{"id":11450,"date":"2011-02-28T00:00:00","date_gmt":"2011-02-27T23:00:00","guid":{"rendered":"https:\/\/idibell.cat\/es\/blog\/2011\/02\/28\/la-proteina-p-rex-podria-ser-una-diana-terapeutica-para-diferentes-tipos-de-cancer\/"},"modified":"2020-05-26T15:47:14","modified_gmt":"2020-05-26T13:47:14","slug":"la-proteina-p-rex-podria-ser-una-diana-terapeutica-para-diferentes-tipos-de-cancer","status":"publish","type":"post","link":"https:\/\/idibell.cat\/es\/2011\/02\/la-proteina-p-rex-podria-ser-una-diana-terapeutica-para-diferentes-tipos-de-cancer\/","title":{"rendered":"\u2018La prote\u00edna P-REX podr\u00eda ser una diana terap\u00e9utica para diferentes tipos de c\u00e1ncer\u2019"},"content":{"rendered":"<p>Pandiella ha explicado que la P-REX activa mecanismos de se\u00f1alizaci\u00f3n relacionados con el sistema HER\/ErbB que contribuyen a la proliferaci\u00f3n del c\u00e1ncer de mama. \u201cEs por tanto un factor pron\u00f3stico negativo\u201d ha afirmado el investigador del CIC. Seg\u00fan Pandiella \u201clos pacientes de mama que presentan P-REX van peor. Esto indica que P-REX puede ser una diana terap\u00e9utica no s\u00f3lo para c\u00e1ncer de mama sino para diferentes tipos de c\u00e1ncer\u201d. De hecho ha afirmado que su laboratorio ya est\u00e1 en contacto con un grupo de investigaci\u00f3n en Estados Unidos para averiguar si estos modelos pre-cl\u00ednicos pueden ser de utilidad para el descubrimiento de nuevas terapias. <b><br \/> <strong>Sobre Pandiella<\/strong> <b><br \/> El Dr. Pandiella obtuvo su doctorado en Medicina y cirug\u00eda por la Universidad de Santiago de Compostela. Su formaci\u00f3n cient\u00edfica incluye cuatro a\u00f1os como investigador pre y post-doctoral en el Ospedale San Raffaele de Mil\u00e1n y tres a\u00f1os en el Memorial Sloan Kettering Center de Nueva York. De 1994 a 2001 form\u00f3 parte del Instituto de Microbiolog\u00eda Bioqu\u00edmica de la Universidad de Salamanca. Actualmente es investigador principal del Instituto de Biolog\u00eda Molecular del C\u00e1ncer Celular (IBMCC) del Centro de Investigaci\u00f3n de C\u00e1ncer dependiente del CSIC y de la Universidad de Salamanca. Su investigaci\u00f3n se centra en la caracterizaci\u00f3n funcional de mol\u00e9culas implicadas en la g\u00e9nesis y progresi\u00f3n de varios tumores humanos, especialmente los tumores mamarios.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sobre Pandiella<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[184],"tags":[],"class_list":["post-11450","post","type-post","status-publish","format-standard","hentry","category-area-cancer"],"publishpress_future_action":{"enabled":false,"date":"2025-05-04 04:36:08","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11450","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=11450"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11450\/revisions"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=11450"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=11450"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=11450"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}