{"id":14174,"date":"2020-08-31T16:21:42","date_gmt":"2020-08-31T14:21:42","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=14174"},"modified":"2025-02-17T10:03:36","modified_gmt":"2025-02-17T09:03:36","slug":"plasticitat-cellular-i-regeneracio","status":"publish","type":"page","link":"https:\/\/idibell.cat\/recerca\/area-medicina-regenerativa\/programa-de-medicina-regenerativa\/plasticitat-cellular-i-regeneracio\/","title":{"rendered":"Plasticitat cel\u00b7lular i regeneraci\u00f3"},"content":{"rendered":"\n
Tenim l’objectiu de millorar la qualitat de vida dels supervivents de c\u00e0ncer que pateixen efectes secundaris de la radioter\u00e0pia, incloent la inflamaci\u00f3 aguda i cr\u00f2nica de l’intest\u00ed. Per assolir aquest objectiu, estudiem els mecanismes cel\u00b7lulars i moleculars implicats en la recuperaci\u00f3 epitelial despr\u00e9s de la lesi\u00f3 per radiaci\u00f3. A m\u00e9s, estudiem l’establiment de l’enteritis cr\u00f2nica indu\u00efda per la radiaci\u00f3 amb una atenci\u00f3 particular a la comunicaci\u00f3 creuada entre de les c\u00e8l\u00b7lules immunit\u00e0ries i les epitelials.<\/p>\n
La funci\u00f3 principal de l’intest\u00ed \u00e9s la digesti\u00f3 i l’absorci\u00f3 de nutrients. L’intest\u00ed prim es compon de criptes proliferatives i vellositats diferenciades. L’intest\u00ed adult est\u00e0 revestit d’epiteli, que \u00e9s mantingut per les c\u00e8l\u00b7lules mare intestinals. La radioter\u00e0pia \u00e9s un tractament habitual que s’utilitza en almenys el 50% dels pacients amb c\u00e0ncer i, malgrat la seva efici\u00e8ncia en l’eradicaci\u00f3 del c\u00e0ncer, indueix toxicitat intestinal. La radiaci\u00f3 provoca l’apoptosi de les c\u00e8l\u00b7lules proliferatives, que despulla la mucosa intestinal i al seu torn provoca una resposta inflamat\u00f2ria; les caracter\u00edstiques principals s\u00f3n inicialment una atr\u00f2fia aguda de la mucosa i en fases posteriors la fibrosi de la paret intestinal. El nombre de supervivents de c\u00e0ncer amb disfunci\u00f3 postradiaci\u00f3 de l’epiteli intestinal augmenta cont\u00ednuament. Tot i aix\u00ed, aquesta condici\u00f3 fins ara no t\u00e9 tractaments efectius. El nostre objectiu principal \u00e9s comprendre els mecanismes que desencadenen aquests processos per desenvolupar opcions terap\u00e8utiques per a aquests pacients. Per assolir aquest objectiu, fem servir tecnologies d’\u00faltima generaci\u00f3 i una gran quantitat d’enfocaments innovadors com ara organoids intestinals derivats del pacient, complementats amb models de ratol\u00ed, rastreig de llinatges, transcript\u00f2mica d’una sola c\u00e8l\u00b7lula i imatges en tres dimensions.<\/p>\n
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<\/p>\n\t\t\t\t\tPublicacions seleccionades<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t <\/p>\n\t\t\t\t\tProjectes seleccionats<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t Plasticitat Cel\u00b7lular i Regeneraci\u00f3 Resum Tenim l’objectiu de millorar la qualitat de vida dels supervivents de c\u00e0ncer que pateixen efectes secundaris de la radioter\u00e0pia, incloent la inflamaci\u00f3 aguda i cr\u00f2nica de l’intest\u00ed. Per assolir aquest objectiu, estudiem els mecanismes cel\u00b7lulars i moleculars implicats en la recuperaci\u00f3 epitelial despr\u00e9s de la lesi\u00f3 per radiaci\u00f3. A m\u00e9s, […]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":3924,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-14174","page","type-page","status-publish","hentry"],"publishpress_future_action":{"enabled":false,"date":"2025-03-01 23:43:13","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages\/14174","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=14174"}],"version-history":[{"count":7,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages\/14174\/revisions"}],"predecessor-version":[{"id":27222,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages\/14174\/revisions\/27222"}],"up":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/pages\/3924"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=14174"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}\n
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\n\t\tNot\u00edcies relacionades\n\t<\/h2>\n\t\t\n\t\t\t\t<\/a>\n\t\t\tLa Marat\u00f3 de 3Cat finan\u00e7a tres projectes de l’IDIBELL en salut sexual i reproductiva<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t22\/11\/2024\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tDescriuen els mecanismes que controlen la transici\u00f3 de les c\u00e8l\u00b7lules mare intestinals de fetals a adultes<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t18\/07\/2023\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tComen\u00e7a el programa d’intercanvi entre IDIBELL i SZBL<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t06\/05\/2022\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tJordi Guiu, nou cap de grup del Programa de Medicina Regenerativa<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t17\/09\/2020\t\t\t\t\t\t\t\n\t\t\n\n","protected":false},"excerpt":{"rendered":"