{"id":13189,"date":"2020-05-15T12:00:19","date_gmt":"2020-05-15T10:00:19","guid":{"rendered":"https:\/\/idibell.cat\/es\/?p=13189"},"modified":"2020-05-19T08:05:18","modified_gmt":"2020-05-19T06:05:18","slug":"el-idibell-ha-participado-en-un-estudio-que-describe-que-la-capacidad-de-producir-proteinas-define-las-celulas-madre-tumorales","status":"publish","type":"post","link":"https:\/\/idibell.cat\/es\/2020\/05\/el-idibell-ha-participado-en-un-estudio-que-describe-que-la-capacidad-de-producir-proteinas-define-las-celulas-madre-tumorales\/","title":{"rendered":"El IDIBELL ha participado en un estudio que describe que la capacidad de producir prote\u00ednas define las c\u00e9lulas madre tumorales"},"content":{"rendered":"

\"\"La<\/span> composici\u00f3n celular de los tumores de <\/span>c\u00e1ncer de colon<\/strong> es heterog\u00e9nea, podemos encontrar desde c\u00e9lulas diferenciadas, semejantes a las del mismo tejido del colon, hasta c\u00e9lulas madre o pluripotentes, responsables del crecimiento del tumor y la met\u00e1stasis. Un estudio publicado en la revista <\/span>Cell Stem Cell<\/em><\/a> liderado por el Dr. Edurad Batlle del Instituto de Investigaci\u00f3n Biom\u00e9dica (<\/span>IRB<\/a>) y en que han participado el equipo del Dr. Alberto Villanueva del <\/span>IDIBELL<\/a> \/ <\/span>ICO<\/a>, demuestra que la capacidad de sintetizar prote\u00ednas, <\/span>capacidad biosint\u00e9tica<\/strong>, es la que convierte las c\u00e9lulas en pluripotentes y la que les permite contribuir en el crecimiento del tumor de manera ilimitada.<\/span><\/span><\/span><\/p>\n

Para estudiar la capacidad biosint\u00e9tica de las c\u00e9lulas madre tumorales se han utilizado varios modelos, entre ellos, la implantaci\u00f3n de tumores de c\u00e1ncer colorrectal humanos en ratones<\/strong>, modelo desarrollado por el equipo del Dr. Villanueva. El conjunto de los modelos ha puesto en evidencia que, al bloquear la capacidad biosint\u00e9tica de las c\u00e9lulas, o al eliminar las c\u00e9lulas que tienen esta capacidad, se frena por completo el crecimiento tumoral, lo que convierte esta funci\u00f3n en una diana ideal para futuros tratamientos.<\/p>\n

El estudio describe que la capacidad de producir prote\u00ednas se encuentra restringida a las regiones del tumor donde se encuentran las c\u00e9lulas pluripotentes, y que adem\u00e1s, los tumores presentan un gradiente de producci\u00f3n de prote\u00ednas, y aquellas c\u00e9lulas que han perdido esta capacidad por completo no pueden volver al estado de c\u00e9lulas madre.<\/p>\n

Texto adaptado de la p\u00e1gina web del IRB: https:\/\/www.irbbarcelona.org\/ca\/news\/la-capacitat-biosintetica-clau-per-erradicar-les-cellules-mare-tumorals<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

La producci\u00f3n de prote\u00ednas es lo que define las c\u00e9lulas madre tumorales, lo que convierte esta funci\u00f3n en una diana terap\u00e9utica ideal.<\/p>\n","protected":false},"author":8,"featured_media":13191,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[184,281,206],"tags":[],"class_list":["post-13189","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-area-cancer","category-programa-de-mecanismos-moleculares-y-terapia-experimental-en-oncologia-oncobell","category-quimioresistencia-tumoral-y-estromal"],"publishpress_future_action":{"enabled":false,"date":"2024-12-25 20:41:39","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/13189","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=13189"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/13189\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media\/13191"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=13189"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=13189"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=13189"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}