{"id":13242,"date":"2020-04-24T12:00:12","date_gmt":"2020-04-24T10:00:12","guid":{"rendered":"https:\/\/idibell.cat\/es\/?p=13242"},"modified":"2020-05-26T16:48:16","modified_gmt":"2020-05-26T14:48:16","slug":"describen-las-vias-de-regulacion-de-un-enzima-clave-en-la-excitacion-de-las-celulas-fotorreceptoras-de-la-retina","status":"publish","type":"post","link":"https:\/\/idibell.cat\/es\/2020\/04\/describen-las-vias-de-regulacion-de-un-enzima-clave-en-la-excitacion-de-las-celulas-fotorreceptoras-de-la-retina\/","title":{"rendered":"Describen las v\u00edas de regulaci\u00f3n de un enzima clave en la excitaci\u00f3n de las c\u00e9lulas fotorreceptoras de la retina"},"content":{"rendered":"<p>La excitaci\u00f3n en respuesta a la luz de las c\u00e9lulas fotorreceptoras de la retina, los conocidos conos y bastones, es altamente dependiente de los niveles intracelulares de la mol\u00e9cula GMPc. El <strong>GMPc<\/strong> regula la apertura de los canales de membrana que frenar\u00e1 la excitaci\u00f3n de los fotorreceptores, es por eso, que en oscuridad encontramos niveles altos de GMPc y en la luz niveles bajos.<\/p>\n<p>El grupo de la Dra. Ana Mendez, del Instituto de Investigaci\u00f3n Biom\u00e9dica de Bellvitge (IDIBELL) i de la Facultad de Medicina y Ciencias de la Salut de la Universidad de Barcelona (UB), ha llevado a cabo un extenso trabajo, encabezado por Anna Plana-Bonamais\u00f3, para profundizar en el conocimiento del metabolismo del GMPc que regula la respuesta a la luz. El foco de este estudio, publicado en la revista <a href=\"https:\/\/elifesciences.org\/articles\/56418\"><em>eLife<\/em><\/a>, se cierne sobre el <strong>enzima IMPDH1<\/strong>, implicado en la producci\u00f3n del sustrato necesario para la formaci\u00f3n de GMPc. Sin la materia prima no podremos producir GMPc, y por lo tanto, no podremos controlar la excitaci\u00f3n de los fotorreceptores.<\/p>\n<p>Las observaciones de este estudio apuntan a que, con la finalidad de adaptar la producci\u00f3n de la materia prima del GMPc a su demanda, en funci\u00f3n de las condiciones de iluminaci\u00f3n, el enzima IMPDH1 es regulado a muchos niveles. Este trabajo revela que la actividad de este enzima<em> in vivo<\/em> es regulada por fosforilaci\u00f3n del dominio sensor de GDP\/GTP (el sustrato o materia prima en la s\u00edntesis de GMPc).\u00a0 La fosforilaci\u00f3n dependiente de luz desensibiliza el enzima de la inhibici\u00f3n por sustrato, de forma que la actividad enzim\u00e1tica aumenta con la intensidad de la luz.\u00a0 En condiciones fisiol\u00f3gicas, este mecanismo contribuir\u00eda a adaptar la fisiolog\u00eda de los fotorreceptores a las condiciones de iluminaci\u00f3n.<\/p>\n<p>Un aspecto de gran inter\u00e9s es que las mutaciones en IMPDH1 asociadas a ceguera se sit\u00faan precisamente en este dominio regulador, lo que apunta que estas mutaciones alterarian este mecanismo de regulaci\u00f3n conllevando la activaci\u00f3n continuada del enzima. Este trabajo sugiere que en las cegueras ligadas a IMPDH1, la neurodegeneraci\u00f3n de la retina estar\u00eda causada por un desequilibrio en los niveles de GMPc, y prev\u00e9 la posibilidad de contemplar el uso de inhibidores espec\u00edficos de IMPDH como potenciales terapias en estas cegueras.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>En funci\u00f3n de los niveles de iluminaci\u00f3n, la enzima IMPDH1 es regulado a muchos niveles, lo que permite adaptar la excitabilidad de los fotorreceptores.<\/p>\n","protected":false},"author":8,"featured_media":13243,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[320,199,277],"tags":[],"class_list":["post-13242","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-area-neurociencias","category-bases-celulares-y-moleculares-de-los-trastornos-sensoriales","category-programa-de-neurociencias"],"publishpress_future_action":{"enabled":false,"date":"2025-05-18 12:02:38","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/13242","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=13242"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/13242\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media\/13243"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=13242"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=13242"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=13242"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}