{"id":20601,"date":"2022-05-10T09:30:48","date_gmt":"2022-05-10T07:30:48","guid":{"rendered":"https:\/\/idibell.cat\/es\/?p=20601"},"modified":"2022-05-10T09:31:42","modified_gmt":"2022-05-10T07:31:42","slug":"presentan-una-nueva-proteina-recombinante-que-revierte-el-estado-proinflamatorio-de-celulas-de-pacientes-con-lupus","status":"publish","type":"post","link":"https:\/\/idibell.cat\/es\/2022\/05\/presentan-una-nueva-proteina-recombinante-que-revierte-el-estado-proinflamatorio-de-celulas-de-pacientes-con-lupus\/","title":{"rendered":"Presentan una nueva prote\u00edna recombinante que revierte el estado proinflamatorio de c\u00e9lulas de pacientes con lupus"},"content":{"rendered":"<p>El grupo de investigaci\u00f3n del IDIBELL liderado por el Dr. Josep Maria Aran acaba de presentar en un art\u00edculo en la revista <a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.883743\/full\"><em>Frontiers in Immunology<\/em><\/a> una prote\u00edna recombinante con una prometedora actividad inmunomoduladora. <strong>La prote\u00edna en cuesti\u00f3n es capaz de hacer pasar las c\u00e9lulas del sistema inmunitario de un estado proinflamatorio a un estado tolerog\u00e9nico y antiinflamatorio.<\/strong><\/p>\n<p>El lupus es una enfermedad autoinmune en la que las c\u00e9lulas del sistema inmunitario atacan a los tejidos propios. Esto puede causar da\u00f1os importantes en muchas partes del cuerpo como articulaciones, ri\u00f1ones o pulmones. En este estudio los investigadores han demostrado que esta prote\u00edna recombinante es capaz de revertir el estado proinflamatorio, y, por tanto, el ataque al mismo cuerpo de las c\u00e9lulas del sistema inmunitario de pacientes con lupus nefritis.<\/p>\n<p>\u00ab<em>Esta capacidad de frenar el estado proinflamatorio de las c\u00e9lulas de los pacientes con lupus pone en evidencia el <strong>gran potencial terap\u00e9utico<\/strong> de esta prote\u00edna recombinante para el tratamiento del lupus y para otras enfermedades autoinmunitarias<\/em>\u00ab, afirma el <strong>Dr. Ar\u00e1n<\/strong>.<\/p>\n<p>La prote\u00edna recombinante que han desarrollado es una reestructuraci\u00f3n de una prote\u00edna reguladora del sistema inmunitario innato, la primera l\u00ednea de defensa de nuestro cuerpo. Los investigadores han identificado y reorganizado los dominios necesarios de esta prote\u00edna reguladora para conseguir el efecto modulador deseado evitando la actividad colateral no deseada de la prote\u00edna original.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><em>El Instituto de Investigaci\u00f3n Biom\u00e9dica de Bellvitge (IDIBELL) es un centro de investigaci\u00f3n en biomedicina creado en 2004. Est\u00e1 participado por el Hospital Universitario de Bellvitge y el Hospital de Viladecans del Instituto Catal\u00e1n de la Salud, el Instituto Catal\u00e1n de Oncolog\u00eda, la Universidad de Barcelona y el Ayuntamiento de L&#8217;Hospitalet de Llobregat.<\/em><\/p>\n<p><em>El IDIBELL es miembro del Campus de Excelencia Internacional de la Universidad de Barcelona HUBc y forma parte de la instituci\u00f3n CERCA de la Generalitat de Catalunya. En 2009 se convirti\u00f3 en uno de los cinco primeros centros de investigaci\u00f3n espa\u00f1oles acreditados como instituto de investigaci\u00f3n sanitaria por el Instituto de Salud Carlos III. Adem\u00e1s, forma parte del programa \u00abHR Excellence in Research\u00bb de la Uni\u00f3n Europea y es miembro de EATRIS y REGIC. Desde el a\u00f1o 2018, IDIBELL es un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>La prote\u00edna en cuesti\u00f3n es capaz de frenar la actividad proinflamatoria de las c\u00e9lulas del sistema inmunitario, y, por tanto, detener el ataque de \u00e9stas al propio cuerpo.<\/p>\n","protected":false},"author":8,"featured_media":20602,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[186,306,297],"tags":[],"class_list":["post-20601","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-area-medicina-traslacional","category-procesos-inmune-inflamatorios-y-terapia-genica","category-programa-de-genes-enfermedad-y-terapia"],"publishpress_future_action":{"enabled":false,"date":"2024-11-23 13:18:40","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/20601","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=20601"}],"version-history":[{"count":1,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/20601\/revisions"}],"predecessor-version":[{"id":20603,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/20601\/revisions\/20603"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media\/20602"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=20601"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=20601"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=20601"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}