Seg\u00fan el estudio, entre los pacientes con c\u00e1ncer rectal localmente avanzado tratados de forma simult\u00e1nea con quimioterapia y radioterapia, y cirug\u00eda posterior, la desaparici\u00f3n completa de c\u00e9lulas cancer\u00edgenas detectables (llamada respuesta patol\u00f3gica completa) tras quimiorradioterapia y cirug\u00eda est\u00e1 ligada a mejores resultados a largo plazo. Estos pacientes sobreviven m\u00e1s a\u00f1os sin enfermedad y tienen menos riesgo de met\u00e1stasis.<\/p>\n
Este hecho, aparentemente obvio, no hab\u00eda podido ser demostrado de forma clara hasta ahora y abre la puerta a personalizar los tratamientos. En el estudio publicado en Lancet Oncology, los investigadores han revisado los datos de 17 estudios publicados en revistas cient\u00edficas. De los 3.105 pacientes que hab\u00edan participado en estas investigaciones, 484 presentaban una respuesta patol\u00f3gica completa tras recibir radioterapia preoperatoria. Cinco a\u00f1os despu\u00e9s, el 83,3% de estos pacientes continuaba sin la enfermedad, comparado con el 65,6% de los afectados que no presentaban desaparici\u00f3n completa de las c\u00e9lulas cancer\u00edgenas tras el tratamiento combinado.<\/p>\n Despu\u00e9s de analizar los principales estudios publicados sobre el tema (realizados muchos de ellos por los mismos autores), los investigadores concluyen que la respuesta patol\u00f3gica completa tras recibir quimioterapia o radioterapia parece ser un predictor de buen pron\u00f3stico en pacientes con c\u00e1ncer rectal localmente avanzado.<\/p>\n El jefe del grupo de investigaci\u00f3n de Patolog\u00eda del Tubo Digestivo del IDIBELL y jefe de secci\u00f3n de Aparato Digestivo del Hospital Universitario de Bellvitge, Sebastiano Biondo, destaca que \u201clas conclusiones del estudio son cl\u00ednicamente relevantes porque permitir\u00edan evitar la realizaci\u00f3n de posteriores tratamientos a los pacientes que responden bien o intensificarlos si no responden\u201d. Incluso, explica el Dr. Biondo, \u201cse podr\u00eda llegar a evitar la cirug\u00eda o hacerla menos invasiva si los pacientes responden excepcionalmente bien al tratamiento combinado de radioterapia y quimioterapia.\u201d Revisi\u00f3n de estudios Referencia del art\u00edculo<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[186,296,235,281,318],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-05 00:51:44","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11483"}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=11483"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11483\/revisions"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=11483"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=11483"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=11483"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Revisi\u00f3n de estudios<\/strong><\/p>\n
Referencia del art\u00edculo<\/strong>
Monique Maas, Patty J Nelemans, Vincenzo Valentini, Prajnan Das, Claus R\u00f6del, Li-Jen Kuo, Felipe A Calvo, Julio Garc\u00eda-Aguilar, Rob Glynne-Jones, Karin Haustermans, Mohammed Mohiuddin, Salvatore Pucciarelli, William Small Jr, Javier Su\u00e1rez, George Theodoropoulos, Sebastiano Biondo*, Regina G H Beets-Tan, Geerard L Beets. Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data. Lancet Oncol 2010; 11: 835\u201344.<\/p>\n","protected":false},"excerpt":{"rendered":"