{"id":19301,"date":"2021-12-29T10:30:27","date_gmt":"2021-12-29T09:30:27","guid":{"rendered":"https:\/\/idibell.cat\/es\/?p=19301"},"modified":"2021-12-23T15:34:46","modified_gmt":"2021-12-23T14:34:46","slug":"se-abren-nuevas-vias-en-el-tratamiento-de-la-fibrosis-quistica","status":"publish","type":"post","link":"https:\/\/idibell.cat\/es\/2021\/12\/se-abren-nuevas-vias-en-el-tratamiento-de-la-fibrosis-quistica\/","title":{"rendered":"Se abren nuevas v\u00edas en el tratamiento de la fibrosis qu\u00edstica"},"content":{"rendered":"<p><span data-contrast=\"auto\">La <strong>fibrosis qu\u00edstica es la enfermedad hereditaria m\u00e1s frecuente<\/strong> en la poblaci\u00f3n cauc\u00e1sica. Esta enfermedad est\u00e1 causada por una mutaci\u00f3n gen\u00e9tica que provoca, entre otras, afectaciones en v\u00edas a\u00e9reas. \u00c9stas se deshidratan y producen una mucosidad mucho m\u00e1s pegajosa que atrapa a los pat\u00f3genos con mayor facilidad, dando lugar a <strong>infecciones e inflamaciones recurrentes<\/strong>, lo que acaba siendo un problema cr\u00f3nico en\u00a0las\u00a0personas con fibrosis qu\u00edstica.<\/span><\/p>\n<p><span data-contrast=\"auto\">Los efectos sobre las <strong>v\u00edas respiratoria<\/strong>s inducen un incremento de las especies reactivas de ox\u00edgeno, mol\u00e9culas inestables que atacan a lo que tienen alrededor y provocan estr\u00e9s oxidativo. El estr\u00e9s oxidativo degrada las c\u00e9lulas y los tejidos y merma la eficacia de las defensas\u00a0contra\u00a0agresiones externas, favoreciendo las infecciones y la inflamaci\u00f3n mencionadas.\u00a0Ante esto,\u00a0las c\u00e9lulas activan una respuesta de protecci\u00f3n muy compleja regulada a nivel gen\u00e9tico.<\/span><\/p>\n<p><span data-contrast=\"auto\">Un estudio del\u00a0grupo\u00a0de\u00a0investigaci\u00f3n\u00a0en\u00a0<\/span><a href=\"https:\/\/idibell.cat\/es\/investigacion\/area-de-medicina-traslacional\/programa-de-genes-enfermedad-y-terapia\/procesos-inmune-inflamatorios-y-terapia-genica\/\"><span data-contrast=\"none\">Procesos\u00a0Inmunoinflamatorios\u00a0y\u00a0Terapia\u00a0G\u00e9nica<\/span><\/a><span data-contrast=\"auto\">\u00a0del IDIBELL con el\u00a0apoyo\u00a0de la\u00a0Unidad\u00a0de\u00a0Bioinform\u00e1tica\u00a0ha\u00a0realizado\u00a0un\u00a0an\u00e1lisis\u00a0con el\u00a0objetivo\u00a0de encontrar\u00a0nuevos\u00a0genes\u00a0y reguladores\u00a0relacionados\u00a0con la\u00a0respuesta\u00a0al\u00a0estr\u00e9s\u00a0oxidativo. Se han\u00a0identificado\u00a0varios\u00a0genes\u00a0y reguladores que\u00a0tienen\u00a0un\u00a0papel\u00a0importante\u00a0y, por\u00a0tanto,\u00a0ser\u00edan\u00a0posibles\u00a0<strong>candidatos\u00a0a la hora de\u00a0dise\u00f1ar\u00a0terapias<\/strong>.\u00a0Adem\u00e1s, en la\u00a0 misma\u00a0investigaci\u00f3n\u00a0tambi\u00e9n\u00a0buscaron\u00a0<strong>f\u00e1rmacos\u00a0ya\u00a0comercializados\u00a0que\u00a0puedan\u00a0ayudar<\/strong>\u00a0a\u00a0combatir\u00a0el\u00a0estr\u00e9s\u00a0oxidativo\u00a0mediante\u00a0los\u00a0genes\u00a0identificados\u00a0anteriormente.\u00a0Este trabajo ha recibido financiaci\u00f3n de la A<\/span><a href=\"https:\/\/fibrosiquistica.org\/es\/\"><span data-contrast=\"none\">sociaci\u00f3n Catalana de Fibrosis Qu\u00edstica<\/span><\/a><span data-contrast=\"auto\">\u00a0(ACFQ).<\/span><\/p>\n<p><i><span data-contrast=\"auto\">\u201cEstos f\u00e1rmacos, solos o combinados con los tratamientos actuales, podr\u00edan beneficiar a los pacientes con fibrosis qu\u00edstica previniendo la degradaci\u00f3n acelerada de los pulmones, que es uno de los peores efectos de la enfermedad\u201d<\/span><\/i><span data-contrast=\"auto\">\u00a0explica el\u00a0<\/span><b><span data-contrast=\"auto\">Dr. Josep\u00a0Maria\u00a0Aran<\/span><\/b><span data-contrast=\"auto\">, quien ha liderado este trabajo,\u00a0<\/span><i><span data-contrast=\"auto\">\u00abpero esto son resultados preliminares y para llevarlos a la pr\u00e1ctica es necesario realizar m\u00e1s experimentos controlados y ensayos cl\u00ednicos\u00bb.<\/span><\/i><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><em>El Instituto de Investigaci\u00f3n Biom\u00e9dica de Bellvitge (IDIBELL) es un centro de investigaci\u00f3n en biomedicina creado en 2004. Est\u00e1 participado por el Hospital Universitario de Bellvitge y el Hospital de Viladecans del Instituto Catal\u00e1n de la Salud, el Instituto Catal\u00e1n de Oncolog\u00eda, la Universidad de Barcelona y el Ayuntamiento de L\u2019Hospitalet de Llobregat.<\/em><\/p>\n<p><em>El IDIBELL es miembro del Campus de Excelencia Internacional de la Universidad de Barcelona HUBc y forma parte de la instituci\u00f3n CERCA de la Generalitat de Catalunya. En 2009 se convirti\u00f3 en uno de los cinco primeros centros de investigaci\u00f3n espa\u00f1oles acreditados como instituto de investigaci\u00f3n sanitaria por el Instituto de Salud Carlos III. Adem\u00e1s, forma parte del programa \u00abHR Excellence in Research\u00bb de la Uni\u00f3n Europea y es miembro de EATRIS y REGIC. Desde el a\u00f1o 2018, IDIBELL es un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un\u00a0grupo\u00a0de\u00a0investigaci\u00f3n\u00a0del IDIBELL ha\u00a0identificado\u00a0genes\u00a0relacionados\u00a0con la\u00a0respuesta\u00a0al\u00a0estr\u00e9s\u00a0oxidativo\u00a0que\u00a0podr\u00edan\u00a0ayudar\u00a0a\u00a0dise\u00f1ar\u00a0nuevos\u00a0tratamientos para la fibrosis qu\u00edstica.<\/p>\n","protected":false},"author":8,"featured_media":19344,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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