{"id":11432,"date":"2011-04-19T00:00:00","date_gmt":"2011-04-18T22:00:00","guid":{"rendered":"https:\/\/idibell.cat\/es\/blog\/2011\/04\/19\/henning-walczak-tenemos-todos-los-mecanismos-a-nuestro-alcance-para-conocer-al-enemigo-y-combatirlo\/"},"modified":"2020-05-26T12:19:46","modified_gmt":"2020-05-26T10:19:46","slug":"henning-walczak-tenemos-todos-los-mecanismos-a-nuestro-alcance-para-conocer-al-enemigo-y-combatirlo","status":"publish","type":"post","link":"https:\/\/idibell.cat\/es\/2011\/04\/henning-walczak-tenemos-todos-los-mecanismos-a-nuestro-alcance-para-conocer-al-enemigo-y-combatirlo\/","title":{"rendered":"Henning Walczak: \u201cTenemos todos los mecanismos a nuestro alcance para conocer al enemigo y combatirlo\u201d"},"content":{"rendered":"<p>El grupo de investigaci\u00f3n de Walczak tiene como objetivo entender c\u00f3mo el sistema inmune ataca espec\u00edficamente al c\u00e1ncer y descubrir los mecanismos utilizados por los tumores para contrarrestar estos ataques. El investigador ha explicado su investigaci\u00f3n en la v\u00eda de se\u00f1alizaci\u00f3n de TRAIL (ligando inductor de apoptosis relacionado con el factor de necrosis tumoral, TNF) para descubrir nuevas dianas terap\u00e9uticas que se puedan combinar con otros f\u00e1rmacos y provoquen la muerte de las c\u00e9lulas tumorales. De forma que, ha explicado Walczak, \u201cpodremos predecir si las combinaciones con f\u00e1rmacos agonistas del receptor de TRAIL se pueden aplicar con \u00e9xito o no en un paciente con un tumor particular\u201d. De hecho actualmente hay varios agonistas de TRAIL-R en fase de ensayo cl\u00ednico pero Henning Walczak opina que \u201cla l\u00f3gica de la industria no est\u00e1 permitiendo, por el momento, encontrar las combinaciones de f\u00e1rmacos adecuadas y que puedan ser efectivas para un tratamiento personalizado del c\u00e1ncer\u201d. <b><br \/> Walczak tambi\u00e9n ha explicado los resultados de un estudio de su grupo publicado a la prestigiosa revista Nature que describe como una prote\u00edna denominada Sharpin interfiere en la muerte celular inducida por TNF, y por lo tanto previene la inflamaci\u00f3n. Los resultados, dice el investigador, evidencian la relevancia de la ubiquitinaci\u00f3n linear <em>in vivo<\/em> en la prevenci\u00f3n de la inflamaci\u00f3n y en la regulaci\u00f3n de la se\u00f1al inmune. Factores que pueden ser claves en el tratamiento de enfermedades inflamatorias y autoinmunes como la artritis reum\u00e1tica o la enfermedad de Cr\u00f6hn entre otras.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>El grupo de investigaci\u00f3n de Walczak tiene como objetivo entender c\u00f3mo el sistema inmune ataca espec\u00edficamente al c\u00e1ncer y descubrir los mecanismos utilizados por los tumores para contrarrestar estos ataques. El investigador ha explicado su investigaci\u00f3n en la v\u00eda de se\u00f1alizaci\u00f3n de TRAIL (ligando inductor de apoptosis relacionado con el factor de necrosis tumoral, TNF) [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-11 14:35:15","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11432"}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=11432"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11432\/revisions"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=11432"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=11432"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=11432"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}