{"id":11469,"date":"2010-12-22T00:00:00","date_gmt":"2010-12-21T23:00:00","guid":{"rendered":"https:\/\/idibell.cat\/es\/blog\/2010\/12\/22\/identifican-en-pacientes-un-nuevo-gen-implicado-en-el-cancer-de-pulmon\/"},"modified":"2020-05-19T19:00:41","modified_gmt":"2020-05-19T17:00:41","slug":"identifican-en-pacientes-un-nuevo-gen-implicado-en-el-cancer-de-pulmon","status":"publish","type":"post","link":"https:\/\/idibell.cat\/es\/2010\/12\/identifican-en-pacientes-un-nuevo-gen-implicado-en-el-cancer-de-pulmon\/","title":{"rendered":"Identifican en pacientes un nuevo gen implicado en el c\u00e1ncer de pulm\u00f3n"},"content":{"rendered":"<p>Gracias a estos avances, un estudio realizado por investigadores del grupo de Genes y C\u00e1ncer del Programa de Epigen\u00e9tica y Biolog\u00eda del C\u00e1ncer del Instituto de Investigaci\u00f3n Biom\u00e9dica de Bellvitge (IDIBELL) ha identificado por primera vez en tejido tumoral primario de enfermos de c\u00e1ncer de pulm\u00f3n la mutaci\u00f3n del gen SMARCA4. En condiciones normales, este gen, tambi\u00e9n conocido con el nombre BRG1, permite producir una prote\u00edna que frena el desarrollo del c\u00e1ncer de pulm\u00f3n. Investigaciones previas realizadas tambi\u00e9n por los mismos investigadores del IDIBELL hab\u00edan detectado esta mutaci\u00f3n en cultivos celulares in vitro. El estudio, liderado por la investigadora Montse S\u00e1nchez-C\u00e9spedes, se acaba de publicar en la edici\u00f3n digital de la revista Human Mutation. <b><br \/> Los investigadores han utilizado una nueva t\u00e9cnica de screening masivo que permite detectar mutaciones de forma m\u00e1s precisa. Mientras que la t\u00e9cnica tradicional requiere que como m\u00ednimo un 10% de la muestra contenga c\u00e9lulas alteradas por poderlas identificar, el nuevo sistema es capaz de detectarlas con un 2%. <b><br \/> La mutaci\u00f3n en el gen SMARCA4 es la cuarta causa m\u00e1s frecuente de c\u00e1ncer de pulm\u00f3n de c\u00e9lula no peque\u00f1a, que supone el 80% de los c\u00e1nceres de pulm\u00f3n. <b><br \/> El estudio se ha publicado en la edici\u00f3n digital de la revista Human Mutation. El primer firmante de la investigaci\u00f3n, Salvador Rodr\u00edguez-Nieto, destaca que la identificaci\u00f3n de este gen en muestras tumorales de pacientes es importante para desarrollar nuevos f\u00e1rmacos en el futuro: \u201cla restauraci\u00f3n de la funci\u00f3n del gen alterado permite revertir el proceso tumoral, cosa que lo convierte en una diana terap\u00e9utica muy prometedora.\u201d <b><br \/> El de pulm\u00f3n es uno de los c\u00e1nceres m\u00e1s frecuentes en el mundo. Es la primera causa de muerte por c\u00e1ncer en los pa\u00edses desarrollados. La tasa de supervivencia de los afectados contin\u00faa siendo muy baja porque es dif\u00edcil detectarlo antes de diseminarse a otros \u00f3rganos del cuerpo. Nueve de cada diez c\u00e1nceres de pulm\u00f3n est\u00e1n causados por el tabaco. <b><br \/> Aunque el c\u00e1ncer de pulm\u00f3n es uno de los m\u00e1s estudiados a nivel gen\u00e9tico, todav\u00eda falta mucho camino para poder identificar todos los genes que intervienen en la aparici\u00f3n y la progresi\u00f3n de la enfermedad. <b><br \/> La investigaci\u00f3n ha contado con la colaboraci\u00f3n de investigadores del Centro Nacional de Investigaciones Oncol\u00f3gicas de Madrid (CNIO), del Hospital Virgen de la Arrixaca de Murcia, del Hospital Universitario Madrid Sanchinarro y del Instituto Nacional de Bioinform\u00e1tica de Madrid. Ha contado con la financiaci\u00f3n del Ministerio de Ciencia e Innovaci\u00f3n y de la Asociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer. <strong><b><br \/><\/strong> <strong>Referencia del art\u00edculo<\/strong> <strong><b><br \/><\/strong> <strong>Rodriguez-Nieto S*<\/strong>, Ca\u00f1ada A, <strong>Pros E*<\/strong>, <strong>Pinto AI*<\/strong>, Torres-Lanzas J, Lopez-Rios F, Sanchez-Verde L, Pisano DG, <strong>Sanchez-Cespedes M<\/strong>. Massive parallel DNA pyrosequencing analysis of the tumor suppressor BRG1\/SMARCA4 in lung primary tumors. Hum Mutat. 2010 Dec 7. [Epub ahead of print]. <b><br \/> <strong>*Investigadores IDIBELL<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Una investigaci\u00f3n del IDIBELL confirma que el gen supresor SMARCA4 est\u00e1 inactivo en tumores primarios de pulm\u00f3n  Referencia del art\u00edculo  Rodriguez-Nieto S* Pros E* Pinto AI* Sanchez-Cespedes M *Investigadores IDIBELL<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[184,286],"tags":[],"class_list":["post-11469","post","type-post","status-publish","format-standard","hentry","category-area-cancer","category-epigenetica-del-cancer-cancer"],"publishpress_future_action":{"enabled":false,"date":"2024-12-30 01:33:52","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11469","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=11469"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11469\/revisions"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=11469"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=11469"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=11469"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}