Un grupo de investigaci\u00f3n multidisciplinar formado por profesionales del IDIBELL, el Hospital Universitario de Bellvitge y el Instituto Catal\u00e1n de Oncolog\u00eda ha evaluado el uso de una plataforma de secuenciaci\u00f3n masiva para encontrar mutaciones que predispongan a desarrollar ciertos tipos de tumores o que ayuden a elegir terapias dirigidas para cada paciente. El estudio ha sido publicado en ESMO Open y es el primer trabajo del Comit\u00e9 Molecular de Tumores y del Laboratorio Core de An\u00e1lisis Molecular del Campus de Bellvitge, en el que participan conjuntamente pat\u00f3logos, onc\u00f3logos, bi\u00f3logos, farmac\u00e9uticos, genetistas y bioinform\u00e1ticos de las tres instituciones.<\/p>\n
En esta primera evaluaci\u00f3n, se han analizado a 200 pacientes con c\u00e1ncer de pulm\u00f3n y se han detectado alteraciones potencialmente tratables en un 26,5% de los casos. Se observa tambi\u00e9n que existe una mayor supervivencia en aquellos enfermos en los que se detecta una diana terap\u00e9utica y que recib\u00edan la terapia dirigida adecuada, comparado con los que no la recib\u00edan o con los pacientes que no presentaban ninguna diana. Actualmente, es fundamental realizar un estudio molecular masivo para poder definir el tratamiento m\u00e1s \u00f3ptimo para los pacientes con c\u00e1ncer de pulm\u00f3n.<\/p>\n
<\/p>\n
La secuenciaci\u00f3n masiva<\/strong><\/p>\n Esta plataforma de secuenciaci\u00f3n masiva NGS permite identificar alteraciones en el ADN y el ARN de m\u00e1s de 500 genes y tambi\u00e9n evaluar otros tipos de marcadores gen\u00e9ticos como pueden ser la inestabilidad de microsat\u00e9lites o la carga mutacional tumoral, los cuales son de gran utilidad para predecir la eficacia de la inmunoterapia. Adem\u00e1s de estudiar los genes m\u00e1s relevantes en la rutina cl\u00ednica oncol\u00f3gica, tambi\u00e9n permite analizar otros genes asociados a la susceptibilidad a desarrollar un tumor o alteraciones moleculares que pueden ser tributarias de terapias experimentales, lo que puede beneficiar a los pacientes y facilitar su acceso nuevas estrategias terap\u00e9uticas.<\/p>\n","protected":false},"excerpt":{"rendered":" El uso de esta plataforma de secuenciaci\u00f3n gen\u00e9tica masiva podr\u00eda mejorar la supervivencia de los pacientes gracias a la detecci\u00f3n de dianas terap\u00e9uticas y mutaciones que predisponen al c\u00e1ncer.<\/p>\n","protected":false},"author":8,"featured_media":23634,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[184,250,245,281],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-18 13:10:02","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/23633"}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=23633"}],"version-history":[{"count":1,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/23633\/revisions"}],"predecessor-version":[{"id":23635,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/23633\/revisions\/23635"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media\/23634"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=23633"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=23633"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=23633"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}