Todas las c\u00e9lulas del cuerpo humano poseen un n\u00facleo central donde se encuentra el ADN (nuestro material gen\u00e9tico), un medio acuoso (citoplasma) donde se producen las prote\u00ednas y tienen lugar los procesos metab\u00f3licos, y una capa perif\u00e9rica que rodea a toda la c\u00e9lula y le da forma (membrana plasm\u00e1tica). Existe un tr\u00e1fico continuo de mol\u00e9culas entre estos tres compartimentos para permitir el buen funcionamiento de la c\u00e9lula. <\/p>\n

El reciente descubrimiento del equipo dirigido por Manel Esteller, investigador ICREA en Barcelona, demuestra que este tr\u00e1fico se interrumpe en las c\u00e9lulas cancerosas. El grupo de peque\u00f1as mol\u00e9culas secuestradas por la c\u00e9lula tumoral en su n\u00facleo son los llamados microARNs que no pueden ejercer su actividad normal de inhibir el desarrollo del c\u00e1ncer. <\/p>\n

\u201cLos tumores descritos\u201d, explica Manel Esteller, \u201cpresentan una mutaci\u00f3n en una prote\u00edna denominada Exportina-5, cuya funci\u00f3n
en una c\u00e9lula sana es la de hacer de taxista y transportar los microARNs desde el n\u00facleo al citoplasma. Pero en estos c\u00e1nceres es incapaz de conducirlos fuera del n\u00facleo, por lo que se pierde su capacidad protectora antitumoral\u201d.<\/p>\n

\u201cEstos resultados tienen consecuencias para mejorar el conocimiento de las causas del c\u00e1ncer, pero tambi\u00e9n para posibles nuevos tratamientos, pues por un lado se descubre una nueva v\u00eda alterada en c\u00e1ncer que se desconoc\u00eda por completo; y, por otro,
se dispone de una nueva diana molecular, lo que deber\u00eda estimular la b\u00fasqueda de nuevos f\u00e1rmacos que ayuden a mejorar el transporte de mol\u00e9culas desde el n\u00facleo\u201d. Referencia del art\u00edculo<\/strong>
Melo SA, Moutinho C, Ropero S, Calin GA, Rossi S, Spizzo R, Fernandez AF, Davalos V, Villanueva A, Montoya G, Yamamoto H, Schwartz Jr, Esteller M. A Genetic Defect in Exportin-5 Traps Precursor MicroRNAs in the Nucleus of Cancer Cells. Cancer Cell<\/p>\n","protected":false},"excerpt":{"rendered":"

Referencia del art\u00edculo<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[286],"tags":[],"class_list":["post-11482","post","type-post","status-publish","format-standard","hentry","category-epigenetica-del-cancer-cancer"],"publishpress_future_action":{"enabled":false,"date":"2025-05-25 11:51:44","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11482","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=11482"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11482\/revisions"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=11482"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=11482"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=11482"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}