{"id":21744,"date":"2022-12-07T11:39:40","date_gmt":"2022-12-07T10:39:40","guid":{"rendered":"https:\/\/idibell.cat\/es\/?p=21744"},"modified":"2022-12-07T11:55:25","modified_gmt":"2022-12-07T10:55:25","slug":"demuestran-la-efectividad-de-un-nuevo-test-para-medir-la-apatia-en-la-enfermedad-de-huntington","status":"publish","type":"post","link":"https:\/\/idibell.cat\/es\/2022\/12\/demuestran-la-efectividad-de-un-nuevo-test-para-medir-la-apatia-en-la-enfermedad-de-huntington\/","title":{"rendered":"Demuestran la efectividad de un nuevo test para medir la apat\u00eda en la enfermedad de Huntington"},"content":{"rendered":"<p><span data-contrast=\"auto\">La investigaci\u00f3n, liderada por la Dra. Estela C\u00e0mara y la investigadora de doctorado Audrey De Paepe, ayuda a entender la apat\u00eda, el perfil m\u00e1s psiqui\u00e1trico de la enfermedad de Huntington, que tiene un impacto muy grande en la calidad de vida de los pacientes.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:360}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">La apat\u00eda, que se define como una falta de motivaci\u00f3n e inter\u00e9s generalizado, es un s\u00edndrome m\u00e1s complejo que se divide en tres subtipos: la apat\u00eda cognitiva (falta de iniciativa para la realizaci\u00f3n de actividades cognitivas), el d\u00e9ficit en la autoactivaci\u00f3n (falta de empuje para empezar las cosas) y la apat\u00eda emocional (disminuci\u00f3n de expresi\u00f3n de emociones). Conocer bien la apat\u00eda es clave, puesto que es una manifestaci\u00f3n patol\u00f3gica en m\u00faltiples des\u00f3rdenes neurol\u00f3gicos. Por ejemplo, en el caso de la enfermedad de Huntington, la apat\u00eda se considera un marcador de progresi\u00f3n.\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:360}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Ahora un grupo del IDIBELL y la Universidad de Barcelona ha demostrado la efectividad de un test para medir la apat\u00eda en la enfermedad de Huntington que adem\u00e1s es capaz de discernir distintos perfiles ap\u00e1ticos. Este test, llamado LARS-s (siglas en ingl\u00e9s de Short-Lille Apathy Rating Scale) consiste en una entrevista estandarizada basada en una escala dicot\u00f3mica estructurada, reduciendo as\u00ed las interpretaciones subjetivas. \u00ab<\/span><i><span data-contrast=\"auto\">Hay mucha variabilidad entre los diferentes tipos ap\u00e1ticos, por tanto, estudiar los perfiles de apat\u00eda de cada paciente puede abrir nuevas perspectivas para entender esta sintomatolog\u00eda que actualmente tiene un tratamiento muy reducido.<\/span><\/i><span data-contrast=\"auto\">\u00bb Adem\u00e1s, \u00ab<\/span><i><span data-contrast=\"auto\">es clave tener escalas cl\u00ednicas que nos permitan establecer un diagn\u00f3stico diferencial apropiado con otros s\u00edntomas como la depresi\u00f3n o el deterioro cognitivo<\/span><\/i><span data-contrast=\"auto\">\u00bb a\u00f1ade la <\/span><b><span data-contrast=\"auto\">Dra. Estela C\u00e0mara<\/span><\/b><span data-contrast=\"auto\">, l\u00edder del proyecto e investigadora principal del IDIBELL.\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:360}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">En paralelo a la validaci\u00f3n del test, el estudio intenta correlacionar los distintos perfiles de apat\u00eda con la activaci\u00f3n de determinadas regiones cerebrales a partir de neuroimagen. Los resultados muestran que anat\u00f3micamente la apat\u00eda est\u00e1 relacionada con redes motoras, cognitivas y l\u00edmbicas, y que existe cierta correspondencia entre los distintos perfiles y la activaci\u00f3n de determinados ganglios corticales y subcorticales. La Dra. Estela C\u00e0mara concluye que \u00ab<\/span><i><span data-contrast=\"auto\">estos descubrimientos incentivan profundizar en el estudio de los subtipos de apat\u00eda para identificar dianas terap\u00e9uticas personalizadas en trastornos neurol\u00f3gicos adem\u00e1s de la enfermedad de Huntington<\/span><\/i><span data-contrast=\"auto\">\u00ab.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:360}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>El test es capaz de distinguir distintos subtipos de apat\u00eda en los pacientes de Huntington, lo que abre nuevas perspectivas a entender esta sintomatolog\u00eda considerada un marcador de progresi\u00f3n.\u00a0<\/p>\n","protected":false},"author":8,"featured_media":21745,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[320,279,277,1],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-09 14:46:03","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/21744"}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=21744"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/21744\/revisions"}],"predecessor-version":[{"id":21747,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/21744\/revisions\/21747"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media\/21745"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=21744"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=21744"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=21744"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}