{"id":23689,"date":"2024-01-12T10:01:32","date_gmt":"2024-01-12T09:01:32","guid":{"rendered":"https:\/\/idibell.cat\/es\/?p=23689"},"modified":"2024-01-12T10:01:32","modified_gmt":"2024-01-12T09:01:32","slug":"presentan-un-virus-oncolitico-dirigido-a-celulas-nk-con-gran-potencial-antitumoral","status":"publish","type":"post","link":"https:\/\/idibell.cat\/es\/2024\/01\/presentan-un-virus-oncolitico-dirigido-a-celulas-nk-con-gran-potencial-antitumoral\/","title":{"rendered":"Presentan un virus oncol\u00edtico dirigido a c\u00e9lulas NK con gran potencial antitumoral"},"content":{"rendered":"<p>C\u00e9lulas inmunitarias como los linfocitos T citot\u00f3xicos (LTc) o las <em>natural killer<\/em> (NK) est\u00e1n especializadas en identificar c\u00e9lulas tumorales y eliminarlas para frenar el crecimiento de tumores, pero las c\u00e9lulas cancerosas tienen herramientas para reprimir la actividad del sistema inmunitario o camuflarse y as\u00ed poder reproducirse indefinidamente. La inmunoterapia del c\u00e1ncer quiere revertir esta inmunosupresi\u00f3n y estimular la actividad de c\u00e9lulas como los LTcs o las NKs para que puedan seguir identificando y eliminando las c\u00e9lulas tumorales y as\u00ed combatir la enfermedad. Un tipo concreto de inmunoterapia utiliza virus oncol\u00edticos, que infectan a las c\u00e9lulas cancerosas para eliminarlas directamente o atraer la respuesta inmunitaria.<\/p>\n<p>Ahora, un grupo de investigaci\u00f3n del IDIBELL y el ICO ha desarrollado un virus oncol\u00edtico concreto, ICOVIR15K-MICAMut, que, al penetrar en las c\u00e9lulas tumorales y expresar su material gen\u00e9tico, atrae y activa las c\u00e9lulas lulas NK. En el laboratorio, los investigadores han comprobado, utilizando ratones como modelo experimental, c\u00f3mo este virus induc\u00eda una respuesta inmunitaria antitumoral m\u00e1s eficiente y un mayor control del crecimiento del c\u00e1ncer. Este resultado abre sus puertas a un futuro ensayo cl\u00ednico.<\/p>\n<p>Los resultados con virus oncol\u00edticos son prometedores, pero todav\u00eda hay que realizar m\u00e1s investigaci\u00f3n para dise\u00f1ar un tratamiento robusto capaz de erradicar un tumor. En este sentido, el Dr. Rafael Moreno, l\u00edder del estudio, asegura que este trabajo \u00abdestaca el papel de las c\u00e9lulas NK en la inmunoterapia y presenta un enfoque innovador que tiene un gran potencial cl\u00ednico\u00bb.<\/p>\n<p><em>\u00a0<\/em><\/p>\n<p><em>\u00a0<\/em><\/p>\n<p><em>El Instituto de Investigaci\u00f3n Biom\u00e9dica de Bellvitge (IDIBELL) es un centro de investigaci\u00f3n en biomedicina creado en 2004. Est\u00e1 participado por el Hospital Universitario de Bellvitge y el Hospital de Viladecans del Instituto Catal\u00e1n de la Salud, el Instituto Catal\u00e1n de Oncolog\u00eda, la Universidad de Barcelona y el Ayuntamiento de L&#8217;Hospitalet de Llobregat.<\/em><\/p>\n<p><em>El IDIBELL es miembro del Campus de Excelencia Internacional de la Universidad de Barcelona HUBc y forma parte de la instituci\u00f3n CERCA de la Generalitat de Catalunya. En 2009 se convirti\u00f3 en uno de los cinco primeros centros de investigaci\u00f3n espa\u00f1oles acreditados como instituto de investigaci\u00f3n sanitaria por el Instituto de Salud Carlos III. Adem\u00e1s, forma parte del programa \u00abHR Excellence in Research\u00bb de la Uni\u00f3n Europea y es miembro de EATRIS y REGIC. Desde el a\u00f1o 2018, IDIBELL es un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un grupo de investigaci\u00f3n del IDIBELL y el ICO ha presentado un virus oncol\u00edtico que estimula la respuesta antitumoral de las c\u00e9lulas NK y ayuda a frenar el crecimiento del c\u00e1ncer.<\/p>\n","protected":false},"author":8,"featured_media":23690,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[184,243,395,371,281],"tags":[],"class_list":["post-23689","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-area-cancer","category-viroterapia-del-cancer","category-inmunidad-inflamacion-y-cancer","category-procure","category-programa-de-mecanismos-moleculares-y-terapia-experimental-en-oncologia-oncobell"],"publishpress_future_action":{"enabled":false,"date":"2024-11-13 00:21:35","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/23689"}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=23689"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/23689\/revisions"}],"predecessor-version":[{"id":23692,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/23689\/revisions\/23692"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media\/23690"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=23689"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=23689"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=23689"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}