{"id":23377,"date":"2023-11-02T12:54:46","date_gmt":"2023-11-02T11:54:46","guid":{"rendered":"https:\/\/idibell.cat\/es\/?p=23377"},"modified":"2023-11-02T12:54:46","modified_gmt":"2023-11-02T11:54:46","slug":"un-estudio-avanza-en-la-comprension-de-los-mecanismos-de-resistencia-de-haemophilus-parainfluenzae","status":"publish","type":"post","link":"https:\/\/idibell.cat\/es\/2023\/11\/un-estudio-avanza-en-la-comprension-de-los-mecanismos-de-resistencia-de-haemophilus-parainfluenzae\/","title":{"rendered":"Un estudio avanza en la comprensi\u00f3n de los mecanismos de resist\u00e8ncia de \u2018Haemophilus parainfluenzae\u2019"},"content":{"rendered":"<p>Un estudio llevado a cabo en el Servicio de Microbiolog\u00eda del Hospital Universitario de Bellvitge y el <a href=\"https:\/\/idibell.cat\/es\/investigacion\/area-de-medicina-traslacional\/programa-de-enfermedades-infecciosas-y-trasplantes\/epidemiologia-de-las-infecciones-bacterianas-investigacion-de-la-patogenesis-y-de-las-bases-moleculares-de-la-resistencia-a-los-antibioticos\/\">Grupo de Investigaci\u00f3n de Infecciones Bacterianas<\/a> del IDIBELL ha detectado por primera vez la adquisici\u00f3n de una beta-lactamasa de espectro extendido (ESBL) CTX-M-15 en cepas multirresistentes de <em>Haemophilus parainfluenzae<\/em> aislados de muestras urogenitales. Este hallazgo, publicado en <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0924857923002650?via%3Dihub\"><em>International Journal of Antimicrobial Agents<\/em><\/a>, destaca la posibilidad de que este mecanismo de resistencia se propague a otros pat\u00f3genos de transmisi\u00f3n sexual.<\/p>\n<p>El pat\u00f3geno oportunista <em>H. parainfluenzae<\/em> coloniza las v\u00edas respiratorias y el tracto urogenital humano. El material gen\u00e9tico de esta bacteria tiene una alta plasticidad, lo que le permite actuar como posible reservorio de genes de resistencia. El aumento de la prevalencia de cepas multirresistentes detectadas en los \u00faltimos a\u00f1os, combinado con el incremento de infecciones urogenitales asociadas a este microorganismo, subraya la necesidad de comprender detalladamente sus mecanismos de adquisici\u00f3n y propagaci\u00f3n de resistencia antibi\u00f3tica.<\/p>\n<p>Este trabajo describe los mecanismos moleculares de resistencia asociados a cuatro cepas multirresistentes de <em>H. parainfluenzae<\/em> aislados en pacientes con uretritis. Las cepas eran resistentes a seis familias de antibi\u00f3ticos, incluyendo beta-lact\u00e1micos, fluoroquinolonas, macr\u00f3lidos, tetraciclina, cloranfenicol y cotrimoxazol. Adem\u00e1s, ten\u00edan como particularidad un perfil de resistencia compatible con la presencia de la enzima ESBL, algo que no se hab\u00eda descrito anteriormente en esta especie. Mediante secuenciaci\u00f3n, se identific\u00f3 una beta-lactamasa blaCTX-M-15 integrada en el genoma debido a la transposici\u00f3n de nuevos elementos gen\u00e9ticos m\u00f3viles que confer\u00edan niveles elevados de resistencia a las cefalosporinas.<\/p>\n<p>\u00c9sta ha sido la primera vez que se detecta esta beta-lactamasa en <em>H. parainfluenzae<\/em>. El potencial de este pat\u00f3geno para acumular determinantes de resistencia antibi\u00f3tica, unido a la posibilidad de transmitir estos elementos a otros pat\u00f3genos asociados a infecciones de transmisi\u00f3n sexual, es un motivo de preocupaci\u00f3n para la salud p\u00fablica.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Este hallazgo, publicado en International Journal of Antimicrobial Agents, destaca la posibilidad de que este mecanismo de resistencia se propague a otros pat\u00f3genos de transmisi\u00f3n sexual.<\/p>\n","protected":false},"author":8,"featured_media":23378,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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