{"id":21830,"date":"2022-12-28T10:00:02","date_gmt":"2022-12-28T09:00:02","guid":{"rendered":"https:\/\/idibell.cat\/es\/?p=21830"},"modified":"2022-12-23T13:02:21","modified_gmt":"2022-12-23T12:02:21","slug":"un-receptor-hasta-ahora-considerado-promotor-de-muerte-en-celulas-tumorales-podria-promover-el-crecimiento-del-cancer-de-pulmon","status":"publish","type":"post","link":"https:\/\/idibell.cat\/es\/2022\/12\/un-receptor-hasta-ahora-considerado-promotor-de-muerte-en-celulas-tumorales-podria-promover-el-crecimiento-del-cancer-de-pulmon\/","title":{"rendered":"Un receptor hasta ahora considerado promotor de muerte en c\u00e9lulas tumorales podr\u00eda promover el crecimiento del c\u00e1ncer de pulm\u00f3n"},"content":{"rendered":"<p>En los \u00faltimos a\u00f1os, los <strong>receptores de la prote\u00edna TRAIL<\/strong> han centrado la atenci\u00f3n de la investigaci\u00f3n oncolog\u00eda ya que su activaci\u00f3n induce la muerte de muchas c\u00e9lulas tumorales sin atacar a las c\u00e9lulas sanas. Sin embargo, ahora, un grupo de investigaci\u00f3n del IDIBELL y del Instituto Catal\u00e1n de Oncolog\u00eda, en colaboraci\u00f3n con la Universidad de \u00c1msterdam, ha descubierto que estos receptores en c\u00e9lulas de c\u00e1ncer de pulm\u00f3n promueven efectos que estimular\u00edan el desarrollo de tumores.<\/p>\n<p>\u201c<em>Nuestros resultados sugieren que en c\u00e1ncer de pulm\u00f3n no es recomendable activar la v\u00eda TRAIL, al contrario, su inhibici\u00f3n se deber\u00eda tener en cuenta como posible opci\u00f3n terap\u00e9utica<\/em>\u201d, apunta la <strong>Dr. Cristina Mu\u00f1oz<\/strong>, jefa de grupo del IDIBELL y l\u00edder del proyecto.<\/p>\n<p>Los resultados publicados en la revista <a href=\"https:\/\/www.nature.com\/articles\/s41419-022-05495-0\"><strong><em>Cell Death and Disease<\/em><\/strong><\/a> muestran que en el c\u00e1ncer de pulm\u00f3n de c\u00e9lulas no peque\u00f1as los receptores de TRAIL promueven la secreci\u00f3n de una prote\u00edna proinflamatoria y proangiogenica llamada <strong>IL-8<\/strong>. De hecho, niveles altos de IL-8 est\u00e1n asociados a un mal pron\u00f3stico y a resistencia a la terapia.<\/p>\n<p>\u201c<em>La inhibici\u00f3n de la secreci\u00f3n de IL-8 ya se hab\u00eda propuesto con anterioridad como posible tratamiento del c\u00e1ncer de pulm\u00f3n y otros tumores s\u00f3lidos<\/em> -asegura <strong>Francesca Favaro<\/strong>, investigadora predoctoral del IDIBELL y la Universidad de \u00c1msterdam, y primera autora del trabajo-, <em>pero \u00bfqu\u00e9 impulsa la secreci\u00f3n de IL-8? Gracias a este trabajo sabemos que la modulaci\u00f3n de los receptores TRAIL podr\u00eda ser una v\u00eda de regulaci\u00f3n<\/em>\u201d.<\/p>\n<p>En <strong>muestras de tumores humanos<\/strong> parece confirmarse el potencial tumorogenico de TRAIL. Los pacientes con niveles elevados de TRAIL y sus receptores presentan mayor expresi\u00f3n de IL-8 y tumores con mayor vascularizaci\u00f3n, indicador de desarrollo tumoral.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><em>El Instituto de Investigaci\u00f3n Biom\u00e9dica de Bellvitge (IDIBELL) es un centro de investigaci\u00f3n en biomedicina creado en 2004. Est\u00e1 participado por el Hospital Universitario de Bellvitge y el Hospital de Viladecans del Instituto Catal\u00e1n de la Salud, el Instituto Catal\u00e1n de Oncolog\u00eda, la Universidad de Barcelona y el Ayuntamiento de L&#8217;Hospitalet de Llobregat.<\/em><\/p>\n<p><em>El IDIBELL es miembro del Campus de Excelencia Internacional de la Universidad de Barcelona HUBc y forma parte de la instituci\u00f3n CERCA de la Generalitat de Catalunya. En 2009 se convirti\u00f3 en uno de los cinco primeros centros de investigaci\u00f3n espa\u00f1oles acreditados como instituto de investigaci\u00f3n sanitaria por el Instituto de Salud Carlos III. Adem\u00e1s, forma parte del programa &#8220;HR Excellence in Research&#8221; de la Uni\u00f3n Europea y es miembro de EATRIS y REGIC. Desde el a\u00f1o 2018, IDIBELL es un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un estudio del IDIBELL y la Universidad de \u00c1msterdam publicado en la revista Cell Death and Disease demuestra que los receptores de la prote\u00edna TRAIL inducen la expresi\u00f3n de IL-8, una prote\u00edna que promueve el desarrollo tumoral y la angiog\u00e9nesis de los tumores pulmonares.<\/p>\n","protected":false},"author":8,"featured_media":21831,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[184,245,281],"tags":[],"class_list":["post-21830","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-area-cancer","category-metabolismo-y-muerte-celular","category-programa-de-mecanismos-moleculares-y-terapia-experimental-en-oncologia-oncobell"],"publishpress_future_action":{"enabled":false,"date":"2025-05-13 04:20:00","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/21830","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=21830"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/21830\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media\/21831"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=21830"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=21830"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=21830"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}