\t\t\t\t\t\t\t
\n- Pe\u00f1uelas Haro, Irene<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es predoctorals\n\t\t\t\t\t\t\t\t\t\t\t
\n- Espinosa Sotelo, Rut<\/li>\n
- Amengual Segura, Josep<\/li>\n
- \u00a0Cantos Cortes Ana<\/li>\n
- Gonfaus Ortiz, Gemma<\/li>\n
- Jim\u00e9nez-Arriola, Mart\u00edn<\/li>\n<\/ul>\n\t\t\t\t\t\tSuport cient\u00edfic\n\t\t\t\t\t\t\t\t\t\t\t
\n- Vinyals Rioseco, Antonia<\/li>\n
- Bertran Rodriguez, Esther<\/li>\n<\/ul>\n\t\t\t\t\t\tCol\u00b7laboradors\/es\n\t\t\t\t\t\t\t\t\t\t\t
\n- Vaquero Rodr\u00edguez, Javier<\/li>\n
- Gonzalez Sanchez, Maria Esther<\/li>\n<\/ul>\n
\n\t\tNot\u00edcies relacionades\n\t<\/h2>\n\t\t\n\t\t\t\t<\/a>\n\t\t\tLa Fundaci\u00f3 ‘la Caixa’ impulsa un estudi prometedor contra el c\u00e0ncer de p\u00e0ncrees<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t24\/11\/2023\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tNous aven\u00e7os en l’an\u00e0lisi dels mecanismes que expliquen el paper dual de TGF-beta en carcinoma hepatocel\u00b7lular<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t31\/08\/2023\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tUn estudi de l’IDIBELL identifica els mecanismes pels quals NOX4 actua com a fre molecular del c\u00e0ncer de fetge<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t01\/09\/2022\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tL’IDIBELL rep m\u00e9s d’un mili\u00f3 i mig d’euros de l’AECC per finan\u00e7ar projectes d’investigaci\u00f3 contra el c\u00e0ncer<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t17\/11\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tL’IDIBELL participa en un estudi per reduir la possibilitat de fallada hep\u00e0tica de donants grans en trasplantaments<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t01\/10\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tInvestigadors de l’IDIBELL participen en un estudi que descriu un nou mecanisme de resist\u00e8ncia al tractament del carcinoma hepatocel\u00b7lular<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t09\/06\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tEstudien la reprogramaci\u00f3 del metabolisme dels l\u00edpids per combatre l’hepatocarcinoma cel\u00b7lular<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t31\/05\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tIsabel Fabregat rep un ajut de la Fundaci\u00f3 Ram\u00f3n Areces per estudiar la fibrosi hep\u00e0tica<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t30\/04\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tL’eliminaci\u00f3 de la prote\u00efna NOX4 millora la regeneraci\u00f3 del fetge<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t03\/02\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tDescobreixen la implicaci\u00f3 d’una nova prote\u00efna en el c\u00e0ncer de fetge<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t28\/10\/2019\t\t\t\t\t\t\t\n\t\t\n\n","protected":false},"excerpt":{"rendered":"Apoptosis y C\u00e1ncer Resum El grup est\u00e0 format per quatre investigadors principals, les l\u00ednies de recerca dels quals tenen com a vincle com\u00fa avan\u00e7ar en el coneixement dels mecanismes moleculars que influencien la plasticitat de la c\u00e8l\u00b7lula tumoral i la interacci\u00f3 tumor-estroma. El grup t\u00e9 gran inter\u00e8s en el paper del factor de creixement transformant […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":448,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"publishpress_future_action":{"enabled":false,"date":"2024-05-11 15:40:26","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages\/1783"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=1783"}],"version-history":[{"count":5,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages\/1783\/revisions"}],"predecessor-version":[{"id":24838,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages\/1783\/revisions\/24838"}],"up":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages\/448"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=1783"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Penuelas Haro I, Espinosa Sotelo R, Crosas Molist E, Herranz Iturbide M, Caballero Diaz D, Alay A, Sole X, Ramos E, Serrano T, Martinez Chantar ML, Knaus UG, Cuezva JM, Zorzano A, Bertran E, Fabregat I. The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression<\/strong>. Hepatology. 2022;doi:10.1002\/hep.32702.<\/p>\n Vaquero J, Pavy A, Gonzalez Sanchez E, Meredith M, Arbelaiz A, Fouassier L. Genetic alterations shaping tumor response to anti-EGFR therapies<\/strong>. Drug Resist Updat. 2022;64100863-100863. doi:10.1016\/j.drup.2022.100863.<\/p>\n Espinet E, Klein L, Pur\u00e9 E, Singh SK. Mechanisms of PDAC subtype heterogeneity and therapy response<\/strong>. Trends Cancer. 2022;8(12):1060-1071. doi:10.1016\/j.trecan.2022.08.005.<\/p>\n Vinyals A, Ferreres JR, Calbet Llopart N, Ramos R, Tell Mart\u00ed G, Carrera C, Marcoval J, Puig S, Malvehy J, Puig Butille JA, Fabra \u00c0. Oncogenic properties via MAPK signaling of the SOX5-RAF1 fusion gene identified in a wild-type NRAS\/BRAF giant congenital nevus<\/strong>. Pigment Cell Melanoma Res. 2022;35(4):450-460. doi:10.1111\/pcmr.13044.<\/p>\n Goikoetxea Usandizaga N, Serrano Maci\u00e1 M, Delgado TC, Sim\u00f3n J, Fern\u00e1ndez Ramos D, Barriales D, Cornide ME, Jim\u00e9nez M, P\u00e9rez Redondo M, Lachiondo Ortega S, Rodr\u00edguez Agudo R, Bizkarguenaga M, Zalamea JD, Pasco ST, Caballero D\u00edaz D, Alfano B, Bravo M, Gonz\u00e1lez Recio I, Mercado G\u00f3mez M, Gil Pitarch C, Mabe J, Gracia Sancho J, Abecia L, Lorenzo \u00d3, Mart\u00edn Sanz P, Abrescia N, Sabio G, Rinc\u00f3n M, Anguita J, Mi\u00f1ambres E, Mart\u00edn C, Berenguer M, Fabregat I, Casado M, Peralta C, Varela Rey M, Mart\u00ednez Chantar ML. Mitochondrial bioenergetics boost macrophages activation promoting liver regeneration in metabolically compromised animals<\/strong>. Hepatology. 2022;75(3):550-566. doi:10.1002\/hep.32149.<\/p>\n\t\t\t\t\tProjectes seleccionats<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t 19MEC012. Nuevas aproximaciones experimentales para analizar el papel de la NADPH oxidasa NOX4 en regeneraci\u00f3n y c\u00e1ncer hep\u00e1ticos. Relaci\u00f3n con la v\u00eda del TGF-beta<\/strong>. Ministerio de Ciencia e Innovaci\u00f3n. Budget: 338800. 2019-2022. PI: Fabregat Romero, Mar\u00eda Isabel.<\/p>\n AEC21009. Towards a precision medicine using TGF-\u00df inhibitors in hepatocellular carcinoma and cholangiocarcinoma<\/strong>. Asociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer (AECC). Budget: 299813,75. 2021-2024. PI: Fabregat Romero, Mar\u00eda Isabel.<\/p>\n 20MEC015. Diseccionando el papel terap\u00e9utico de la NADPH oxidasa NOX4 en colangiocarcinoma por medio de secuenciaci\u00f3n masiva de RNA en c\u00e9lula \u00fanica (NOX4CHOL)<\/strong>. Ministerio de Ciencia e Innovaci\u00f3n. Budget: 181500. 2020-2023. PI: Vaquero Rodr\u00edguez, Javier.<\/p>\n 20MEC023. DESARROLLO PRECL\u00cdNICO DE UN NUEVO ACTIVO MODULADOR DE LA FIBROSIS Y LA SENESCENCIA PARA EL TRATAMIENTO DE LA ENFERMEDAD DE H\u00cdGADO GRASO NO-ALCOH\u00d3LICO (HEPATOSEN)<\/strong>. Ministerio de Ciencia e Innovaci\u00f3n. Budget: 159287,29. 2020-2022. PI: Fabregat Romero, Mar\u00eda Isabel.<\/p>\n 21PSJ005. Dissecting the role of the hepatocyte Epidermal Growth Factor Receptor (EGFR) pathway in the cellular interactome within the liver fibrotic niche<\/strong>. FUNDACI\u00d3N RAM\u00d3N ARECES. Budget: 112000. 2021-2024. PI: Fabregat Romero, Mar\u00eda Isabel.<\/p>\n\t\t\t\t\tTransfer\u00e8ncia de tecnologia<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\tLicense: ANTINOX Apoptosis y C\u00e1ncer Resum El grup est\u00e0 format per quatre investigadors principals, les l\u00ednies de recerca dels quals tenen com a vincle com\u00fa avan\u00e7ar en el coneixement dels mecanismes moleculars que influencien la plasticitat de la c\u00e8l\u00b7lula tumoral i la interacci\u00f3 tumor-estroma. El grup t\u00e9 gran inter\u00e8s en el paper del factor de creixement transformant […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":448,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"publishpress_future_action":{"enabled":false,"date":"2024-05-11 15:40:26","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages\/1783"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=1783"}],"version-history":[{"count":5,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages\/1783\/revisions"}],"predecessor-version":[{"id":24838,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages\/1783\/revisions\/24838"}],"up":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages\/448"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=1783"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nPI: Dra. Isabel Fabregat\n\t\t\t\t\tM\u00e9s informaci\u00f3<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t\n
\n\n\t\tFabregat Romero, Maria Isabel\n\t<\/h4>\n
\n\t\t\n\t\tifabregat@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n
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\n\n\t\tFabregat Romero, Maria Isabel\n\t<\/h4>\n
\n\t\t\n\t\tifabregat@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t
\n\n\t\tFabra Fres, Angels\n\t<\/h4>\n
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\n\n\t\tEspinet, Elisa\n\t<\/h4>\n
\n\t\t\n\t\teespinet@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n
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\n\t\t\n\t\t@IsabelFabregat\n\t\t<\/a>\n\t<\/h4>\n
\n\t\tEquip\n\t<\/h2>\n\t\t\t\t\t\t\t\t\t\t\t\tCaps de grup\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadors\/es principals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadors\/es cl\u00ednics\/ques\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadors\/es postdoctorals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadors\/es predoctorals\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tSuport cient\u00edfic\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tCol\u00b7laboradors\/es\t\t\t\t<\/a>\n\t\t\t\t\t\tCaps de grup\n\t\t\t\t\t\t\t\t\t\t\t
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\n\t\tNot\u00edcies relacionades\n\t<\/h2>\n\t\t\n\t\t\t\t<\/a>\n\t\t\tLa Fundaci\u00f3 ‘la Caixa’ impulsa un estudi prometedor contra el c\u00e0ncer de p\u00e0ncrees<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t24\/11\/2023\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tNous aven\u00e7os en l’an\u00e0lisi dels mecanismes que expliquen el paper dual de TGF-beta en carcinoma hepatocel\u00b7lular<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t31\/08\/2023\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tUn estudi de l’IDIBELL identifica els mecanismes pels quals NOX4 actua com a fre molecular del c\u00e0ncer de fetge<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t01\/09\/2022\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tL’IDIBELL rep m\u00e9s d’un mili\u00f3 i mig d’euros de l’AECC per finan\u00e7ar projectes d’investigaci\u00f3 contra el c\u00e0ncer<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t17\/11\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tL’IDIBELL participa en un estudi per reduir la possibilitat de fallada hep\u00e0tica de donants grans en trasplantaments<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t01\/10\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tInvestigadors de l’IDIBELL participen en un estudi que descriu un nou mecanisme de resist\u00e8ncia al tractament del carcinoma hepatocel\u00b7lular<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t09\/06\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tEstudien la reprogramaci\u00f3 del metabolisme dels l\u00edpids per combatre l’hepatocarcinoma cel\u00b7lular<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t31\/05\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tIsabel Fabregat rep un ajut de la Fundaci\u00f3 Ram\u00f3n Areces per estudiar la fibrosi hep\u00e0tica<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t30\/04\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tL’eliminaci\u00f3 de la prote\u00efna NOX4 millora la regeneraci\u00f3 del fetge<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t03\/02\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tDescobreixen la implicaci\u00f3 d’una nova prote\u00efna en el c\u00e0ncer de fetge<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t28\/10\/2019\t\t\t\t\t\t\t\n\t\t\n\n","protected":false},"excerpt":{"rendered":"