{"id":15545,"date":"2020-11-20T10:20:57","date_gmt":"2020-11-20T09:20:57","guid":{"rendered":"https:\/\/idibell.cat\/es\/?p=15545"},"modified":"2023-08-01T18:24:38","modified_gmt":"2023-08-01T16:24:38","slug":"la-combinacion-de-dos-farmacos-inmunomoduladores-podria-ser-beneficioso-para-los-pacientes-mas-graves-de-covid-19","status":"publish","type":"post","link":"https:\/\/idibell.cat\/es\/2020\/11\/la-combinacion-de-dos-farmacos-inmunomoduladores-podria-ser-beneficioso-para-los-pacientes-mas-graves-de-covid-19\/","title":{"rendered":"La combinaci\u00f3n de dos f\u00e1rmacos inmunomoduladores podr\u00eda ser beneficioso para los pacientes m\u00e1s graves de Covid-19"},"content":{"rendered":"<p>Hasta un total de 44 investigadores del Instituto de Investigaci\u00f3n Biom\u00e9dica de Bellvitge (<a href=\"https:\/\/idibell.cat\/es\/investigacion\/area-de-medicina-traslacional\/programa-de-enfermedades-cardiovasculares-respiratorias-sistemicas-y-de-envejecimiento-celular\/enfermedades-sistemicas-y-envejecimiento\/\">IDIBELL<\/a>) y del Hospital Universitario de Bellvitge (<a href=\"https:\/\/bellvitgehospital.cat\/es\/inicio\">HUB<\/a>) firman conjuntamente un art\u00edculo en la revista International <a href=\"https:\/\/www.ijidonline.com\/article\/S1201-9712(20)32202-5\/fulltext\"><em>Journal of Infectious Diseases<\/em><\/a>, d\u00f3nde demuestran el efecto beneficioso del uso de corticoesteroides a\u00f1adidos al tratamiento con tocilizumab para mejorar el pron\u00f3stico de los enfermos graves de Covid-19.<\/p>\n<p>Los resultados que tenemos hasta el momento indican que los estadios m\u00e1s avanzados y graves de la Covid-19 podr\u00edan estar causados \u200b\u200bpor una fuerte reacci\u00f3n inmunol\u00f3gica de los pacientes, es por eso que se ha recomendado el uso de <strong>f\u00e1rmacos inmunomoduladores<\/strong>, como el tocilizumab o los corticoesteroides, en este tipo de pacientes. Hay varios estudios que indican que el efecto del tocilizumab resulta beneficioso, sin embargo, hasta el momento no hab\u00eda evidencias de si la combinaci\u00f3n con corticoesteroides podr\u00eda representar una ventaja. Por este motivo, desde el IDIBELL y el Hopsital Universitario de Bellvitge se inici\u00f3 un estudio retrospectivo para evaluar la respuesta de los pacientes que hab\u00edan sido tratados s\u00f3lo con tocilizumab, o bien, con tocilizumab y corticoesteroides.<\/p>\n<p>El inter\u00e9s del art\u00edculo radica tanto en sus relevantes resultados como en el inusual n\u00famero de firmantes del art\u00edculo, lo que constituye un homenaje a la importante labor que los profesionales del IDIBELL y el HUB est\u00e1n haciendo de manera transversal.<\/p>\n<p>El estudio ha incluido <strong>186 enfermos de Covidien-19<\/strong> tratados con tocilizumab los meses de marzo y abril -una de las series m\u00e1s largas publicadas-, de los cuales 129 recibieron tambi\u00e9n corticoesteroides. Las conclusiones, adem\u00e1s de revelar el efecto beneficioso de los corticoesteroides a\u00f1adidos a tocilizumab en el pron\u00f3stico de los enfermos graves, indican tambi\u00e9n que la mortalidad se asoci\u00f3 a la edad avanzada, la insuficiencia card\u00edaca cr\u00f3nica, y en la enfermedad hep\u00e1tica. Aun as\u00ed, la idoneidad del uso de tocilizumab para los casos de Covid-19, con esteroides o sin, es todav\u00eda objeto de debate.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hasta un total de 44 investigadores del Instituto de Investigaci\u00f3n Biom\u00e9dica de Bellvitge (IDIBELL) y del Hospital Universitario de Bellvitge (HUB) firman conjuntamente un art\u00edculo en la revista International Journal of Infectious Diseases, d\u00f3nde demuestran el efecto beneficioso del uso de corticoesteroides a\u00f1adidos al tratamiento con tocilizumab para mejorar el pron\u00f3stico de los enfermos graves de Covid-19.<\/p>\n","protected":false},"author":8,"featured_media":15546,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[186,308],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-09 14:50:10","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/15545"}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=15545"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/15545\/revisions"}],"predecessor-version":[{"id":23125,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/15545\/revisions\/23125"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media\/15546"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=15545"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=15545"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=15545"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}