grupo de Neurooncolog\u00eda<\/strong><\/a> del IDIBELL, el ICO y el HUB.<\/p>\nLos investigadores han administrado a las c\u00e9lulas tumorales una sustancia derivada de la planta del algod\u00f3n, el gossipol, que potencia la actividad de DFF40\/CAD. El resultado es que, en las c\u00e9lulas tratadas, el proceso de fragmentaci\u00f3n se completa y la c\u00e9lula muere. Al contrario de otros f\u00e1rmacos, el gossipol permite que la DFF40\/CAD se mantenga en el n\u00facleo celular durante m\u00e1s tiempo, promoviendo su fragmentaci\u00f3n. Con este estudio se demuestra que compuestos como el gossipol pueden dirigir las c\u00e9lulas de glioblastoma hasta un punto de no retorno despu\u00e9s de poner en marcha el proceso de muerte celular sin necesidad de modificarlas gen\u00e9ticamente.<\/p>\n
Tal y como explican los investigadores, promover que la apoptosis finalice adecuadamente en las c\u00e9lulas tumorales de los pacientes podr\u00eda ser una buena estrategia terap\u00e9utica para tratar el glioblastoma. Los nuevos resultados ayudan a comprender mejor la biolog\u00eda de este tumor tan agresivo y pueden proporcionar nuevas herramientas para el desarrollo de estrategias m\u00e1s eficaces. Esto es especialmente interesante porque actualmente no existe ning\u00fan tratamiento para esta enfermedad.<\/p>\n
Este estudio es el resultado de una estrecha colaboraci\u00f3n entre investigaci\u00f3n b\u00e1sica y cl\u00ednica. El Dr. V\u00edctor J. Yuste del INc ha liderado un equipo multidisciplinar de investigadores b\u00e1sicos, neuro-onc\u00f3logos, pat\u00f3logos y neurocirujanos, de la UAB, del Instituto de Investigaci\u00f3n Biom\u00e9dica de Bellvitge (IDIBELL) – Hospital Universitario de Bellvitge (HUB ), del Instituto Catal\u00e1n de Oncolog\u00eda (ICO), del Instituto Catal\u00e1n de Nanociencia y Nanotecnolog\u00eda (ICN2) y del Instituto de Investigaci\u00f3n de Biom\u00e9dica de Lleida (IRBLleida). Esta investigaci\u00f3n ha sido financiada por el Ministerio de Ciencia e Innovaci\u00f3n y cofinanciada con fondos FEDER.<\/p>\n","protected":false},"excerpt":{"rendered":"
La apoptosis es el mecanismo por el que las c\u00e9lulas defectuosas del cuerpo promueven su propia muerte para proteger al organismo. Se trata de un proceso complejo, con muchas etapas, en el que las distintas partes de la c\u00e9lula se van degradando. Pero en las c\u00e9lulas de glioblastoma, aunque la apoptosis comienza, se detiene en […]<\/p>\n","protected":false},"author":8,"featured_media":19178,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[184,252,281],"tags":[],"class_list":["post-19177","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-area-cancer","category-neuro-oncologia","category-programa-de-mecanismos-moleculares-y-terapia-experimental-en-oncologia-oncobell"],"publishpress_future_action":{"enabled":false,"date":"2024-11-28 23:50:18","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/19177","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=19177"}],"version-history":[{"count":1,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/19177\/revisions"}],"predecessor-version":[{"id":19179,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/19177\/revisions\/19179"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media\/19178"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=19177"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=19177"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=19177"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}